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41. 发明授权

US07237898B1 Customized corneal profiling 有权
标题翻译：定制角膜分析
公开(公告)号：US07237898B1
公开(公告)日：2007-07-03
申请号：US10110922
申请日：2000-10-20
申请人： Kristian Hohla , Gerhard Youssefi , Charles R. Broadus , Timothy N. Turner
发明人： Kristian Hohla , Gerhard Youssefi , Charles R. Broadus , Timothy N. Turner
IPC分类号： A61B3/00 , A61B3/103 , A61B3/107
CPC分类号： A61F9/00806 , A61B5/117 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , G06F19/00 , G06K9/00597
摘要： A customized corneal profile is provided by combining corneal topography data with captured wavefront aberration data to form a course of refractive treatment of the eye. In one embodiment, the captured wavefront data is employed within the area of a pupil, while the corneal topography data is employed in the area outside of the pupil. In other embodiments, the topography data is adjusted based on the wavefront data, a course of refractive treatment is simulated and displayed upon the topography data, and an initial evaluation of the suitability of a patient for treatment is performed based on the topography data.
摘要翻译：通过将角膜形貌数据与捕获的波前像差数据组合以形成眼睛的折射治疗过程来提供定制的角膜轮廓。在一个实施例中，在瞳孔的区域内采用所捕获的波前数据，而在瞳孔外的区域使用角膜地形数据。在其他实施例中，基于波前数据来调整地形数据，在地形数据上模拟和显示折射处理的过程，并且基于地形数据执行用于治疗的患者的适合性的初始评估。

42. 发明申请

US20070055222A1 Iris recognition and tracking for optical treatment 有权
标题翻译：虹膜识别和跟踪光学治疗
公开(公告)号：US20070055222A1
公开(公告)日：2007-03-08
申请号：US11595386
申请日：2006-11-09
申请人： Kristian Hohla , Thomas Neuhann , Gerhard Youssefi , Roland Toennies
发明人： Kristian Hohla , Thomas Neuhann , Gerhard Youssefi , Roland Toennies
IPC分类号： A61F9/008
CPC分类号： G06K9/00597 , A61B5/117 , A61F9/00804 , A61F9/00806 , A61F2009/00846 , A61F2009/00872 , A61F2009/00876 , A61F2009/0088 , A61F2009/00882
摘要： A system and method are provided in which an iris or eye image is taken during a refractive diagnostic analysis. The image is employed for aligning data from the analysis with data from other refractive analysis instruments, as well as aligning a refractive surgical tool, such as a laser, with the eye for treatment. Further, the stored iris image is compared with the patient's iris before treatment, verifying that the correct eye is to be treated with a developed treatment pattern. A variety of refractive instruments can be used, such as corneal topography systems and wavefront aberration systems.
摘要翻译：提供了一种系统和方法，其中在折射诊断分析期间拍摄虹膜或眼睛图像。该图像用于将来自分析的数据与来自其它折射分析仪器的数据进行对准，以及将屈光手术工具（例如激光）与眼睛对准以进行治疗。此外，将存储的虹膜图像与治疗前的患者虹膜进行比较，验证是否以开发的治疗模式治疗正确的眼睛。可以使用各种屈光仪器，例如角膜地形系统和波前像差系统。

43. 发明申请

US20060152677A1 Wavefront sensor having multi-power beam modes, independent adjustment camera, and accommodation range measurement 有权
公开(公告)号：US20060152677A1
公开(公告)日：2006-07-13
申请号：US11369105
申请日：2006-03-06
申请人： Gerhard Youssefi , Hans-Joachim Polland , Christoph Sappel
发明人： Gerhard Youssefi , Hans-Joachim Polland , Christoph Sappel
IPC分类号： A61B3/10 , A61B3/00
CPC分类号： A61B3/1015 , G01J9/00
摘要： An improved wavefront sensor is provided that enhances the initial focus and precision of imaged spots used to determine the monochromatic wave aberrations of the eye. The wavefront sensor includes an adjustment camera that is independent of a lenslet camera. A laser in a lower power mode is projected onto the retina of the eye and is brought into more precise or sharp focus by a control system employing data from the adjustment camera, which aids in focusing the imaged spots. “Trombone”-type optics are used to adjust the focus of the light projected onto the retina and the imaged spots onto a sensor. The laser has a higher power mode used when acquiring data of the imaged spots from the sensor.

44. 发明授权

US07022117B1 Customized refractive correction 有权
$Customized refractive correction$
标题翻译：定制屈光矫正
公开(公告)号：US07022117B1
公开(公告)日：2006-04-04
申请号：US10110894
申请日：2000-10-20
申请人： Kristian Hohla , Gerhard Youssefi , Roland Toennies
发明人： Kristian Hohla , Gerhard Youssefi , Roland Toennies
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00846 , A61F2009/00855 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： An aperture card is provided for insertion into a laser refractive ablation system for use in laser ablating the cornea. The aperture card is designed for single surgical use for surgical precautionary considerations and to achieve the highest quality ablations, in addition to reproducibility. The aperture card is loaded into the laser refractive ablation system in a path between the laser system and the eye. The aperture card is precisely located by positioning means and ablative lasing action is inhibited if the card is not positioned within tolerance. Alternatively, the laser system can determine the position of the aperture card and adjust a computed ablation profile or otherwise adjust the optical system to adapt for any misalignment of the apertures in the aperture card. The card contains a “soft spot” aperture capable of shaping a spatial intensity distribution with a unique profile. The profile has a substantially flat top while the sides of the profile slope until an ablation intensity threshold is reached, at which point the sides become substantially vertical. The card can contain more than one soft spot aperture along with a “hard spot” aperture that creates a square-shaped profile used for testing fluence. Each soft spot aperture is formed by a central aperture and a plurality of holes of different sizes surrounding the central aperture and arranged such that the overall diffractive effect produces a soft spot spatial intensity profile compared to the hard, square-sided profile.
摘要翻译：提供孔卡用于插入到用于激光烧蚀角膜的激光折射消融系统中。孔卡被设计用于单次外科手术用于手术预防性考虑，并且除了重现性之外还实现了最高质量的消融。孔径卡在激光系统和眼睛之间的路径中被加载到激光折射消融系统中。光圈卡通过定位装置精确定位，如果卡未位于公差范围内，则禁止消融激光作用。或者，激光系统可以确定光圈卡的位置并调整计算的切割轮廓，或者调整光学系统以适应孔径卡中的孔的任何未对准。该卡包含一个能够形成具有独特轮廓的空间强度分布的“软点”孔。轮廓具有基本上平坦的顶部，而轮廓的侧面倾斜直到达到消融强度阈值，此时侧面基本上垂直。该卡可以包含多个软点孔径以及一个“硬点”孔径，创建用于测试注量的方形轮廓。每个软点孔由围绕中心孔的中心孔和不同尺寸的多个孔形成，并且布置成使得与硬的正方形轮廓相比，整体衍射效应产生软斑空间强度分布。

45. 发明授权

US09345620B2 Apparatus and method for providing a laser shot file 有权
标题翻译：用于提供激光拍摄文件的装置和方法
公开(公告)号：US09345620B2
公开(公告)日：2016-05-24
申请号：US13098267
申请日：2011-04-29
申请人： Gerhard Youssefi , Ernst Hegels
发明人： Gerhard Youssefi , Ernst Hegels
IPC分类号： A61B19/00 , A61F9/008
CPC分类号： A61F9/008 , A61F9/00806 , A61F2009/00848 , A61F2009/00857 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： The invention relates to an apparatus, an algorithm and a method for providing a laser shot file for use in a laser. The laser may be an excimer laser. The shot file may be applied for performing a refractive laser treatment of an eye or for producing a customized contact lens or an intraocular lens. According to the invention information with respect to a desired ablation profile is provided and a first series of laser shot positions is calculated based on the desired ablation profile. A simulated ablation profile is generated using said first series of laser shot positions and using information about pulse characteristics of a single laser shot. The simulated ablation profile is compared with the desired ablation profile and residual structures are determined.
摘要翻译：本发明涉及一种用于提供用于激光器的激光射击文件的装置，算法和方法。激光可以是准分子激光器。射击文件可以用于执行眼睛的折射激光治疗或用于制造定制的隐形眼镜或眼内透镜。根据本发明，提供关于期望的消融轮廓的信息，并且基于期望的消融轮廓来计算第一系列的激光拍摄位置。使用所述第一系列激光拍摄位置并使用关于单个激光射击的脉冲特性的信息来生成模拟消融轮廓。将模拟的消融轮廓与期望的消融轮廓进行比较，并确定残余结构。

46. 发明授权

US09186059B2 Ophthalmic instrument alignment apparatus and method of using same 有权
标题翻译：眼科仪器对准装置及其使用方法
公开(公告)号：US09186059B2
公开(公告)日：2015-11-17
申请号：US12334896
申请日：2008-12-15
申请人： Gerhard Youssefi , Rupert Veith
发明人： Gerhard Youssefi , Rupert Veith
IPC分类号： A61B3/15 , A61F9/008
CPC分类号： A61B3/152 , A61F9/008 , A61F2009/00872
摘要： An ophthalmic instrument for use with a subject's eye, comprising an interferometer having a test arm in which the subject's eye is to be positioned and a reference arm, the reference arm including a mirror adapted to be positioned such that the reference arm has a predetermined length, and an ophthalmic apparatus coupled to the interferometer such that, by altering a test arm length, a length between the ophthalmic apparatus and the eye is also altered. The mirror is positioned to achieve the predetermined length and a length of the test arm is adjusted such that interference between the light reflected from the eye and the light reflected from the mirror is achieved, the ophthalmic apparatus is optically aligned with the eye.
摘要翻译：一种用于受试者的眼睛的眼科仪器，包括具有被测者的眼睛要被定位的测试臂的干涉仪和参考臂，所述参考臂包括适于被定位成使得所述参考臂具有预定长度的反射镜以及耦合到所述干涉仪的眼科装置，使得通过改变测试臂长度，眼科装置和眼睛之间的长度也被改变。反射镜被定位成达到预定长度，并且调整测试臂的长度，使得实现从眼睛反射的光和从反射镜反射的光之间的干涉，眼科装置与眼睛光学对准。

47. 发明申请

US20140135749A1 SYSTEM AND METHOD FOR FEMTO-FRAGMENTATION OF A CRYSTALLINE LENS 有权
标题翻译：一种用于晶体管镜片分解的系统和方法
公开(公告)号：US20140135749A1
公开(公告)日：2014-05-15
申请号：US13795641
申请日：2013-03-12
申请人： Toh Seng Goh , Brian D. McCary , David Haydn Mordaunt , Frieder Loesel , Jochen Kandulla , Gerhard Youssefi , Werner Banghard
发明人： Toh Seng Goh , Brian D. McCary , David Haydn Mordaunt , Frieder Loesel , Jochen Kandulla , Gerhard Youssefi , Werner Banghard
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61B2218/007 , A61F9/00804 , A61F9/00812 , A61F9/00821 , A61F9/00825 , A61F2009/0087 , A61F2009/00872 , A61F2009/00878 , A61F2009/00887 , A61F2009/00897
摘要： A system and method for performing a femto-fragmentation procedure on tissue in the crystalline lens of an eye requires that a laser beam be directed and focused to a focal point in the crystalline lens of the eye. The focal point is then guided, relative to an axis defined by the eye, to create a segment cluster by causing Laser Induced Optical Breakdown (LIOB) of tissue in the crystalline lens. The resultant segment cluster includes a plurality of contiguous, elongated segments in the crystalline lens that are individually tapered from an anterior end-area to a posterior end-area. Specifically, this is done to facilitate the removal of individual segments from the segment cluster in the crystalline lens.
摘要翻译：用于对眼睛的晶状体中的组织执行毫微微碎裂过程的系统和方法要求激光束被引导并聚焦到眼晶状体中的焦点。然后相对于由眼睛定义的轴引导焦点，以通过引起晶状体中的组织的激光诱导光学细分（LIOB）来创建片段簇。所得到的片段簇包括晶状体中的多个相邻细长的片段，其从前端部区域到后端区域分别逐渐变细。具体地说，这是为了便于从晶状体中的片段簇中去除各个片段。

48. 发明申请

US20130172861A1 System and Method for Postoperative Capsular Bag Control 有权
标题翻译：术后囊袋控制系统及方法
公开(公告)号：US20130172861A1
公开(公告)日：2013-07-04
申请号：US13338872
申请日：2011-12-28
申请人： Gerhard Youssefi
发明人： Gerhard Youssefi
IPC分类号： A61B18/20
CPC分类号： A61F9/00825 , A61F2009/00851 , A61F2009/0087 , A61F2009/00887
摘要： In accordance with the present invention, a system and method are provided for controlling postoperative shrinkage of the capsular bag, after the lens has been removed from the capsular bag. The purpose is to establish a proper optical alignment for a prosthetic Intraocular Lens (IOL). Included in the system are a laser unit for generating a laser beam, a detector for creating an image of the prosthetic IOL in the capsular bag, and a computer for evaluating the image to determine an alignment difference between the IOL axis and a defined axis of the eye. The computer is also used for guiding the laser beam to alter selected tissue in the eye, to thereby influence postoperative shrinkage of the capsular bag and minimize any potential alignment difference between the IOL axis and the defined axis of the eye during capsular bag shrinkage.
摘要翻译：根据本发明，提供了一种系统和方法，用于控制在从胶囊袋中取出镜片之后胶囊袋的术后收缩。目的是为假眼内镜（IOL）建立适当的光学对准。系统中包括用于产生激光束的激光单元，用于在囊袋中产生假体IOL的图像的检测器，以及用于评估图像的计算机，以确定IOL轴和所定义的轴的定义轴线之间的对准差眼。计算机还用于引导激光束改变眼睛中的选定组织，从而影响囊袋的术后收缩，并且使囊袋收缩期间IOL轴与眼睛的限定轴线之间的任何潜在对准差异最小化。

49. 发明授权

US07771053B2 Method and apparatus for online contact lens evaluation 有权
标题翻译：在线隐形眼镜评估方法和装置
公开(公告)号：US07771053B2
公开(公告)日：2010-08-10
申请号：US10565877
申请日：2004-07-22
申请人： Hans-Joachim Polland , Stefan Seitz , Kristian Hohla , Gerhard Youssefi , Ernst Hegels , Birte Jansen , Christoph Sappel
发明人： Hans-Joachim Polland , Stefan Seitz , Kristian Hohla , Gerhard Youssefi , Ernst Hegels , Birte Jansen , Christoph Sappel
IPC分类号： A61B3/00 , G02C7/04 , A61B3/10
CPC分类号： G02C7/021 , G02C7/04 , G02C7/047
摘要： A selectively marked contact lens having, in one aspect, marks in an optical zone region on a surface thereof and, in another aspect, different marks outside an optical zone region of the lens, for an in-vivo lens. With the lens in-vivo, the subject's eye is illuminated and the lens is imaged. A fast algorithm is used to determine the mark coordinates in relation to a measured pupil coordinate to determine position and/or orientation of the contact lens. A wavefront aberration measurement can also be obtained simultaneously with the contact lens position measurement, as well as pupil size. A fast algorithm provides for online measurements; i.e., at a repetition rate of 10 Hz or greater, over a selected time interval. Blinking periods are determined and anomalous lens position and/or wavefront information is discarded. A most frequently occurring wavefront and/or contact lens position/orientation is determined over the selected time interval.
摘要翻译：一个选择性标记的隐形眼镜，在一个方面，在其表面上的光学区域中标记，并且在另一方面，对于体内透镜，在透镜的光学区域外部具有不同的标记。使用镜片在体内，受试者的眼睛被照亮并且镜片被成像。使用快速算法来确定相对于测量的瞳孔坐标的标记坐标以确定隐形眼镜的位置和/或取向。也可以与隐形眼镜位置测量以及瞳孔尺寸同时获得波前像差测量。快速算法提供在线测量; 即在10Hz或更大的重复频率下，在选定的时间间隔内。确定闪烁周期，并丢弃异常透镜位置和/或波前信息。在所选择的时间间隔内确定最频繁出现的波前和/或隐形眼镜位置/取向。

50. 发明申请

US20080246916A1 Method and Apparatus for Determining the Visual Acuity of an Eye 有权
标题翻译：用于确定眼睛视力的方法和装置
公开(公告)号：US20080246916A1
公开(公告)日：2008-10-09
申请号：US12093500
申请日：2006-11-08
申请人： Ernst Hegels , Gerhard Youssefi
发明人： Ernst Hegels , Gerhard Youssefi
IPC分类号： A61B3/103
CPC分类号： A61B3/1015
摘要： The invention relates to a method for determining the visual acuity of an eye and a respective apparatus. The method comprises the steps of: providing the wavefront information of the eye, generating a point spread function based on the wavefront information of the eye, said point spread function representing a specific intensity distribution for a corresponding pupil size. After comparing the intensities of the point spread function with a selectable intensity level of intensity, those parts of the point spread function having an intensity being larger than the selectable intensity level are determined as a relevant part of the point spread function.
摘要翻译：本发明涉及一种用于确定眼睛和相应装置的视敏度的方法。该方法包括以下步骤：提供眼睛的波前信息，基于眼睛的波前信息生成点扩散函数，所述点扩散函数表示对应的瞳孔大小的特定强度分布。在将点扩散函数的强度与可选择的强度水平进行比较之后，将具有大于可选强度水平的强度的点扩散函数的那些部分确定为点扩散函数的相关部分。

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