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1. 发明授权

US09592157B2 System and method for femto-fragmentation of a crystalline lens 有权
标题翻译：用于晶状体的毫微微碎裂的系统和方法
公开(公告)号：US09592157B2
公开(公告)日：2017-03-14
申请号：US13795641
申请日：2013-03-12
申请人： Toh Seng Goh , Brian D. McCary , David Haydn Mordaunt , Frieder Loesel , Jochen Kandulla , Gerhard Youssefi , Werner Banghard
发明人： Toh Seng Goh , Brian D. McCary , David Haydn Mordaunt , Frieder Loesel , Jochen Kandulla , Gerhard Youssefi , Werner Banghard
IPC分类号： A61B18/18 , A61F9/008
CPC分类号： A61F9/008 , A61B2218/007 , A61F9/00804 , A61F9/00812 , A61F9/00821 , A61F9/00825 , A61F2009/0087 , A61F2009/00872 , A61F2009/00878 , A61F2009/00887 , A61F2009/00897
摘要： A system and method for performing a femto-fragmentation procedure on tissue in the crystalline lens of an eye requires that a laser beam be directed and focused to a focal point in the crystalline lens of the eye. The focal point is then guided, relative to an axis defined by the eye, to create a segment cluster by causing Laser Induced Optical Breakdown (LIOB) of tissue in the crystalline lens. The resultant segment cluster includes a plurality of contiguous, elongated segments in the crystalline lens that are individually tapered from an anterior end-area to a posterior end-area. Specifically, this is done to facilitate the removal of individual segments from the segment cluster in the crystalline lens.
摘要翻译：用于对眼睛的晶状体中的组织执行毫微微碎裂过程的系统和方法要求激光束被引导并聚焦到眼晶状体中的焦点。然后相对于由眼睛定义的轴引导焦点，以通过引起晶状体中的组织的激光诱导光学细分（LIOB）来创建片段簇。所得到的片段簇包括晶状体中的多个相邻细长的片段，其从前端部区域到后端区域分别逐渐变细。具体地说，这是为了便于从晶状体中的片段簇中去除各个片段。

2. 发明申请

US20140135749A1 SYSTEM AND METHOD FOR FEMTO-FRAGMENTATION OF A CRYSTALLINE LENS 有权
标题翻译：一种用于晶体管镜片分解的系统和方法
公开(公告)号：US20140135749A1
公开(公告)日：2014-05-15
申请号：US13795641
申请日：2013-03-12
申请人： Toh Seng Goh , Brian D. McCary , David Haydn Mordaunt , Frieder Loesel , Jochen Kandulla , Gerhard Youssefi , Werner Banghard
发明人： Toh Seng Goh , Brian D. McCary , David Haydn Mordaunt , Frieder Loesel , Jochen Kandulla , Gerhard Youssefi , Werner Banghard
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61B2218/007 , A61F9/00804 , A61F9/00812 , A61F9/00821 , A61F9/00825 , A61F2009/0087 , A61F2009/00872 , A61F2009/00878 , A61F2009/00887 , A61F2009/00897
摘要： A system and method for performing a femto-fragmentation procedure on tissue in the crystalline lens of an eye requires that a laser beam be directed and focused to a focal point in the crystalline lens of the eye. The focal point is then guided, relative to an axis defined by the eye, to create a segment cluster by causing Laser Induced Optical Breakdown (LIOB) of tissue in the crystalline lens. The resultant segment cluster includes a plurality of contiguous, elongated segments in the crystalline lens that are individually tapered from an anterior end-area to a posterior end-area. Specifically, this is done to facilitate the removal of individual segments from the segment cluster in the crystalline lens.
摘要翻译：用于对眼睛的晶状体中的组织执行毫微微碎裂过程的系统和方法要求激光束被引导并聚焦到眼晶状体中的焦点。然后相对于由眼睛定义的轴引导焦点，以通过引起晶状体中的组织的激光诱导光学细分（LIOB）来创建片段簇。所得到的片段簇包括晶状体中的多个相邻细长的片段，其从前端部区域到后端区域分别逐渐变细。具体地说，这是为了便于从晶状体中的片段簇中去除各个片段。

3. 发明授权

US10716706B2 System and method for performing lens fragmentation 有权
公开(公告)号：US10716706B2
公开(公告)日：2020-07-21
申请号：US13436352
申请日：2012-03-30
申请人： Frieder Loesel , Jochen Kandulla , Friedrich Moritz , Gwillem Mosedale , Holger Schlueter , Roland Toennies , Gerhard Youssefi , David Haydn Mordaunt
发明人： Frieder Loesel , Jochen Kandulla , Friedrich Moritz , Gwillem Mosedale , Holger Schlueter , Roland Toennies , Gerhard Youssefi , David Haydn Mordaunt
IPC分类号： A61F9/008
摘要： A system and method are provided for fragmenting a crystalline lens, to facilitate its removal from the lens bag during an ophthalmic laser surgery. First, a predetermined pattern is used to make Laser Induced Optical Breakdown (LIOB) cuts that section the lens into asymmetrical, operational segments. At least one operational segment is then selected and softened with a plurality of compact LIOB cuts. Once softened, the selected segment is aspirated. The remaining operational segments are then subsequently removed. During a procedure, an imaging unit can monitor movements of the lens bag to ensure proper placement of the LIOB cuts on the lens.

4. 发明申请

US20120259320A1 System and Method for Performing Lens Fragmentation 审中-公开
标题翻译：执行镜头碎片的系统和方法
公开(公告)号：US20120259320A1
公开(公告)日：2012-10-11
申请号：US13436352
申请日：2012-03-30
申请人： Frieder Loesel , Jochen Kandulla , Friedrich Moritz , Gwillem Mosedale , Holger Schlueter , Roland Toennies , Gerhard Youssefi , David Haydn Mordaunt
发明人： Frieder Loesel , Jochen Kandulla , Friedrich Moritz , Gwillem Mosedale , Holger Schlueter , Roland Toennies , Gerhard Youssefi , David Haydn Mordaunt
IPC分类号： A61B18/20
CPC分类号： A61F9/00825 , A61F2009/00851 , A61F2009/0087 , A61F2009/00887
摘要： A system and method are provided for fragmenting a crystalline lens, to facilitate its removal from the lens bag during an ophthalmic laser surgery. First, a predetermined pattern is used to make Laser Induced Optical Breakdown (LIOB) cuts that section the lens into asymmetrical, operational segments. At least one operational segment is then selected and softened with a plurality of compact LIOB cuts. Once softened, the selected segment is aspirated. The remaining operational segments are then subsequently removed. During a procedure, an imaging unit can monitor movements of the lens bag to ensure proper placement of the LIOB cuts on the lens.
摘要翻译：提供了一种用于使晶状体碎裂的系统和方法，以便于在眼科激光手术期间从晶状体袋移除晶状体。首先，使用预定的图案来制造将透镜划分为不对称的，可操作的部分的激光诱导光学分解（LIOB）切割。然后，利用多个紧凑的LIOB切割来选择和软化至少一个操作段。一旦软化，所选择的部分被吸出。其余的操作段随后被移除。在一个过程中，成像单元可以监控透镜袋的运动，以确保LIOB切口在透镜上的正确放置。

5. 发明申请

US20130190735A1 System and Method for Performing a Presbyopic Correction 审中-公开
标题翻译：执行老化矫正的系统和方法
公开(公告)号：US20130190735A1
公开(公告)日：2013-07-25
申请号：US13550908
申请日：2012-07-17
申请人： Kristian Hohla , Frieder Loesel , Gerhard Youssefi
发明人： Kristian Hohla , Frieder Loesel , Gerhard Youssefi
IPC分类号： A61F9/008
CPC分类号： A61F9/00808 , A61F9/008 , A61F2009/00872 , A61F2009/0088 , A61F2009/00895
摘要： The system according to the present invention is used to create an ablation such that the surface of the cornea comprises a central region having a convex central steepening with a first radius of curvature and a surrounding region having a convex shape with a second radius of curvature, wherein the first radius of curvature is smaller than the second radius of curvature for performing a presbyopic correction. The ablation depth in the central region varies between a minimum ablation depth in the center and a maximum ablation depth at the border of the central region. The ablation depth in the surrounding region is the same as the maximum ablation depth at the border of the central region.
摘要翻译：根据本发明的系统用于产生消融，使得角膜的表面包括具有第一曲率半径的凸起中心陡化的中心区域和具有第二曲率半径的凸形的周围区域，其中所述第一曲率半径小于用于执行远视校正的所述第二曲率半径。中心区域的消融深度在中心的最小消融深度和中心区域边界处的最大消融深度之间变化。周围区域的消融深度与中心区域边界处的最大消融深度相同。

6. 发明申请

US20110276043A1 Apparatus and method for providing a laser shot file 有权
标题翻译：用于提供激光拍摄文件的装置和方法
公开(公告)号：US20110276043A1
公开(公告)日：2011-11-10
申请号：US13098267
申请日：2011-04-29
申请人： Gerhard Youssefi , Ernst Hegels
发明人： Gerhard Youssefi , Ernst Hegels
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/00806 , A61F2009/00848 , A61F2009/00857 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： The invention relates to an apparatus, an algorithm and a method for providing a laser shot file for use in a laser. The laser may be an excimer laser. The shot file may be applied for performing a refractive laser treatment of an eye or for producing a customized contact lens or an intraocular lens. According to the invention information with respect to a desired ablation profile is provided and a first series of laser shot positions is calculated based on the desired ablation profile. A simulated ablation profile is generated using said first series of laser shot positions and using information about pulse characteristics of a single laser shot. The simulated ablation profile is compared with the desired ablation profile and residual structures are determined.
摘要翻译：本发明涉及一种用于提供用于激光器的激光射击文件的装置，算法和方法。激光可以是准分子激光器。射击文件可以用于执行眼睛的折射激光治疗或用于制造定制的隐形眼镜或眼内透镜。根据本发明，提供关于期望的消融轮廓的信息，并且基于期望的消融轮廓来计算第一系列的激光拍摄位置。使用所述第一系列激光拍摄位置并使用关于单个激光射击的脉冲特性的信息来生成模拟消融轮廓。将模拟的消融轮廓与期望的消融轮廓进行比较，并确定残余结构。

7. 发明申请

US20110208172A1 Eye measurement and modeling techniques 审中-公开
标题翻译：眼睛测量和建模技术
公开(公告)号：US20110208172A1
公开(公告)日：2011-08-25
申请号：US13035174
申请日：2011-02-25
申请人： Gerhard Youssefi , Julia Hoff , Birgit Lutzenberger , Anton Hilger
发明人： Gerhard Youssefi , Julia Hoff , Birgit Lutzenberger , Anton Hilger
IPC分类号： A61F9/01
CPC分类号： A61F9/00804 , A61B3/102 , A61F9/00827 , A61F2009/00844 , A61F2009/00872 , A61F2009/0088
摘要： A refractive surgical system, comprising a refractive treatment apparatus adapted to alter multiple localized regions of a cornea and an ophthalmic measurement device adapted to measure a corneal shape parameter at at least two locations on the cornea. A corneal modeling apparatus and method to calculate anticipated corneal shape parameters at two or more locations based on parameters of a refractive treatment, and compare shape parameters measured at two or more locations on the cornea corresponding to the two or more locations of the anticipated corneal shape parameters.
摘要翻译：一种屈光手术系统，包括适于改变角膜的多个局部区域的折射治疗装置和适于在角膜上的至少两个位置处测量角膜形状参数的眼科测量装置。一种角膜造型装置和方法，用于基于屈光治疗的参数计算两个或多个位置处的预期角膜形状参数，并且比较对应于预期角膜形状的两个或多个位置的角膜上的两个或多个位置处测量的形状参数参数。

8. 发明申请

US20110007945A1 FAST ALGORITHM FOR STREAMING WAVEFRONT 有权
标题翻译：用于流动WAVEFRONT的快速算法
公开(公告)号：US20110007945A1
公开(公告)日：2011-01-13
申请号：US12866122
申请日：2009-03-13
申请人： Gerhard Youssefi , Hans-Joachim Polland
发明人： Gerhard Youssefi , Hans-Joachim Polland
IPC分类号： G06K9/00
CPC分类号： A61B3/1015 , A61B3/112 , G06T7/246
摘要： The invention is generally directed to the field of image processing, and more particularly to a method and an apparatus for determining a wavefront of an object, in particular a human eye. The invention discloses a method and an apparatus for real-time wavefront sensing of an optical system utilizing two different algorithms for detecting centroids of a centroid image as provided by a Hartmann-Shack wavefront sensor. A first algorithm detects an initial position of all centroids and a second algorithm detects incremental changes of all centroids detected by said first algorithm.
摘要翻译：本发明一般涉及图像处理领域，更具体地涉及一种用于确定物体，特别是人眼的波前的方法和装置。本发明公开了一种利用两种不同的算法来检测由Hartmann-Shack波前传感器提供的质心图像的质心的光学系统的实时波前感测的方法和装置。第一算法检测所有质心的初始位置，第二算法检测由所述第一算法检测到的所有质心的增量变化。

9. 发明授权

US06926710B2 Method and system for improving vision 有权
公开(公告)号：US06926710B2
公开(公告)日：2005-08-09
申请号：US10045694
申请日：2001-10-19
申请人： Ian G. Cox , Timothy N. Turner , Gerhard Youssefi
发明人： Ian G. Cox , Timothy N. Turner , Gerhard Youssefi
IPC分类号： A61F9/01 , A61F9/013 , A61B18/18
CPC分类号： A61F9/008 , A61F9/00806 , A61F9/013 , A61F2009/00846 , A61F2009/00857 , A61F2009/00859 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： Methods and apparatus for improving vision incorporate the effects of biodynamical and biomechanical (biological) responses of the eye. The eye produces a biological response to trauma, such as a LASIK keratectomy or other necessary traumatic procedure in preparation for refractive surgery. By observing the biological response, a prospective treatment to correct higher order aberrations is adjusted to compensate for the biological effects. An improved photorefractive surgery system incorporates one or more suitable diagnostic devices that provide biological response information in such a manner that the patient need not change position from that assumed for the surgical procedure.

10. 发明授权

US06814729B2 Laser vision correction apparatus and control method 有权
标题翻译：激光视力矫正装置及控制方法
公开(公告)号：US06814729B2
公开(公告)日：2004-11-09
申请号：US10184441
申请日：2002-06-27
申请人： Gerhard Youssefi , Kristian Hohla , Stefan Lang
发明人： Gerhard Youssefi , Kristian Hohla , Stefan Lang
IPC分类号： A61B9007
CPC分类号： A61F9/008 , A61F9/00806 , A61F9/00808 , A61F9/00817 , A61F2009/00859 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： A device readable medium for use in controlling a laser vision correction system includes a storage structure having stored therein a pre-programmed first, readable, corrective instruction reference that corresponds to an encoded customized corrective instruction determined by a calculation module external to the medium. The encoded customized corrective instruction is executable by a laser vision correction laser platform for correction of a refractive defect when the corrective instruction reference is properly recognized. A laser vision correction system including the device readable medium is described. A remunerative model relating to the device readable medium is disclosed.

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