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41. 发明授权

US5766224A Temporary, post-heart surgery cardioverting and pacing system and lead systems for use therein 失效
标题翻译：临床，心脏手术后心脏转复和起搏系统及其使用的引导系统
公开(公告)号：US5766224A
公开(公告)日：1998-06-16
申请号：US627688
申请日：1996-04-02
申请人： Clifton A. Alferness , John M. Adams , Gregory M. Ayers , Hugo X. Gonzalez
发明人： Clifton A. Alferness , John M. Adams , Gregory M. Ayers , Hugo X. Gonzalez
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/0587
摘要： A post-surgical atrial cardioverting, atrial pacing, and ventricular pacing system and lead system provides for cardioverting the atria, pacing the atria, and/or pacing the ventricles of the heart of a post-surgical heart patient. The system includes a first lead and a second lead providing a pair of atrial cardioverting electrodes, an atrial pacing electrode, and a ventricular pacing electrode. The electrodes are electrically isolated from each other. The system further includes at least one anchor releasably disposing the electrodes beneath the skin of the patient with each atrial cardioverting electrode electrically contacting a respective given one of the atria, the atrial pacing electrode electrically contacting one of the atria, and the ventricular pacing electrode electrically contacting a ventricle. The system further includes at least one of an external cardiovertor coupled to the cardioverting electrodes for cardioversion, an external atrial pacer coupled to the atrial pacing electrode and one of the atrial cardioverting electrodes for pacing the atria, and an external ventricular pacer coupled to the ventricular pacing electrode and one of the atrial cardioverting electrodes for pacing the ventricles.
摘要翻译：手术后心房心律转复，心房起搏和心室起搏系统和牵引系统提供心脏转移心房，起搏心房和/或起搏手术后心脏病人心脏的心室。该系统包括提供一对心房心脏转复电极，心房起搏电极和心室起搏电极的第一引线和第二引线。电极彼此电隔离。所述系统还包括至少一个锚定器，其可释放地将电极设置在患者皮肤下方，每个心房心脏转复电极与相应的心房起搏器电气接触，心房起搏电极与心房起搏器电气接触，接触心室。该系统还包括耦合到用于心脏复律的复律电极的外部心脏转换器中的至少一个，耦合到心房起搏电极的外部心房起搏器和用于起搏心房的心房心律转换电极之一和与心室联接的外部心室起搏器起搏电极和心房心律转复电极之一用于起搏心室。

42. 发明授权

US5279291A Method for atrial defibrillation 失效
标题翻译：心房除颤方法
公开(公告)号：US5279291A
公开(公告)日：1994-01-18
申请号：US924323
申请日：1992-08-03
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/3918 , A61N1/056 , A61N1/0563 , A61N1/3956 , A61N1/3962 , A61N1/395 , A61N1/3987 , A61N2001/0585
摘要： An implantable atrial defibrillator provides a pulse of defibrillating electrical energy to the atria of the heart in synchronism with sensed R waves in response to non-coincident sensing of an R wave at first and second areas of the heart. The defibrillating pulse is provided after a predetermined number of consecutive R waves are non-coincidently sensed to assure reliable synchronization. The atrial defibrillator is also operational in a marker mode wherein a number of synchronization marker pulses are delivered to the heart for detection on an externally generated electrocardiogram. The atrial fibrillation detector of the defibrillator is normally disabled and is activated when the sensed ventricular activity indicates a probability of atrial fibrillation to conserve a depletable power source. An endocardial lead is also described which ensures that the delivered atrial defibrillating electrical energy is substantially confined to the atria of the heart.
摘要翻译：可植入心房除颤器响应于在心脏的第一和第二区域处的R波的不一致的感测，与感测到的R波同步地向心脏的心房提供除颤电脉冲。在不一致地感测到预定数量的连续R波之后提供除颤脉冲，以确保可靠的同步。心房除颤器还可以在标记模式中操作，其中多个同步标记脉冲被传送到心脏以便在外部产生的心电图上进行检测。除颤器的心房颤动检测器通常被禁用，并且当感测到的心室活动指示心房颤动的概率以节省可消耗的电源时被激活。还描述了一种心内膜导联，其确保输送的心房除颤电能基本上限于心脏的心房。

43. 发明授权

US08337523B2 Tissue fixation assembly having prepositioned fasteners and method 有权
标题翻译：具有预定位紧固件和方法的组织固定组件
公开(公告)号：US08337523B2
公开(公告)日：2012-12-25
申请号：US12460247
申请日：2009-07-15
申请人： Steve G. Baker , Brett J. Carter , Stefan J. M. Kraemer , Clifton A. Alferness , John M. Adams , Raymond Michael Wolniewicz, III
发明人： Steve G. Baker , Brett J. Carter , Stefan J. M. Kraemer , Clifton A. Alferness , John M. Adams , Raymond Michael Wolniewicz, III
IPC分类号： A61B17/10 , A61B17/08
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/068 , A61B17/1114 , A61B2017/00827 , A61B2017/0409 , A61B2017/0414 , A61B2017/0419
摘要： A tissue fastener assembly delivers a fastener for deployment. The assembly includes a fastener including a first member, a second member, the first and second members having first and second ends, and a flexible connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members. The first member has a longitudinal axis and a through channel along the axis. The assembly further includes a deployment wire slidingly received within the through channel of the first member that pierces into the tissue and guides the first member through the tissue, a guide structure defining a lumen that receives the fastener and deployment wire and guides the deployment wire and fastener to the tissue, and a fastener configuration structure that orientates the second member in a predetermined position relative to the first member within the lumen for dependable deployment.
摘要翻译：组织紧固件组件递送用于展开的紧固件。所述组件包括紧固件，所述紧固件包括第一构件，第二构件，所述第一和第二构件具有第一和第二端;以及柔性连接构件，其固定到所述第一和第二构件中的每一个，所述第一和第二构件在所述第一和第二端之间延伸，和第二名成员。第一构件具有沿轴线的纵向轴线和贯通通道。组件还包括滑动地容纳在第一构件的穿过通道内的展开线，其穿透组织并引导第一构件穿过组织;限定内腔的引导结构，其接纳紧固件和展开线并引导展开线，并且紧固件到组织，以及紧固件配置结构，其将第二构件相对于管腔内的第一构件定位在预定位置以进行可靠的展开。

44. 发明授权

US07828843B2 Mitral valve therapy device, system and method 有权
标题翻译：二尖瓣治疗装置，系统及方法
公开(公告)号：US07828843B2
公开(公告)日：2010-11-09
申请号：US10925571
申请日：2004-08-24
申请人： Clifton A. Alferness , John M. Adams , John Melmoth Power
发明人： Clifton A. Alferness , John M. Adams , John Melmoth Power
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , Y10S623/904
摘要： An assembly and method for effecting the condition of a mitral valve annulus of a heart includes a guide wire configured to be fed into the coronary sinus of the heart, and a mitral valve annulus therapy device configured to be slidingly received on the guide wire and advanced into the coronary sinus of the heart on the guide wire. A guide tube may further be employed for guiding the device into the coronary sinus. An introducer which may be employed for pushing the device into or pulling device out of the heart has a mechanism for releasably locking to the device. This enables substitution of the device if needed. Also, the crossover point of the circumflex artery and coronary sinus may be determined and avoided when the device is deployed.
摘要翻译：用于实现心脏二尖瓣环的状态的组件和方法包括：构造成供给到心脏的冠状窦内的导线，以及构造成滑动地容纳在导丝上并提前的二尖瓣环空间治疗装置进入导丝的心脏冠状窦。还可以使用导管来将装置引导到冠状窦中。可以用于将装置推入或拉出装置离开心脏的导引器具有用于可释放地锁定到装置的机构。如果需要，这可以替代设备。此外，当部署装置时，可以确定并避免回旋动脉和冠状窦的交叉点。

45. 发明授权

US07713262B2 Disposable infusion device with linear peristaltic pump 有权
标题翻译：一次性输液装置，带有线性蠕动泵
公开(公告)号：US07713262B2
公开(公告)日：2010-05-11
申请号：US11516456
申请日：2006-09-06
申请人： John M. Adams , Clifton A. Alferness , Daniel Hawkins
发明人： John M. Adams , Clifton A. Alferness , Daniel Hawkins
IPC分类号： A61K9/22
CPC分类号： A61M5/14248 , A61M5/152
摘要： A wearable infusion device delivers a liquid medicant, such as insulin, to a patient. The infusion device comprises a base that contacts a patient's skin and a reservoir arranged to contain a liquid medicant to be delivered beneath a patient's skin. The reservoir has an outlet through which the medicant flows. The infusion device further includes a flexible conduit communicating with the outlet of the reservoir and a pump that causes the medicant to flow down the conduit.
摘要翻译：可佩戴的输注装置将诸如胰岛素的液体药物递送给患者。输注装置包括接触患者皮肤的基部和布置成容纳要在患者皮肤下方递送的液体药物的储存器。储存器具有药物流过的出口。输液装置还包括与储存器的出口连通的柔性导管和使得药物沿管道流下的泵。

46. 发明申请

US20090192471A1 DISPOSABLE INFUSION DEVICE WITH LOCKED CANNULA 审中-公开
标题翻译：具有锁定肛门的可移植输液装置
公开(公告)号：US20090192471A1
公开(公告)日：2009-07-30
申请号：US12418929
申请日：2009-04-06
申请人： Brett J. Carter , Clifton A. Alferness , John M. Adams , Daniel Hawkins
发明人： Brett J. Carter , Clifton A. Alferness , John M. Adams , Daniel Hawkins
IPC分类号： A61M5/14
CPC分类号： A61M5/14248 , A61M5/152 , A61M2005/14252 , A61M2005/14256 , A61M2005/1585 , A61M2209/045
摘要： An infusion assembly comprises a disposable wearable infusion device having a body arranged to be adhered to a patient's skin and a cannula arranged to be received by the device body to deploy the cannula for delivering a medicament to beneath the patient's skin. A lock locks the cannula within the device body when the cannula is deployed in the device.
摘要翻译：输液组件包括一次性穿戴式输注装置，其具有被布置成粘附到患者皮肤的主体和布置成由装置主体接收的插管，以将药剂展开以将药物递送到患者皮肤下方。当套管部署在设备中时，锁将套管锁定在装置主体内。

47. 发明申请

US20080167620A1 Disposable infusion device facilitating tissue fold formation for cannula deployment and method 审中-公开
标题翻译：一次性输液装置促进组织折叠形成用于插管部署和方法
公开(公告)号：US20080167620A1
公开(公告)日：2008-07-10
申请号：US11651425
申请日：2007-01-09
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61M5/32
CPC分类号： A61M5/14248 , A61M5/425 , A61M2005/1405 , A61M2005/1585
摘要： A device and method facilitates the forming of a skin fold during deployment of a cannula. The device may be a disposable infusion device and the method comprises adhering, to a skin surface, a base member having a port for receiving a cannula, forming a skin fold having skin surfaces sloping away from opposite sides of the base member, driving a cannula through the port of the base member while maintaining the skin fold, and releasing the skin fold. To facilitate the forming of the skin fold, the device comprises a base having a base surface and a flexible layer member. The flexible layer member has a first surface adjacent the base surface and a second surface adapted to be adhered to a patient's skin. The first surface has a first portion adhered to a portion of the base surface and a second portion adherable to the base surface.
摘要翻译：装置和方法有助于在插管期间形成皮肤褶皱。该装置可以是一次性输注装置，并且该方法包括将具有用于接收套管的端口的基部构件粘附到皮肤表面，形成具有从基部构件的相对侧倾斜的皮肤表面的皮肤褶皱，驱动套管通过基底构件的端口，同时保持皮肤折叠，并释放皮肤褶皱。为了促进皮肤褶皱的形成，该装置包括具有基底表面和柔性层部件的基部。柔性层构件具有邻近基底表面的第一表面和适于粘附到患者皮肤的第二表面。第一表面具有粘附到基部表面的一部分的第一部分和可粘附到基底表面的第二部分。

48. 发明授权

US5674253A Cardioversion system with cardioverting energy attenuator 失效
标题翻译：心律转复系统与心律转换能量衰减器
公开(公告)号：US5674253A
公开(公告)日：1997-10-07
申请号：US708218
申请日：1996-09-06
申请人： John M. Adams , Clifton A. Alferness , Darrell O. Wagner
发明人： John M. Adams , Clifton A. Alferness , Darrell O. Wagner
IPC分类号： A61N1/39
CPC分类号： A61N1/3931
摘要： A defibrillation system for providing post-cardiac surgery atrial cardioversion includes a lead system having defibrillation electrodes for electrical contact with the heart beneath the skin of a patient and a non-implantable external defibrillator for providing defibrillation electrical energy. An interface unit is coupled between the external defibrillator and the lead system and includes an attenuator circuit for attenuating the defibrillation electrical energy provided by the external defibrillator.
摘要翻译：用于提供心脏外手术心房复律的除颤系统包括具有用于与患者皮肤下的心脏电接触的除颤电极的引导系统和用于提供除颤电能的非植入式外部除颤器。接口单元耦合在外部除颤器和引导系统之间，并且包括用于衰减由外部除颤器提供的除颤电能的衰减器电路。

49. 发明授权

US5509925A Atrial fibrillation detector and defibrillator using the same 失效
标题翻译：心房颤动检测器和除颤器使用相同
公开(公告)号：US5509925A
公开(公告)日：1996-04-23
申请号：US346484
申请日：1994-11-29
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/3918 , A61N1/056 , A61N1/0563 , A61N1/3956 , A61N1/3962 , A61N1/395 , A61N1/3987 , A61N2001/0585
摘要： An implantable atrial defibrillator provides a pulse of defibrillating electrical energy to the atria of the heart in synchronism with sensed R waves in response to non-coincident sensing of an R wave at first and second areas of the heart. The defibrillating pulse is provided after a predetermined number of consecutive R waves are non-coincidently sensed to assure reliable synchronization. The atrial defibrillator is also operational in a marker mode wherein a number of synchronization marker pulses are delivered to the heart for detection on an externally generated electrocardiogram. The atrial fibrillation detector of the defibrillator is normally disabled and is activated when the sensed ventricular activity indicates a probability of atrial fibrillation to conserve a depletable power source. An endocardial lead is also described which ensures that the delivered atrial defibrillating electrical energy is substantially confined to the atria of the heart.
摘要翻译：可植入心房除颤器响应于在心脏的第一和第二区域处的R波的不一致的感测，与感测到的R波同步地向心脏的心房提供除颤电脉冲。在不一致地感测到预定数量的连续R波之后提供除颤脉冲，以确保可靠的同步。心房除颤器还可以在标记模式中操作，其中多个同步标记脉冲被传送到心脏以便在外部产生的心电图上进行检测。除颤器的心房颤动检测器通常被禁用，并且当感测到的心室活动指示心房颤动的概率以节省可消耗的电源时被激活。还描述了一种心内膜导联，其确保输送的心房除颤电能基本上限于心脏的心房。

50. 发明授权

US5433729A Atrial defibrillator, lead systems, and method 失效
标题翻译：心房除颤器，牵引系统和方法
公开(公告)号：US5433729A
公开(公告)日：1995-07-18
申请号：US856514
申请日：1992-03-24
申请人： John M. Adams , Clifton A. Alferness , Paul E. Krevenhagen
发明人： John M. Adams , Clifton A. Alferness , Paul E. Krevenhagen
IPC分类号： A61N1/05 , A61N1/372 , A61N1/39
CPC分类号： A61N1/3918 , A61N1/056 , A61N1/0563 , A61N1/3956 , A61N1/3962 , A61N1/395 , A61N1/3987 , A61N2001/0585
摘要： An implantable atrial defibrillator provides a pulse of defibrillating electrical energy to the atria of the heart in synchronism with sensed R waves in response to non-coincident sensing of an R wave at first and second areas of the heart. The defibrillating pulse is provided after a predetermined number of consecutive R waves are non-coincidently sensed to assure reliable synchronization. The atrial defibrillator is also operational in a marker mode wherein a number of synchronization marker pulses are delivered to the heart for detection on an externally generated electrocardiogram. The atrial fibrillation detector of the defibrillator is normally disabled and is activated when the sensed ventricular activity indicates a probability of atrial fibrillation to conserve a depletable power source. A plurality of lead systems are also described for use with the atrial defibrillator which reduce the quantity of electrical energy required to defibrillate the heart and ensure that the delivered atrial defibrillating electrical energy is substantially confined to the atria of the heart.
摘要翻译：可植入心房除颤器响应于在心脏的第一和第二区域处的R波的不一致的感测，与感测到的R波同步地向心脏的心房提供除颤电脉冲。在不一致地感测到预定数量的连续R波之后提供除颤脉冲，以确保可靠的同步。心房除颤器还可以在标记模式中操作，其中多个同步标记脉冲被传送到心脏以便在外部产生的心电图上进行检测。除颤器的心房颤动检测器通常被禁用，并且当感测到的心室活动指示心房颤动的概率以节省可消耗的电源时被激活。还描述了与心房除颤器一起使用的多个引导系统，其减少了除颤心脏所需的电能的量，并确保输送的心房除颤电能基本上限于心脏的心房。

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