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1. 发明授权

US10253289B2 Method and apparatus for measuring biological activity with single cell resolution 有权
公开(公告)号：US10253289B2
公开(公告)日：2019-04-09
申请号：US15304205
申请日：2015-04-17
申请人： Zulfiya Orynbayeva , Gennady Friedman , Yury Gogotsi , Yang Gao
发明人： Zulfiya Orynbayeva , Gennady Friedman , Yury Gogotsi , Yang Gao
IPC分类号： C12M1/00 , G01N33/50 , G01N33/52 , G01N33/497 , C12M1/12 , C12M1/34 , B01L3/02
摘要： A method and apparatus for carrying out measurements on single cells, either one or many single cells at a time in order to characterize the cellular response to stimuli in a perfused liquid. The apparatus for performing the respirometry includes a double-barrel pipette probe.

2. 发明授权

US09885080B2 Kit, a device and a method for detecting copy number of fetal chromosomes or tumor cell chromosomes 有权
公开(公告)号：US09885080B2
公开(公告)日：2018-02-06
申请号：US13811634
申请日：2011-05-31
申请人： Yang Gao , Daixing Zhou , Jianguang Zhang , Feng Tian
发明人： Yang Gao , Daixing Zhou , Jianguang Zhang , Feng Tian
IPC分类号： C12Q1/68 , G06F19/20
CPC分类号： C12Q1/6874 , C12Q1/6809 , C12Q1/6869 , G06F19/20 , C12Q2535/122 , C12Q2537/16 , C12Q2537/165 , C12Q2563/159
摘要： The invention relates to a kit, a device and a method for detecting the copy number of fetal chromosomes and tumor cell chromosomes. The method for detecting the copy number of fetal chromosomes or tumor cell chromosomes of the invention includes the following steps: collecting maternal plasma or plasma of tumor patient; separating the plasma from blood cells in blood; preparing Deoxyribonucleic Acids (DNA) in the plasma into a sequencing library; sequencing the DNA sequencing library; comparing a sequencing result with a genomic sequence map to determine which chromosome the DNA sequence comes from and the length of each DNA sequence; and calculating the ratio of the DNA segments from the chromosomes to be detected to all DNA segments in the same sample by a sequencing and comparison result of DNA, correcting the ratio according to a GC content of the DNA segments from the chromosomes to be detected, and calculating the variation of the corrected ratio of the DNA segments from the chromosomes to be detected in a sample to be detected, and determining the copy number of the chromosomes to be detected according to degree of variation.

3. 发明授权

US09589572B2 Stepsize determination of adaptive filter for cancelling voice portion by combining open-loop and closed-loop approaches 有权
标题翻译：通过组合开环和闭环方法，来逐步确定自适应滤波器来消除语音部分
公开(公告)号：US09589572B2
公开(公告)日：2017-03-07
申请号：US14702687
申请日：2015-05-02
申请人： Yang Gao
发明人： Yang Gao
IPC分类号： A61F11/06 , G10L21/0208 , G10L21/0216
CPC分类号： G10L21/0208 , G10L2021/02166
摘要： In accordance with an embodiment of the present invention, a noise reduction method for speech processing includes estimating a noise/interference component signal by subtracting voice component signal from a first microphone input signal wherein the voice component signal is evaluated as a first replica signal produced by passing a second microphone input signal through a first adaptive filter; a stepsize is estimated to control adaptive update of the first adaptive filter, wherein the stepsize is evaluated by combing an open-loop approach and a closed-loop approach, the open-loop approach comprising voice/noise/interference classification and SNR estimation in voice area, and the closed-loop approach comprising calculating a normalized correlation between the first replica signal and the first microphone input signal. A noise/interference reduced signal is outputted by subtracting a second replica signal from a target signal which is the first microphone input signal or the second microphone input signal, wherein the second replica signal is produced by passing the estimated noise/interference component signal through a second adaptive filter.
摘要翻译：根据本发明的实施例，用于语音处理的噪声降低方法包括：通过从第一麦克风输入信号中减去语音分量信号来估计噪声/干扰分量信号，其中语音分量信号被评估为第一复制信号，其由通过第一自适应滤波器传递第二麦克风输入信号; 估计步长来控制第一自适应滤波器的自适应更新，其中通过组合开环方法和闭环方法评估步长，包括语音/噪声/干扰分类和声音中的SNR估计的开环方法区域和闭环方法，包括计算第一复制信号和第一麦克风输入信号之间的归一化相关性。通过从作为第一麦克风输入信号或第二麦克风输入信号的目标信号减去第二复制信号来输出噪声/干扰降低信号，其中通过将估计的噪声/干扰分量信号通过一个第二自适应滤波器。

4. 发明授权

US09540687B2 DNA fragment detection method, DNA fragment detection kit and the use thereof 有权
标题翻译： DNA片段检测方法，DNA片段检测试剂盒及其用途
公开(公告)号：US09540687B2
公开(公告)日：2017-01-10
申请号：US14347113
申请日：2012-07-11
申请人： Jianguang Zhang , Zhongchun Zhou , Daixing Zhou , Genming Xu , Yang Gao , Feng Tian
发明人： Jianguang Zhang , Zhongchun Zhou , Daixing Zhou , Genming Xu , Yang Gao , Feng Tian
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q2521/501 , C12Q2525/307
摘要： The disclosure claims a cleaved Deoxyribonucleic acid (DNA) detection method, a DNA fragment detection kit and use thereof. Wherein, the method includes the steps of: designing primers according to a test site or a test region of the DNA fragment; cyclizing the DNA fragment to obtain acyclized DNA; implementing Polymerase Chain Reaction (PCR) amplification for the cyclized DNA by using the primers; and detecting the PCR amplification product. In the disclosure, by cyclizing the DNA fragment, the amplification can be implemented even if only one PCR primer can match with a template, thus, the adaption range and effective template amount of the primer amplification can be greatly increased, and the detection sensitivity of the DNA fragment can be greatly improved.
摘要翻译：本公开要求切割的脱氧核糖核酸（DNA）检测方法，DNA片段检测试剂盒及其用途。其中该方法包括以下步骤：根据DNA片段的测试位点或测试区设计引物; 使DNA片段环化以获得非环化DNA; 通过使用引物对环化DNA进行聚合酶链反应（PCR）扩增; 并检测PCR扩增产物。在本公开中，通过使DNA片段环化，即使只有一个PCR引物可以与模板匹配，也可以实现扩增，因此可以大大增加引物扩增的适应范围和有效模板量，并且检测灵敏度 DNA片段可以大大提高。

5. 发明授权

US09510096B2 Noise energy controlling in noise reduction system with two microphones 有权
标题翻译：具有两个麦克风的降噪系统中的噪声能量控制
公开(公告)号：US09510096B2
公开(公告)日：2016-11-29
申请号：US14702688
申请日：2015-05-02
申请人： Yang Gao
发明人： Yang Gao
IPC分类号： G10K11/16 , H04R3/00 , G10K11/178 , H04R5/04
CPC分类号： H04R3/005 , G10K11/178 , H04R3/002 , H04R5/04 , H04R2201/403 , H04R2410/01
摘要： In accordance with an embodiment of the present invention, a noise reduction method for speech processing includes cancelling or reducing noise/interference component signal in speech signal enhancement processing, the method comprising estimating the noise/interference component signal by subtracting voice component signal from a first microphone input signal wherein the voice component signal is evaluated as a first replica signal produced by passing a second microphone input signal through a first adaptive filter. Energy variation of the noise/interference component signal is adjusted based on noise stability detection and/or energy explosion detection, wherein the energy of the noise/interference component signal is reduced or smoothed in voice area or energy explosion area if the stable noise is detected and/or the energy explosion is detected. A noise/interference reduced signal is outputted by subtracting a second replica signal from the target signal, wherein the second replica signal is produced by passing the adjusted noise/interference component signal through a second adaptive filter.
摘要翻译：根据本发明的实施例，用于语音处理的噪声降低方法包括：消除或减少语音信号增强处理中的噪声/干扰分量信号，所述方法包括：通过从第一信号中减去语音分量信号来估计噪声/干扰分量信号麦克风输入信号，其中语音分量信号被评估为通过使第二麦克风输入信号通过第一自适应滤波器而产生的第一复制信号。基于噪声稳定性检测和/或能量爆炸检测来调整噪声/干扰分量信号的能量变化，其中如果检测到稳定的噪声，噪声/干扰分量信号的能量在话音区域或能量爆炸区域被减少或平滑和/或检测到能量爆炸。通过从目标信号中减去第二副本信号来输出噪声/干扰减小信号，其中通过使调整的噪声/干扰分量信号通过第二自适应滤波器来产生第二复制信号。

6. 发明授权

US09443531B2 Single MIC detection in beamformer and noise canceller for speech enhancement 有权
标题翻译：用于语音增强的波束形成器和噪声消除器中的单个MIC检测
公开(公告)号：US09443531B2
公开(公告)日：2016-09-13
申请号：US14702686
申请日：2015-05-02
申请人： Yang Gao
发明人： Yang Gao
IPC分类号： G10L21/00 , G10L21/0208 , G10L21/0216
CPC分类号： G10L21/0208 , G10L2021/02163 , G10L2021/02166
摘要： In accordance with an embodiment of the present invention, a noise reduction method for speech processing includes detecting if two signals from two microphones are so close to each other in non voice area that the two microphones are equivalent to Single-Microphone for noise/interference reduction processing. Single-Microphone noise/interference reduction processing algorithm is selected if the equivalent Single-Microphone is detected; Multiple-Microphone noise/interference reduction processing algorithm is selected if the equivalent Single-Microphone is not detected.
摘要翻译：根据本发明的实施例，用于语音处理的噪声降低方法包括检测来自两个麦克风的两个信号是否在非语音区域中彼此如此接近，使得两个麦克风相当于用于噪声/干扰减少的单麦克风处理。如果检测到等效的单麦克风，则选择单麦克风噪声/干扰减少处理算法; 如果未检测到等效的单麦克风，则选择多麦克风噪声/干扰减少处理算法。

7. 发明授权

US09401156B2 Adaptive tilt compensation for synthesized speech 有权
标题翻译：合成语音的自适应倾斜补偿
公开(公告)号：US09401156B2
公开(公告)日：2016-07-26
申请号：US12215649
申请日：2008-06-27
申请人： Huan-Yu Su , Yang Gao
发明人： Huan-Yu Su , Yang Gao
IPC分类号： G10L19/09 , G10L19/12 , G10L19/18 , G10L19/20 , G10L25/90 , G10L19/02 , G10L19/00
CPC分类号： G10L19/12 , G10L19/0204 , G10L19/09 , G10L19/18 , G10L19/20 , G10L25/90 , G10L2019/0002 , G10L2019/0016
摘要： There is provided a method of using an adaptive tilt compensation by a speech decoder. The method comprises receiving a bit stream including a plurality of parameters representative of a speech signal; identifying an adaptive code vector and a fixed code vector using the plurality of parameters; scaling the adaptive code vector and the fixed code vector to generate a scaled adaptive code vector and a scaled fixed code vector; summing the scaled adaptive code vector and the scaled fixed code vector to generate a synthesized output; calculating a first reflection coefficient based on the plurality of parameters representative of the speech signal; multiplying the first reflection coefficient by a factor to generate a tilt factor; and applying the tilt factor to the synthesized output based on an encoding bit rate.
摘要翻译：提供了一种通过语音解码器使用自适应倾斜补偿的方法。该方法包括：接收包括表示语音信号的多个参数的比特流; 使用所述多个参数来识别自适应码矢量和固定码矢量; 缩放自适应码矢量和固定码矢量以生成缩放的自适应码矢量和缩放的固定码矢量; 对经缩放的自适应码矢量和缩放的固定码矢量求和以产生合成输出; 基于表示所述语音信号的多个参数来计算第一反射系数; 将第一反射系数乘以因子以产生倾斜因子; 以及基于编码比特率将所述倾斜因子应用于所述合成输出。

8. 发明授权

US09373950B2 Modular multilevel converter valve protection method 有权
标题翻译：模块化多电平转换器阀门保护方法
公开(公告)号：US09373950B2
公开(公告)日：2016-06-21
申请号：US14005267
申请日：2011-11-29
申请人： Yang Gao , Yuefeng Yang , Renqiu Wang , Zhiyuan He , Xinggang Zhang , Minhua Xie
发明人： Yang Gao , Yuefeng Yang , Renqiu Wang , Zhiyuan He , Xinggang Zhang , Minhua Xie
IPC分类号： H02H7/00 , H02H3/08 , H02M1/32 , H02M7/483
CPC分类号： H02H3/085 , H02M1/32 , H02M2001/0003 , H02M2001/325 , H02M2007/4835
摘要： The invention relates to Modular multilevel converter valve protection method, the modular multilevel converter valve consists of 6 arms, the arm includes sub modules, 1 arm is controlled by 1 control host, 6 control hosts is controlled by 1 summary control host, the method of the invention includes that the arm realizes locking sub module, bypass sub module, trip requests and system switching request and the summary control host implements summary and control response. The invention improves the reliability of two protection system through the use of dual redundancy protection method, clears the protection division through the layered protection frame of the upper summary control host and multi arm control host. And finally, it improves the whole safety and reliability of the modular multilevel converter valve.
摘要翻译：本发明涉及模块化多级转换器阀门保护方法，模块化多级转换阀由6臂组成，臂包括子模块，1臂由1个控制主机控制，6个控制主机由1个控制主机控制，本发明包括实现锁定子模块，旁路子模块，跳闸请求和系统切换请求，汇总控制主机实现汇总和控制响应。本发明通过使用双重冗余保护方法提高了两个保护系统的可靠性，通过上位概要控制主机和多臂控制主机的分层保护框架，清除了保护划分。最后，提高了模块化多级转换阀的整体安全性和可靠性。

9. 发明申请

US20150371656A1 Acoustic Echo Preprocessing for Speech Enhancement 审中-公开
公开(公告)号：US20150371656A1
公开(公告)日：2015-12-24
申请号：US14740656
申请日：2015-06-16
申请人： Yang Gao
发明人： Yang Gao
IPC分类号： G10L21/0208 , G10K11/16
CPC分类号： G10L21/0208 , G10K11/16 , G10L21/0224 , G10L2021/02082 , H04M9/082
摘要： A method for cancelling/reducing acoustic echoes in speech/audio signal enhancement processing comprises selecting a long-term filter based on an echo tail length detection or an echo reverberation time detection of an microphone input signal; a reference signal is pre-processed with the selected long-term filter; the pre-processed reference signal is used to excite an adaptive filter wherein the output of the adaptive filter forms a replica signal of acoustic echo and/or acoustic echo tail; the replica signal of acoustic echo and/or acoustic echo tail is subtracted from a microphone input signal to suppress the acoustic echo and/or acoustic echo tail in the microphone input signal. The echo tail length or the echo reverberation time is detected by analyzing and comparing the microphone input signal and a received signal which is sent to a speaker. A strong long-term filter is selected if the detected echo tail length or the detected echo reverberation time is long; a weak long-term filter is selected if the detected echo tail length or the detected echo reverberation time is not long.

10. 发明申请

US20150319528A1 Noise Energy Controlling In Noise Reduction System With Two Microphones 审中-公开
标题翻译：具有两个麦克风的降噪系统噪声能量控制
公开(公告)号：US20150319528A1
公开(公告)日：2015-11-05
申请号：US14702688
申请日：2015-05-02
申请人： Yang Gao
发明人： Yang Gao
IPC分类号： H04R3/00
CPC分类号： H04R3/005 , G10K11/178 , H04R3/002 , H04R5/04 , H04R2201/403 , H04R2410/01
摘要： In accordance with an embodiment of the present invention, a noise reduction method for speech processing includes cancelling or reducing noise/interference component signal in speech signal enhancement processing, the method comprising estimating the noise/interference component signal by subtracting voice component signal from a first microphone input signal wherein the voice component signal is evaluated as a first replica signal produced by passing a second microphone input signal through a first adaptive filter. Energy variation of the noise/interference component signal is adjusted based on noise stability detection and/or energy explosion detection, wherein the energy of the noise/interference component signal is reduced or smoothed in voice area or energy explosion area if the stable noise is detected and/or the energy explosion is detected. A noise/interference reduced signal is outputted by subtracting a second replica signal from the target signal, wherein the second replica signal is produced by passing the adjusted noise/interference component signal through a second adaptive filter.
摘要翻译：根据本发明的实施例，用于语音处理的噪声降低方法包括：消除或减少语音信号增强处理中的噪声/干扰分量信号，所述方法包括：通过从第一信号中减去语音分量信号来估计噪声/干扰分量信号麦克风输入信号，其中语音分量信号被评估为通过使第二麦克风输入信号通过第一自适应滤波器而产生的第一复制信号。基于噪声稳定性检测和/或能量爆炸检测来调整噪声/干扰分量信号的能量变化，其中如果检测到稳定的噪声，噪声/干扰分量信号的能量在话音区域或能量爆炸区域被减少或平滑和/或检测到能量爆炸。通过从目标信号中减去第二副本信号来输出噪声/干扰减小信号，其中通过使调整的噪声/干扰分量信号通过第二自适应滤波器来产生第二复制信号。

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