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1. 发明授权

US09555061B2 Synthesis and analysis of compounds capable of inducing differentiation of human mesenchymal stems cells into hepatocytes 有权
标题翻译：能够诱导人间充质干细胞分化为肝细胞的化合物的合成和分析
公开(公告)号：US09555061B2
公开(公告)日：2017-01-31
申请号：US14111757
申请日：2012-04-02
申请人： Goshi Shiota , Yoshiko Hoshikawa , Noriko Matsumoto , Yoshiaki Matsumi , Minoru Morimoto , Takayuki Tonoi , Hiroyuki Saimoto , Kazuo Ohashi , Teruo Okano
发明人： Goshi Shiota , Yoshiko Hoshikawa , Noriko Matsumoto , Yoshiaki Matsumi , Minoru Morimoto , Takayuki Tonoi , Hiroyuki Saimoto , Kazuo Ohashi , Teruo Okano
IPC分类号： A01N63/00 , A61K35/407 , C07C251/86 , C07C43/225 , C07D487/04 , C07D307/52 , A61L27/38
CPC分类号： A61K35/407 , A61L27/3804 , A61L27/3834 , A61L2430/28 , C07C43/225 , C07C251/86 , C07D307/52 , C07D487/04
摘要： The invention relates to low-molecular-weight compounds which are capable of inducing differentiation of mesenchymal stem cell into hepatocytes.
摘要翻译：本发明涉及能够诱导间充质干细胞分化为肝细胞的低分子量化合物。

2. 发明申请

US20140112892A1 SYNTHESIS AND ANALYSIS OF NOVEL COMPOUND CAPABLE OF INDUCING DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELL INTO HEPATOCYTE 有权
标题翻译：诱导人脑细胞分化为肝细胞分化的新型化合物的合成与分析
公开(公告)号：US20140112892A1
公开(公告)日：2014-04-24
申请号：US14111757
申请日：2012-04-02
申请人： Goshi Shiota , Yoshiko Hoshikawa , Noriko Matsumoto , Yoshiaki Matsumi , Minoru Morimoto , Takayuki Tonoi , Hiroyuki Saimoto , Kazuo Ohashi , Teruo Okano
发明人： Goshi Shiota , Yoshiko Hoshikawa , Noriko Matsumoto , Yoshiaki Matsumi , Minoru Morimoto , Takayuki Tonoi , Hiroyuki Saimoto , Kazuo Ohashi , Teruo Okano
IPC分类号： A61K35/407
CPC分类号： A61K35/407 , A61L27/3804 , A61L27/3834 , A61L2430/28 , C07C43/225 , C07C251/86 , C07D307/52 , C07D487/04
摘要： The purpose is to select low-molecular-weight compounds which are effective in inducing differentiation of mesenchymal stem cell into hepatocyte and to develop a safe differentiation-inducing method having excellent efficiency of differentiating mesenchymal stem cell into hepatocyte. Provided are at least one compound selected from the group consisting of compounds represented by formulae (1) and (2), a salt thereof, or a solvate of them; a differentiation inducer comprising at least one compound selected from the group consisting of compounds represented by formulae (1) and (2), a salt thereof, or a solvate of them; and a differentiation inducer comprising a compound represented by formula (8), a salt thereof, or a solvate of them.
摘要翻译：目的是选择有效诱导间充质干细胞分化为肝细胞的低分子量化合物，并开发出一种安全的分化诱导方法，其具有优良的间充质干细胞分化为肝细胞的效率。提供至少一种选自由式（1）和（2）表示的化合物，其盐或它们的溶剂化物的化合物; 包含至少一种选自由式（1）和（2）表示的化合物，其盐或它们的溶剂化物的化合物的分化诱导剂; 以及包含由式（8）表示的化合物，其盐或它们的溶剂合物的分化诱导剂。

3. 发明申请

US20070178461A1 Cancer diagnostic method 审中-公开
标题翻译：癌症诊断方法
公开(公告)号：US20070178461A1
公开(公告)日：2007-08-02
申请号：US10580415
申请日：2004-11-18
申请人： Norimasa Miura , Goshi Shiota
发明人： Norimasa Miura , Goshi Shiota
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/158
摘要： To provide a cancer diagnostic method capable of detecting evidence presenting the presence of cancer cells in early stage cancer. Cancer diagnostic method comprised of; a process to obtain the sample containing RNA only as a somatic cell and cancer cell fraction from body fluid and a process having a reverse transcription reaction step to generate cDNA using reverse transcriptase from the sample containing said RNA only and a PCR reaction step utilizing fluorescent dye using the following primers for hTERT, CGGAAGAGTGTCTGGAGCAA and GGATGAAGCGGAGTCTGGA to quantify the PCR product amplified by the PCR reaction using the fluorescent dye binding to the PCR product.
摘要翻译：提供能够检测呈现早期癌症中癌细胞存在的证据的癌症诊断方法。癌症诊断方法由获得仅含有体细胞RNA的样品和来自体液的癌细胞级分的样品的方法以及具有逆转录反应步骤的方法以从仅含有所述RNA的样品中使用逆转录酶产生cDNA的方法和利用荧光染料的PCR反应步骤使用hTERT，CGGAAGAGTGTCTGGAGCAA和GGATGAAGCGGAGTCTGGA的以下引物来定量通过使用与PCR产物结合的荧光染料通过PCR反应扩增的PCR产物。

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