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1. 发明授权

US08529891B2 Inhibitors of extracellular HSP90 有权
公开(公告)号：US08529891B2
公开(公告)日：2013-09-10
申请号：US12951737
申请日：2010-11-22
申请人： Daniel G Jay , Brenda K Eustace , Takashi Sakurai
发明人： Daniel G Jay , Brenda K Eustace , Takashi Sakurai
IPC分类号： A61K39/395 , A61K39/00 , G01N33/53 , G01N33/574 , C07K16/00 , C12P21/08
CPC分类号： G01N33/574 , A61K31/366 , A61K31/395 , A61K39/39558 , A61K47/6939 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/622 , G01N33/57484
摘要： The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.

2. 发明申请

US20130216536A1 INHIBITORS OF EXTRACELLULAR HSP90 审中-公开
标题翻译：细胞HSP90抑制剂
公开(公告)号：US20130216536A1
公开(公告)日：2013-08-22
申请号：US13870955
申请日：2013-04-25
申请人： Daniel G Jay , Brenda K Eustace , Takashi Sakurai
发明人： Daniel G Jay , Brenda K Eustace , Takashi Sakurai
IPC分类号： A61K39/395
CPC分类号： G01N33/574 , A61K31/366 , A61K31/395 , A61K39/39558 , A61K47/6939 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/622 , G01N33/57484
摘要： The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.
摘要翻译：本发明描述了细胞外Hsp90的抑制剂。细胞外Hsp90的抑制导致肿瘤细胞侵袭性的降低。此外，本发明涉及抑制胞外Hsp90功能的分子在制备用于治疗或预防癌细胞的侵袭和/或转移潜力的药物中的用途。

3. 发明申请

US20110150881A1 INHIBITORS OF EXTRACELLULAR HSP90 有权
标题翻译：细胞HSP90抑制剂
公开(公告)号：US20110150881A1
公开(公告)日：2011-06-23
申请号：US12951737
申请日：2010-11-22
申请人： Daniel G. Jay , Brenda K. Eustace , Takashi Sakurai
发明人： Daniel G. Jay , Brenda K. Eustace , Takashi Sakurai
IPC分类号： A61K39/395 , G01N33/574 , C12Q1/02 , A61P35/04
CPC分类号： G01N33/574 , A61K31/366 , A61K31/395 , A61K39/39558 , A61K47/6939 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/622 , G01N33/57484
摘要： The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.
摘要翻译：本发明描述了细胞外Hsp90的抑制剂。细胞外Hsp90的抑制导致肿瘤细胞侵袭性的降低。此外，本发明涉及抑制胞外Hsp90功能的分子在制备用于治疗或预防癌细胞的侵袭和/或转移潜力的药物中的用途。

4. 发明授权

US07959915B2 Inhibitors of extracellular Hsp90 有权
标题翻译：细胞外Hsp90的抑制剂
公开(公告)号：US07959915B2
公开(公告)日：2011-06-14
申请号：US11224726
申请日：2005-09-12
申请人： Daniel G. Jay , Brenda K. Eustace , Takashi Sakurai
发明人： Daniel G. Jay , Brenda K. Eustace , Takashi Sakurai
IPC分类号： A61K39/395 , G01N33/53 , G01N33/574 , G01N33/00 , C07K16/00
CPC分类号： G01N33/574 , A61K31/366 , A61K31/395 , A61K39/39558 , A61K47/6939 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/622 , G01N33/57484
摘要： The present invention describes inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medicament for the treatment or prevention of invasion and/or metastatic potential of cancer cells.
摘要翻译：本发明描述了细胞外Hsp90的抑制剂。细胞外Hsp90的抑制导致肿瘤细胞侵袭性的降低。此外，本发明涉及抑制胞外Hsp90功能的分子在制备用于治疗或预防癌细胞的侵袭和/或转移潜力的药物中的用途。

5. 发明授权

US08977031B2 Method and device for identifying multipotent stem cell colony, and method and device for automatically culturing multipotent stem cells 有权
标题翻译：用于识别多能干细胞集落的方法和装置，以及用于自动培养多能干细胞的方法和装置
公开(公告)号：US08977031B2
公开(公告)日：2015-03-10
申请号：US13805767
申请日：2011-06-22
申请人： Keizo Watakabe , Takashi Sakurai , Osamu Ohji , Katsumi Nakashima
发明人： Keizo Watakabe , Takashi Sakurai , Osamu Ohji , Katsumi Nakashima
IPC分类号： G06K9/00 , G06T7/60 , C12M1/34
CPC分类号： C12M41/46
摘要： A method and device achieves identification on whether a colony on a cultivation container is differentiated or undifferentiated on an occasion of cultivation of multipotent stem cell, and a method and device achieves a rapid culture of undifferentiated multipotent stem cells. Undifferentiated colony containing only undifferentiated multipotent stem cells is identified from other types of colonies by means of the circularity C of the colony in an image-processed taken image of the inside of cultivation container of a multipotent stem cell. More specifically, when a first threshold of the circularity of the colony is C1, and a second predetermined threshold is C2 (C1
摘要翻译：一种方法和装置能够确定培养容器上的菌落在培养多能干细胞的情况下是分化还是未分化，并且方法和装置实现未分化多能干细胞的快速培养。通过在多能干细胞培养容器内部的图像处理的拍摄图像中的菌落的圆形度C，从其他类型的菌落中鉴定到仅含有未分化的多能干细胞的未分化菌落。更具体地说，当菌落的圆形度的第一阈值为C1，第二预定阈值为C2（C1

6. 发明授权

US08254083B2 Ceramic electronic component and method for producing same 有权
标题翻译：陶瓷电子部件及其制造方法
公开(公告)号：US08254083B2
公开(公告)日：2012-08-28
申请号：US12851106
申请日：2010-08-05
申请人： Takashi Sakurai , Shinya Yoshihara , Ko Onodera , Hisayuki Abe , Masahiko Konno , Satoshi Kurimoto , Hiroshi Shindo , Akihiro Horita , Genichi Watanabe , Yoshikazu Ito
发明人： Takashi Sakurai , Shinya Yoshihara , Ko Onodera , Hisayuki Abe , Masahiko Konno , Satoshi Kurimoto , Hiroshi Shindo , Akihiro Horita , Genichi Watanabe , Yoshikazu Ito
IPC分类号： H01G4/06
CPC分类号： H01G4/2325 , B23K1/0016 , H01G4/30
摘要： There are provided a ceramic electronic component and a method for producing the ceramic electronic component, where a ground electrode layer can be directly coated with lead-free solder without lowering reliabilities. Terminal electrode 3 is provided with a ground electrode layer 21 of Cu having been formed by firing, a solder layer 22 formed of a lead-free solder based on five elements of Sn—Ag—Cu—Ni—Ge, and a diffusion layer 23 having been formed by the diffusion of Ni between the ground electrode layer 21 and the solder layer 22. Because the diffusion layer 23 of Ni is formed between the ground electrode layer 21 and the solder layer 22, the diffusion layer 23, which functions as a barrier layer, suppresses the solder leach of Cu from the ground electrode layer 21. The diffusion layer 23 of Ni can also suppress the growth of fragile intermetallic compounds of Sn—Cu. Therefore, a decrease in the bonding strength between the ground electrode layer 21 and the solder layer 22 can be prevented.
摘要翻译：提供陶瓷电子部件和陶瓷电子部件的制造方法，其中接地电极层可以直接涂覆无铅焊料，而不降低可靠性。端子电极3设置有通过烧制形成的Cu的接地电极层21，基于Sn-Ag-Cu-Ni-Ge的五个元素的无铅焊料形成的焊料层22和扩散层23 这是由于接地电极层21和焊料层22之间的Ni的扩散而形成的。由于在接地电极层21和焊料层22之间形成有Ni的扩散层23，所以作为从接地电极层21抑制Cu的浸出.Ni的扩散层23也可以抑制Sn-Cu的易碎金属间化合物的生长。因此，可以防止接地电极层21和焊料层22之间的接合强度的降低。

7. 发明授权

US07811440B2 Plating apparatus and plating method 有权
标题翻译：电镀装置及电镀方法
公开(公告)号：US07811440B2
公开(公告)日：2010-10-12
申请号：US11494672
申请日：2006-07-28
申请人： Kou Onodera , Hiroshi Shindo , Takashi Sakurai
发明人： Kou Onodera , Hiroshi Shindo , Takashi Sakurai
IPC分类号： C25D17/16
CPC分类号： C25D17/16 , C25D5/08 , C25D17/002 , C25D21/10
摘要： A plating apparatus performs a plating process while placing a work in a pod disposed in a plating bath storing a plating solution. The pod has a pair of meshes that allow the plating solution to pass but substantially inhibit the work from passing. The plating apparatus is provided with a solution flowing mechanism for flowing the plating solution out of the pod through one of the pair of meshes.
摘要翻译：电镀装置在将工件放置在容纳电镀溶液的电镀槽中的容器中进行电镀处理。荚具有一对允许电镀溶液通过但大大抑制工作通过的网状物。电镀装置设置有溶液流动机构，用于使电镀液通过一对网格之一流出荚果。

8. 发明申请

US20100149470A1 PRECURSOR FILM FOR RETARDATION FILMS, RETARDATION FILM, AND LIQUID CRYSTAL DISPLAY DEVICE 审中-公开
标题翻译：用于延迟膜，延迟膜和液晶显示装置的前置膜
公开(公告)号：US20100149470A1
公开(公告)日：2010-06-17
申请号：US12593537
申请日：2007-09-25
申请人： Kyoko Hino , Toshihiko Suzuki , Hiroaki Takahata , Takashi Sakurai
发明人： Kyoko Hino , Toshihiko Suzuki , Hiroaki Takahata , Takashi Sakurai
IPC分类号： G02F1/13363 , G02B1/08
CPC分类号： G02B5/3083 , C08J5/18 , C08J2323/14 , C08J2353/00 , C09K19/02 , C09K19/544 , C09K2219/03 , Y10T428/1036
摘要： Provided is a film that is made of a propylene-based copolymer selected from among propylene-based random copolymers and propylene-based block copolymers, the film being useful as a precursor film for the production of a retardation film by stretching. The propylene-based copolymer forming the film contains crystals containing smectic crystals, wherein the percentage of smectic crystals to all the crystals of the propylene-based copolymer. The film has an in-plane retardation of 50 nm or less and a thickness falling within the range of 30 to 200 μm. The propylene-based copolymer is a copolymer that has a parameter (A) falling within the range of from 0.0007 to 0.1, the parameter (A) being calculated from Formula (1) defined for a stress-strain curve produced as a result of stretching a film made of the polymer at a tensile rate of 100 mm/minute at a temperature at which a stress of 0.8±0.1 MPa is produced at a strain of 200%: (A)=(B600−B200)/400 Formula (1) wherein B600 and B200 represent a stress (MPa) at a strain of 600% and a stress (MPa) at a strain of 200%, respectively.
摘要翻译：提供一种由丙烯类无规共聚物和丙烯类嵌段共聚物中选出的丙烯系共聚物制成的膜，该膜可用作通过拉伸制造延迟膜的前体膜。形成该膜的丙烯类共聚物含有含有近晶构成的结晶，其中，近晶构成对丙烯系共聚物的全部结晶的百分比。该膜的面内相位差为50nm以下，厚度为30〜200μm的范围。丙烯类共聚物是参数（A）在0.0007〜0.1的范围内的共聚物，由作为拉伸结果生成的应力 - 应变曲线而定义的式（1）计算出的参数（A）在200％的应变下，在应力为0.8±0.1MPa的温度下以100mm /分钟的拉伸速度由聚合物制成的膜：（A）=（B600-B200）/ 400式（1 ），其中B600和B200分别表示应变为600％的应力（MPa）和应变为200％的应力（MPa）。

9. 发明申请

US20070079313A1 Information processing apparatus and control method thereof 审中-公开
标题翻译：信息处理装置及其控制方法
公开(公告)号：US20070079313A1
公开(公告)日：2007-04-05
申请号：US11528301
申请日：2006-09-26
申请人： Takashi Sakurai
发明人： Takashi Sakurai
IPC分类号： G11B33/14
CPC分类号： H05K7/20209 , G06F1/206
摘要： According to one embodiment, an information processing apparatus includes: a fan; a measurement unit which measures sound volume produced by the fan; a data processing unit which processes data while performing at least one playback quality improvement process; and a control unit which controls execution of each of the at least one playback quality improvement process based on the sound volume measured by the measurement unit.
摘要翻译：根据一个实施例，一种信息处理设备包括：风扇; 测量由风扇产生的音量的测量单元; 数据处理单元，其在执行至少一个播放质量改进处理的同时处理数据; 以及控制单元，其基于由测量单元测量的音量来控制所述至少一个播放质量改进处理中的每一个的执行。

10. 发明授权

US07183811B2 Comparing circuit, comparator, level determining circuit and threshold voltage setting method 有权
标题翻译：比较电路，比较器，电平确定电路和阈值电压设置方法
公开(公告)号：US07183811B2
公开(公告)日：2007-02-27
申请号：US11019296
申请日：2004-12-23
申请人： Masakiyo Horie , Takashi Sakurai
发明人： Masakiyo Horie , Takashi Sakurai
IPC分类号： H03K5/22
CPC分类号： H03K5/086 , H03K5/249
摘要： In a comparing circuit, an input signal switching circuit has a first input terminal, a second input terminal, a first output terminal and a second output terminal. The input signal switching circuit is configured to receive a first input signal inputted to the first input terminal and a second input signal inputted to the second input terminal. The input signal switching circuit is also configured to output the first input signal to switchably one of the first and second output terminals and the second input signal to other thereof in accordance with a switching signal. A comparator has a reverse input terminal and a non-reverse input terminal and configured to receive through the reverse input terminal a first signal outputted from the first output terminal, and receive through the non-reverse input terminal a second signal outputted from the second output terminal.
摘要翻译：在比较电路中，输入信号切换电路具有第一输入端子，第二输入端子，第一输出端子和第二输出端子。输入信号切换电路被配置为接收输入到第一输入端的第一输入信号和输入到第二输入端的第二输入信号。输入信号切换电路还被配置为根据切换信号将第一输入信号切换到第一和第二输出端中的一个，将第二输入信号输出到其它输入信号。比较器具有反向输入端子和非反向输入端子，并且被配置为通过反向输入端子接收从第一输出端子输出的第一信号，并且通过非反向输入端子接收从第二输出端输出的第二信号终奌站。

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