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1. 发明申请

US20050004607A1 Cardiac stimulating and detecting device, system and method for identifying far field signals 有权
标题翻译：用于识别远场信号的心脏刺激和检测装置，系统和方法
公开(公告)号：US20050004607A1
公开(公告)日：2005-01-06
申请号：US10864064
申请日：2004-06-09
申请人： Anders Bjorling , Sven-Erik Hedberg , Nils Holmstrom
发明人： Anders Bjorling , Sven-Erik Hedberg , Nils Holmstrom
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/37 , A61N1/3627 , A61N1/3684 , Y10S128/901
摘要： In an implantable heart stimulating device, system and method, a control circuit has first and second circuits for sensing and pacing. The first circuit can be connected to a first electrode member suited to be positioned in or at a first ventricle of the heart. The second circuit can be connected to a second electrode member suited to be positioned in or at a second ventricle of the heart. The control circuit is able to detect whether signals sensed by the second circuit are likely to be far field signals. The control circuit performs this detection by at least determining whether, during a predetermined time (length, more signals are sensed by the second circuit than by the first circuit.
摘要翻译：在可植入心脏刺激装置，系统和方法中，控制电路具有用于感测和起搏的第一和第二电路。第一电路可以连接到适于定位在心脏的第一心室中或第一心室处的第一电极构件。第二电路可以连接到适于定位在心脏的第二心室中或第二心室处的第二电极构件。控制电路能够检测由第二电路感测的信号是否可能是远场信号。控制电路通过至少确定在预定时间（长度，由第二电路感测到的信号多于第一电路的信号）来执行该检测。

2. 发明申请

US20080091239A1 Cardiac assist device and method using epicardially placed microphone 审中-公开
标题翻译：使用心外膜放置麦克风的心脏辅助装置和方法
公开(公告)号：US20080091239A1
公开(公告)日：2008-04-17
申请号：US11582211
申请日：2006-10-16
申请人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
发明人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
IPC分类号： A61N1/36 , A61N1/362 , A61N1/39
CPC分类号： A61N1/36514 , A61N1/3956
摘要： In a cardiac assist device and method, a microphone is placed in contact with the epicardium of the heart of a patient, and heart and lung sounds are simultaneously detected at the placement location of the microphone. The heart and lung sounds are automatically analyzed to set an appropriate cardiac therapy for the patient.
摘要翻译：在心脏辅助装置和方法中，将麦克风放置成与患者心脏的心外膜接触，并且在麦克风的放置位置同时检测心脏和肺部的声音。自动分析心脏和肺部声音，为患者设定适当的心脏治疗。

3. 发明授权

US09162066B2 Method and system for stimulating a heart 有权
标题翻译：刺激心脏的方法和系统
公开(公告)号：US09162066B2
公开(公告)日：2015-10-20
申请号：US13508968
申请日：2011-05-31
申请人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
发明人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： A first ventricle is stimulated at a stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node is computed. A similar process is used to compute a second activation time interval for the other ventricle. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined.
摘要翻译：在刺激部位刺激第一脑室，估计从刺激产生的至少一个去极化波到达AV节点的时间点，并且基本对应于至少一个去极化所需的时间间隔的第一激活时间间隔计算从第一脑室的刺激部位到AV节点的波。使用类似的过程来计算另一个心室的第二激活时间间隔。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗。

4. 发明授权

US5935158A Electrode lead and device for tissue stimulation and/or detection of tissue response 失效
标题翻译：用于组织刺激和/或检测组织反应的电极引线和装置
公开(公告)号：US5935158A
公开(公告)日：1999-08-10
申请号：US915756
申请日：1997-08-21
申请人： Nils Holmstrom , Sven-Erik Hedberg , Kenth Nilsson
发明人： Nils Holmstrom , Sven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61N1/05 , A61N1/362 , A61N1/39 , A61N1/04
CPC分类号： A61N1/0565
摘要： An implantable electrode for stimulating tissue has a piezoelectric electrode for electrically and mechanically stimulating tissue and for detecting electrical and mechanical evoked response of the stimulated tissue. An implantable lead and an implantable stimulation device employing such an electrode are described including diagnostic circuitry for making a diagnosis of the heart condition using such an electrode.
摘要翻译：用于刺激组织的可植入电极具有用于电和机械刺激组织并用于检测受刺激组织的电和机械诱发反应的压电电极。描述了使用这种电极的可植入引线和可植入刺激装置，其包括使用这种电极进行心脏病症诊断的诊断电路。

5. 发明申请

US20140257423A1 METHOD AND SYSTEM FOR STIMULATING A HEART 有权
标题翻译：用于刺激心脏的方法和系统
公开(公告)号：US20140257423A1
公开(公告)日：2014-09-11
申请号：US13508968
申请日：2011-05-31
申请人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
发明人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： The present invention relates generally to implantable medical devices and more particularly to systems and methods for stimulating a heart of a patient. A first ventricle is activated by delivering stimulation to at least one stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the first ventricle is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node using the estimated point of time for arrival of the depolarization wave and a point of time for delivery of stimulation is computed. Thereafter, the other ventricle is stimulated by delivering stimulation to at least one stimulation site. A point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the other ventricle is then estimated and a second activation time interval substantially corresponding to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node using the estimated arrival of the depolarization wave and the point of time for delivery of stimulation is computed. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined, wherein the first ventricle is paced prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and the other ventricle is paced prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.
摘要翻译：本发明一般涉及可植入医疗装置，更具体地涉及用于刺激患者心脏的系统和方法。通过向至少一个刺激部位递送刺激来激活第一脑室，估计到达在第一脑室刺激产生的至少一个去极化波的AV节点的时间点，并且基本对应于计算使用去极化波的到达的估计时间点和用于递送刺激的时间点的至少一个去极化波从第一脑室的刺激部位行进到AV节点所需的时间间隔。此后，通过将刺激递送至至少一个刺激部位刺激另一个心室。然后估计到达AV节点对于在另一个心室中的刺激产生的至少一个去极化波的时间点，并且基本对应于至少一个去极化波从刺激行进所需的时间的第二激活时间间隔计算使用去极化波的估计到达和输送刺激的时间点在AV节点的另一脑室中的位置。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗，其中如果激活时间差指示第一激活时间间隔长于第二心室第二激活时间间隔，则第一心室在另一心室激活之前起搏如果所述激活时间差指示所述第二激活时间间隔长于所述第一激活时间间隔，则所述激活时间间隔和所述另一个心室在所述第一心室激活之前起步。

6. 发明申请

US20090076560A1 Biventricular Heart Stimulator and Method of Controlling a Biventricular Heart Stimulator 有权
标题翻译：双心室心脏刺激器和控制双心室心脏刺激器的方法
公开(公告)号：US20090076560A1
公开(公告)日：2009-03-19
申请号：US11885326
申请日：2005-03-02
申请人： Anders Bjorling , Nils Holmstrom
发明人： Anders Bjorling , Nils Holmstrom
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： In a biventricular heart stimulator and a method for controlling such a biventricular heart stimulator, successive stimulation pulses are delivered to the ventricles of a heart such that stimulation pulses in a single heartbeat cycle are respectively first delivered to the first ventricle and then to the second ventricle. Capture or loss of capture in response to stimulation pulses delivered to one ventricle is detected. As a result of a detected loss of capture, preventative measures are taken for preventing loss of capture in the other ventricle.
摘要翻译：在双心室心脏刺激器和用于控制这种双心室心脏刺激器的方法中，连续的刺激脉冲被递送到心脏的心室，使得单个心跳周期中的刺激脉冲分别首先被传送到第一脑室，然后被传送到第二脑室。检测到响应于输送到一个脑室的刺激脉冲的捕获或丢失。由于检测到的捕获损失，采取预防措施来防止在另一脑室中的捕获损失。

7. 发明申请

US20120184866A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MULTISITE MEASUREMENT OF INTRACARDIAC IMPEDANCE 审中-公开
标题翻译：可植入医疗装置和方法用于多药耐药的测量
公开(公告)号：US20120184866A1
公开(公告)日：2012-07-19
申请号：US13498568
申请日：2009-09-29
申请人： Nils Holmstrom , Anders Bjorling
发明人： Nils Holmstrom , Anders Bjorling
IPC分类号： A61B5/0408
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/686 , A61N1/3627 , A61N1/3702 , A61N1/3956
摘要： The present invention generally relates to an implantable medical device and method for detecting and monitoring cardiac status of a patient using simultaneous multisite measurements of the intracardiac impedance and in particular to ischemia detection using the simultaneous multisite measurements. The device comprises an impedance measuring unit being connectable to a plurality of electrode configurations including a current generating device adapted to generate a current and apply the current between two electrodes of a current injecting electrode configuration of the electrode configurations and a voltage sensing device including a plurality of voltage sensing circuits arranged in parallel. Each voltage sensing circuit being connectable to a specific voltage sensing electrode configuration of the electrode configurations and being arranged to sense a voltage over the voltage sensing electrode configuration resulting from the applied current, wherein the voltage sensing circuits are capable of sensing the resulting voltages simultaneously. The device further comprises an impedance calculating module adapted to calculate a plurality of impedance values, each impedance value being based on the applied current and a resulting voltage.
摘要翻译：本发明总体上涉及一种可植入医疗装置和方法，用于使用同时进行心脏内阻抗的多站点测量来检测和监测患者的心脏状态，特别是使用同时多站点测量的缺血检测。该装置包括阻抗测量单元，其可连接到多个电极配置，包括适于产生电流的电流产生装置，并施加电极配置的电流注入电极配置的两个电极之间的电流;以及电压感测装置，包括多个的电压感测电路并联布置。每个电压感测电路可连接到电极配置的特定电压感测电极配置，并且布置成感测由所施加的电流产生的电压感测电极配置上的电压，其中电压感测电路能够同时感测所得到的电压。该装置还包括适于计算多个阻抗值的阻抗计算模块，每个阻抗值基于所施加的电流和所得到的电压。

8. 发明授权

US07546161B1 Methods for loss of capture and fusion avoidance in biventricular pacing therapy 有权
标题翻译：双心室起搏治疗中捕获和融合避免的方法
公开(公告)号：US07546161B1
公开(公告)日：2009-06-09
申请号：US11330316
申请日：2006-01-11
申请人： Anders Bjorling , Xiaoyi Min , Richard Williamson , Karin Jarverud , Nils Holmstrom
发明人： Anders Bjorling , Xiaoyi Min , Richard Williamson , Karin Jarverud , Nils Holmstrom
IPC分类号： A61N1/368
CPC分类号： A61N1/3712 , A61B5/0452 , A61N1/3684
摘要： An exemplary method includes delivering biventricular pacing therapy using one or more timing parameters, detecting loss of capture, deciding if fusion exists without adjusting the one or more timing parameters and, based on the deciding, calling for fusion avoidance or calling for a capture threshold search. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括使用一个或多个定时参数提供双心室起搏治疗，检测捕获的丢失，确定融合是否存在而不调整一个或多个定时参数，以及基于决定呼叫融合避免或调用捕获阈值搜索。还公开了各种其它示例性方法，装置，系统等。

9. 发明申请

US20090030470A1 IMPLANTABLE HEART STIMULATION DEVICE WITH REMEDIAL RESPONSE TO ANODAL CAPTURE 审中-公开
标题翻译：具有针对阳极捕获的补救措施的可植入心脏刺激装置
公开(公告)号：US20090030470A1
公开(公告)日：2009-01-29
申请号：US12160849
申请日：2006-01-26
申请人： Nils Holmstrom , Anders Bjorling
发明人： Nils Holmstrom , Anders Bjorling
IPC分类号： A61N1/368
CPC分类号： A61N1/371 , A61N1/3684
摘要： An implantable heart stimulating device has a left ventricular coronary sinus electrode lead provided with a tip electrode, a right ventricular electrode lead provided with a ring electrode, and a pulse generator connected to the leads that applies stimulation pulses between the tip electrode and the ring electrode, with the tip electrode serving as the anode. A monitoring unit monitors for and detects anodal capture at the right ventricular ring electrode subsequent to a stimulation. If anodal capture is detected, either a threshold search is performed by varying the pulse width and/or pulse amplitude of stimulation pulses in order to identify stimulation pulse characteristics that avoid anodal capture at the ring electrode, or at least one further electrode is activated to function as an indifferent electrode together with the ring electrode, also in order to avoid anodal capture at the ring electrode.
摘要翻译：可植入心脏刺激装置具有设置有尖端电极的左心室冠状窦电极引线，设置有环形电极的右心室电极引线和连接到引线的脉冲发生器，其在尖端电极和环形电极之间施加刺激脉冲，尖端电极用作阳极。监测单元在刺激之后监测和检测右心室环电极处的阳极捕获。如果检测到阳极捕获，则通过改变刺激脉冲的脉冲宽度和/或脉冲幅度来执行阈值搜索，以便识别避免在环形电极处的阳极捕获的刺激脉冲特性，或者至少一个另外的电极被激活与环形电极一起作为无关电极，也是为了避免在环形电极处的阳极捕获。

10. 发明申请

US20080281373A1 Implantable Heart Stimulator and Method for Operation Thereof 有权
标题翻译：可植入心脏刺激仪及其操作方法
公开(公告)号：US20080281373A1
公开(公告)日：2008-11-13
申请号：US11793478
申请日：2004-12-17
申请人： Anders Bjorling , Nils Holmstrom
发明人： Anders Bjorling , Nils Holmstrom
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61N1/3712
摘要： In an implantable heart stimulator and a method for operation thereof, stimulation pulses are delivered to a heart. The amplitude of the delivered stimulation pulses can be selectively set. For setting the amplitude, threshold searches are performed at selected time intervals. Each threshold search determines a threshold value required for achieving capture. The amplitudes of the respective stimulation pulses are set to a value that exceeds the determined threshold value by a safety margin. The safety margin is selected as a function of the selected time intervals.
摘要翻译：在可植入心脏刺激器及其操作方法中，将刺激脉冲输送到心脏。输送的刺激脉冲的幅度可以选择性地设定。为了设置幅度，以选定的时间间隔执行阈值搜索。每个阈值搜索确定实现捕获所需的阈值。相应的刺激脉冲的振幅被设置为超过所确定的阈值的安全裕度的值。根据所选择的时间间隔选择安全裕度。

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