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41. 发明申请

US20050227979A1 Non-imidazole aryloxypiperidines 有权
标题翻译：非咪唑芳氧基哌啶
公开(公告)号：US20050227979A1
公开(公告)日：2005-10-13
申请号：US11138631
申请日：2005-05-26
申请人： Richard Apodaca , Nicholas Carruthers , Curt Dvorak , Chandravadan Shah , Wei Xiao
发明人： Richard Apodaca , Nicholas Carruthers , Curt Dvorak , Chandravadan Shah , Wei Xiao
IPC分类号： C07D295/08 , A61K31/4402 , A61K31/445 , A61K31/4465 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , A61K51/00 , A61P9/00 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/16 , A61P37/08 , A61P43/00 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/32 , C07D207/325 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D233/42 , C07D233/54 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D257/04 , C07D277/36 , C07D295/092 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/20 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/12 , C07D401/14 , C07D471/08 , C07D521/00 , C07D413/02 , C07D43/02
CPC分类号： C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要： Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
摘要翻译：取代的非咪唑芳氧基哌啶化合物，含有它们的组合物，以及制备和使用它们来治疗或预防组胺介导的病症的方法。

42. 发明授权

US06569468B2 Cinnamomi and poria composition, method to prepare same and uses thereof 有权
公开(公告)号：US06569468B2
公开(公告)日：2003-05-27
申请号：US09951070
申请日：2001-09-13
申请人： Wei Xiao
发明人： Wei Xiao
IPC分类号： A65K3578
CPC分类号： A61K36/54 , A61K36/076 , A61K36/23 , A61K36/65 , A61K36/736 , G01N30/02 , A61K2300/00
摘要： This invention provides a method for identifying a composition of Cinnamomi and Poria. This invention further provides a composition comprising: Ramulus Cinnamomi, Poria Cortex, Moutan Radicis, Radix Paeonize Alba, and Semen Persicae. This invention provides various uses of these compositions.

43. 发明授权

US06214805B1 RNase L activators and antisense oligonucleotides effective to treat RSV infections 失效
标题翻译： RNase L激活剂和有效治疗RSV感染的反义寡核苷酸
公开(公告)号：US06214805B1
公开(公告)日：2001-04-10
申请号：US08962690
申请日：1997-11-03
申请人： Paul F. Torrence , Robert Hugh Silverman , Nick Mario Cirino , Guiying Li , Wei Xiao , Mark R. Player
发明人： Paul F. Torrence , Robert Hugh Silverman , Nick Mario Cirino , Guiying Li , Wei Xiao , Mark R. Player
IPC分类号： A61K3170
CPC分类号： C12N15/1131 , A61K38/00 , A61K47/549 , C07H21/00 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/3521
摘要： The present invention relates to methods of inhibiting infection by RNA viruses with complexes of an activator of RNase L and an oligonucleotide that is capable of binding to the genome, antigenome or mRNAs of a negative strand RNA virus to specifically cleave the genomic or antigenomic RNA strand of the virus. In accordance with the present invention, the methods and complexes of the invention may be applied to target any negative strand RNA virus. The invention in one embodiment relates to a covalently linked complex of an oligonucleotide that is capable of binding to the genomic or antigenomic template RNA strand of a negative strand RNA virus and/or binding to an mRNA of a viral protein (an “antisense oligonucleotide”) coupled to an activator of RNase L. In a preferred embodiment of the present invention, the oligonucleotide component of the complex is complementary to a region of the viral genomic RNA strand characterized by repeated or consensus sequences.
摘要翻译：本发明涉及通过RNA酶L的活化剂和能够结合到负链RNA病毒的基因组，反义基团或mRNA的寡核苷酸的复合物来抑制RNA病毒感染以特异性切割基因组或反基因组RNA链的方法的病毒。根据本发明，本发明的方法和复合物可以用于靶向任何负链RNA病毒。一个实施方案中的本发明涉及能够结合负链RNA病毒的基因组或反基因组模板RNA链和/或与病毒蛋白的mRNA结合的寡核苷酸的共价连接的复合物（“反义寡核苷酸” ）与RNase L的活化剂偶联。在本发明的优选实施方案中，复合物的寡核苷酸组分与以重复或共有序列为特征的病毒基因组RNA链的区域互补。

44. 发明授权

US08914497B1 System and method for throttling service requests having non-uniform workloads 有权
标题翻译：用于限制具有不均匀工作负载的服务请求的系统和方法
公开(公告)号：US08914497B1
公开(公告)日：2014-12-16
申请号：US13327620
申请日：2011-12-15
申请人： Wei Xiao , David A. Lutz , Timothy Andrew Rath , Maximiliano Maccanti , Miguel Mascarenhas Filipe , David C. Yanacek
发明人： Wei Xiao , David A. Lutz , Timothy Andrew Rath , Maximiliano Maccanti , Miguel Mascarenhas Filipe , David C. Yanacek
IPC分类号： G06F15/173 , G06F11/00
CPC分类号： H04L67/16 , G06F9/505 , G06F11/3433 , G06F11/3452 , G06F11/3485 , G06F2201/81 , G06F2209/504 , H04L67/42 , Y02D10/22
摘要： A system that provides services to clients may receive and service requests, various ones of which may require different amounts of work. The system may determine whether it is operating in an overloaded or underloaded state based on a current work throughput rate, a target work throughput rate, a maximum request rate, or an actual request rate, and may dynamically adjust the maximum request rate in response. For example, if the maximum request rate is being exceeded, the maximum request rate may be raised or lowered, dependent on the current work throughput rate. If the target or committed work throughput rate is being exceeded, but the maximum request rate is not being exceeded, a lower maximum request rate may be proposed. Adjustments to the maximum request rate may be made using multiple incremental adjustments. Service request tokens may be added to a leaky token bucket at the maximum request rate.
摘要翻译：向客户端提供服务的系统可以接收和服务请求，其中各种可能需要不同的工作量。系统可以基于当前工作吞吐率，目标工作吞吐率，最大请求速率或实际请求速率来确定其是否处于过载或欠载状态，并且可以动态地调整响应的最大请求速率。例如，如果超过最大请求速率，则可以根据当前的工作吞吐率来提高或降低最大请求速率。如果超过了目标或提交的工作吞吐率，但不超过最大请求率，则可能会提出较低的最大请求率。可以使用多个增量调整来调整最大请求率。可以以最大请求率将服务请求令牌添加到泄漏令牌桶中。

45. 发明授权

US08886523B2 Audio decoding based on audio class with control code for post-processing modes 有权
标题翻译：基于音频类的音频解码，具有后处理模式的控制码
公开(公告)号：US08886523B2
公开(公告)日：2014-11-11
申请号：US12893526
申请日：2010-09-29
申请人： David Sylvain Thierry Virette , Yang Gao , Wei Xiao
发明人： David Sylvain Thierry Virette , Yang Gao , Wei Xiao
IPC分类号： G10L19/02 , G10L21/02 , G10L19/26 , G10L25/18
CPC分类号： G10L19/00 , G10L19/26 , G10L25/18
摘要： In accordance with an embodiment, a method of generating an encoded audio signal, the method includes estimating a time-frequency energy of an input audio signal from a time-frequency filter bank, computing a global variance of the time-frequency energy, determining a post-processing method according to the global variance, and transmitting an encoded representation of the input audio signal along with an indication of the determined post-processing method.
摘要翻译：根据实施例，一种生成编码音频信号的方法，所述方法包括估计来自时频滤波器组的输入音频信号的时频能量，计算时频能量的全局方差，确定根据全局方差的后处理方法，以及输出音频信号的编码表示以及所确定的后处理方法的指示。

46. 发明授权

US08530476B2 Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase 有权
公开(公告)号：US08530476B2
公开(公告)日：2013-09-10
申请号：US12557650
申请日：2009-09-11
申请人： Richard Apodaca , J. Guy Breitenbucher , Kanaka Pattabiraman , Mark Seierstad , Wei Xiao
发明人： Richard Apodaca , J. Guy Breitenbucher , Kanaka Pattabiraman , Mark Seierstad , Wei Xiao
IPC分类号： A61K31/497 , C07D403/00 , C07D405/06 , C07D401/06
CPC分类号： C07D295/195 , C07D207/335 , C07D209/08 , C07D209/14 , C07D209/82 , C07D211/16 , C07D213/38 , C07D213/56 , C07D213/61 , C07D213/75 , C07D215/12 , C07D215/18 , C07D239/42 , C07D241/42 , C07D295/20 , C07D295/215 , C07D307/79 , C07D307/81 , C07D317/46 , C07D317/58 , C07D319/16 , C07D319/18 , C07D333/58 , C07D333/60 , C07D401/12 , C07D405/12 , C07D417/12
摘要： Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).

47. 发明授权

US08380526B2 Method, device and system for enhancement layer signal encoding and decoding 有权
标题翻译：用于增强层信号编码和解码的方法，装置和系统
公开(公告)号：US08380526B2
公开(公告)日：2013-02-19
申请号：US13111834
申请日：2011-05-19
申请人： Chen Hu , Zexin Liu , Lei Miao , Longyin Chen , Qing Zhang , Wei Xiao , Herve Marcel Taddei
发明人： Chen Hu , Zexin Liu , Lei Miao , Longyin Chen , Qing Zhang , Wei Xiao , Herve Marcel Taddei
IPC分类号： G10L19/00 , G10L19/12
CPC分类号： G10L21/00 , G10L19/24
摘要： A method, device and system for signal encoding and decoding are disclosed. The method includes: encoding a core layer signal to obtain a core layer signal code; selecting an enhancement sample point that requires enhancement layer signal encoding according to the core layer signal code and the number of bits that can be used by an enhancement layer; obtaining an enhancement layer signal code of the enhancement sample point; and outputting a bit stream, where the bit stream includes the core layer signal code and the enhancement layer signal code. In embodiments of the present invention, according to the number of bits that can be used by the enhancement layer, the enhancement sample point that requires enhancement layer signal encoding is selected; the enhancement layer signal of the selected enhancement sample point is encoded and decoded; when no sufficient bits are available for the enhancement layer, the enhancement quality of the core layer can be improved.
摘要翻译：公开了用于信号编码和解码的方法，装置和系统。该方法包括：编码核心层信号以获得核心层信号码; 选择需要根据核心层信号码的增强层信号编码和增强层可以使用的位数的增强采样点; 获得增强采样点的增强层信号码; 并输出比特流，其中比特流包括核心层信号码和增强层信号码。在本发明的实施例中，根据增强层可以使用的比特数，选择需要增强层信号编码的增强采样点; 所选择的增强采样点的增强层信号被编码和解码; 当没有足够的比特可用于增强层时，可以提高核心层的增强质量。

48. 发明授权

US08140343B2 Method, device and system for signal encoding and decoding 有权
标题翻译：用于信号编码和解码的方法，装置和系统
公开(公告)号：US08140343B2
公开(公告)日：2012-03-20
申请号：US13210127
申请日：2011-08-15
申请人： Chen Hu , Zexin Liu , Lei Miao , Longyin Chen , Qing Zhang , Wei Xiao , Herve Marcel Taddei
发明人： Chen Hu , Zexin Liu , Lei Miao , Longyin Chen , Qing Zhang , Wei Xiao , Herve Marcel Taddei
IPC分类号： G10L19/00 , G10L21/04
CPC分类号： G10L21/00 , G10L19/24
摘要： A method, device and system for signal encoding and decoding, the method comprising: encoding a core layer signal to obtain a core layer signal code; selecting an enhancement sample point that requires enhancement layer signal encoding according to the core layer signal code and the number of bits that can be used by an enhancement layer; obtaining an enhancement layer signal code of the enhancement sample point; and outputting a bit stream, where the bit stream includes the core layer signal code and the enhancement layer signal code. In embodiments of the present invention, according to the number of bits that can be used by the enhancement layer, the enhancement sample point that requires enhancement layer signal encoding is selected; the enhancement layer signal of the selected enhancement sample point is encoded and decoded; when no sufficient bits are available for the enhancement layer, the enhancement quality of the core layer can be improved.
摘要翻译：一种用于信号编码和解码的方法，装置和系统，所述方法包括：对核心层信号进行编码以获得核心层信号码; 选择需要根据核心层信号码的增强层信号编码和增强层可以使用的位数的增强采样点; 获得增强采样点的增强层信号码; 并输出比特流，其中比特流包括核心层信号码和增强层信号码。在本发明的实施例中，根据增强层可以使用的比特数，选择需要增强层信号编码的增强采样点; 所选择的增强采样点的增强层信号被编码和解码; 当没有足够的比特可用于增强层时，可以提高核心层的增强质量。

49. 发明授权

US08103515B2 Signal classification processing method, classification processing device, and encoding system 有权
标题翻译：信号分类处理方法，分类处理装置和编码系统
公开(公告)号：US08103515B2
公开(公告)日：2012-01-24
申请号：US13160115
申请日：2011-06-14
申请人： Longyin Chen , Zexin Liu , Lei Miao , Chen Hu , Wei Xiao , Marcel Taddei Herve , Qing Zhang
发明人： Longyin Chen , Zexin Liu , Lei Miao , Chen Hu , Wei Xiao , Marcel Taddei Herve , Qing Zhang
IPC分类号： G10L19/00
CPC分类号： G10L19/22 , G10L19/025
摘要： A signal classification processing method, a classification processing device, and an encoding system are provided. The signal classification processing method includes: obtaining a high band input signal; determining a signal type of the obtained high band input signal according to a time domain characteristic parameter and/or a frequency domain characteristic parameter of the high band input signal; and determining an encoding mode corresponding to the signal type. The classification processing device includes: a receiving unit, configured to obtain a high band input signal; and a processing unit, configured to determine a signal type of the obtained high band input signal according to a time domain characteristic parameter and/or a frequency domain characteristic parameter of the high band input signal and determine an encoding mode corresponding to the signal type. An encoding system is also provided. Therefore, type subdivision and processing are performed on the high band input signal, so as to facilitate encoding and decoding processing of the signal.
摘要翻译：提供信号分类处理方法，分类处理装置和编码系统。信号分类处理方法包括：获得高频带输入信号; 根据高频带输入信号的时域特性参数和/或频域特性参数，确定所获得的高频带输入信号的信号类型; 以及确定与所述信号类型对应的编码模式。分类处理装置包括：接收单元，被配置为获得高频带输入信号; 以及处理单元，被配置为根据所述高频带输入信号的时域特性参数和/或频域特性参数来确定所获得的高频带输入信号的信号类型，并且确定与所述信号类型对应的编码模式。还提供了编码系统。因此，对高频带输入信号进行类型细分处理，便于信号的编码和解码处理。

50. 发明申请

US20110257984A1 System and Method for Audio Coding and Decoding 有权
标题翻译：用于音频编码和解码的系统和方法
公开(公告)号：US20110257984A1
公开(公告)日：2011-10-20
申请号：US12893526
申请日：2010-09-29
申请人： David Sylvain Thierry Virette , Yang Gao , Wei Xiao
发明人： David Sylvain Thierry Virette , Yang Gao , Wei Xiao
IPC分类号： G10L21/04
CPC分类号： G10L19/00 , G10L19/26 , G10L25/18
摘要： In accordance with an embodiment, a method of generating an encoded audio signal, the method includes estimating a time-frequency energy of an input audio signal from a time-frequency filter bank, computing a global variance of the time-frequency energy, determining a post-processing method according to the global variance, and transmitting an encoded representation of the input audio signal along with an indication of the determined post-processing method.
摘要翻译：根据实施例，一种生成编码音频信号的方法，所述方法包括估计来自时频滤波器组的输入音频信号的时频能量，计算时频能量的全局方差，确定根据全局方差的后处理方法，以及输出音频信号的编码表示以及所确定的后处理方法的指示。

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