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41. 发明授权

US5945309A Cytostatin III nucleic acids encoding 失效
标题翻译：细胞抑素III核酸编码
公开(公告)号：US5945309A
公开(公告)日：1999-08-31
申请号：US820825
申请日：1997-03-19
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： C07K14/475 , C12N1/21 , C07K14/435 , C12N5/10
CPC分类号： C07K14/475 , C07K2319/00
摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

42. 发明授权

US5849286A Ubiquitin conjugating enzymes 7,8 and 9 失效
标题翻译：泛素缀合酶7,8和9
公开(公告)号：US5849286A
公开(公告)日：1998-12-15
申请号：US464604
申请日：1995-06-05
申请人： Jian Ni , Reiner Gentz , Mark D. Adams
发明人： Jian Ni , Reiner Gentz , Mark D. Adams
IPC分类号： A61K38/00 , C12N9/00 , A61K38/51 , C12N9/10
CPC分类号： C12N9/93 , C12Y603/02019 , A61K38/00
摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.
摘要翻译：公开了人类UCE 7，UCE 8和UCE 9多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽来治疗恶性细胞增殖的方法。还公开了抗这种多肽的拮抗剂及其作为治疗性阿尔茨海默氏病，萎缩性骨骼肌，非洲猪瘟病毒和凋亡性细胞死亡的治疗剂的用途。还公开了用于检测与UCE 7,8和9核酸序列中的突变相关的疾病的诊断测定以及由这些序列编码的多肽的浓度。

43. 发明授权

US5844081A Cytostatin I 失效
标题翻译：细胞抑素I
公开(公告)号：US5844081A
公开(公告)日：1998-12-01
申请号：US470298
申请日：1995-06-06
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other metastases.
摘要翻译：公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其他转移的方法。

44. 发明申请

US20070298459A1 Human Tumor Necrosis Factor Receptor TR9 有权
标题翻译：人类肿瘤坏死因子受体TR9
公开(公告)号：US20070298459A1
公开(公告)日：2007-12-27
申请号：US11780643
申请日：2007-07-20
申请人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
IPC分类号： C12P21/00 , C07H21/00 , C07K14/00 , C07K16/00 , C12N1/00 , C12N15/63
CPC分类号： C07K16/1271 , A61K38/00 , C07K14/4747 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
摘要翻译：本发明涉及肿瘤坏死因子受体家族的新成员。特别地，提供编码人TR9受体的分离的核酸分子。还提供TR9多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定TR9受体活性的激动剂和拮抗剂的筛选方法。

45. 发明申请

US20060193861A1 Tumor necrosis factor receptors 6 alpha & 6 beta 有权
标题翻译：肿瘤坏死因子受体6α和6β
公开(公告)号：US20060193861A1
公开(公告)日：2006-08-31
申请号：US11416310
申请日：2006-05-03
申请人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
发明人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/24 , C12N1/18 , C12N5/06
CPC分类号： A61K48/005 , A61K38/00 , A61K48/0058 , C07K14/4703 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides and antibodies that bind TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。还提供TNFR-6α和-6β多肽和结合TNFR-6α和-6β多肽的抗体，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

46. 发明申请

US20060159686A1 Natural killer cell activating factor II 失效
公开(公告)号：US20060159686A1
公开(公告)日：2006-07-20
申请号：US11378243
申请日：2006-03-20
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner Gentz
IPC分类号： A61K39/395 , G01N33/567 , G01N33/53 , C07K16/28
CPC分类号： C07K16/28 , A61K38/00 , C07K14/52
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

47. 发明申请

US20060142199A1 CD-44 like protein 审中-公开
标题翻译： CD-44像蛋白质
公开(公告)号：US20060142199A1
公开(公告)日：2006-06-29
申请号：US11359509
申请日：2006-02-23
申请人： Jian Ni , Reiner Gentz , Patrick Dillon
发明人： Jian Ni , Reiner Gentz , Patrick Dillon
IPC分类号： A61K38/17 , C07K14/74 , C07H21/04 , C12P21/06
CPC分类号： C07K14/70585 , A61K38/00 , C12N2799/026
摘要： The present invention concerns a novel CD44-like protein receptor. In particular, isolated nucleic acid molecules are provided encoding the CD44-like protein. CD44-like polypeptides are also provided, as are screening methods for identifying agonists and antagonists capable of enhancing or inhibiting CD44-like protein-mediated signaling. The invention further concerns therapeutic methods for treating diseases associated with processes mediated by CD44-like protein signaling.
摘要翻译：本发明涉及一种新型的CD44样蛋白受体。特别地，提供编码CD44样蛋白质的分离的核酸分子。还提供CD44样多肽，以及用于鉴定能够增强或抑制CD44样蛋白介导的信号传导的激动剂和拮抗剂的筛选方法。本发明还涉及用于治疗与由CD44样蛋白信号传导介导的过程相关的疾病的治疗方法。

48. 发明授权

US07049402B2 Tumor necrosis factor receptor-5 失效
标题翻译：肿瘤坏死因子受体-5
公开(公告)号：US07049402B2
公开(公告)日：2006-05-23
申请号：US09826212
申请日：2001-04-05
申请人： Ying-Fei Wei , Reiner Gentz , Jian Ni , Steven M Ruben
发明人： Ying-Fei Wei , Reiner Gentz , Jian Ni , Steven M Ruben
IPC分类号： C07K14/00
CPC分类号： C07K14/70578 , A61K48/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

49. 发明申请

US20060068463A1 NATURAL KILLER CELL ACTIVATING FACTOR II 失效
标题翻译：自然杀伤细胞活化因子II
公开(公告)号：US20060068463A1
公开(公告)日：2006-03-30
申请号：US10192611
申请日：2002-07-11
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner Gentz
IPC分类号： C12N9/12 , C07H21/04 , C12P21/02 , C12N5/06
CPC分类号： C07K16/28 , A61K38/00 , C07K14/52
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

50. 发明申请

US20050069945A1 Human chemotactic cytokine I polypeptides 审中-公开
标题翻译：人类趋化性细胞因子I多肽
公开(公告)号：US20050069945A1
公开(公告)日：2005-03-31
申请号：US10994821
申请日：2004-11-23
申请人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner Gentz , Jeffrey Su
发明人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner Gentz , Jeffrey Su
IPC分类号： C07H21/04 , C07K14/52 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/52 , C07H21/04
摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

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