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41. 发明申请

US20100234597A1 PROCESS FOR PRODUCING IMIDAZO[1,2-b]PYRIDAZINE COMPOUND 有权
标题翻译：制备咪唑并[1,2-b]吡啶化合物的方法
公开(公告)号：US20100234597A1
公开(公告)日：2010-09-16
申请号：US12064832
申请日：2006-08-22
申请人： Ichiro Komoto , Kazuaki Sasaki , Tomohiko Gotou
发明人： Ichiro Komoto , Kazuaki Sasaki , Tomohiko Gotou
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： A process for producing an imidazo[1,2-b]pyridazine compound represented by the formula (2): wherein R1, R2 and R3 are the same or different and each represents a hydrogen atom, a halogen atom, an alkyl group which may be substituted with a halogen atom or atoms, an alkenyl group which may be substituted with a halogen atom or atoms, or an alkoxy group which may be substituted with a halogen atom or atoms, which comprises reacting a 2,3-dihydropyridazine compound represented by the formula (1): wherein R1, R2 and R3 are the same meanings as defined above, with a phosphorus oxyhalide in the presence of an organic base which is in an amount of 0.5 mole or more relative to 1 mole of the 2,3-dihydropyridazine compound and 1 mole or less relative to 1 mole of the phosphorus oxyhalide.
摘要翻译：一种制备由式（2）表示的咪唑并[1,2-b]哒嗪化合物的方法：其中R 1，R 2和R 3相同或不同，各自表示氢原子，卤素原子，可以被卤原子或原子取代，可被卤原子或原子取代的烯基，或可以被卤原子或原子取代的烷氧基，其包括使由2,3-二氢哒嗪化合物式（1）：其中R1，R2和R3与上述定义相同，在有机碱的存在下，相对于1摩尔2,3的量，为0.5摩尔以上 - 二氢哒嗪化合物，相对于1摩尔的卤氧化磷为1摩尔以下。

42. 发明授权

US07699779B2 Ultrasonic treatment equipment 失效
标题翻译：超声波处理设备
公开(公告)号：US07699779B2
公开(公告)日：2010-04-20
申请号：US10557237
申请日：2004-05-18
申请人： Kazuaki Sasaki , Takashi Azuma , Ken-ichi Kawabata , Shin-ichiro Umemura , Takashi Okai , Tetsuya Ishikawa
发明人： Kazuaki Sasaki , Takashi Azuma , Ken-ichi Kawabata , Shin-ichiro Umemura , Takashi Okai , Tetsuya Ishikawa
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/06 , A61B8/13 , A61B2090/378
摘要： Ultrasonic treatment equipment is provided which repeats therapeutic ultrasound exposure while measuring a degree of vessel constriction on a therapeutic ultrasound exposure basis. This equipment includes: a therapeutic ultrasonic transducer 2 which exposes a blood vessel of an affected part to a focused therapeutic ultrasonic wave for a specified period of exposure time; an imaging ultrasonic probe 3 which images an ultrasound tomographic image of the affected part; a display unit 24 which displays the ultrasound tomographic image; means 21 for detecting a blood flow signal from a signal received by the imaging ultrasonic probe and determining the blood flow velocity of the blood vessels of the affected part; means 21 for calculating a rate of change in blood flow velocity during the exposure to the therapeutic ultrasonic wave or before and after the exposure to the therapeutic ultrasonic wave; and means 23 for controlling exposure conditions of the therapeutic ultrasonic wave on the basis of the rate of change in blood flow velocity, and thereby controlling the therapeutic ultrasonic transducer.
摘要翻译：提供超声波处理设备，其在治疗超声暴露基础上测量血管收缩程度时重复治疗性超声波暴露。该设备包括：治疗超声波换能器2，其将受影响部分的血管暴露于聚焦的治疗超声波达指定的曝光时间; 成像超声波探头3，其对受影响部分的超声断层图像进行成像; 显示单元24，其显示超声断层图像; 用于从由成像超声波探头接收的信号中检测血流信号并确定受影响部分的血管的血流速度的装置21; 用于计算暴露于治疗超声波期间或暴露于治疗超声波之前和之后的血流速度变化率的装置21; 以及基于血流速度变化率来控制治疗超声波的暴露条件的装置23，由此控制治疗用超声波换能器。

43. 发明授权

US07074427B2 Medicine, carrier for medicine, method of producing medicine, and method of tumor treatment 失效
公开(公告)号：US07074427B2
公开(公告)日：2006-07-11
申请号：US10198178
申请日：2002-07-19
申请人： Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki
发明人： Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki
IPC分类号： A61K9/48 , A61K9/14 , A61K9/16 , A61K9/50
CPC分类号： A61K41/0033
摘要： A medicinal preparation capable of lowering the threshold of cavitation and generating active oxygen species via acoustic cavitation caused by an ultrasound is provided. The preparation, which is to be used in combination with ultrasonic irradiation, comprises a shell within the internal space of which a gas is enclosed and which contains or retains a substance capable of generating active oxygen species upon ultrasonic irradiation of the shell.

44. 发明申请

US20060038186A1 Light-emitting diode and its manufacturing method 有权
公开(公告)号：US20060038186A1
公开(公告)日：2006-02-23
申请号：US11256001
申请日：2005-10-24
申请人： Kazuaki Sasaki , Junichi Nakamura
发明人： Kazuaki Sasaki , Junichi Nakamura
IPC分类号： H01L33/00
CPC分类号： H01L33/30 , H01L33/14 , Y10S438/937
摘要： It is an object of the present invention to provides the light emitting diode having a light emitting part of an AlGaInP type, and having a current diffusion layer which includes In on a light emitting side of the light emitting part, so that the generation of hillocks is effectively inhibited and the brightness of the light emitting diode is increased.

45. 发明授权

US06511428B1 Ultrasonic medical treating device 失效
标题翻译：超声医疗处理装置
公开(公告)号：US06511428B1
公开(公告)日：2003-01-28
申请号：US09830423
申请日：2001-04-26
申请人： Takashi Azuma , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Katsuhiro Kuroda , Ryuichi Shinomura , Yuichi Miwa , Kazunari Ishida , Jun Kubota
发明人： Takashi Azuma , Kenichi Kawabata , Shinichiro Umemura , Kazuaki Sasaki , Katsuhiro Kuroda , Ryuichi Shinomura , Yuichi Miwa , Kazunari Ishida , Jun Kubota
IPC分类号： A61B800
CPC分类号： A61N7/022 , A61B8/12 , A61B2017/00154 , A61B2017/00274 , A61B2018/00547 , A61B2090/378 , A61B2090/3782
摘要： An ultrasound therapy apparatus delivers focused ultrasound for therapeutical purposes which can be correctly targeted to a target region, and also, a positional shift from the target region under irradiation of ultrasound can be effectively avoided. An ultrasound transducer is inside an applicator with an imaging ultrasonic probe. Another ultrasound transducer monitors a position of a target and a positional shift is inside a catheter which is inserted into a urethral tube. An imaging system drives the ultrasound probe to display an ultrasound tomographic image of a region in the vicinity of a target region. The ultrasound transducer is driven in a pulse-shaped mode at the same frequency as the imaging ultrasound and also at such timing when the imaging ultrasound is reached. As a result, a point-shaped sound source image is superimposed and displayed on an ultrasound tomographic image.
摘要翻译：超声治疗装置将聚焦超声波提供给治疗目的，可以正确地瞄准目标区域，并且可以有效地避免从超声照射下的目标区域的位置偏移。超声波换能器在具有成像超声波探头的施加器内部。另一个超声波传感器监测目标的位置，位置偏移在插入尿道管内的导管内。成像系统驱动超声波探头以显示目标区域附近的区域的超声断层图像。超声波换能器以与成像超声相同的频率以及在达到成像超声的这种定时以脉冲模式驱动。结果，点状声源图像被叠加并显示在超声断层图像上。

46. 发明授权

US06268525B1 Process for producing optically active chrysanthemic acid 有权
标题翻译：光学活性菊酸的制备方法
公开(公告)号：US06268525B1
公开(公告)日：2001-07-31
申请号：US09238503
申请日：1999-01-27
申请人： Makoto Itagaki , Goufu Suzukamo , Kazuaki Sasaki , Kunihiko Fujita
发明人： Makoto Itagaki , Goufu Suzukamo , Kazuaki Sasaki , Kunihiko Fujita
IPC分类号： C07B5500
CPC分类号： C07C51/487 , Y02P20/582 , C07C61/37
摘要： The present invention provides an advantageous method for producing an optically active chrysanthemic acid. Disclosed is a method for producing an optically active chrysanthemic acid whose trans isomer ratio and optical purity are improved, which comprises reacting chrysanthemic acid having a trans isomer ratio of not less than 50% and an optical purity of not less than 10% e.e. with an optically active organic amine to optically resolve said chrysanthemic acid.
摘要翻译：本发明提供了制备光学活性菊酸的有利方法。公开了一种旋光异构体比例和光学纯度提高的光学活性菊酸的制造方法，其特征在于，使反异构体比率不低于50％的菊酸与光学纯度不小于10％e.e。与光学活性有机胺一起旋光分解所述菊酸。

47. 发明授权

US06246078B1 Semiconductor light emitting element 失效
标题翻译：半导体发光元件
公开(公告)号：US06246078B1
公开(公告)日：2001-06-12
申请号：US09015052
申请日：1998-01-28
申请人： Kazuaki Sasaki , Junichi Nakamura
发明人： Kazuaki Sasaki , Junichi Nakamura
IPC分类号： H01L3300
CPC分类号： H01L33/30 , H01L33/0066 , H01L33/14 , H01L33/145
摘要： The semiconductor light emitting element of the present invention includes: a compound semiconductor substrate having a first conductivity type; a light emitting layer; a compound semiconductor interface layer having a second conductivity type and not containing Al; and a current diffusion layer having the second conductivity type and being made of a compound semiconductor not containing Al.
摘要翻译：本发明的半导体发光元件包括：具有第一导电类型的化合物半导体衬底; 发光层; 具有第二导电类型且不含Al的化合物半导体界面层; 以及具有第二导电类型并由不含有Al的化合物半导体制成的电流扩散层。

48. 发明授权

US5571750A Method for producing a semiconductor laser device 失效
公开(公告)号：US5571750A
公开(公告)日：1996-11-05
申请号：US314585
申请日：1994-09-28
申请人： Masanori Watanabe , Ken Ohbayashi , Kazuaki Sasaki , Osumu Yamamoto , Mitsuhiro Matsumoto
发明人： Masanori Watanabe , Ken Ohbayashi , Kazuaki Sasaki , Osumu Yamamoto , Mitsuhiro Matsumoto
IPC分类号： H01S5/02 , H01S5/028 , H01S5/042 , H01S5/16 , H01L21/20
CPC分类号： H01S5/0425 , H01S5/164 , H01S5/0201 , H01S5/0281 , Y10S148/026 , Y10S148/095 , Y10S148/104 , Y10S148/106 , Y10S148/143 , Y10S438/945
摘要： A method for producing a semiconductor laser device includes the steps of: forming window layers on either one of a top surface of an internal structure or a reverse surface of a substrate and on light-emitting end facets of the internal structure; forming a reflection film on the light-emitting end facets; removing the window layer formed on either one of the top surface or the reverse surface by using an etchant which hardly etches the reflection film; and forming electrodes on the surface from which the window layer is removed by etching and on the other surface. Another method for producing a semiconductor laser device includes the steps of: forming window layers on light-emitting end facets of the bars; inserting the bars into an apparatus having openings for forming electrodes and a supporting portion for preventing a positional shift between the bars and the openings, and forming the electrodes on the top surfaces and the reverse surfaces of the bars; and cutting the bars into the chips.

49. 发明授权

US08334379B2 Process for producing imidazo[1,2-b]pyridazine compound 有权
标题翻译：咪唑并[1,2-b]哒嗪化合物的制备方法
公开(公告)号：US08334379B2
公开(公告)日：2012-12-18
申请号：US12064832
申请日：2006-08-22
申请人： Ichiro Komoto , Kazuaki Sasaki , Tomohiko Gotou
发明人： Ichiro Komoto , Kazuaki Sasaki , Tomohiko Gotou
IPC分类号： C07D487/00
CPC分类号： C07D487/04
摘要： A process for producing an imidazo[1,2-b]pyridazine compound represented by the formula (2): wherein R1, R2 and R3 are the same or different and each represents a hydrogen atom, a halogen atom, an alkyl group which may be substituted with a halogen atom or atoms, an alkenyl group which may be substituted with a halogen atom or atoms, or an alkoxy group which may be substituted with a halogen atom or atoms, which comprises reacting a 2,3-dihydropyridazine compound represented by the formula (1): wherein R1, R2 and R3 are the same meanings as defined above, with a phosphorus oxyhalide in the presence of an organic base which is in an amount of 0.5 mole or more relative to 1 mole of the 2,3-dihydropyridazine compound and 1 mole or less relative to 1 mole of the phosphorus oxyhalide.
摘要翻译：一种制备由式（2）表示的咪唑并[1,2-b]哒嗪化合物的方法：其中R 1，R 2和R 3相同或不同，各自表示氢原子，卤素原子，可以被卤原子或原子取代，可被卤原子或原子取代的烯基，或可以被卤原子或原子取代的烷氧基，其包括使由2,3-二氢哒嗪化合物式（1）：其中R1，R2和R3与上述定义相同，在有机碱的存在下，相对于1摩尔2,3的量，为0.5摩尔以上 - 二氢哒嗪化合物，相对于1摩尔的卤氧化磷为1摩尔以下。

50. 发明申请

US20110134431A1 NON-DESTRUCTIVE INSPECTION DEVICE FOR OXYGEN CONCENTRATION IN BAG-SHAPED CONTAINER 有权
标题翻译：用于包装容器中氧气浓缩的非破坏性检查装置
公开(公告)号：US20110134431A1
公开(公告)日：2011-06-09
申请号：US13057496
申请日：2009-06-24
申请人： Takayasu Yokobayashi , Kazuaki Sasaki , Tohru Hosokawa
发明人： Takayasu Yokobayashi , Kazuaki Sasaki , Tohru Hosokawa
IPC分类号： G01N21/39
CPC分类号： G01N21/3504 , G01N21/0303 , G01N21/90 , G01N35/025 , G01N2021/0364 , G01N2021/399 , G01N2201/06113
摘要： A non-destructive inspection device for an oxygen concentration in a bag-shaped container includes: right and left affixing plates provided so as to be moved toward and away from the bag-shaped container; a laser emitting section for measuring an oxygen concentration that is provided on one of the affixing plates; and a laser receiving section on the other affixing plate, wherein the end faces of the emitting section and the receiving section have gas-filled chambers that include gas chambers with a constant length and are made of a translucent material. In the measurement of an oxygen concentration, the affixing plates are brought close to each other, the thickness of a gas phase portion is kept constant, and air is removed between the end faces of the emitting section and the receiving section and the surfaces of the container.
摘要翻译：用于袋状容器中的氧浓度的非破坏性检查装置包括：左右固定板，设置成朝向和远离袋形容器移动; 用于测量设置在所述固定板之一上的氧浓度的激光发射部分; 以及在另一固定板上的激光接收部分，其中发射部分和接收部分的端面具有气体填充室，其包括具有恒定长度的气室并且由半透明材料制成。在氧浓度的测量中，固定板彼此靠近，气相部分的厚度保持恒定，并且在发射部分的端面与接收部分之间以及容器。

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