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41. 发明授权

US08481883B2 Welding method and apparatus 有权
标题翻译：焊接方法及装置
公开(公告)号：US08481883B2
公开(公告)日：2013-07-09
申请号：US13069469
申请日：2011-03-23
申请人： David Yang , Pei-Chung Wang
发明人： David Yang , Pei-Chung Wang
IPC分类号： B23K9/00 , B23K15/00 , B23K26/00
CPC分类号： B23K26/40 , B23K26/60 , B23K2101/35 , B23K2103/10 , B23K2103/50
摘要： A welding apparatus for welding a work-piece includes an energy source configured to generate a weld in a zone of the work-piece, with the work-piece characterized by a layer. The apparatus also includes a first wheel characterized by a first circumference and a first set of protrusions disposed on the first circumference, and a second wheel characterized by a second circumference and a second set of protrusions disposed on the second circumference. Each of the first and second wheels is configured to rotate relative to the work-piece, and the first and second sets of protrusions are configured to disrupt the layer as the work-piece is traversed between the first and second wheels. The energy source generates the weld in the zone of the work-piece following the disruption of the layer. A method employing the disclosed welding apparatus is also provided.
摘要翻译：用于焊接工件的焊接装置包括被配置为在工件的区域中产生焊接的能量源，工件的特征在于一层。该设备还包括第一轮，其特征在于第一圆周和设置在第一圆周上的第一组突起，以及第二轮，其特征在于设置在第二圆周上的第二圆周和第二组突起。第一和第二轮中的每一个构造成相对于工件旋转，并且第一和第二组突起构造成当工件在第一和第二轮之间横穿时破坏该层。能量源在层的破坏之后在工件的区域中产生焊缝。还提供了采用所公开的焊接设备的方法。

42. 发明申请

US20120241421A1 WELDING METHOD AND APPARATUS 有权
标题翻译：焊接方法和装置
公开(公告)号：US20120241421A1
公开(公告)日：2012-09-27
申请号：US13069469
申请日：2011-03-23
申请人： David Yang , Pei-Chung Wang
发明人： David Yang , Pei-Chung Wang
IPC分类号： B23K9/00 , B23K15/00 , B23K26/00
CPC分类号： B23K26/40 , B23K26/60 , B23K2101/35 , B23K2103/10 , B23K2103/50
摘要： A welding apparatus for welding a work-piece includes an energy source configured to generate a weld in a zone of the work-piece, with the work-piece characterized by a layer. The apparatus also includes a first wheel characterized by a first circumference and a first set of protrusions disposed on the first circumference, and a second wheel characterized by a second circumference and a second set of protrusions disposed on the second circumference. Each of the first and second wheels is configured to rotate relative to the work-piece, and the first and second sets of protrusions are configured to disrupt the layer as the work-piece is traversed between the first and second wheels. The energy source generates the weld in the zone of the work-piece following the disruption of the layer. A method employing the disclosed welding apparatus is also provided.
摘要翻译：用于焊接工件的焊接装置包括被配置为在工件的区域中产生焊接的能量源，工件的特征在于一层。该设备还包括第一轮，其特征在于第一圆周和设置在第一圆周上的第一组突起，以及第二轮，其特征在于设置在第二圆周上的第二圆周和第二组突起。第一和第二轮中的每一个构造成相对于工件旋转，并且第一和第二组突起构造成当工件在第一和第二轮之间横穿时破坏该层。能量源在层的破坏之后在工件的区域中产生焊缝。还提供了采用所公开的焊接设备的方法。

43. 发明授权

US08147805B2 Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications 有权
标题翻译：双重成像和放射化学治疗的结合体：组成，制造和应用
公开(公告)号：US08147805B2
公开(公告)日：2012-04-03
申请号：US11326117
申请日：2006-01-05
申请人： David Yang , Dongfang Yu , Mithu Chanda , Ali Azhdarinia , Changsok Oh , E. Edmund Kim
发明人： David Yang , Dongfang Yu , Mithu Chanda , Ali Azhdarinia , Changsok Oh , E. Edmund Kim
IPC分类号： A61K49/04 , A61K51/00 , A61M36/14
CPC分类号： A61K47/48092 , A61K47/549 , A61K47/61 , A61K49/0002 , A61K49/0438 , A61K51/0491 , C08B37/00 , C08B37/003
摘要： Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.
摘要翻译：公开了用于双重成像和双重化疗和放疗的组合物和方法。更具体地，本发明涉及包含结构X1-Y-X2的化合物，其中Y包含彼此共价连接的两个或更多个碳水化合物残基，X1和X2是共价连接到Y的诊断或治疗部分，条件是当Y不包含氨基葡萄糖残基X1和X2是诊断部分。本发明还涉及这些化合物的合成方法，这种化合物在双成像和治疗过度增殖性疾病中的应用，以及用于制备放射性标记的治疗或诊断化合物的试剂盒。

44. 发明授权

US07841615B2 Foldable telescope golf cart having a balancing mechanism 失效
标题翻译：具有平衡机构的可折叠望远镜高尔夫球车
公开(公告)号：US07841615B2
公开(公告)日：2010-11-30
申请号：US11189960
申请日：2005-07-27
申请人： David Yang
发明人： David Yang
IPC分类号： B62B1/20
CPC分类号： A63B55/60 , A63B2210/50 , B62B1/045 , B62B2202/404 , Y10S280/06
摘要： A swing arm assembly becomes a balancing mechanism for a foldable telescope golf cart. The swing arm assembly adjusts the inclined angle of the golf beg on the golf cart, and thus adjusts the location of the center of gravity of the cart. The golf cart is maintained in a balanced state when the center of gravity falls upon the centerline of the cart wheels. The golf cart and swing arm assembly can be converted from compact size to full size, or vice versa, by a single action.
摘要翻译：摆臂组件成为可折叠望远镜高尔夫球车的平衡机构。摇臂组件调节高尔夫球车上的高尔夫乞讨的倾斜角度，从而调节推车重心的位置。当重心落在推车车轮的中心线上时，高尔夫球车保持平衡状态。高尔夫球车和摆臂组件可以通过单一动作从紧凑尺寸转换成全尺寸，反之亦然。

45. 发明申请

US20100104511A1 METHODS AND COMPOSITIONS USING CHELATOR-ANTIBODY CONJUGATES 审中-公开
标题翻译：方法和组合物使用治疗 - 抗体结合
公开(公告)号：US20100104511A1
公开(公告)日：2010-04-29
申请号：US12516172
申请日：2007-11-14
申请人： Razelle Kurzrock , Jing Gong , David Yang , Saady Kohanim
发明人： Razelle Kurzrock , Jing Gong , David Yang , Saady Kohanim
IPC分类号： A61K51/00 , C07K16/00 , A61P35/04 , A61P29/00
CPC分类号： A61K51/103 , A61K49/0002 , A61K51/0474
摘要： Disclosed are pharmaceutical compositions that include a chelator and an antibody directed against a phosphorylation site of a protein, wherein the antibody is conjugated to the chelator to form a chelator-antibody conjugate. For example, the antibody may recognize a phosphorylated tyrosine residue or a phosphorylated serine residue of a cell surface receptor. Also disclosed are methods of synthesizing a radiolabeled chelator-antibody conjugate, wherein the antibody is directed against a phosphorylation site of a protein. Also disclosed are methods for imaging a site in a subject that involve administering to the subject an effective amount of a composition that includes a valent metal ion-labeled chelator-antibody conjugate, wherein the antibody is an antibody directed against a phosphorylation site of a protein, and detecting a radioactive signal from the site in the subject following administration of an effective amount of the composition. The method of imaging can be applied in diagnosing a tumor, such as a tumor that can be responsive to therapy using a tyrosine kinase inhibitor, and in the treatment of a tumor, such as by targeting therapy to cell surface receptors that include phosphorylation sites.
摘要翻译：公开了包含螯合剂和针对蛋白质的磷酸化位点的抗体的药物组合物，其中抗体与螯合剂缀合以形成螯合剂 - 抗体缀合物。例如，抗体可以识别细胞表面受体的磷酸化酪氨酸残基或磷酸化丝氨酸残基。还公开了合成放射性标记的螯合剂 - 抗体缀合物的方法，其中抗体针对蛋白质的磷酸化位点。还公开了用于对受试者中的位点成像的方法，其涉及向受试者施用有效量的包含价值金属离子标记的螯合剂 - 抗体缀合物的组合物，其中所述抗体是针对蛋白质的磷酸化位点的抗体并且在施用有效量的组合物之后从受试者的部位检测放射性信号。成像方法可以应用于诊断肿瘤，例如可以使用酪氨酸激酶抑制剂对治疗有反应的肿瘤，以及治疗肿瘤，例如通过靶向包括磷酸化位点的细胞表面受体的治疗。

46. 发明申请

US20080035542A1 Automated system for formulating radiopharmaceuticals 失效
标题翻译：空值
公开(公告)号：US20080035542A1
公开(公告)日：2008-02-14
申请号：US11726853
申请日：2007-03-23
申请人： Firas Mourtada , Ali Azhdarinia , David Yang , Changsok Oh
发明人： Firas Mourtada , Ali Azhdarinia , David Yang , Changsok Oh
IPC分类号： B01D21/30 , B01D15/08
CPC分类号： G21G4/08 , B01D15/10 , B01D15/325 , B01D15/362 , B01D15/363 , G21G1/0005 , G21H5/02
摘要： The present invention provides automated systems for the purification of radioisotopes, the formulation of radiopharmaceuticals or both. In preferred embodiments the radioisotopes are produced by a generator. In further preferred embodiments the automated systems comprise replaceable cassettes for easy replacement of the system's networks of tubing. Also provided are replaceable cassettes and kits for use with the automated systems of the invention.The invention further provides methods of using an automated system to purify radioisotopes, formulate radiopharmaceuticals or to do both in series.
摘要翻译：本发明提供用于纯化放射性同位素的自动化系统，放射性药物的配方或两者。在优选实施方案中，放射性同位素由发生器产生。在进一步的优选实施例中，自动化系统包括可更换的盒，用于容易地更换系统的管道网络。还提供了与本发明的自动化系统一起使用的可更换盒和套件。本发明还提供了使用自动化系统来净化放射性同位素，配制放射性药物或两者串联的方法。

47. 发明授权

US07222833B2 Picture frame hanger 失效
标题翻译：相框吊架
公开(公告)号：US07222833B2
公开(公告)日：2007-05-29
申请号：US11181963
申请日：2005-07-15
申请人： David Yang
发明人： David Yang
IPC分类号： A47G1/16
CPC分类号： A47G1/20
摘要： The hanger of present invention comprises of an integral hook and anchor sections in the upper and lower parts of hanger respectively. The hook section forms an U-hook for suspending and retaining the hanging wire of a picture frame. The anchor section guides a fastener such as a nail to drive through the anchor section and into the wall in inclined position. The hanger of present invention allows the hanging wire of the picture frame to directly engage into the U-hook without interference when a person holds the picture frame against the wall, and slides the picture frame downward to approach the hanger from the top of hanger.
摘要翻译：本发明的衣架分别包括衣架上部和下部的整体钩和锚固部分。钩部形成用于悬挂和保持相框吊挂线的U形钩。锚定部引导诸如钉子的紧固件以倾斜的位置驱动穿过锚固部分并进入壁部。本发明的衣架使得当人将相框抵住墙壁时，相框的悬挂线直接接合到U形钩中，而不会受到干扰，并且将画框向下滑动以从衣架的顶部接近吊架。

48. 发明申请

US20060188438A1 Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging 有权
公开(公告)号：US20060188438A1
公开(公告)日：2006-08-24
申请号：US11405334
申请日：2006-04-17
申请人： David Yang , Chun Liu , Dong-Fang Yu , E. Kim
发明人： David Yang , Chun Liu , Dong-Fang Yu , E. Kim
IPC分类号： A61K51/00 , C07F13/00
CPC分类号： A61K51/088 , A61K51/04 , A61K51/0478 , A61K51/0491 , A61K51/0497 , A61K51/087
摘要： The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.

49. 发明申请

US20060135404A1 Water soluble paclitaxel derivatives 审中-公开
公开(公告)号：US20060135404A1
公开(公告)日：2006-06-22
申请号：US11285392
申请日：2005-11-23
申请人： Chun Li , Sidney Wallace , Dong-Fang Yu , David Yang
发明人： Chun Li , Sidney Wallace , Dong-Fang Yu , David Yang
IPC分类号： A61K38/16
CPC分类号： A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要： Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.

50. 发明授权

US07036263B2 Snag-free and stress-free fish catcher 失效
标题翻译：无捕捞和无压力的捕鱼者
公开(公告)号：US07036263B2
公开(公告)日：2006-05-02
申请号：US10704309
申请日：2003-11-10
申请人： David Yang , Wayne Yang
发明人： David Yang , Wayne Yang
IPC分类号： A01K77/00
CPC分类号： A01K77/00
摘要： A snag-free and stress-free fish catcher includes a supporting frame, a fish pocket, having a fish cavity, supported by the supporting frame, and a tension resting bed, having a tension surface, supported within the fish cavity, wherein the tension surface of the tension resting bed has a predetermined tension larger than a weight of the fish. Therefore, when the fish is captured within the fish cavity of the fish pocket, the fish lies on the tension surface of the tension resting bed in a flatten manner.
摘要翻译：无阻力和无压力的捕鱼器包括支撑框架，具有鱼腔的鱼窝，由支撑框架支撑，以及张紧床，其具有支撑在鱼腔内的张力表面，其中张力张力搁置床的表面具有大于鱼的重量的预定张力。因此，当鱼被捕获在鱼袋的鱼腔中时，鱼以平坦的方式位于张力休息床的张力表面上。

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