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1. 发明授权

US4555274A Ion selective electrode and process of preparing the same 失效
标题翻译：离子选择电极及其制备方法
公开(公告)号：US4555274A
公开(公告)日：1985-11-26
申请号：US618285
申请日：1984-06-07
申请人： Masao Kitajima , Osamu Seshimoto , Shigemitsu Mizutani
发明人： Masao Kitajima , Osamu Seshimoto , Shigemitsu Mizutani
IPC分类号： G01N27/28 , G01N27/333 , C25F5/00
CPC分类号： G01N27/3335
摘要： An ion selective electrode comprising a support having provided thereon, in sequence, a conductive layer and an ion selective layer, which is characterized by having at least one groove through the conductive layer and covering the surface of the groove with the ion selective layer is disclosed. Half cells or electrodes useful for the measurement of ionic activity of chlorine, sodium, potassium or, carbonate or hydrogen carbonate ions in blood or other aqueous sample liquids can be prepared in an extremely simple manner. The single ion selective electrode element comprising paired ion selective electrodes in accordance with the present invention are electrochemically equivalent. A process for forming the same is also disclosed.
摘要翻译：公开了一种离子选择电极，其包括依次具有导电层和离子选择层的载体，其特征在于，具有通过导电层的至少一个沟槽和用离子选择层覆盖沟槽的表面。用于测量血液或其他含水样品液体中氯，钠，钾或碳酸氢根离子或碳酸氢根离子的离子活性的半电池或电极可以非常简单的方式制备。根据本发明的包括成对离子选择性电极的单离子选择电极元件是电化学等效的。还公开了其形成方法。

2. 发明授权

US4528085A Ion selective electrode and process of preparing the same 失效
公开(公告)号：US4528085A
公开(公告)日：1985-07-09
申请号：US475672
申请日：1983-03-15
申请人： Masao Kitajima , Osamu Seshimoto , Shigemitsu Mizutani
发明人： Masao Kitajima , Osamu Seshimoto , Shigemitsu Mizutani
IPC分类号： G01N27/28 , G01N27/333 , G01N27/46
CPC分类号： G01N27/3335
摘要： An ion selective electrode comprising a support having provided thereon, in sequence, a conductive layer and an ion selective layer, which is characterized by having at least one groove through the conductive layer and covering the surface of the groove with the ion selective layer is disclosed. Half cells or electrodes useful for the measurement of ionic activity of chlorine, sodium, potassium or, carbonate or hydrogen carbonate ions in blood or other aqueous sample liquids can be prepared in an extremely simple manner. The single ion selective electrode element comprising paired ion selective electrodes in accordance with the present invention are electrochemically equivalent. A process for forming the same is also disclosed.

3. 发明授权

US5122969A Biochemical analysis apparatus, method for correcting the results of biochemical analyses, and correction value recording medium for the same 失效
标题翻译：生物化学分析装置，校正生物化学分析结果的方法和校正值记录介质
公开(公告)号：US5122969A
公开(公告)日：1992-06-16
申请号：US480466
申请日：1990-02-15
申请人： Osamu Seshimoto , Masao Kitajima
发明人： Osamu Seshimoto , Masao Kitajima
IPC分类号： G01N21/78 , G01N1/00 , G01N27/26 , G01N35/00 , G01N35/04
CPC分类号： G01N35/00029 , G01N35/00594 , G01N35/00693 , G01N35/00732 , G01N2035/00039 , G01N2035/00356 , G01N2035/00702 , G01N2035/00752
摘要： A biochemical analysis apparatus comprises a movement device which moves analysis media containing a reagent or an electrochemical sensor, which will interact with a specific biochemical substance contained in liquid samples and give rise to changes in the analysis media, along a movement path connecting an introducing section and an ejecting section. While the analysis media are present in the movement path, a measurement device measures changes which have occurred in analysis media. A reading device reads information about correction values, which are to be used in order to correct a calibration curve so that it becomes suitable for analysis media used in analyses, from a correction value recording medium. A correction device corrects the calibration curve on the basis of the correction values. An operation device uses the corrected calibration curve in order to determine the concentration or the activity of the specific biochemical substance in a liquid sample from the value measured by the measurement device.

4. 发明授权

US4437970A Device for determining ionic activity 失效
标题翻译：用于测定离子活性的装置
公开(公告)号：US4437970A
公开(公告)日：1984-03-20
申请号：US500600
申请日：1983-06-02
申请人： Masao Kitajima , Osamu Seshimoto , Kikuo Kubotera , Akira Yamaguchi
发明人： Masao Kitajima , Osamu Seshimoto , Kikuo Kubotera , Akira Yamaguchi
IPC分类号： G01N27/28 , G01N27/46 , G01N27/58
CPC分类号： G01N27/307 , G01N27/3335
摘要： A device for determining ionic activity composed of, as essential components, plural pairs of ion-selective solid electrodes each pair having two electrodes (one electrode on each of two sides) and each pair having a different ion-selective layer; two liquid distribution porous members, each member disposed over all the electrodes of each said side of the plural pairs; and a porous capillary bridge disposed on or between the liquid distribution porous members. The bridge can be in liquid contact with all the electrodes through the liquid distribution porous members and achieve electrical conduction between two electrodes in each pair after spotting a test solution and a reference solution. The device preferably further comprises a support frame and a cover having two apertures for liquid spotting. The device can simultaneously determine ionic activities of a plurality of different ions in a test solution, such as whole blood, plasma, serum, urine, etc., by spotting a test solution and a reference solution each in one operation and measuring an electrical potential difference of each pair.
摘要翻译：用于确定离子活性的装置，作为必要组分，每对具有两对电极（两侧各一个电极）和每对具有不同离子选择层的多对离子选择性固体电极，两个液体分配多孔构件，每个构件设置在多对的每个所述侧的所有电极上; 以及布置在液体分配多孔构件之间或之间的多孔毛细管桥。桥接器可以通过液体分配多孔构件与所有电极液体接触，并且在点样测试溶液和参考溶液之后实现每对中两个电极之间的导电。该装置优选地还包括支撑框架和具有用于液体点样的两个孔的盖。该装置可以通过在一个操作中分别检测测试溶液和参考溶液来测量测试溶液中的多种不同离子的离子活性，例如全血，血浆，血清，尿等，并测量电位每对差异。

5. 发明授权

US06217540B1 Blood filter cartridge 失效
标题翻译：血液滤芯
公开(公告)号：US06217540B1
公开(公告)日：2001-04-17
申请号：US09349173
申请日：1999-07-09
申请人： Kenichiro Yazawa , Keiichi Ishizaki , Takeshi Igarashi , Masao Kitajima , Shigeru Tezuka , Takaki Arai , Toshihisa Ito , Osamu Seshimoto
发明人： Kenichiro Yazawa , Keiichi Ishizaki , Takeshi Igarashi , Masao Kitajima , Shigeru Tezuka , Takaki Arai , Toshihisa Ito , Osamu Seshimoto
IPC分类号： A61M3700
CPC分类号： G01N33/491
摘要： The invention provides a blood filter cartridge which is made so that the filtrate discharged from the filtrate outlet is not drawn back to the inside of the filtering chamber. The blood filter cartridge includes a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver which receives the filtrate discharged from the filtrate outlet. The blood filter catridge is provided with a means for preventing the filtrate in the filtrate receiver from returning to inside of the holder upon finishing filtration. Such means include the following: removing opposite faces around the filtrate outlet, making length of lower end of the filtrate outlet 0.8 mm or more, smoothing surface around the filtrate outlet, and forming surface around the filtrate outlet by a material having a small surface energy.
摘要翻译：本发明提供了一种血液过滤器滤芯，其被制成使得从滤液出口排出的滤液不会被抽回到过滤室的内部。血液过滤器滤芯包括血液过滤材料，含有血液过滤材料并具有血液入口和滤液出口的保持器和接收从滤液出口排出的滤液的滤液接收器。血液过滤器夹具设置有用于防止滤液接收器中的滤液在完成过滤时返回到保持器内部的装置。这样的方法包括以下步骤：除去滤液出口周围的相对面，使滤液出口的下端长度为0.8mm以上，使滤液出口周围的表面光滑，并且通过具有小表面能的材料在滤液出口周围形成表面。

6. 发明授权

US4732849A Multilayered chemical analysis material for analysis of aqueous liquids 失效
标题翻译：用于水性液体分析的多层化学分析材料
公开(公告)号：US4732849A
公开(公告)日：1988-03-22
申请号：US828562
申请日：1986-02-10
申请人： Osamu Seshimoto , Masao Kitajima
发明人： Osamu Seshimoto , Masao Kitajima
IPC分类号： G01N31/22 , C12Q1/58 , G01N33/52 , G01N33/62
CPC分类号： G01N33/525 , C12Q1/58 , Y10S435/805
摘要： A multi-layered, chemical analysis material for analysis of an aqueous liquid, which comprises in one embodiment(a) a light-transmitting, water-impermeable support having provided thereon in sequence(b) a reagent layer and(c) a porous, sample-spreading layer, with(i) the reagent layer (b) containing a lake dye precursor dispersed in a hydrophilic binder,(ii) urease incorporated in the reagent layer (b) or in a layer adjacent the reagent layer (b), and(iii) a lake forming metal salt or lake forming metal oxide, which does not substantially inhibit the activity of urease, incorporated in the reagent layer (b) or in a layer adjacent the reagent layer (b) or a lake forming metal salt or oxide incorporated in a layer adjacent the reagent layer (b); and in a second embodiment the chemical analysis material includes(d) a radiation-blocking layer interposed between said reagent layer (b) and said porous, sample-spreading layer (c).
摘要翻译：一种用于分析水性液体的多层化学分析材料，其包括在一个实施方案中（a）在序列（b）中提供试剂层的透光性不透水性载体，（c）多孔，样品扩散层，（i）包含分散在亲水性粘合剂中的色淀前体的试剂层（b），（ii）引入试剂层（b）中的脲酶或与试剂层（b）相邻的层中的脲酶，并且（iii）形成金属盐或形成湖的金属氧化物的湖，其基本上不抑制尿素酶的活性，掺入试剂层（b）或试剂层（b）附近的层或形成湖的金属盐或掺入与试剂层（b）相邻的层中的氧化物; 在第二实施方案中，化学分析材料包括（d）插入在所述试剂层（b）和所述多孔样品扩散层（c）之间的辐射阻挡层。

7. 发明授权

US5460777A Analytical element for whole blood analysis 失效
标题翻译：全血分析的分析要素
公开(公告)号：US5460777A
公开(公告)日：1995-10-24
申请号：US29799
申请日：1993-03-11
申请人： Masao Kitajima , Masashi Ogawa , Osamu Seshimoto
发明人： Masao Kitajima , Masashi Ogawa , Osamu Seshimoto
IPC分类号： G01N33/49
CPC分类号： G01N33/491
摘要： An analytical element for whole blood which comprises a blood cell-separating layer having a volume smaller than the upper limit of the diffused volume of a whole blood sample having a hematocrit value of 70% provided on a porous layer, and a method of measuring an analyte which comprises spotting a whole blood sample onto the above analytical element removing the blood cell-separating layer after blood plasma portion of the sample is diffused into the porous layer, supplying a fixed amount of measuring reagent solution having a diffused area smaller than the diffused area of the blood plasma to measure the analyte. According to the invention, the analytical error caused by scattering of hematocrit values is removed, and analysis can be conducted in a high accuracy.
摘要翻译：一种全血分析元件，其特征在于，具有比多孔层上具有血细胞比容值为70％的全血样品的扩散体积的上限容积小的血细胞分离层，分析物，其包括将全血样品点样到所述分析元件上，在样品的血浆部分扩散到多孔层中之后去除血细胞分离层，提供固定量的测量试剂溶液，其扩散面积小于扩散区血浆的面积来测量分析物。根据本发明，消除了血细胞比容值散射引起的分析误差，可以高精度地进行分析。

8. 发明授权

US4612290A Method of bilirubin detection 失效
标题翻译：胆红素检测方法
公开(公告)号：US4612290A
公开(公告)日：1986-09-16
申请号：US542569
申请日：1983-10-19
申请人： Kenichiro Yazawa , Osamu Seshimoto , Masao Kitajima , Asaji Kondo
发明人： Kenichiro Yazawa , Osamu Seshimoto , Masao Kitajima , Asaji Kondo
IPC分类号： G01N31/22 , G01N33/72
CPC分类号： G01N33/728 , Y10T436/146666 , Y10T436/255
摘要： A method for quantitative determination of bilirubin is disclosed. The method comprises bringing a bilirubin-containing aqueous liquid sample into contact with a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin. The amine extracts the bilirubin in said aqueous liquid sample. Photometry is then used to determine the concentration of bilirubin extracted with the bilirubin extracting composition. A device for use in this method is also disclosed. The device has a layer containing a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin.
摘要翻译：公开了一种定量测定胆红素的方法。该方法包括使含胆红素的含水液体样品与含有能够提取胆红素的疏水性胺的疏水性胆红素提取组合物接触。胺提取所述含水液体样品中的胆红素。然后使用光度测定法测定用胆红素提取组合物提取的胆红素的浓度。还公开了一种用于该方法的装置。该装置具有包含含有能够提取胆红素的疏水性胺的疏水性胆红素提取组合物的层。

9. 发明授权

US4877579A Multilayer device for detecting bilurubin 失效
标题翻译：用于检测胆红素的多层装置
公开(公告)号：US4877579A
公开(公告)日：1989-10-31
申请号：US198590
申请日：1988-05-23
申请人： Kenichiro Yazawa , Osamu Seshimoto , Masao Kitajima , Asaji Kondo
发明人： Kenichiro Yazawa , Osamu Seshimoto , Masao Kitajima , Asaji Kondo
IPC分类号： G01N31/22 , G01N33/72
CPC分类号： G01N33/728 , Y10T436/146666 , Y10T436/255
摘要： A method for quantitative determination of bilirubin is disclosed. The method comprises bringing a bilirubin-containing aqueous liquid sample into contact with a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin. The amine extracts the bilirubin in said aqueous liquid sample. Photometry is then used to determine the concentration of bilirubin extracted with the bilirubin extracting composition. A device for use in this method is also disclosed. The device has a layer containing a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin.
摘要翻译：公开了一种定量测定胆红素的方法。该方法包括使含胆红素的含水液体样品与含有能够提取胆红素的疏水性胺的疏水性胆红素提取组合物接触。胺提取所述含水液体样品中的胆红素。然后使用光度测定法测定用胆红素提取组合物提取的胆红素的浓度。还公开了一种用于该方法的装置。该装置具有包含含有能够提取胆红素的疏水性胺的疏水性胆红素提取组合物的层。

10. 发明授权

US4463083A Thermal recording elements 失效
标题翻译：热敏记录元件
公开(公告)号：US4463083A
公开(公告)日：1984-07-31
申请号：US377100
申请日：1982-05-11
申请人： Masao Kitajima , Osamu Seshimoto , Tomizo Namiki , Fumiaki Shinozaki , Tomoaki Ikeda , Yuzo Mizobuchi
发明人： Masao Kitajima , Osamu Seshimoto , Tomizo Namiki , Fumiaki Shinozaki , Tomoaki Ikeda , Yuzo Mizobuchi
IPC分类号： B41M5/26 , G11B7/24 , G11B7/254 , G03C1/74 , G01D15/34
CPC分类号： G11B7/2575 , G11B7/2542 , G11B2007/2431 , G11B2007/24312 , G11B2007/24324 , G11B2007/24326 , G11B7/252 , G11B7/2535 , Y10S430/146 , Y10S430/151 , Y10S430/162 , Y10S430/165
摘要： A thermal recording element comprising a support having formed thereon a recording layer, a first protective layer comprising an organic high molecular weight material having a softening point below about 70.degree. C. formed on the recording layer, and a second protective layer comprising an organic high molecular weight material having high mechanical strength.
摘要翻译：一种热敏记录元件，包括其上形成有记录层的支撑体，第一保护层，包含形成在记录层上的软化点低于约70℃的有机高分子量材料，以及包含有机高分子量的第二保护层具有高机械强度的分子量材料。

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