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1. 发明授权

US4587100A Multilayer analytical element for the detection of hydrogen peroxide 失效
标题翻译：用于检测过氧化氢的多层分析元件
公开(公告)号：US4587100A
公开(公告)日：1986-05-06
申请号：US530207
申请日：1983-09-08
申请人： Yoshikazu Amano , Fuminori Arai , Masao Kitajima
发明人： Yoshikazu Amano , Fuminori Arai , Masao Kitajima
IPC分类号： C12Q1/00 , C12Q1/26 , C12Q1/28 , C12Q1/54 , C12Q1/60 , G01N31/22 , G01N33/52 , G01N21/78
CPC分类号： C12Q1/28 , C12Q1/54 , C12Q1/60 , G01N31/22 , G01N33/525 , C12Q2326/96
摘要： A multilayer analytical element comprising a water-impermeable, light-transmissive support, a reagent layer containing at least a peroxidase, and a porous spreading layer, which are superposed in this order, in which at least one layer other than said support contains a water-soluble monocarboxylic acid or a salt thereof having solubility of not less than 1 g. in 100 g. of water at 25.degree. C.
摘要翻译：一种多层分析元件，其包含不透水的透光性载体，至少含有过氧化物酶的试剂层和多孔扩散层，其中所述载体中除了所述载体以外的至少一层包含水 - 可溶性单羧酸或其盐的溶解度不小于1g。在100克。的水在25℃

2. 发明授权

US4783315A Analysis material sheet 失效
标题翻译：分析材料表
公开(公告)号：US4783315A
公开(公告)日：1988-11-08
申请号：US758562
申请日：1985-07-23
申请人： Fuminori Arai , Kenichiro Yazawa , Hideaki Takeuchi , Masao Kitajima
发明人： Fuminori Arai , Kenichiro Yazawa , Hideaki Takeuchi , Masao Kitajima
IPC分类号： G01N31/22 , G01N33/52 , G01N33/66
CPC分类号： G01N33/525 , Y10T428/31736 , Y10T428/3175
摘要： An analysis material sheet is disclosed which is comprised of layers of material with strong adhesion for one another. The sheet includes a water-impermeable support having provided directly or indirectly thereon a layer of fabric. The fabric contains a hydrophobic organic polymer fiber and is physically activated on at least one surface thereof, with the physically activated surface being adhered directly or indirectly to the support. A reagent layer can be provided directly or indirectly on the liquid sample-spreading layer of fabric. By utilizing a fabric containing a hydrophobic organic polymer fiber, body fluids to be analyzed can be quickly and uniformly spread and by utilizing the physically activated surface of the fabric, strong adhesion between the layers can be obtained.
摘要翻译：公开了一种分析材料片，其由彼此具有强粘合性的材料层组成。片材包括直接或间接地在其上提供织物层的不透水支撑体。织物含有疏水性有机聚合物纤维，并在其至少一个表面上物理活化，物理活化表面直接或间接地粘附到载体上。试剂层可以直接或间接地提供在织物的液体样品铺展层上。通过使用含有疏水性有机聚合物纤维的织物，可以快速且均匀地分散待分析的体液，并且通过利用织物的物理活化表面，可以获得层间的强粘合性。

3. 发明授权

US4540670A Method for measurement of liquid samples 失效
标题翻译：液体样品测量方法
公开(公告)号：US4540670A
公开(公告)日：1985-09-10
申请号：US466256
申请日：1983-02-14
申请人： Fuminori Arai , Masao Kitajima
发明人： Fuminori Arai , Masao Kitajima
IPC分类号： G01N33/66 , G01N21/86 , G01N31/22 , G01N33/52 , G01N21/78
CPC分类号： G01N21/8483 , G01N33/525 , Y10S435/805
摘要： In a method for assaying an analyte comprising applying a liquid sample containing an analyte to a spreading layer of a multilayer analysis element comprising a support having laminated thereon at least one reagent layer containing a substrate capable of converting a detectable chemical species upon reaction with the analyte and a liquid sample-spreading layer and then detecting the chemical species, a wetting liquid is applied onto the spreading layer, prior to applying the liquid sample to the spreading layer. A liquid sample having a high analyte content can be measured with high accuracy.
摘要翻译：在用于测定分析物的方法中，包括将含有分析物的液体样品施加到多层分析元件的铺展层上，所述多层分析元件包括其上层压有至少一个试剂层的载体，所述试剂层含有能够与分析物反应转化可检测化学物质的底物和液体样品扩散层，然后检测化学物质，在将液体样品施加到扩散层之前，将润湿液体施加到扩散层上。可以高精度地测量具有高分析物含量的液体样品。

4. 发明授权

US4292272A Multilayer analysis sheet for analyzing liquid samples 失效
标题翻译：用于分析液体样品的多层分析表
公开(公告)号：US4292272A
公开(公告)日：1981-09-29
申请号：US157737
申请日：1980-06-09
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
IPC分类号： G01M3/04 , G01M3/20 , G01N31/22 , G01N33/52 , G01N21/84 , G01N33/50
CPC分类号： G01N33/525
摘要： A multilayer analysis sheet for analyzing liquid samples is described, comprising, in sequence, a light transmitting hydrophobic support having on one side thereof at least one layer containing at least one reagent in a binder and a liquid sample spreading layer made of fabric, which layers are laminated to form an integral unit together with the support, wherein said fabric has the ability to supply a liquid sample placed on the surface thereof to the reagent-containing layer at a substantially constant volume per unit area, which ability is conferred upon the fabric by rendering it hydrophilic; the multilayer analysis sheet can be economically manufactured without variations in quality, and improves the spreading capability of liquid samples.
摘要翻译：描述了用于分析液体样品的多层分析片，其中依次包括透光性疏水性支持体，其透光性疏水性支持体的一面上具有至少一层含有粘合剂中的至少一种试剂和由织物构成的液体样品扩散层，层叠以与支撑体一起形成整体单元，其中所述织物具有以每单位面积基本上恒定的体积供应将其表面上的液体样品供应到含有试剂的层的能力，该能力被赋予织物通过使其亲水; 可以经济地制造多层分析片而不产生质量变化，并提高液体样品的铺展能力。

5. 发明授权

US3951851A Process of producing aspirin-containing capsules 失效
标题翻译：生产含阿司匹林胶囊的方法
公开(公告)号：US3951851A
公开(公告)日：1976-04-20
申请号：US364478
申请日：1973-05-29
申请人： Masao Kitajima , Asaji Kondo , Fuminori Arai
发明人： Masao Kitajima , Asaji Kondo , Fuminori Arai
IPC分类号： A61K9/62 , A61K9/50 , A61K31/60 , B01J13/02
CPC分类号： A61K9/5047 , A61K31/60 , A61K9/5089 , Y10T428/2989
摘要： Process of producing aspirin-containing capsules which comprises (1) dispersing aspirin particles in a solution of a cellulose derivative in an organic solvent partially miscible with water; (2) adding the dispersion to an encapsulation medium comprising water containing organic solvent(s) partially miscible with water with or without aspirin; (3) stirring the mixture to form a fine dispersion of the aspirin; and (4) evaporating off the organic solvent to deposit the cellulose derivative around the aspirin particles.
摘要翻译：制备含阿司匹林胶囊的方法，其包括（1）将阿司匹林颗粒分散在纤维素衍生物在与水部分混溶的有机溶剂中的溶液中; （2）将分散体加入到包含含有有机溶剂的水的包封介质中，所述有机溶剂与或不与阿斯匹林部分混溶; （3）搅拌混合物形成阿司匹林的精细分散体; 和（4）蒸发掉有机溶剂以将纤维素衍生物沉积在阿司匹林颗粒周围。

6. 发明授权

US4452887A Integral multi-layered element containing glucose oxidase for determining glucose 失效
标题翻译：含葡萄糖氧化酶的整体多层元素用于测定葡萄糖
公开(公告)号：US4452887A
公开(公告)日：1984-06-05
申请号：US389344
申请日：1982-06-17
申请人： Masao Kitajima , Fuminori Arai , Harumi Katsuyama
发明人： Masao Kitajima , Fuminori Arai , Harumi Katsuyama
IPC分类号： C12Q1/26 , C12Q1/00 , C12Q1/28 , C12Q1/54 , G01N33/52 , G01N33/66
CPC分类号： C12Q1/54 , G01N33/526 , Y10S435/805
摘要： In a dry-type multilayer liquid analysis material for glucose determination composed of a transparent water-impermeable support having formed thereon in sequence at least a reagent layer containing a reactive component forming a detectable material by the action of hydrogen peroxide, a non-porous light-shielding layer, and a porous spreading layer, the coloring efficiency for colorimetry using the liquid analysis material is improved by incorporating a glucose oxidase enzyme in at least one layer disposed above the reagent layer.
摘要翻译：在用于葡萄糖测定的干式多层液体分析材料中，其由透明的不透水支持体组成，其中至少在其上形成有通过过氧化氢的作用形成可检测材料的反应性成分的试剂层，非多孔光并且多孔扩散层，通过在设置在试剂层上方的至少一层中并入葡萄糖氧化酶来提高使用液体分析材料的比色法的着色效率。

7. 发明授权

US4340565A Hematocrit value determining element 失效
标题翻译：血细胞比容值确定元件
公开(公告)号：US4340565A
公开(公告)日：1982-07-20
申请号：US221183
申请日：1980-12-29
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
IPC分类号： G01N33/49 , G01N31/22 , G01N33/48 , G01N33/52 , G01N33/50
CPC分类号： G01N33/48 , G01N33/525
摘要： A hematocrit value determining element comprising, in one embodiment, a water-impermeable planar support having integrally provided thereon a hydrophilic porous spreading layer, the porous spreading layer being such that blood spreads therethrough depending upon the viscosity of the blood and, in a second embodiment, a hematocrit value determining element as described above and a binder layer provided between the planar support and the porous spreading layer.
摘要翻译：一种血细胞比容值确定元件，在一个实施方案中包括在其上整体设置有亲水性多孔扩散层的不透水平面支撑体，所述多孔扩散层使得血液通过其中的血液扩散，这取决于血液的粘度，并且在第二实施方案中，如上所述的血细胞比容值确定元件和设置在平面支撑体和多孔扩散层之间的粘合剂层。

8. 发明授权

US4270920A Integrated material for chemical analysis and a method of using the same 失效
标题翻译：用于化学分析的综合材料及其使用方法
公开(公告)号：US4270920A
公开(公告)日：1981-06-02
申请号：US71618
申请日：1979-08-31
申请人： Asaji Kondo , Fuminori Arai , Masao Kitajima
发明人： Asaji Kondo , Fuminori Arai , Masao Kitajima
IPC分类号： G01N31/22 , G01N33/52 , G01N33/62 , G01N33/66 , G01N33/72
CPC分类号： G01N31/22 , G01N33/525
摘要： An integrated material for chemical analysis comprising three or more reagent layer units on a support and a porous spreading layer, said units containing reagents for different chemical analyses and being proximately arranged on a support such that approximately equal portions thereof are within a spreading circle defined by the diffusion of a liquid sample as it passes through the porous spreading layer, and a method for analyzing blood using the same.
摘要翻译：一种用于化学分析的综合材料，其包括在支撑体上的三个或更多个试剂层单元和多孔扩散层，所述单元包含用于不同化学分析的试剂，并且近似地布置在支撑体上，使得其大致相等的部分在由液体样品在通过多孔扩散层时的扩散，以及使用其分析血液的方法。

9. 发明授权

US4255384A Multilayered integral element for the chemical analysis of the blood 失效
标题翻译：用于化学分析血液的多层积分元素
公开(公告)号：US4255384A
公开(公告)日：1981-03-10
申请号：US66363
申请日：1979-08-14
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
IPC分类号： G01N33/52 , G01N31/22
CPC分类号： G01N33/525
摘要： An integral multilayered element for the chemical analysis of the blood comprising a combination of a porous spreading layer, a reagent layer, and a radiation-blocking layer, said radiation-blocking layer being water-permeable and containing at least one elemental metal or an alloy thereof.
摘要翻译：一种用于血液化学分析的整体多层元件，包括多孔扩散层，试剂层和辐射阻挡层的组合，所述辐射阻挡层是透水性的并且包含至少一种元素金属或合金其中。

10. 发明授权

US4578245A Multilayer analytical element 失效
标题翻译：多层分析元件
公开(公告)号：US4578245A
公开(公告)日：1986-03-25
申请号：US534085
申请日：1983-09-20
申请人： Fuminori Arai , Yoshio Inagaki , Masao Kitajima
发明人： Fuminori Arai , Yoshio Inagaki , Masao Kitajima
IPC分类号： G01N33/92 , C12Q1/00 , C12Q1/28 , G01N31/22 , G01N33/52 , G01N21/78
CPC分类号： C12Q1/28 , G01N31/22 , G01N33/525 , C12Q2326/00 , C12Q2326/96
摘要： A multilayer analytical element comprising a water-impermeable, light-transmissive support, a reagent layer containing a color forming reagent composition for detection of hydrogen peroxide including at least combination of a chromogen and a coupler (a color indicator composition), and peroxidase, which produces a detectable change in the presence of peroxidase and hydrogen peroxide, and a porous spreading layer, which are superposed in this order,in which said chromogen is a 1,2,3-tri-substituted compound of 4-amino-3-pyrazolin-5-one having solubility in water at 25.degree. C. of lower than that of 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one.
摘要翻译：一种多层分析元件，包括不透水的透光性载体，含有用于检测至少包括色原和成色剂的组合物的过氧化氢的成色剂组合物（颜色指示剂组合物）的试剂层和过氧化物酶，在过氧化物酶和过氧化氢的存在下产生可检测的变化，以及以该顺序重叠的多孔扩散层，其中所述色原是4-氨基-3-吡唑啉的1,2,3-三取代化合物 -5-酮在25℃下在水中的溶解度低于4-氨基-2,3-二甲基-1-苯基-3-吡唑啉-5-酮的溶解度。

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