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41. 发明授权

US08269196B2 Heavy ion radiation therapy system with stair-step modulation 有权
标题翻译：具有梯级调制的重离子放射治疗系统
公开(公告)号：US08269196B2
公开(公告)日：2012-09-18
申请号：US12439440
申请日：2008-02-27
申请人： Patrick M. Hill , Thomas R. Mackie , Jihad H. Al-Sadah
发明人： Patrick M. Hill , Thomas R. Mackie , Jihad H. Al-Sadah
IPC分类号： G21K5/04 , G21K3/00 , A61N5/10
CPC分类号： A61N5/1042 , A61N2005/1087 , A61N2005/1095
摘要： A system for modulating a fan beam for radiation treatment employs shutters that may move rapidly into and out of different beamlets of a fan beam, the shutters having a systematic weighting so that a limited number of shutters may obtain a far greater number of regularly spaced energy reductions.
摘要翻译：用于调制用于辐射处理的风扇光束的系统使用可快速移入和移出风扇光束的不同子束的百叶窗，快门具有系统加权，使得有限数量的百叶窗可以获得更大数量的规则间隔的能量减少

42. 发明授权

US08076657B2 Ion radiation therapy system having magnetic fan beam former 有权
标题翻译：离子放射治疗系统具有磁扇形光束
公开(公告)号：US08076657B2
公开(公告)日：2011-12-13
申请号：US12439390
申请日：2008-02-27
申请人： Thomas R. Mackie , David C. Westerly
发明人： Thomas R. Mackie , David C. Westerly
IPC分类号： A61N5/10 , A61N5/01 , G21K5/04 , G21K5/10
CPC分类号： A61N5/10 , A61N5/103 , A61N2005/1087 , A61N2005/1095
摘要： An improved beam forming system for ions used in radiation treatment employs a magnet system of successive quadrupole magnets to convert an ion pencil beam to a fan beam with reduced neutrons production compared with conventional beam spreading techniques using scattering foils.
摘要翻译：用于辐射处理的离子改进的束形成系统使用连续的四极磁体的磁体系统，与使用散射箔的常规光束扩展技术相比，将离子笔束转换成具有减小的中子产生的扇形束。

43. 发明授权

US07977648B2 Scanning aperture ion beam modulator 有权
标题翻译：扫描孔径离子束调制器
公开(公告)号：US07977648B2
公开(公告)日：2011-07-12
申请号：US12305554
申请日：2008-02-27
申请人： David C. Westerly , Thomas R. Mackie , Ryan T. Flynn
发明人： David C. Westerly , Thomas R. Mackie , Ryan T. Flynn
IPC分类号： H01J3/14 , A61N5/00
CPC分类号： A61N5/10 , A61N5/103 , A61N2005/1087 , A61N2005/1095 , G21K1/046
摘要： A modulator for ions such as protons employs multiple shutter pairs to create independently movable apertures effecting a multiple pencil beam treatment of the patient thereby increasing treatment speed by eliminating the need for a custom compensator.
摘要翻译：用于诸如质子之类的离子的调制器采用多个快门对来创建独立可移动的孔，从而通过消除对定制补偿器的需要来增加治疗速度，从而提高治疗速度。

44. 发明申请

US20100252728A1 Mass Spectrometer Using An Accelerating Traveling Wave 有权
标题翻译：使用加速旅行波的质谱仪
公开(公告)号：US20100252728A1
公开(公告)日：2010-10-07
申请号：US12419745
申请日：2009-04-07
申请人： Thomas R. Mackie , Adam A. Hecht , Joseph J. Bisognano
发明人： Thomas R. Mackie , Adam A. Hecht , Joseph J. Bisognano
IPC分类号： B01D59/44 , H01J49/40
CPC分类号： H01J49/403
摘要： A mass spectrogram employs a set of controllable electrodes to produce a time varying axially inhomogenous electric field and enhance separation of charged particles by exposing the charged particles to different electric field strengths based on their spatial positions. The fields may be tailored to provide a traveling wave that expands portions of a spectrographic plot of the particles and/or to provide focusing or other effects.
摘要翻译：质谱图使用一组可控电极来产生时变轴向非均匀电场，并且通过基于它们的空间位置将带电粒子暴露于不同的电场强度来增强带电粒子的分离。场可以被定制以提供扩展颗粒的光谱图的部分和/或提供聚焦或其他效果的行波。

45. 发明授权

US5317616A Method and apparatus for radiation therapy 失效
标题翻译：放射治疗的方法和装置
公开(公告)号：US5317616A
公开(公告)日：1994-05-31
申请号：US854521
申请日：1992-03-19
申请人： Stuart Swerdloff , Thomas R. Mackie , Timothy Holmes
发明人： Stuart Swerdloff , Thomas R. Mackie , Timothy Holmes
IPC分类号： A61B6/00 , A61B6/03 , A61N5/01 , A61N5/10 , G21K1/04 , G21K5/04 , G21K5/10
CPC分类号： A61B6/032 , A61B6/00 , A61N5/01 , A61N5/1042 , G21K1/04 , G21K1/046 , G21K5/04 , G21K5/10 , A61N2005/1061 , A61N5/1067
摘要： A radiation therapy apparatus includes a compensator having a plurality of leaves to divide the radiation beam into rays each of which may be effectively and individually attenuated over a range of attenuations by controlling the duty cycle of the leaves position between the open and closed states. An apparatus for controlling the compensator accounts for scattering of radiation through the deconvolution of a terma map and calculates a sinogram for controlling the compensator at a variety of angles about a patient using iterated forward and back projections efficiently calculated in frequency space.
摘要翻译：辐射治疗装置包括具有多个叶片的补偿器，以将辐射束分成射线，每个叶片可以通过控制打开和关闭状态之间的叶片位置的占空比在一定范围的衰减中被有效地和单独地衰减。用于控制补偿器的装置考虑了通过术语映射的去卷积的辐射散射，并且计算用于使用在频率空间中有效计算的迭代前向和后向投影以关于患者的各种角度来控制补偿器的正弦图。

46. 发明申请

US20130189435A1 Three-Dimensional Printing System Using Dual Rotation Axes 有权
标题翻译：使用双旋转轴的三维打印系统
公开(公告)号：US20130189435A1
公开(公告)日：2013-07-25
申请号：US13355400
申请日：2012-01-20
申请人： Thomas R. Mackie , Nathan James Patterson , Benjamin L. Cox , Nathan D. Schumacher , George Wicks Petry
发明人： Thomas R. Mackie , Nathan James Patterson , Benjamin L. Cox , Nathan D. Schumacher , George Wicks Petry
IPC分类号： B05D1/26 , B05C11/00
CPC分类号： B29C64/106 , B33Y30/00 , B33Y40/00
摘要： A 3-D printer system moves a printed tool over a print surface with a mechanism controlling a rotational angle of an arm holding the print tool and a revolutionary angle of axis of rotation of the printable area to eliminate the disadvantages of conventionally used linear motion mechanisms
摘要翻译： 3-D打印机系统通过控制保持打印工具的臂的旋转角度和可打印区域的旋转轴线的旋转角度的机构将打印的工具移动到打印表面上，以消除常规使用的直线运动机构的缺点

47. 发明授权

US08309915B2 Mass spectrometer using an accelerating traveling wave 有权
标题翻译：使用加速行波的质谱仪
公开(公告)号：US08309915B2
公开(公告)日：2012-11-13
申请号：US12419745
申请日：2009-04-07
申请人： Thomas R. Mackie , Adam A. Hecht , Joseph J. Bisognano
发明人： Thomas R. Mackie , Adam A. Hecht , Joseph J. Bisognano
IPC分类号： B01D59/44
CPC分类号： H01J49/403
摘要： A mass spectrogram employs a set of controllable electrodes to produce a time varying axially inhomogenous electric field and enhance separation of charged particles by exposing the charged particles to different electric field strengths based on their spatial positions. The fields may be tailored to provide a traveling wave that expands portions of a spectrographic plot of the particles and/or to provide focusing or other effects.
摘要翻译：质谱图使用一组可控电极来产生时变轴向非均匀电场，并且通过基于它们的空间位置将带电粒子暴露于不同的电场强度来增强带电粒子的分离。场可以被定制以提供扩展颗粒的光谱图的部分和/或提供聚焦或其他效果的行波。

48. 发明授权

US08129701B2 Areal modulator for intensity modulated radiation therapy 有权
标题翻译：强度调制放射治疗的面积调制器
公开(公告)号：US08129701B2
公开(公告)日：2012-03-06
申请号：US12038659
申请日：2008-02-27
申请人： Jihad H. Al-Sadah , David C. Westerly , Patrick M. Hill , Thomas R. Mackie
发明人： Jihad H. Al-Sadah , David C. Westerly , Patrick M. Hill , Thomas R. Mackie
IPC分类号： A61N5/00
CPC分类号： A61N5/1042 , A61N2005/1087 , A61N2005/1095
摘要： A modulator for radiation therapy provides modulation of an area beam to decrease treatment time. Separate channels passing modulated “beamlets” are possible by spacing the channels such that spreading of the beams and multiple angles of treatment eliminate cold spots. The space between the channels allows well-defined channel walls and space for modulator mechanisms.
摘要翻译：用于放射治疗的调制器提供面积波束的调制以减少治疗时间。通过间隔通道使得通过调制的“子束”的分离的通道是可能的，使得光束的扩展和多个处理角度消除冷点。通道之间的空间允许明确的通道壁和调制器机构的空间。

49. 发明授权

US08093568B2 Ion radiation therapy system with rocking gantry motion 有权
标题翻译：离子放射治疗系统具有摇摆门架运动
公开(公告)号：US08093568B2
公开(公告)日：2012-01-10
申请号：US12438255
申请日：2008-02-27
申请人： Thomas R. Mackie , Michael William Kissick , Ryan Thomas Flynn
发明人： Thomas R. Mackie , Michael William Kissick , Ryan Thomas Flynn
IPC分类号： A61N5/10 , A61N5/02
CPC分类号： A61N5/10 , A61N5/103 , A61N5/1081 , A61N2005/1087 , A61N2005/1095
摘要： A radiation therapy system for heavy ions employs a rocking motion of a fan beam used to treat the patient, the fan beam having individually modulated beamlets, the rocking limited in angular extent to provide improved conformance of the dose to a tumor while shielding distal tissue from radiation.
摘要翻译：用于重离子的放射治疗系统使用用于治疗患者的风扇梁的摇摆运动，扇形束具有单独调制的子束，摇摆受角度限制，以提供剂量对肿瘤的一致性，同时屏蔽远端组织辐射。

50. 发明授权

US07856082B2 System and method for optimization of a radiation therapy plan in the presence of motion 有权
标题翻译：运动放射治疗计划优化的系统和方法
公开(公告)号：US07856082B2
公开(公告)日：2010-12-21
申请号：US12440055
申请日：2008-02-27
申请人： Ryan T. Flynn , Thomas R. Mackie
发明人： Ryan T. Flynn , Thomas R. Mackie
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1037 , A61N5/1042 , A61N2005/1041 , G21K1/046
摘要： A computer-implemented method for optimizing a radiation treatment plan for a radiotherapy machine providing independently controlled radiation along a plurality of rays j directed toward a patient and configured to account for the effects of patient motion. The method includes generating a probability distribution function quantitatively expressing patient motion, identifying a prescribed total dose Dip at the voxels i in a treatment area, assigning a fluence value wj for each ray j based on an iterative function, calculating an actual total dose Did produced each voxel i within the assigned fluence values and calculating an expectation value of the dose per energy fluence, dij based on the actual total dose Did and the probability distribution function.
摘要翻译：一种用于优化放射治疗机的辐射治疗计划的计算机实现的方法，所述放射治疗机器沿着朝向患者的多个射线j提供独立控制的辐射，并且被配置为考虑患者运动的影响。该方法包括产生定量表达患者运动的概率分布函数，识别治疗区域中的体素i处的规定总剂量Dip，基于迭代函数分配每个射线j的注量值wj，计算实际总剂量每个体素i在指定的能量密度值内，并根据实际总剂量和概率分布函数计算每个能量流量的剂量的期望值dij。

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