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41. 发明授权

US06184352B2 Adseverin protein 有权
标题翻译： Adseverin蛋白
公开(公告)号：US06184352B2
公开(公告)日：2001-02-06
申请号：US09469253
申请日：1999-12-22
申请人： Seiji Nakamura , Takashi Sakurai , Juni-ichi Nezu
发明人： Seiji Nakamura , Takashi Sakurai , Juni-ichi Nezu
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A61K38/00
摘要： A DNA containing a base sequence encoding an amino acid sequence represented by SEQ ID NO: 4 or 6 in Sequence Listing, which optionally has partial replacement, deletion or addition, or a base sequence hybridizable therewith; a recombinant vector containing this gene; a transformant constructed by using this vector; a process for producing adseverin by using the above-mentioned gene; a recombinant adseverin protein obtained by this production process; an oligonucleotide hybridizable specifically with a base sequence encoding an amino acid sequence represented by SEQ ID NO: 4 or 6; a method for regulating the formation of adseverin in an animal which comprises administering the above-mentioned oligonucleotide to the animal; and an antibody capable of recognizing adseverin protein.
摘要翻译：含有编码序列表中SEQ ID NO：4或6所示的氨基酸序列的碱基序列的DNA，其任选具有部分置换，缺失或添加，或与其可杂交的碱基序列; 含有该基因的重组载体; 通过使用该载体构建的转化体; 通过使用上述基因产生adseverin的方法; 通过该生产方法获得的重组adseverin蛋白; 与编码SEQ ID NO：4或6所示的氨基酸序列的碱基序列特异性杂交的寡核苷酸; 一种用于调节动物中adseverin形成的方法，其包括向动物施用上述寡核苷酸; 和能够识别adseverin蛋白的抗体。

42. 发明授权

US6009715A Refrigerating apparatus, refrigerator, air-cooled type condensor unit for refrigerating apparatus and compressor unit 失效
标题翻译：制冷装置，冰箱，制冷装置的风冷式冷凝器和压缩机组
公开(公告)号：US6009715A
公开(公告)日：2000-01-04
申请号：US44168
申请日：1998-03-19
申请人： Takashi Sakurai , Hideo Takemoto
发明人： Takashi Sakurai , Hideo Takemoto
IPC分类号： F25B1/00 , F25B1/04 , F25B9/00 , F25B31/00 , F25B39/04 , F25B40/02 , F25B43/00 , F25B41/04
CPC分类号： F25B39/04 , F25B2400/16 , F25B31/008 , F25B40/02 , F25B43/006 , F25B9/006
摘要： In a refrigerating apparatus using an HFC group refrigerant, the performance is improved by increasing the refrigerating capacity and a stable operation is made possible. In order to achieve this, a cycle system in a refrigerator is structured so as to connect a compressor, a condenser, a liquid receiver and a supercooler in this order. In an air-cooled separation type refrigerator, the liquid receiver is disposed within an air-cooled type condenser unit. Further, in the case where a flush gas is liable to be generated in a liquid pipe, a vapor-liquid separator is disposed within the compressor unit integral with an accumulator and separated therefrom by a partition plate.
摘要翻译：在使用HFC类制冷剂的制冷装置中，通过提高制冷量来提高性能，能够进行稳定的运转。为了实现这一点，在冰箱中的循环系统被构造成按顺序连接压缩机，冷凝器，液体接收器和过冷却器。在风冷式分离式冰箱中，液体接收器设置在风冷式冷凝器单元内。此外，在液体管中容易产生冲洗气体的情况下，气液分离器配置在压缩机单元内，与蓄能器一体化并与隔板分离。

43. 发明授权

US5948716A Cubic boron nitride based sintered material and its producing method 失效
标题翻译：立方氮化硼基烧结材料及其制备方法
公开(公告)号：US5948716A
公开(公告)日：1999-09-07
申请号：US997731
申请日：1997-12-24
申请人： Shoichi Kume , Kazutaka Suzuki , Yoshinori Nishida , Haruo Yoshida , Yasuhiro Enya , Akinari Ishikawa , Takashi Sakurai
发明人： Shoichi Kume , Kazutaka Suzuki , Yoshinori Nishida , Haruo Yoshida , Yasuhiro Enya , Akinari Ishikawa , Takashi Sakurai
IPC分类号： C04B35/58 , C04B35/583 , C04B35/5831
CPC分类号： C04B35/581 , C04B35/58014 , C04B35/5831 , C04B35/645 , Y10T428/2991 , Y10T428/2993
摘要： The purpose of the present invention is to provide a cubic boron nitride based sintered material having excellent durability and capable of cutting at least spheroidal graphite cast iron at high speed and usable in a cutting tool having a long life, and a production method of this cubic boron nitride based sintered material. The present invention resides in a production method of a cubic boron nitride based sintered material characterized in that a mixing raw material is produced by mixing powder of Ti.sub.(1-x) Al.sub.x N(x=0.05.about.0.70) and the powder of a cubic boron nitride, and is next sintered. A compounding ratio of the above mixing raw material is preferably set such that this mixing raw material includes 10 to 90% of the above Ti.sub.(1-x) Al.sub.x N(x=0.05.about.0.70) by volume and 10 to 90% of the above cubic boron nitride by volume.
摘要翻译：本发明的目的是提供一种立柱氮化硼基烧结材料，它具有优异的耐久性，能够高速切割至少球墨铸铁，并且可用于具有长寿命的切削工具中，并且该立方体的制造方法氮化硼基烧结材料。本发明在于一种立方氮化硼基烧结体的制造方法，其特征在于，混合原料是通过混合Ti（1-x）Al x N（x = 0.05 DIFFERENCE 0.70）的粉末和立方晶硼氮化物，然后烧结。上述混合原料的配混比优选设定为使得该混合原料含有10〜90％的上述Ti（1-x）Al x N（x = 0.05，差异0.70）和10〜90％的上述立方氮化硼。

44. 发明授权

US4758805A High frequency interference prevention filter for electric instruments 失效
标题翻译：用于电器的高频防干扰滤波器
公开(公告)号：US4758805A
公开(公告)日：1988-07-19
申请号：US664292
申请日：1984-10-24
申请人： Toworu Yamazaki , Takashi Sakurai
发明人： Toworu Yamazaki , Takashi Sakurai
IPC分类号： H01P1/203 , H02H9/00 , H03H7/01 , H01P1/20
CPC分类号： H03H7/0123 , H02H9/005 , G01S13/931 , G01S2007/027 , G01S2013/9375 , G01S2013/9385
摘要： A high frequency filter for an electric instrument including a conductive casing insulated on a stationary structure, an internal electric circuit arranged within the casing, and a connector mounted on the casing for connecting the internal electric circuit to an external electric circuit. The filter comprises an insulation thin plate arranged between the connector and the internal electric circuit and being folded at its intermediate portion, a pair of conductive thin plates secured to opposite surfaces of the insulation thin plate and extending along the folded portion of the insulation thin plate, one of the conductive thin plates being connected at its one end to the connector and at its other end to the internal electric circuit, and the other conductive thin plate being connected to a portion of the casing to provide a short circuit. In such arrangement, the conductive thin plates are opposed to each other through the insulation thin plate to provide a distributed constant circuit.
摘要翻译：一种用于电气仪器的高频滤波器，包括在固定结构上绝缘的导电壳体，布置在壳体内的内部电路，以及安装在壳体上用于将内部电路连接到外部电路的连接器。滤波器包括布置在连接器和内部电路之间并在其中间部分折叠的绝缘薄板，一对固定在绝缘薄板的相对表面上并沿着绝缘薄板的折叠部分延伸的导电薄板其中一个导电薄板的一端连接到连接器，另一端连接到内部电路，另一个导电薄板连接到壳体的一部分以提供短路。在这种布置中，导电薄板通过绝缘薄板彼此相对以提供分布常数电路。

45. 发明授权

US4638294A Unauthorized entry detection system 失效
标题翻译：未经授权的进入检测系统
公开(公告)号：US4638294A
公开(公告)日：1987-01-20
申请号：US633443
申请日：1984-07-23
申请人： Takashi Sakurai
发明人： Takashi Sakurai
IPC分类号： B60Q5/00 , B60R25/10 , B60R25/31 , G01V3/12 , G08B13/24 , B60R25/00 , G08B13/18
CPC分类号： G08B13/2491 , B60R25/1018 , B60R25/1004
摘要： In an unauthorized entry detection system for automotive vehicles, an oscillator is installed within the passenger compartment of the vehicle to generate an electromagnetic wave with a predetermined frequency defined by the interior size of the compartment, a first antenna connected to the oscillator to propagate the electromagnetic wave in the whole interior of the compartment in such a manner that the compartment resonates as a cavity resonator when all the doors and windows are closed, a second antenna arranged within the compartment to generate an induced voltage in response to the magnetic field component of the propagated electromagnetic wave, and a detecting circuit connected to the second antenna to detect a change of the induced voltage level caused by entry of a human body into the compartment and/or opening of the doors or windows, thereby to generate a detection signal therefrom.
摘要翻译：在用于机动车辆的未授权进入检测系统中，振荡器安装在车辆的乘客舱内，以产生具有由隔室内部尺寸限定的预定频率的电磁波，第一天线连接到振荡器以传播电磁在隔室的整个内部以这样的方式波动，使得当所有的门和窗都关闭时，隔室作为空腔谐振器共振;第二天线布置在隔间内，以响应于所述的门磁场分量产生感应电压以及与第二天线连接的检测电路，以检测由于人体进入室内和/或门的开启而引起的感应电压水平的变化，由此产生检测信号。

46. 发明授权

US08529891B2 Inhibitors of extracellular HSP90 有权
公开(公告)号：US08529891B2
公开(公告)日：2013-09-10
申请号：US12951737
申请日：2010-11-22
申请人： Daniel G Jay , Brenda K Eustace , Takashi Sakurai
发明人： Daniel G Jay , Brenda K Eustace , Takashi Sakurai
IPC分类号： A61K39/395 , A61K39/00 , G01N33/53 , G01N33/574 , C07K16/00 , C12P21/08
CPC分类号： G01N33/574 , A61K31/366 , A61K31/395 , A61K39/39558 , A61K47/6939 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/622 , G01N33/57484
摘要： The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.

47. 发明申请

US20130216536A1 INHIBITORS OF EXTRACELLULAR HSP90 审中-公开
标题翻译：细胞HSP90抑制剂
公开(公告)号：US20130216536A1
公开(公告)日：2013-08-22
申请号：US13870955
申请日：2013-04-25
申请人： Daniel G Jay , Brenda K Eustace , Takashi Sakurai
发明人： Daniel G Jay , Brenda K Eustace , Takashi Sakurai
IPC分类号： A61K39/395
CPC分类号： G01N33/574 , A61K31/366 , A61K31/395 , A61K39/39558 , A61K47/6939 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/622 , G01N33/57484
摘要： The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.
摘要翻译：本发明描述了细胞外Hsp90的抑制剂。细胞外Hsp90的抑制导致肿瘤细胞侵袭性的降低。此外，本发明涉及抑制胞外Hsp90功能的分子在制备用于治疗或预防癌细胞的侵袭和/或转移潜力的药物中的用途。

48. 发明授权

US08400710B2 Observing device 有权
标题翻译：观察装置
公开(公告)号：US08400710B2
公开(公告)日：2013-03-19
申请号：US12085197
申请日：2006-11-29
申请人： Susumu Terakawa , Takashi Sakurai , Hisao Osawa , Yasujiro Kiyota
发明人： Susumu Terakawa , Takashi Sakurai , Hisao Osawa , Yasujiro Kiyota
IPC分类号： G02B21/06
CPC分类号： G02B21/0004 , G01N21/4738 , G01N21/4788 , G01N2021/4773 , G01N2021/8822 , G02B21/06 , G02B21/125 , G02B21/14 , G02B21/36
摘要： The observing apparatus is being equipped with an image-forming optical system which forms an image of light emitted from a specimen, an imaging unit which picks up the image of the specimen formed by the image-forming optical system, and an illuminating unit which illuminates the specimen with a surface illuminant in which bright areas and dark areas are arranged alternately in order to provide an observing apparatus suitable to observe a transparent specimen with a wide field of view. If the position of the surface illuminant and the pitch of contrasting are set properly, each partial area of the specimen is illuminated obliquely at a small angle by each bright area of the surface illuminant. Therefore, the imaging unit can acquire a dark-field observation image of each partial area.
摘要翻译：观察装置配备有成像光学系统，其形成从样本发射的光的图像，拾取由成像光学系统形成的样本的图像的成像单元和照亮单元具有交替布置明亮区域和暗区域的表面发光体的样品，以提供适合于观察具有宽视野的透明样品的观察装置。如果表面光源的位置和对比度的间距适当地设定，则样品的每个部分区域以表面光源的每个亮区域以小角度被倾斜地照射。因此，成像单元可以获取每个局部区域的暗视场图像。

49. 发明授权

US08262387B2 Atmosphere heat treatment apparatus and method of operating the same 有权
标题翻译：大气热处理装置及其操作方法
公开(公告)号：US08262387B2
公开(公告)日：2012-09-11
申请号：US11883569
申请日：2006-02-02
申请人： Tomihiko Nishiyama , Hiroyoshi Suzuki , Shinichi Takemoto , Kouji Abe , Toshiaki Ohashi , Takashi Sakurai
发明人： Tomihiko Nishiyama , Hiroyoshi Suzuki , Shinichi Takemoto , Kouji Abe , Toshiaki Ohashi , Takashi Sakurai
IPC分类号： F28C3/12
CPC分类号： C21D1/74 , C23C8/20 , F27B17/0016 , F27D7/00 , F27D7/06 , F27D99/0033
摘要： An object of the present invention is to provide an atmosphere heat treatment apparatus that is operable without relying on experiences and/or intuitions of an operator, and a method of operating the same. The atmosphere heat treatment apparatus includes an entrance side exhaust path (26) for exhausting an inside atmosphere from an entrance side of a carburizing chamber (10) to which a transforming gas is supplied, an exit side exhaust path (35) for exhausting the inside atmosphere from an exit side of the heat treatment chamber, and an opening degree adjusting lid (28) attached for adjusting an opening degree of the entrance side exhaust path (26), in which a part or whole of the exit side exhaust path (35) is constituted of a pipe (46) having a predetermined inside diameter. It is checked in advance a relationship of a supplying amount A of the transforming gas with a ratio B:C of an exhaust amount B from the exit side exhaust path (35) and an exhaust amount C from the entrance side exhaust path (26) when a pressure in the carburizing chamber (10) is adjusted to a predetermined furnace pressure by adjusting an opening degree of the entrance side exhaust path (26) with the opening degree adjusting lid (28), and when treating a work (W), the supplying amount A of the transforming gas and a furnace pressure are adjusted so as to control the ratio B:C of the exhaust amount B from the exit side exhaust path (35) and the exhaust amount C from the entrance side exhaust path (26) to be within a predetermined range.
摘要翻译：本发明的目的是提供一种在不依赖操作者的经验和/或直觉的情况下操作的气氛热处理装置及其操作方法。气氛热处理装置具有从供给变换气体的渗碳室（10）的入口侧排出内部气氛的入口侧排气路（26），排出内侧的排出侧排气通路（35）气氛从所述热处理室的出口侧开放，所述开度调整盖（28）被安装用于调节所述入口侧排气通路（26）的开度，所述开口调节盖（28）的一部分或整体位于所述出口侧排气通路）由具有预定内径的管（46）构成。预先检查转换气体的供给量A与排出侧排气通路35的排气量B的比率B和C与从入口侧排气路径26排出的排气量C的关系，当通过利用开度调节盖（28）调节入口侧排气路径（26）的开度来将渗碳室（10）中的压力调节到预定的炉压时，并且当处理工件（W）时，调整转化气体的供给量A和炉压，从而控制排出侧排气通路35的排气量B的比率B和来自入口侧排气路径26的排出量C ）在预定范围内。

50. 发明申请

US20110150881A1 INHIBITORS OF EXTRACELLULAR HSP90 有权
标题翻译：细胞HSP90抑制剂
公开(公告)号：US20110150881A1
公开(公告)日：2011-06-23
申请号：US12951737
申请日：2010-11-22
申请人： Daniel G. Jay , Brenda K. Eustace , Takashi Sakurai
发明人： Daniel G. Jay , Brenda K. Eustace , Takashi Sakurai
IPC分类号： A61K39/395 , G01N33/574 , C12Q1/02 , A61P35/04
CPC分类号： G01N33/574 , A61K31/366 , A61K31/395 , A61K39/39558 , A61K47/6939 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/622 , G01N33/57484
摘要： The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.
摘要翻译：本发明描述了细胞外Hsp90的抑制剂。细胞外Hsp90的抑制导致肿瘤细胞侵袭性的降低。此外，本发明涉及抑制胞外Hsp90功能的分子在制备用于治疗或预防癌细胞的侵袭和/或转移潜力的药物中的用途。

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