专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20120107930A1 METHOD FOR INDUCING DIFFERENTIATION OF EMBRYONIC STEM CELLS OR ARTIFICIAL PLURIPOTENT STEM CELLS 审中-公开
标题翻译：诱导胚胎干细胞或人工细胞干细胞分化的方法
公开(公告)号：US20120107930A1
公开(公告)日：2012-05-03
申请号：US13320777
申请日：2010-05-21
申请人： Daisuke Sasaki , Tatsuya Shimizu , Teruo Okano
发明人： Daisuke Sasaki , Tatsuya Shimizu , Teruo Okano
IPC分类号： C12N5/071
CPC分类号： A61L27/3834 , A61K35/12 , A61L27/16 , A61L2430/20 , C12N5/0657 , C12N2506/02 , C12N2513/00 , C12N2535/10 , C12N2539/10 , C08L33/00
摘要： Differentiation of a large number of embryonic stem cells or artificial pluripotent stem cells such as induced pluripotent stem cells can be readily induced by the following method. A substrate surface having a cell non-adhesive region on the periphery of a cell adhesive region is used, and (1) the cells are allowed to adhere to the cell adhesive region of the substrate surface in a differentiation-inducing medium; (2) the cells are subsequently allowed to grow on the cell adhesive surface to reach confluence; (3) the culture is further continued to three-dimensionally stratify the cells from the boundary with the cell non-adhesive region surrounding the cell adhesive region; and (4) a plurality of the stratified portions formed in the cell adhesive region is finally bound to one another to produce a cell agglomerate spreading over the entire cell adhesive region with a certain thickness.
摘要翻译：通过以下方法可以容易地诱导大量胚胎干细胞或人造多能干细胞如诱导多能干细胞的分化。使用在细胞粘附区域的周围具有细胞非粘合区域的基板表面，（1）允许细胞在分化诱导介质中粘附到基板表面的细胞粘附区域; （2）随后使细胞在细胞粘附剂表面上生长以达到汇合; （3）进一步将培养物与细胞粘附区域周围的细胞非粘合区域从边界三维地分层化，和（4）形成在电池粘合剂区域中的多个分层部分最终彼此结合以产生在整个电池粘合剂区域上以一定厚度铺展的电池团聚体。

42. 发明申请

US20120052524A1 CELL EVALUATION SYSTEM USING CELL SHEET AND METHOD FOR USING THE SYSTEM 审中-公开
标题翻译：使用细胞片的细胞评估系统和使用该系统的方法
公开(公告)号：US20120052524A1
公开(公告)日：2012-03-01
申请号：US13254040
申请日：2010-03-04
申请人： Masahiro Kinooka , Yasunori Takezawa , Masahito Taya , Atsuhiro Saito , Yoshiki Sawa , Tatsuya Shimizu , Teruo Okano
发明人： Masahiro Kinooka , Yasunori Takezawa , Masahito Taya , Atsuhiro Saito , Yoshiki Sawa , Tatsuya Shimizu , Teruo Okano
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G01N33/5008 , C12M41/46 , C12Q1/025 , G01N33/5026 , G01N33/5029 , G01N33/5064
摘要： Three-dimensional information on a biological parameter relating to at least one selected from viability, proliferating ability, migration, and differentiation of cultured cells can be obtained by a simple two-dimensional analytical technique by constructing a cell evaluation system including a multilayered cell sheet, target cells, and a two-dimensional analyzer.
摘要翻译：通过简单的二维分析技术，可以通过构建包括多层细胞片的细胞评估系统来获得关于选自生殖力，增殖能力，迁移和培养细胞分化中的至少一种的生物学参数的三维信息，靶细胞和二维分析仪。

43. 发明申请

US20090011504A1 Cultured cell construct which contains spheroids of cultured animal cells and the use thereof 有权
标题翻译：含有培养的动物细胞的球体的培养细胞构建体及其用途
公开(公告)号：US20090011504A1
公开(公告)日：2009-01-08
申请号：US12230916
申请日：2008-09-08
申请人： Kazunori Kataoka , Hidenori Otsuka , Teruo Okano , Yukio Nagasaki , Yasuhiro Horiike
发明人： Kazunori Kataoka , Hidenori Otsuka , Teruo Okano , Yukio Nagasaki , Yasuhiro Horiike
IPC分类号： C12N5/06
CPC分类号： C12N5/0671 , C12N5/0697 , C12N2502/14 , C12N2502/28 , C12N2533/30 , C12N2533/40 , C12N2535/10
摘要： Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a function which is specific to the parenchymal cells over a long period of time.
摘要翻译：将实质细胞培养在培养的内皮细胞或培养的成纤维细胞上，这些成纤维细胞已经被特定的亲水性聚合物的表面分离并且已被图案化。因此本发明提供了含有如此形成的培养实质细胞的图案化球体的培养物。该培养物保持长时间对实质细胞特异的功能。

44. 发明申请

US20050224415A1 Temperature-responsive polymer compound and process for producing the same 审中-公开
标题翻译：温度敏感性高分子化合物及其制造方法
公开(公告)号：US20050224415A1
公开(公告)日：2005-10-13
申请号：US11132675
申请日：2005-05-19
申请人： Yoshikatsu Akiyama , Kimihiro Yoshizako , Yukio Hasegawa , Teruo Okano
发明人： Yoshikatsu Akiyama , Kimihiro Yoshizako , Yukio Hasegawa , Teruo Okano
IPC分类号： B01J20/26 , C08F20/28 , C08F20/36 , C08F20/58 , C08F20/60 , G01N30/54 , B01D15/08
CPC分类号： B01J20/265 , B01D15/20 , B01D15/3876 , B01J20/261 , B01J20/285 , B01J2220/54 , C08F20/28 , C08F20/36 , C08F20/58 , C08F20/60 , C08F220/60 , G01N30/54
摘要： A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by varying the side chain is provided. The process for production thereof and the use thereof are also provided.
摘要翻译：提供了在侧链的一个或多个位置处分别具有酯键和/或酰胺键的温度敏感性聚合物和聚合物材料，并且可以通过改变侧链任意控制。还提供了其生产方法及其用途。

45. 发明授权

US6090317A Polyoxyethylene having a sugar on one end and a different functional group on the other end and a method of production thereof 有权
标题翻译：在一端具有糖并且在另一端具有不同官能团的聚氧乙烯及其制备方法
公开(公告)号：US6090317A
公开(公告)日：2000-07-18
申请号：US361958
申请日：1999-07-27
申请人： Kazunori Kataoka , Yukio Nagasaki , Masao Kato , Teruo Okano , Teruo Nakamura
发明人： Kazunori Kataoka , Yukio Nagasaki , Masao Kato , Teruo Okano , Teruo Nakamura
IPC分类号： C08G65/32 , A61K47/48 , C08G63/664 , C08G65/26 , C08G65/329 , C08L71/02 , B01J13/02 , B01J13/04 , B01J13/20
CPC分类号： A61K47/48215 , A61K47/488 , C08G63/664 , C08G65/2606 , C08G65/329 , C08L71/02 , Y10T428/2984 , Y10T428/2985
摘要： This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula: ##STR1## wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula ##STR2## wherein R.sup.1 and R.sup.2 independently denote lower alkyl, aralkyl or aryl,X denotes a single bond or --CH.sub.2 CH.sub.2 --, Z denotes a group forming an unsaturated ester or ether, or a functional group such as halogen which binds to --CH.sub.2 CH.sub.2 --, n denotes an integer of 5-10,000, and m denotes an integer of 0 or 2-10,000.This invention also provides a process to produce the above oligomer or polymer, and further a high molecular-micelle with use of a polyethylene oxide-polyester block polymer which has a sugar residue at its terminal. Said oligomer or polymer is expected to exhibit excellent bioavailability, and is also expected to be utilized in the field such as carriers for drug delivery or diagnostic reagents.
摘要翻译：本发明提供了由下式表示的异炔属低聚物或聚合物：其中A表示糖残基，L表示由下式表示的连接基团，其中R 1和R 2独立地表示低级烷基，芳烷基或芳基，X表示单键或-CH 2 CH 2 - ，Z表示不饱和酯或醚的基团，或与-CH 2 CH 2 - 结合的官能团例如卤素，n表示5-10,000的整数，m表示0或2的整数， 10,000。本发明还提供了使用在其末端具有糖残基的聚环氧乙烷 - 聚酯嵌段聚合物制备上述低聚物或聚合物以及进一步的高分子量胶束的方法。预期所述低聚物或聚合物表现出优异的生物利用度，并且还预期在现场使用，例如用于药物递送或诊断试剂的载体。

46. 发明授权

US5510103A Physical trapping type polymeric micelle drug preparation 失效
公开(公告)号：US5510103A
公开(公告)日：1996-04-23
申请号：US465499
申请日：1995-06-05
申请人： Masayuki Yokoyama , Yasuhisa Sakurai , Teruo Okano , Kazunori Kataoka
发明人： Masayuki Yokoyama , Yasuhisa Sakurai , Teruo Okano , Kazunori Kataoka
IPC分类号： A61K9/00 , A61K9/107 , A61K9/51 , A61K47/34 , A61K47/48 , C08G69/10 , A61K31/74 , A61K9/127
CPC分类号： C08G69/10 , A61K9/1075 , Y10T428/2985 , Y10T428/2989
摘要： The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.

47. 发明授权

US5228370A Method of manufacturing molding material containing metal fibers and apparatus therefor 失效
标题翻译：含有金属纤维的成型材料的制造方法及其设备
公开(公告)号：US5228370A
公开(公告)日：1993-07-20
申请号：US824877
申请日：1992-01-24
申请人： Akira Yanagisawa , Teruo Okano
发明人： Akira Yanagisawa , Teruo Okano
IPC分类号： B29B9/02 , B29B9/14 , G11C8/00
CPC分类号： G11C8/00 , B29B9/02 , B29B9/14 , Y10T156/1052 , Y10T156/1061 , Y10T156/108 , Y10T82/10
摘要： A method of manufacturing a molding material includes the steps of winding a thin metal strip on the peripheral surface of a rotary shaft a plurality of turns with a resin material being interposed between the resulting layers of metal, cutting an end surface of the metal strip and the resin material which have been wound by a cutting blade while rotating said rotary shaft to obtain a mixture of metal fibers and resin fibers, and heating the fiber mixture to a temperature at which the resin fibers can be softened. In this way, a molding material in which the metal fibers are substantially uniformly dispersed in the resin material in a closely contacted state can be obtained easily. Furthermore, the contents of the metal fibers by volume in the molding material can be arbitrarily adjusted by changing the rate at which the metal strip and the resin material are wound around the rotary shaft.
摘要翻译：制造成型材料的方法包括以下步骤：在旋转轴的圆周表面上缠绕多个匝，其中树脂材料插入在所得的金属层之间，切割金属带的端面和所述树脂材料在旋转所述旋转轴的同时由切割刀片卷绕以获得金属纤维和树脂纤维的混合物，并且将所述纤维混合物加热到所述树脂纤维可以软化的温度。以这种方式，可以容易地获得其中金属纤维基本均匀地分散在树脂材料中的紧密接触状态的成型材料。此外，可以通过改变金属带和树脂材料缠绕在旋转轴上的速率来任意调节成型材料中的金属纤维的体积含量。

48. 发明授权

US09617519B2 Method for manufacturing multilayered cell sheet, multilayered cell sheet having vascular network obtained thereby, and method of use thereof 有权
公开(公告)号：US09617519B2
公开(公告)日：2017-04-11
申请号：US13823007
申请日：2011-09-14
申请人： Katsuhisa Sakaguchi , Tatsuya Shimizu , Hidekazu Sekine , Mitsuo Umezu , Teruo Okano
发明人： Katsuhisa Sakaguchi , Tatsuya Shimizu , Hidekazu Sekine , Mitsuo Umezu , Teruo Okano
IPC分类号： C12N5/071 , A61F2/02 , C12M3/00 , C12M1/12 , C12N5/077
CPC分类号： C12N5/0691 , A61F2/02 , C12M21/08 , C12M25/02 , C12N5/0657 , C12N2502/28 , C12N2513/00 , C12N2533/54 , C12N2533/56
摘要： A method for manufacturing a multilayered cell sheet characterized in fabricating a vascular bed that constructs a vascular network extending to the surface from a channel for perfusing a medium, the channel being embedded in a gel; and layering a cell sheet onto the vascular bed to construct a vascular network in the cell sheet. This manufacturing method makes it possible to construct a vascular network in the cell sheet and to fabricate a thick multilayered cell sheet in a simple manner by layering cell sheets. Such a thick multilayered cell sheet is useful as an in-vivo tissue substitute in regenerative medicine involving a variety of tissues.

49. 发明授权

US09555061B2 Synthesis and analysis of compounds capable of inducing differentiation of human mesenchymal stems cells into hepatocytes 有权
标题翻译：能够诱导人间充质干细胞分化为肝细胞的化合物的合成和分析
公开(公告)号：US09555061B2
公开(公告)日：2017-01-31
申请号：US14111757
申请日：2012-04-02
申请人： Goshi Shiota , Yoshiko Hoshikawa , Noriko Matsumoto , Yoshiaki Matsumi , Minoru Morimoto , Takayuki Tonoi , Hiroyuki Saimoto , Kazuo Ohashi , Teruo Okano
发明人： Goshi Shiota , Yoshiko Hoshikawa , Noriko Matsumoto , Yoshiaki Matsumi , Minoru Morimoto , Takayuki Tonoi , Hiroyuki Saimoto , Kazuo Ohashi , Teruo Okano
IPC分类号： A01N63/00 , A61K35/407 , C07C251/86 , C07C43/225 , C07D487/04 , C07D307/52 , A61L27/38
CPC分类号： A61K35/407 , A61L27/3804 , A61L27/3834 , A61L2430/28 , C07C43/225 , C07C251/86 , C07D307/52 , C07D487/04
摘要： The invention relates to low-molecular-weight compounds which are capable of inducing differentiation of mesenchymal stem cell into hepatocytes.
摘要翻译：本发明涉及能够诱导间充质干细胞分化为肝细胞的低分子量化合物。

50. 发明授权

US09291572B2 Method and apparatus for measuring pH of medium solution 有权
标题翻译：测量介质溶液pH值的方法和装置
公开(公告)号：US09291572B2
公开(公告)日：2016-03-22
申请号：US13441630
申请日：2012-04-06
申请人： Mitsuhiro Oura , Hirotsugu Kubo , Sunao Takeda , Teruo Okano , Tatsuya Shimizu
发明人： Mitsuhiro Oura , Hirotsugu Kubo , Sunao Takeda , Teruo Okano , Tatsuya Shimizu
IPC分类号： G01N21/31 , G06F19/00 , G01N21/80 , G01N31/22 , C12M1/34
CPC分类号： G01N21/80 , C12M41/26 , G01N31/221 , G01N2021/3148 , G01N2021/3181 , G01N2201/0627
摘要： A pH measuring method includes: illuminating a medium solution, which includes: a first material; and a second material, with a plurality of light beams, which includes: a first light beam, a wavelength of which corresponds to a first absorption peak; a second light beam, a wavelength of which corresponds to a second absorption peak or a second convergence point; a third light beam, a wavelength of which corresponds to a third absorption peak or a third convergence point; and a fourth light beam, a wavelength of the fourth light beam at which an absorbance of at least one of the first and second materials is converged irrespective of a pH; receiving transmitted or reflected light beams of the first to fourth light beams; measuring absorbances at the wavelengths of the received light beams respectively; and calculating a pH of the medium solution based on the absorbances.
摘要翻译： pH测量方法包括：照射介质溶液，其包括：第一材料; 以及具有多个光束的第二材料，其包括：第一光束，其波长对应于第一吸收峰; 第二光束，其波长对应于第二吸收峰或第二会聚点; 第三光束，其波长对应于第三吸收峰或第三会聚点; 以及第四光束，所述第四光束的波长，其中所述第一和第二材料中的至少一个的吸光度在不同pH下会聚; 接收第一至第四光束的透射或反射光束; 分别测量接收光束波长处的吸光度; 并基于吸光度计算介质溶液的pH。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式