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41. 发明授权

US5098910A Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as their use in drugs 失效
标题翻译：血管紧张素转换酶抑制剂与钙拮抗剂的组合以及其在药物中的用途
公开(公告)号：US5098910A
公开(公告)日：1992-03-24
申请号：US358427
申请日：1989-05-30
申请人： Reinhard Becker , Rainer Henning , Wolfgang Ruger , Volker Teetz , Hansjorg Urbach
发明人： Reinhard Becker , Rainer Henning , Wolfgang Ruger , Volker Teetz , Hansjorg Urbach
IPC分类号： A61K31/40 , A61K31/401 , A61K31/435 , A61K31/44 , A61K38/05 , A61K38/55 , A61K45/06 , A61P3/00 , A61P3/14 , A61P9/12 , A61P43/00
CPC分类号： A61K38/556 , Y10S514/929
摘要： The invention relates to combinations of angiotensin-converting enzyme inhibitors with calcium antagonists, processes for their preparation and their use as medicaments.
摘要翻译：本发明涉及血管紧张素转换酶抑制剂与钙拮抗剂的组合，其制备方法及其作为药物的用途。

42. 发明授权

US5055591A Process for the preparation of octahydropenta(b)pyrrole carboxylates 失效
标题翻译：制备甲氧基苯甲酸的方法（B）羧甲基纤维素
公开(公告)号：US5055591A
公开(公告)日：1991-10-08
申请号：US173024
申请日：1988-03-23
申请人： Hansjorg Urbach , Rainer Henning , Hans Wissmann , Volker Teetz
发明人： Hansjorg Urbach , Rainer Henning , Hans Wissmann , Volker Teetz
IPC分类号： C07K14/81 , A61K38/00 , A61P43/00 , C07K1/10 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号： C07K5/0222 , A61K38/00
摘要： The invention relates to a process for the preparation of compounds of the formula I ##STR1## in which n is 1 or 2, R denotes hydrogen or an organic radical, R.sup.1 denotes an organic radical, R.sup.2 and R.sup.3 are identical or different and denote hydrogen or an organic radical, and R.sup.4 and R.sup.5, together with the atoms bearing them, form a monocyclic, bicyclic or tricyclic heterocyclic ring system having 3 to 15 carbon atoms, which process comprises reacting compounds of the formula II defined in the description with compounds of the formula III defined in the description, in the presence of alkanephosphonic anhydrides, where appropriate eliminating radicals which have been introduced to protect other functional groups and, where appropriate, esterifying free carboxyl groups in a manner known per se.
摘要翻译：本发明涉及一种制备式I化合物（I）的方法，其中n为1或2，R表示氢或有机基团，R1表示有机基团，R2和R3相同或不同并且表示氢或有机基团，并且R 4和R 5与带有它们的原子一起形成具有3至15个碳原子的单环，双环或三环杂环体系，该方法包括使在说明书中定义的式II化合物在描述中定义的式III化合物，在烷基膦酸酐存在下，在适当的情况下，消除已经引入以保护其它官能团的基团，并且在适当的情况下，以本身已知的方式酯化游离羧基。

43. 发明授权

US5015642A Benzothiazinone oxides, processes for their preparation, medicaments containing them and the use thereof, and intermediates for their preparation 失效
标题翻译：苯并噻嗪酮氧化物，其制备方法，含有它们的药物及其用途，以及其制备中间体
公开(公告)号：US5015642A
公开(公告)日：1991-05-14
申请号：US230407
申请日：1988-08-10
申请人： Ulrich Lerch , Rainer Henning , Hansjorg Urbach , Joachim Kaiser
发明人： Ulrich Lerch , Rainer Henning , Hansjorg Urbach , Joachim Kaiser
IPC分类号： A61K31/54 , A61K31/5415 , A61P3/00 , A61P3/14 , A61P9/00 , C07D279/16 , C07D417/12
CPC分类号： C07D417/12 , C07D279/16
摘要： Compounds I ##STR1## in which R(1) and R(4) equal H, alkyl, alkoxy, Hal, CF.sub.3, NO.sub.2, OH, acetamido or amino;R(2) equals H, alk(en)yl or phenylalkyl (optionally substituted);R(3) equals H, (cyclo)alk(en)yl-(alkyl), phenyl or phenylalkyl (optionally substituted);A equal CHOH, CO, CH.dbd.CH, C.tbd.C, CH.sub.2, O or S;m equals 1 or 2;n equals 1 to 3;p equals 0 to 4;R(5) equals some amino groups, and their salts, exhibit excellent calcium-antagonistic activity.Processes for their preparation are described.
摘要翻译：其中R（1）和R（4）等于H，烷基，烷氧基，Hal，CF 3，NO 2，OH，乙酰氨基或氨基的化合物I（I） R（2）等于H，alk（en）或苯基烷基（任选取代的）; R（3）等于H，（环）烷基（en） - （烷基），苯基或苯基烷基（任选取代的）; 相同的CHOH，CO，CH = CH，C 3BOND C，CH 2，O或S; m等于1或2; n等于1到3; p等于0到4; R（5）等于一些氨基，它们的盐表现出优异的钙拮抗作用。描述其制备方法。

44. 发明授权

US5008400A Bicyclic aminoacids as intermediates 失效
标题翻译：双环氨基酸作为中间体
公开(公告)号：US5008400A
公开(公告)日：1991-04-16
申请号：US673605
申请日：1984-11-21
申请人： Hansjorg Urbach , Rainer Henning , Volker Teetz , Rolf Geiger , Reinhard Becker , Holger Gaul
发明人： Hansjorg Urbach , Rainer Henning , Volker Teetz , Rolf Geiger , Reinhard Becker , Holger Gaul
IPC分类号： A61K38/55 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P7/10 , A61P9/08 , A61P9/12 , C07D209/02 , C07D209/08 , C07D209/32 , C07D209/34 , C07D209/42 , C07D209/52 , C07D215/22 , C07D215/227 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06
CPC分类号： C07D215/227 , C07D209/08 , C07D209/34 , C07D209/42 , C07D209/52 , C07K5/0222 , A61K38/00
摘要： Disclosed are cis, exo- and trans-compounds of the formula I ##STR1## in which n denotes 0,1 or 2, R.sub.1 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl which can optionally by substituted by amino, (C.sub.1 -C.sub.4)-acyl- or bezoylamino, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl, (C.sub.5 -C.sub.9)-cycloalkenyl, (C.sub.5 -C.sub.7)-cycloalkyl-(C.sub.1 -C.sub.4)-alkyl, aryl or partially hydrogenated aryl, which can, in each case, be substituted by (C.sub.1 -C.sub.2)-alkyl, (C.sub.2 -C.sub.2)-alkoxy or halogen, aryl-(C.sub.1 -C.sub.4)-alkyl, /which can be substituted as defined previously in the aryl radical/, a monocyclic or bicyclic sulfur or nitrogen and/or nitrogen heterocyclic radical, or a side chain of naturally occurring aminoacid, R.sub.2 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl or aryl-(C.sub.1 -C.sub.4)-alkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen, X denotes (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl or aryl which can be mono-, di- or tri- substituted by (C.sub.1 - C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, hydroxyl, halogen, nitro, amino, (C.sub.1 -C.sub.4)-alkylamino, di-(C.sub.1 -C.sub.4)-alkylamino or methylenedioxy, or indol-3-yl, or physiologically acceptable salts thereof, a process for the preparation thereof, agents containing them, their use as a medicine and intermediates for the preparation thereof.

45. 发明授权

US4933361A Derivatives of bicyclic aminoacids agents containing these compounds and their use 失效
标题翻译：含有这些化合物的双环氨基酸试剂的衍生物及其用途
公开(公告)号：US4933361A
公开(公告)日：1990-06-12
申请号：US346339
申请日：1989-04-28
申请人： Hansjorg Urbach , Rainer Henning , Volker Teetz , Rolf Geiger , Reinhard Becker , Holger Gaul
发明人： Hansjorg Urbach , Rainer Henning , Volker Teetz , Rolf Geiger , Reinhard Becker , Holger Gaul
IPC分类号： A61K38/55 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P7/10 , A61P9/08 , A61P9/12 , C07D209/02 , C07D209/08 , C07D209/32 , C07D209/34 , C07D209/42 , C07D209/52 , C07D215/22 , C07D215/227 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06
CPC分类号： C07D215/227 , C07D209/08 , C07D209/34 , C07D209/42 , C07D209/52 , C07K5/0222 , A61K38/00
摘要： Disclosed are cis, exo- and trans-compounds of the formula I ##STR1## in which n denotes 0, 1 or 2, R.sub.1 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl which can optionally be substituted by amino, (C.sub.1 -C.sub.4)-acyl- or bezoylamino, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl, (C.sub.5 -C.sub.9)-cycloalkenyl, (C.sub.5 -C.sub.7)-cycloalkyl-(C.sub.1 -C.sub.4)-alkyl, aryl or partially hydrogenated aryl, which can, in each case, be substituted by (C.sub.1 -C.sub.2)-alkyl, (C.sub.1 -C.sub.2)-alkoxy or halogen, aryl-(C.sub.1 -C.sub.4)-alkyl, /which can be substituted as defined previously in the aryl radical/, a monocyclic or bicyclic sulfur or nitrogen and/or nitrogen heterocyclic radical, or a side chain of naturally occurring aminoacid, R.sub.2 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl or aryl-(C.sub.1 -C.sub.4)-alkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen, X denotes (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.6 -C.sub.9)-cycloalkyl or aryl which can be mono-, di- or tri- substituted by (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, hydroxyl, halogen, nitro, amino, (C.sub.1 -C.sub.4)-alkylamino, di-(C.sub.1 -C.sub.4 -alkylamino or methylenedioxy, or indol-3-yl, or physiologically acceptable salts thereof, a process of the preparation thereof, agents containing them, their use as a medicine and intermediates for the preparation thereof.
摘要翻译：公开了式I的顺式，外转和反式化合物，其中n表示0,1或2，R 1表示氢，可任选被氨基取代的（C 1 -C 6） - 烷基，（C 1 -C 6 - （C 5 -C 9） - 环烷基，（C 5 -C 9） - 环烯基，（C 5 -C 7） - 环烷基 - （C 1 -C 4） - 烷基，芳基或部分氢化的芳基，在每种情况下均可被（C 1 -C 2） - 烷基，（C 1 -C 2） - 烷氧基或卤素，芳基 - （C 1 -C 4） - 烷基取代，在芳基/，单环或双环硫或氮和/或氮杂环基或天然存在的氨基酸的侧链中，R 2表示氢，（C 1 -C 6） - 烷基，（C 2 -C 6） - 烯基或芳基 - （C1-C4） - 烷基，Y表示氢或羟基，Z表示氢或Y，Z表示氧，X表示（C1-C6） - 烷基，（C2-C6） - 烯基，（C6-C9）环烷基或芳基，其可以被（C 1 -C 4） - 烷基，（C 1 -C 4） - 烷氧基，羟基，卤素，硝基，氨基，（C 1 -C 4）烷基氨基，二 - （C 1 -C 4 - 烷基氨基或亚甲二氧基或吲哚-3-基）或其生理上可接受的盐，其制备方法，含有它们的试剂，它们作为药物的用途和制备它们的中间体。

46. 发明授权

US4886827A Cis,endo-2-azabicycloalkane-3-carboxylic acid derivatives, their use and intermediates in their preparation 失效
标题翻译：顺式，内-2-氮杂双环链烷-3-羧酸衍生物，其用途及其制备中间体
公开(公告)号：US4886827A
公开(公告)日：1989-12-12
申请号：US205001
申请日：1988-06-02
申请人： Hansjorg Urbach , Rainer Henning , Winfried Hertzsch
发明人： Hansjorg Urbach , Rainer Henning , Winfried Hertzsch
IPC分类号： C07D209/42 , A61K31/40 , C07D207/42 , C07D209/02 , C07D209/52
CPC分类号： C07D207/42 , C07D209/52
摘要： The invention relates to compounds of the formula I ##STR1## in which n is 1, 2 or 3,Z.sup.1 and Z.sup.2, and Z.sup.3 and Z.sup.4, in each case together represent a chemical bond orZ.sup.1, Z.sup.2, Z.sup.3 and Z.sup.4 in each case represent hydrogen,Z.sup.1 and Z.sup.2 being in the cis configuration relative to one another and the COR.sup.1 group on C atom 3 being in the endo configuration relative to the bicyclic ring system,R.sup.1 denotes hydroxyl, alkoxy, aralkoxy, amino, alkylamino or dialkylamino andR.sup.2 denotes hydrogen, alkyl, aryl, aralkyl, cycloalkyl or alkylcycloalkyl,processes for their preparation and their use.
摘要翻译：本发明涉及式Ⅰ（I）化合物，其中n为1,2或3，Z 1和Z 2，Z 3和Z 4各自在一起代表化学键或Z 1，Z 2，Z 3和Z 4 在每种情况下代表氢，Z1和Z2相对于彼此处于顺式构型，并且C原子3上的COR1基团相对于双环系统处于内部构型，R1表示羟基，烷氧基，芳烷氧基，氨基，烷基氨基或二烷基氨基，R 2表示氢，烷基，芳基，芳烷基，环烷基或烷基环烷基，其制备及其用途。

47. 发明授权

US4849524A Process of preparing proline derivatives 失效
标题翻译：制备脯氨酸衍生物的方法
公开(公告)号：US4849524A
公开(公告)日：1989-07-18
申请号：US122380
申请日：1987-11-19
申请人： Rainer Henning , Hansjorg Urbach
发明人： Rainer Henning , Hansjorg Urbach
IPC分类号： A61K31/40 , A61K31/401 , A61K31/403 , A61K31/404 , A61P9/12 , B01J25/02 , C07B61/00 , C07D207/16 , C07D209/02 , C07D209/18 , C07D209/42 , C07D209/52 , C07D209/54 , C07D209/96 , C07D265/02
CPC分类号： C07D209/52 , C07D207/16 , C07D209/42 , C07D209/96 , C07D265/02
摘要： The invention relates to a process for preparing compounds of the formula I ##STR1## in which R stands for hydrogen, alkyl or aralkyl and R.sup.1 to R.sup.5 are identical or different radicals, (substituted) alkyl, cycloalkyl or (substituted) aryl or in which the pairs of radicals R.sup.1 and R.sup.2, R.sup.2 and R.sup.3, and R.sup.4 and R.sup.5 together with the carbon atom(s) supporting them form a mono- or bicyclic ring system and the other radicals are hydrogen, by treating a compound of the formula II ##STR2## in which R and R.sup.1 and R.sup.5 have the abovementioned meaning and R.sup.6 and R.sup.7 denote alkyl or aralkyl or together with the nitrogen atom supporting them form a heterocycle which can additionally contain an oxygen atom, with a reducing agent.
摘要翻译：本发明涉及一种制备式I的化合物的方法，其中R代表氢，烷基或芳烷基，R 1至R 5是相同或不同的基团，（取代的）烷基，环烷基或（取代的）芳基或在其中基团R 1和R 2，R 2和R 3以及R 4和R 5与支持它们的碳原子一起形成单环或双环环系，而其它基团是氢，通过将式II化合物其中R和R 1和R 5具有上述含义，并且R 6和R 7表示烷基或芳烷基，或与支持它们的氮原子一起形成可另外含有氧原子的杂环与还原剂反应。

48. 发明授权

US10174213B2 Coating system 有权
公开(公告)号：US10174213B2
公开(公告)日：2019-01-08
申请号：US14344775
申请日：2012-09-14
申请人： Juliane Kruesemann , Thomas Frey , Rainer Henning , Annegret Pietsch , Claudia Sierakowski , Tom Landuydt
发明人： Juliane Kruesemann , Thomas Frey , Rainer Henning , Annegret Pietsch , Claudia Sierakowski , Tom Landuydt
IPC分类号： C09D7/00 , C09D101/14 , C09D123/06 , C09D5/33 , C09D5/02 , C09D5/00 , C09D7/41 , C09D7/61
摘要： A coating formed on a substrate is provided which coating comprises (a) an organic NIR-transparent pigment and/or an inorganic NIR-reflective pigment; (b) a dye having a transmittance of at least 75% in the range of from 700 to 2500 nm; and (c) optionally an effect pigment; wherein said coating exhibits a total solar reflectance (TSR) of (i) ≥40%, if 60

49. 发明授权

US07897574B2 Pharmaceutical composition for treating haemorrhagic shock and its consecutive symptoms 失效
标题翻译：用于治疗出血性休克及其连续症状的药物组合物
公开(公告)号：US07897574B2
公开(公告)日：2011-03-01
申请号：US12158670
申请日：2006-11-10
申请人： Peter Petzelbauer , Rainer Henning
发明人： Peter Petzelbauer , Rainer Henning
IPC分类号： A61K38/36
CPC分类号： A61K38/16 , Y02A50/411
摘要： The invention is concerned with the use of a peptide comprising the N-terminal sequence Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro-Ala- Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg (SEQ ID NO: 1) or any allelic variant or derivative of said peptide possessing the biological property of matching the inducible VE-cadherin binding motif on the Bβ-chain (i.e. Bβ15-42) of human fibrin for the preparation of a pharmaceutical preparation for the treatment of shock, more specifically of hemorrhagic shock.
摘要翻译：本发明涉及使用包含N-末端序列Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro- （SEQ ID NO：1）或具有与诱导型VE-钙粘蛋白结合基序匹配的生物学特性的所述肽的任何等位基因变体或衍生物（Pro-Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg 在人类纤维蛋白的B＆bgr-chain（即B＆Bgr; 15-42）上制备用于治疗休克的药物制剂，更具体地说是出血性休克。

50. 发明申请

US20100267615A1 METHODS FOR TREATMENT AND/OR PREVENTION OF A DISEASE ASSOCIATED WITH VASCULAR LEAK 审中-公开
标题翻译：治疗和/或预防与血管通透相关的疾病的方法
公开(公告)号：US20100267615A1
公开(公告)日：2010-10-21
申请号：US12793388
申请日：2010-06-03
申请人： Peter Petzelbauer , Rainer Henning , Sonja Reingruber , Waltraud Pasteiner , Marion Gröger
发明人： Peter Petzelbauer , Rainer Henning , Sonja Reingruber , Waltraud Pasteiner , Marion Gröger
IPC分类号： A61K38/16 , A61P5/00 , A61P11/06 , A61P35/00 , A61P27/06 , A61P27/02 , A61P3/10
CPC分类号： G01N33/5064 , G01N33/5088 , G01N2400/50 , G01N2800/328
摘要： The present invention is directed to methods for treatment and/or prevention of a disease associated with vascular leak in a patient comprising administering to the patient an effective amount of SEQ ID NO: 1.
摘要翻译：本发明涉及用于治疗和/或预防与患者血管渗漏相关的疾病的方法，其包括向患者施用有效量的SEQ ID NO：1。

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