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41. 发明授权

US06225130B1 Method of separating serum from whole blood 失效
标题翻译：从全血中分离血清的方法
公开(公告)号：US06225130B1
公开(公告)日：2001-05-01
申请号：US09252310
申请日：1999-02-18
申请人： Masao Kitajima , Akemi Higo , Shigeru Tezuka
发明人： Masao Kitajima , Akemi Higo , Shigeru Tezuka
IPC分类号： G01N118
CPC分类号： G01N33/491 , B01L3/502 , Y10T436/106664 , Y10T436/119163 , Y10T436/25 , Y10T436/25375
摘要： A method for separating serum from whole blood in a vessel at an insertion speed of 30 cm/sec or less and maintaining the suction pressure of the suction nozzle at 400 mm Hg or less. Improved analytical results are obtained because the serum can be produced without hemolysis.
摘要翻译：以30cm /秒以下的插入速度将容器中的血液从血液中分离出来并将吸嘴的吸入压力维持在400mmHg以下的方法。获得改进的分析结果，因为血清可以在没有溶血的情况下产生。

42. 发明授权

US06217540B1 Blood filter cartridge 失效
标题翻译：血液滤芯
公开(公告)号：US06217540B1
公开(公告)日：2001-04-17
申请号：US09349173
申请日：1999-07-09
申请人： Kenichiro Yazawa , Keiichi Ishizaki , Takeshi Igarashi , Masao Kitajima , Shigeru Tezuka , Takaki Arai , Toshihisa Ito , Osamu Seshimoto
发明人： Kenichiro Yazawa , Keiichi Ishizaki , Takeshi Igarashi , Masao Kitajima , Shigeru Tezuka , Takaki Arai , Toshihisa Ito , Osamu Seshimoto
IPC分类号： A61M3700
CPC分类号： G01N33/491
摘要： The invention provides a blood filter cartridge which is made so that the filtrate discharged from the filtrate outlet is not drawn back to the inside of the filtering chamber. The blood filter cartridge includes a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver which receives the filtrate discharged from the filtrate outlet. The blood filter catridge is provided with a means for preventing the filtrate in the filtrate receiver from returning to inside of the holder upon finishing filtration. Such means include the following: removing opposite faces around the filtrate outlet, making length of lower end of the filtrate outlet 0.8 mm or more, smoothing surface around the filtrate outlet, and forming surface around the filtrate outlet by a material having a small surface energy.
摘要翻译：本发明提供了一种血液过滤器滤芯，其被制成使得从滤液出口排出的滤液不会被抽回到过滤室的内部。血液过滤器滤芯包括血液过滤材料，含有血液过滤材料并具有血液入口和滤液出口的保持器和接收从滤液出口排出的滤液的滤液接收器。血液过滤器夹具设置有用于防止滤液接收器中的滤液在完成过滤时返回到保持器内部的装置。这样的方法包括以下步骤：除去滤液出口周围的相对面，使滤液出口的下端长度为0.8mm以上，使滤液出口周围的表面光滑，并且通过具有小表面能的材料在滤液出口周围形成表面。

43. 发明授权

US06170671B2 Blood filter unit 失效
标题翻译：血液过滤器单元
公开(公告)号：US06170671B2
公开(公告)日：2001-01-09
申请号：US09290650
申请日：1999-04-12
申请人： Masao Kitajima , Kenichiro Yazawa , Shigeru Tezuka , Fumio Sugaya , Akemi Higo , Kiyotaka Fujiwara
发明人： Masao Kitajima , Kenichiro Yazawa , Shigeru Tezuka , Fumio Sugaya , Akemi Higo , Kiyotaka Fujiwara
IPC分类号： B01D2900
CPC分类号： B01D39/2017 , B01D61/18 , B01D61/20 , B01D69/12 , G01N33/491
摘要： The blood filter unit of the invention is composed of a blood filtering material made of glass fiber filter and microporous membrane and a holder having a blood inlet and a filtrate outlet. The holder accommodates the blood filtering material so that the microporous membrane is located on the filtrate outlet side, provides a space between the blood filtering material and the filtrate outlet, and provides a means for preventing adhesion of the blood filtering material on the filtrate outlet side. By using the blood filter unit, a necessary volume of plasma or serum for analysis can be separated surely, irrespective of hematocrit value of the blood.
摘要翻译：本发明的血液过滤器单元由玻璃纤维过滤器和微孔膜制成的血液过滤材料和具有血液入口和滤液出口的保持器构成。保持器容纳血液过滤材料，使得微孔膜位于滤液出口侧，提供血液过滤材料和滤液出口之间的空间，并提供防止血液过滤材料在滤液出口侧粘附的手段。通过使用血液过滤器单元，可以确定地分离所需体积的血浆或血清，而不管血液的血细胞比容值如何。

44. 发明授权

US5876605A Preparation of plasma or serum sample from whole blood 失效
标题翻译：从全血制备血浆或血清样品
公开(公告)号：US5876605A
公开(公告)日：1999-03-02
申请号：US784480
申请日：1997-01-17
申请人： Masao Kitajima , Kenichiro Yazawa
发明人： Masao Kitajima , Kenichiro Yazawa
IPC分类号： G01N33/48 , G01N1/28 , G01N33/50 , B01D61/00
CPC分类号： G01N33/491 , G01N33/5002 , Y10T436/25375 , Y10T436/255
摘要： The method of the invention is for preparing a plasma or serum sample from whole blood and includes mixing an aqueous solution of an inorganic salt or an amino acid or salt thereof with the whole blood in an amount of 20% or less of the whole blood volume so that concentration of the inorganic salt or the amino acid or salt thereof becomes 10 to 200 .mu.mol/1 ml whole blood, and then, filtering the whole blood to remove blood cell components. According to the method of the invention, plasma separation from whole blood can be achieved efficiently, and recovered volume of plasma can be increased. By selecting reagent, good plasma which has no deviation in component viewpoint, and which is possible to measure in the same level accuracy as a plasma obtained by centurifuging, can be obtained through a simple filtration operation.
摘要翻译：本发明的方法是从全血中制备血浆或血清样品，包括将无机盐或其氨基酸或其盐的水溶液与全血的全血量的20％或更少的量混合使无机盐或其氨基酸或其盐的浓度成为10〜200μmol/ ml全血，然后过滤全血以除血细胞成分。根据本发明的方法，能够有效地实现全血的血浆分离，能够提高等离子体的回收体积。通过选择试剂，可以通过简单的过滤操作获得组分观点没有偏差的良好的等离子体，并且可以以与通过中间脱色获得的等离子体相同的精度测量。

45. 发明授权

US4783315A Analysis material sheet 失效
标题翻译：分析材料表
公开(公告)号：US4783315A
公开(公告)日：1988-11-08
申请号：US758562
申请日：1985-07-23
申请人： Fuminori Arai , Kenichiro Yazawa , Hideaki Takeuchi , Masao Kitajima
发明人： Fuminori Arai , Kenichiro Yazawa , Hideaki Takeuchi , Masao Kitajima
IPC分类号： G01N31/22 , G01N33/52 , G01N33/66
CPC分类号： G01N33/525 , Y10T428/31736 , Y10T428/3175
摘要： An analysis material sheet is disclosed which is comprised of layers of material with strong adhesion for one another. The sheet includes a water-impermeable support having provided directly or indirectly thereon a layer of fabric. The fabric contains a hydrophobic organic polymer fiber and is physically activated on at least one surface thereof, with the physically activated surface being adhered directly or indirectly to the support. A reagent layer can be provided directly or indirectly on the liquid sample-spreading layer of fabric. By utilizing a fabric containing a hydrophobic organic polymer fiber, body fluids to be analyzed can be quickly and uniformly spread and by utilizing the physically activated surface of the fabric, strong adhesion between the layers can be obtained.
摘要翻译：公开了一种分析材料片，其由彼此具有强粘合性的材料层组成。片材包括直接或间接地在其上提供织物层的不透水支撑体。织物含有疏水性有机聚合物纤维，并在其至少一个表面上物理活化，物理活化表面直接或间接地粘附到载体上。试剂层可以直接或间接地提供在织物的液体样品铺展层上。通过使用含有疏水性有机聚合物纤维的织物，可以快速且均匀地分散待分析的体液，并且通过利用织物的物理活化表面，可以获得层间的强粘合性。

46. 发明授权

US4732849A Multilayered chemical analysis material for analysis of aqueous liquids 失效
标题翻译：用于水性液体分析的多层化学分析材料
公开(公告)号：US4732849A
公开(公告)日：1988-03-22
申请号：US828562
申请日：1986-02-10
申请人： Osamu Seshimoto , Masao Kitajima
发明人： Osamu Seshimoto , Masao Kitajima
IPC分类号： G01N31/22 , C12Q1/58 , G01N33/52 , G01N33/62
CPC分类号： G01N33/525 , C12Q1/58 , Y10S435/805
摘要： A multi-layered, chemical analysis material for analysis of an aqueous liquid, which comprises in one embodiment(a) a light-transmitting, water-impermeable support having provided thereon in sequence(b) a reagent layer and(c) a porous, sample-spreading layer, with(i) the reagent layer (b) containing a lake dye precursor dispersed in a hydrophilic binder,(ii) urease incorporated in the reagent layer (b) or in a layer adjacent the reagent layer (b), and(iii) a lake forming metal salt or lake forming metal oxide, which does not substantially inhibit the activity of urease, incorporated in the reagent layer (b) or in a layer adjacent the reagent layer (b) or a lake forming metal salt or oxide incorporated in a layer adjacent the reagent layer (b); and in a second embodiment the chemical analysis material includes(d) a radiation-blocking layer interposed between said reagent layer (b) and said porous, sample-spreading layer (c).
摘要翻译：一种用于分析水性液体的多层化学分析材料，其包括在一个实施方案中（a）在序列（b）中提供试剂层的透光性不透水性载体，（c）多孔，样品扩散层，（i）包含分散在亲水性粘合剂中的色淀前体的试剂层（b），（ii）引入试剂层（b）中的脲酶或与试剂层（b）相邻的层中的脲酶，并且（iii）形成金属盐或形成湖的金属氧化物的湖，其基本上不抑制尿素酶的活性，掺入试剂层（b）或试剂层（b）附近的层或形成湖的金属盐或掺入与试剂层（b）相邻的层中的氧化物; 在第二实施方案中，化学分析材料包括（d）插入在所述试剂层（b）和所述多孔样品扩散层（c）之间的辐射阻挡层。

47. 发明授权

US4587100A Multilayer analytical element for the detection of hydrogen peroxide 失效
标题翻译：用于检测过氧化氢的多层分析元件
公开(公告)号：US4587100A
公开(公告)日：1986-05-06
申请号：US530207
申请日：1983-09-08
申请人： Yoshikazu Amano , Fuminori Arai , Masao Kitajima
发明人： Yoshikazu Amano , Fuminori Arai , Masao Kitajima
IPC分类号： C12Q1/00 , C12Q1/26 , C12Q1/28 , C12Q1/54 , C12Q1/60 , G01N31/22 , G01N33/52 , G01N21/78
CPC分类号： C12Q1/28 , C12Q1/54 , C12Q1/60 , G01N31/22 , G01N33/525 , C12Q2326/96
摘要： A multilayer analytical element comprising a water-impermeable, light-transmissive support, a reagent layer containing at least a peroxidase, and a porous spreading layer, which are superposed in this order, in which at least one layer other than said support contains a water-soluble monocarboxylic acid or a salt thereof having solubility of not less than 1 g. in 100 g. of water at 25.degree. C.
摘要翻译：一种多层分析元件，其包含不透水的透光性载体，至少含有过氧化物酶的试剂层和多孔扩散层，其中所述载体中除了所述载体以外的至少一层包含水 - 可溶性单羧酸或其盐的溶解度不小于1g。在100克。的水在25℃

48. 发明授权

US4555274A Ion selective electrode and process of preparing the same 失效
标题翻译：离子选择电极及其制备方法
公开(公告)号：US4555274A
公开(公告)日：1985-11-26
申请号：US618285
申请日：1984-06-07
申请人： Masao Kitajima , Osamu Seshimoto , Shigemitsu Mizutani
发明人： Masao Kitajima , Osamu Seshimoto , Shigemitsu Mizutani
IPC分类号： G01N27/28 , G01N27/333 , C25F5/00
CPC分类号： G01N27/3335
摘要： An ion selective electrode comprising a support having provided thereon, in sequence, a conductive layer and an ion selective layer, which is characterized by having at least one groove through the conductive layer and covering the surface of the groove with the ion selective layer is disclosed. Half cells or electrodes useful for the measurement of ionic activity of chlorine, sodium, potassium or, carbonate or hydrogen carbonate ions in blood or other aqueous sample liquids can be prepared in an extremely simple manner. The single ion selective electrode element comprising paired ion selective electrodes in accordance with the present invention are electrochemically equivalent. A process for forming the same is also disclosed.
摘要翻译：公开了一种离子选择电极，其包括依次具有导电层和离子选择层的载体，其特征在于，具有通过导电层的至少一个沟槽和用离子选择层覆盖沟槽的表面。用于测量血液或其他含水样品液体中氯，钠，钾或碳酸氢根离子或碳酸氢根离子的离子活性的半电池或电极可以非常简单的方式制备。根据本发明的包括成对离子选择性电极的单离子选择电极元件是电化学等效的。还公开了其形成方法。

49. 发明授权

US4540670A Method for measurement of liquid samples 失效
标题翻译：液体样品测量方法
公开(公告)号：US4540670A
公开(公告)日：1985-09-10
申请号：US466256
申请日：1983-02-14
申请人： Fuminori Arai , Masao Kitajima
发明人： Fuminori Arai , Masao Kitajima
IPC分类号： G01N33/66 , G01N21/86 , G01N31/22 , G01N33/52 , G01N21/78
CPC分类号： G01N21/8483 , G01N33/525 , Y10S435/805
摘要： In a method for assaying an analyte comprising applying a liquid sample containing an analyte to a spreading layer of a multilayer analysis element comprising a support having laminated thereon at least one reagent layer containing a substrate capable of converting a detectable chemical species upon reaction with the analyte and a liquid sample-spreading layer and then detecting the chemical species, a wetting liquid is applied onto the spreading layer, prior to applying the liquid sample to the spreading layer. A liquid sample having a high analyte content can be measured with high accuracy.
摘要翻译：在用于测定分析物的方法中，包括将含有分析物的液体样品施加到多层分析元件的铺展层上，所述多层分析元件包括其上层压有至少一个试剂层的载体，所述试剂层含有能够与分析物反应转化可检测化学物质的底物和液体样品扩散层，然后检测化学物质，在将液体样品施加到扩散层之前，将润湿液体施加到扩散层上。可以高精度地测量具有高分析物含量的液体样品。

50. 发明授权

US4528085A Ion selective electrode and process of preparing the same 失效
公开(公告)号：US4528085A
公开(公告)日：1985-07-09
申请号：US475672
申请日：1983-03-15
申请人： Masao Kitajima , Osamu Seshimoto , Shigemitsu Mizutani
发明人： Masao Kitajima , Osamu Seshimoto , Shigemitsu Mizutani
IPC分类号： G01N27/28 , G01N27/333 , G01N27/46
CPC分类号： G01N27/3335
摘要： An ion selective electrode comprising a support having provided thereon, in sequence, a conductive layer and an ion selective layer, which is characterized by having at least one groove through the conductive layer and covering the surface of the groove with the ion selective layer is disclosed. Half cells or electrodes useful for the measurement of ionic activity of chlorine, sodium, potassium or, carbonate or hydrogen carbonate ions in blood or other aqueous sample liquids can be prepared in an extremely simple manner. The single ion selective electrode element comprising paired ion selective electrodes in accordance with the present invention are electrochemically equivalent. A process for forming the same is also disclosed.

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