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41. 发明授权

US08527051B1 Detection and reduction of phrenic nerve stimulation 有权
标题翻译：检测和减少膈神经刺激
公开(公告)号：US08527051B1
公开(公告)日：2013-09-03
申请号：US13545776
申请日：2012-07-10
申请人： Sven-Erik Hedberg , Tomas Svensson , Kjell Noren , Stuart Rosenberg , Kyungmoo Ryu , Edward Karst
发明人： Sven-Erik Hedberg , Tomas Svensson , Kjell Noren , Stuart Rosenberg , Kyungmoo Ryu , Edward Karst
IPC分类号： A61N1/37
CPC分类号： A61N1/36521 , A61N1/3702
摘要： The present invention provides implantable medical devices for detecting phrenic nerve stimulation. A pacing module is configured to deliver pacing pulses having a predetermined pulse amplitude and/or width within the refractory period of the left ventricle. The pacing pulses are repeatedly delivered during a number of cardiac cycles, and the pacing pulses are delivered at different delays relative to an onset of the refractory period of the left ventricle in different cardiac cycles. An impedance measurement module is configured to measure impedance signals in time windows synchronized with the delivery of pacing pulses in the refractory period of the left ventricle. A phrenic nerve stimulation, PNS, detection module is configured to gather at least one impedance signal from each time window, create aggregated impedance signals using the impedance signals from the different time windows, and analyze the aggregated impedance signals to detect PNS.
摘要翻译：本发明提供了用于检测膈神经刺激的可植入医疗装置。起搏模块被配置为在左心室的不应期内输送具有预定脉冲幅度和/或宽度的起搏脉冲。起搏脉冲在多个心动周期期间重复递送，起搏脉冲相对于不同心脏周期中左心室的不应期的开始以不同的延迟递送。阻抗测量模块被配置为测量与在左心室的不应期中递送起搏脉冲同步的时间窗内的阻抗信号。膈神经刺激，PNS检测模块配置为从每个时间窗口收集至少一个阻抗信号，使用来自不同时间窗口的阻抗信号创建聚合阻抗信号，并分析聚合阻抗信号以检测PNS。

42. 发明授权

US08068908B2 Implantable cardiac stimulator, system, device and method for monitoring cardiac synchrony 有权
标题翻译：可植入式心脏刺激器，系统，装置和监测心脏同步的方法
公开(公告)号：US08068908B2
公开(公告)日：2011-11-29
申请号：US12094543
申请日：2005-11-30
申请人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
发明人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location of a heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the first sensor measures said cardiac wall movements at the first cardiac wall location and emits a first sensor output signal corresponding thereto, a second sensor is positioned at a second cardiac wall location of the heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the second sensor measures the cardiac wall movements at the second cardiac wall location and emits a second sensor output signal corresponding thereto. A lead arrangement is electrically connected to the first and second sensors and conducts the first and second sensor output signals therefrom to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.
摘要翻译：在用于监测人心脏心脏同步的系统和方法中，第一传感器位于心脏的第一心脏壁位置处，该第一心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动有关的运动，第一传感器传感器测量在第一心脏壁位置处的心脏壁运动，并且发射与其对应的第一传感器输出信号，第二传感器定位在心脏的第二心脏壁位置处，该第二心脏壁位置受到与沿着纵向的纵向瓣膜平面运动相关的运动并且第二传感器测量第二心脏壁位置处的心脏壁移动，并且发出与其对应的第二传感器输出信号。引线装置电连接到第一和第二传感器，并将第一和第二传感器输出信号传送到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在各个阀平面运动中同步的同步信号第一和第二心脏壁位置。

43. 发明申请

US20100106210A1 IMPLANTABLE MEDICAL SYSTEM FOR DETECTING INCIPIENT EDEMA 有权
标题翻译：用于检测机动车辆的可植入医疗系统
公开(公告)号：US20100106210A1
公开(公告)日：2010-04-29
申请号：US12531793
申请日：2007-04-24
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
IPC分类号： A61N1/365 , A61B6/00 , A61B5/00
CPC分类号： A61N1/05 , A61B5/0084 , A61B5/0086 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/7207 , A61N1/025 , A61N1/056 , A61N1/362
摘要： An implantable medical system for detecting incipient edema has an implantable medical lead including an optical sensor having a light source and a light detector. The medical system further has an edema detection circuit that activates the light source to emit light, the light being directed into lung tissue of a patient and that obtains a light intensity value corresponding to an intensity of light received by the light detector, and that evaluates the light intensity value to detect a consistency with incipient edema.
摘要翻译：用于检测初期水肿的可植入医疗系统具有包括具有光源和光检测器的光学传感器的可植入医疗引线。医疗系统还具有水肿检测电路，其激活光源发光，将光引导到患者的肺组织，并获得与由光检测器接收的光的强度对应的光强度值，并且评估光强值检测与初期水肿的一致性。

44. 发明申请

US20100058480A1 INFORMATION MANAGEMENT IN DEVICES WORN BY A USER 审中-公开
标题翻译：用户信息管理
公开(公告)号：US20100058480A1
公开(公告)日：2010-03-04
申请号：US12373545
申请日：2006-07-13
申请人： Sven-Erik Hedberg , Patrik Malmberg , Leif Lychou , Jürgen Kerstna , Ellen Tjälldin
发明人： Sven-Erik Hedberg , Patrik Malmberg , Leif Lychou , Jürgen Kerstna , Ellen Tjälldin
IPC分类号： G06F21/00 , H04L9/32 , G06Q50/00 , G08B23/00
CPC分类号： A61N1/37211 , A61B5/0402 , A61B5/6843 , A61N1/37282 , G16H40/63
摘要： An implantable medical device that is physically connectable to the body of a user has an information manager that manages sensitive information associated with the user or the device. A sensor is connected to the device that senses whether the device is physically connected to the body of the user, and generates a signal indicating whether the device is actually connected to the body of the user. The information manager is connected to the sensor, and is responsive to the sensor signal so as to perform information managing functions based on the signal. Among other things, fraudulent retrieval of sensitive data from the device is prevented if the device is not connected to or implanted in the body of the user.
摘要翻译：物理上可连接到用户身体的可植入医疗设备具有管理与用户或设备相关联的敏感信息的信息管理器。感测器连接到感测设备物理连接到用户身体的设备，并且产生指示设备是否实际连接到用户身体的信号。信息管理器连接到传感器，并响应于传感器信号，以便根据信号执行信息管理功能。除此之外，如果设备未连接到或植入用户的身体，则防止来自设备的敏感数据的欺诈性检索。

45. 发明授权

US07483742B2 Detection of diastolic heart failure 有权
标题翻译：舒张性心力衰竭的检测
公开(公告)号：US07483742B2
公开(公告)日：2009-01-27
申请号：US10562109
申请日：2004-04-26
申请人： Sven-Erik Hedberg , Anders Björling , Maria Torpo , Karin Ljungström
发明人： Sven-Erik Hedberg , Anders Björling , Maria Torpo , Karin Ljungström
IPC分类号： A61N1/00
CPC分类号： A61B5/021 , A61B5/02154 , A61N1/3627 , A61N1/36564 , A61N1/3702 , G06F19/00
摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. The DHF determining device includes a pressure measuring unit for measuring pulse pressure in a cardiac cycle for a predetermined workload situation of the patient as the blood pressure parameter, and a comparator compares the measured pulse pressure with a predetermined reference value. A pacemaker includes such an apparatus and a control unit that optimizes pacing therapy depending on the result of the comparison of the measured pulse pressures with the predetermined reference values. A corresponding method of detecting diastolic heart failure, DHF, includes the step of determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient by determining, as said blood pressure parameter, the pulse pressure in a cardiac cycle for a predetermined workload situation of the patient, and the determined pulse pressure is compared with a predetermined reference value.
摘要翻译：用于检测舒张性心力衰竭的可植入医疗装置DHF具有用于确定用于检测患者心脏的DHF状态的至少一个血压参数的DHF确定装置。 DHF确定装置包括：压力测量单元，用于在患者的预定工作情况下测量心动周期中的脉搏压力作为血压参数，并且比较器将测量的脉搏压力与预定参考值进行比较。起搏器包括这样的装置和控制单元，其根据所测量的脉搏压力与预定参考值的比较结果优化起搏治疗。检测舒张性心力衰竭DHF的相应方法包括以下步骤：通过将作为所述血压参数的心脏周期中的脉搏压力确定为心动周期中的脉搏压力来确定用于检测患者心脏的DHF状态的至少一个血压参数患者的预定工作情况，并将确定的脉搏压力与预定的参考值进行比较。

46. 发明授权

US06950696B2 Method and circuit for detecting cardiac rhythm abnormalities by analyzing time differences between unipolar signals from a lead with a multi-electrode tip 失效
标题翻译：通过分析来自具有多电极尖端的引线的单极信号之间的时间差来检测心律异常的方法和电路
公开(公告)号：US06950696B2
公开(公告)日：2005-09-27
申请号：US09995198
申请日：2001-11-27
申请人： Anders Björling , Sven-Erik Hedberg , Ulf Lindegren , Anders Lindgren
发明人： Anders Björling , Sven-Erik Hedberg , Ulf Lindegren , Anders Lindgren
IPC分类号： A61N1/362 , A61N1/39 , A61B5/046
CPC分类号： A61N1/3622 , A61N1/3956 , Y10S128/923
摘要： A circuit and method for detecting cardiac rhythm abnormalities employ unipolar signals respectively obtained from a cardiac lead having a tip at which a number of separate electrodes are disposed, the electrodes being simultaneously in contact with cardiac tissue. The respective unipolar signals which are obtained from the multiple electrodes exhibit a time relationship relative to each other, and this time relationship is analyzed to determine whether a cardiac rhythm abnormality is present or one or more of the unipolar signals is compared to a template which is known to represent a cardiac abnormality. Analysis of the time relation is undertaken by determining the absolute value of a time offset between any two of the unipolar signals, or by correlating any two of the unipolar signals.
摘要翻译：用于检测心律异常的电路和方法使用分别从具有设置有多个分离电极的尖端的心脏引线获得的单极信号，电极同时与心脏组织接触。从多个电极获得的各个单极信号相对于彼此呈现时间关系，并且分析该时间关系以确定是否存在心律异常，或者将一个或多个单极信号与模板相比较已知代表心脏异常。时间关系的分析是通过确定任何两个单极信号之间的时间偏移的绝对值，或通过将任意两个单极信号相关来进行的。

47. 发明授权

US06915162B2 Implantable medical device for measuring ventricular pressure 有权
标题翻译：用于测量心室压力的可植入医疗器械
公开(公告)号：US06915162B2
公开(公告)日：2005-07-05
申请号：US10002496
申请日：2001-11-15
申请人： Kjell Noren , Charlotte Kjellmann , Kenth Nilsson , Sven-Erik Hedberg
发明人： Kjell Noren , Charlotte Kjellmann , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61B5/0215 , A61N1/365 , A61B5/04
CPC分类号： A61N1/36564 , A61B5/0215 , A61B5/7239
摘要： An implantable medical device has a pressure sensing arrangement to measure right ventricular pressure of a heart including a pressure sensor adapted to be positioned in the right ventricle of the heart, to measure the pressure and to generate a pressure signal in response to the measured pressure. The pressure sensing arrangement also has a pressure signal processor and a timing unit. The processor determines from the pressure signal, using diastolic timing signals from the timing unit based on the pressure signal identifying the diastolic phase, a diastolic pressure signal representing the ventricular pressure only during the diastolic phase of the heart cycle.
摘要翻译：可植入医疗装置具有用于测量心脏的右心室压力的压力感测装置，包括适于定位在心脏右心室的压力传感器，以测量压力并响应于测量的压力产生压力信号。压力感测装置还具有压力信号处理器和定时单元。处理器根据压力信号，基于识别舒张期的压力信号使用来自定时单元的舒张定时信号，仅在心脏周期舒张期期间表示心室压力的舒张压信号。

48. 发明申请

US20050004607A1 Cardiac stimulating and detecting device, system and method for identifying far field signals 有权
标题翻译：用于识别远场信号的心脏刺激和检测装置，系统和方法
公开(公告)号：US20050004607A1
公开(公告)日：2005-01-06
申请号：US10864064
申请日：2004-06-09
申请人： Anders Bjorling , Sven-Erik Hedberg , Nils Holmstrom
发明人： Anders Bjorling , Sven-Erik Hedberg , Nils Holmstrom
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/37 , A61N1/3627 , A61N1/3684 , Y10S128/901
摘要： In an implantable heart stimulating device, system and method, a control circuit has first and second circuits for sensing and pacing. The first circuit can be connected to a first electrode member suited to be positioned in or at a first ventricle of the heart. The second circuit can be connected to a second electrode member suited to be positioned in or at a second ventricle of the heart. The control circuit is able to detect whether signals sensed by the second circuit are likely to be far field signals. The control circuit performs this detection by at least determining whether, during a predetermined time (length, more signals are sensed by the second circuit than by the first circuit.
摘要翻译：在可植入心脏刺激装置，系统和方法中，控制电路具有用于感测和起搏的第一和第二电路。第一电路可以连接到适于定位在心脏的第一心室中或第一心室处的第一电极构件。第二电路可以连接到适于定位在心脏的第二心室中或第二心室处的第二电极构件。控制电路能够检测由第二电路感测的信号是否可能是远场信号。控制电路通过至少确定在预定时间（长度，由第二电路感测到的信号多于第一电路的信号）来执行该检测。

49. 发明授权

US06529777B1 Electrode for tissue stimulation 失效
标题翻译：电极组织刺激
公开(公告)号：US06529777B1
公开(公告)日：2003-03-04
申请号：US09622817
申请日：2000-08-23
申请人： Nils Holmström , Sven-Erik Hedberg , Kenth Nilsson
发明人： Nils Holmström , Sven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61N105
CPC分类号： A61N1/371 , A61N1/0565 , A61N1/362 , A61N1/36585
摘要： In an implantable electrode for an electrode lead for a stimulation device for stimulating tissue, the electrode is formed as a biocompatible piezoelectric electrode which is adapted to be in direct electrical contact with tissue for electrically and mechanically stimulating the tissue and for detecting electrical and mechanical evoked response of the stimulated tissue. The stimulation device can include circuitry for making a diagnosis of a heart condition using signals received from the implantable electrode.
摘要翻译：在用于刺激组织的刺激装置的电极引线的可植入电极中，电极形成为生物相容性压电电极，其适于与组织直接电接触，用于电和机械刺激组织并检测电和机械诱发刺激组织的反应。刺激装置可以包括使用从可植入电极接收的信号进行心脏状况诊断的电路。

50. 发明授权

US6078835A Pacemaker wherein emission of stimulation pulses is controlled dependent on stretching of the ventricular wall 失效
标题翻译：其中刺激脉冲的发射取决于心室壁的拉伸来控制起搏器
公开(公告)号：US6078835A
公开(公告)日：2000-06-20
申请号：US242278
申请日：1998-02-12
申请人： Sven-Erik Hedberg , Karin Jarverud , Kjell Noren , Staffan Bowald
发明人： Sven-Erik Hedberg , Karin Jarverud , Kjell Noren , Staffan Bowald
IPC分类号： A61N1/365
CPC分类号： A61N1/36564
摘要： A pacemaker has control circuits contained in an enclosure and a lead containing an electrical conductor connected to an electrode for delivering electrical stimulation pulses to a heart. The stretching of a wall in the ventricle, corresponding to adequate filling of the ventricle in the heart, is determined in order to identify a time of emitting the stimulation pulses. This stretching is measured indirectly by measurement of pressure in the ventricle using a pressure sensor disposed near the lead in the ventricle. The signal from the sensor is supplied via the lead to circuitry in the enclosure, wherein the signal is amplified and is supplied to an edge detector, which detects an increasing or positive edge of the signal. The edge detector compares the incoming signal with a threshold value, and when the pressure indicated by the signal increases so as to exceed the threshold value, the edge detector supplies a signal to the control circuit which, in turn, triggers the emission of a stimulation pulse from a pulse generator, with or without a delay. The aforementioned stretching can also be measured using a strain gauge or a distance sensor attached to the ventricle wall.
摘要翻译： PCT No.PCT / SE97 / 01239 Sec。 371日期1999年2月12日 102（e）1999年2月12日PCT PCT 1997年7月4日PCT公布。公开号WO98 / 06454 日期1998年2月19日起搏器具有包含在外壳中的控制电路和包含连接到电极的电导体的引线，用于将电刺激脉冲传递到心脏。为了确定发射刺激脉冲的时间，确定对应于心脏中心室充分填充的心室中的壁的拉伸。使用设置在心室中的引线附近的压力传感器通过测量心室中的压力来间接测量该拉伸。来自传感器的信号通过导线提供给外壳中的电路，其中信号被放大并被提供给检测信号的增加或上升沿的边缘检测器。边缘检测器将输入信号与阈值进行比较，并且当信号指示的压力增加以超过阈值时，边缘检测器向控制电路提供信号，该信号又触发了刺激的发射来自脉冲发生器的脉冲，有或没有延迟。上述拉伸也可以使用附着于心室壁的应变计或距离传感器来测量。

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