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1. 发明申请

US20100104511A1 METHODS AND COMPOSITIONS USING CHELATOR-ANTIBODY CONJUGATES 审中-公开
标题翻译：方法和组合物使用治疗 - 抗体结合
公开(公告)号：US20100104511A1
公开(公告)日：2010-04-29
申请号：US12516172
申请日：2007-11-14
申请人： Razelle Kurzrock , Jing Gong , David Yang , Saady Kohanim
发明人： Razelle Kurzrock , Jing Gong , David Yang , Saady Kohanim
IPC分类号： A61K51/00 , C07K16/00 , A61P35/04 , A61P29/00
CPC分类号： A61K51/103 , A61K49/0002 , A61K51/0474
摘要： Disclosed are pharmaceutical compositions that include a chelator and an antibody directed against a phosphorylation site of a protein, wherein the antibody is conjugated to the chelator to form a chelator-antibody conjugate. For example, the antibody may recognize a phosphorylated tyrosine residue or a phosphorylated serine residue of a cell surface receptor. Also disclosed are methods of synthesizing a radiolabeled chelator-antibody conjugate, wherein the antibody is directed against a phosphorylation site of a protein. Also disclosed are methods for imaging a site in a subject that involve administering to the subject an effective amount of a composition that includes a valent metal ion-labeled chelator-antibody conjugate, wherein the antibody is an antibody directed against a phosphorylation site of a protein, and detecting a radioactive signal from the site in the subject following administration of an effective amount of the composition. The method of imaging can be applied in diagnosing a tumor, such as a tumor that can be responsive to therapy using a tyrosine kinase inhibitor, and in the treatment of a tumor, such as by targeting therapy to cell surface receptors that include phosphorylation sites.
摘要翻译：公开了包含螯合剂和针对蛋白质的磷酸化位点的抗体的药物组合物，其中抗体与螯合剂缀合以形成螯合剂 - 抗体缀合物。例如，抗体可以识别细胞表面受体的磷酸化酪氨酸残基或磷酸化丝氨酸残基。还公开了合成放射性标记的螯合剂 - 抗体缀合物的方法，其中抗体针对蛋白质的磷酸化位点。还公开了用于对受试者中的位点成像的方法，其涉及向受试者施用有效量的包含价值金属离子标记的螯合剂 - 抗体缀合物的组合物，其中所述抗体是针对蛋白质的磷酸化位点的抗体并且在施用有效量的组合物之后从受试者的部位检测放射性信号。成像方法可以应用于诊断肿瘤，例如可以使用酪氨酸激酶抑制剂对治疗有反应的肿瘤，以及治疗肿瘤，例如通过靶向包括磷酸化位点的细胞表面受体的治疗。

2. 发明申请

US20050100506A1 Mechanism-based targeted pancreatic beta cell imaging and therapy 有权
标题翻译：基于机制的靶向胰腺β细胞成像和治疗
公开(公告)号：US20050100506A1
公开(公告)日：2005-05-12
申请号：US10942615
申请日：2004-09-16
申请人： David Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
发明人： David Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
IPC分类号： A61K31/175 , A61K31/426 , A61K31/4439 , A61K51/00 , A61K51/04
CPC分类号： A61K51/0497
摘要： Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
摘要翻译：用于成像胰腺β细胞的组合物包含螯合剂 - 抗糖尿病药物缀合物和任选的螯合金属。

3. 发明申请

US20070248537A1 Compositions and Methods for Cellular Imaging and Therapy 有权
标题翻译：细胞成像和治疗的组合和方法
公开(公告)号：US20070248537A1
公开(公告)日：2007-10-25
申请号：US11737694
申请日：2007-04-19
申请人： David Yang , Chang-Sok Oh , Dong-Fang Yu , Ali Azhdarinia , Saady Kohanim
发明人： David Yang , Chang-Sok Oh , Dong-Fang Yu , Ali Azhdarinia , Saady Kohanim
IPC分类号： A61K51/00 , A61K49/10 , C07F5/00 , C07K16/46
CPC分类号： C07F13/005 , A61K47/547 , A61K51/0474 , A61K51/0491
摘要： The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving N4 compounds and derivatives.
摘要翻译：本发明一般涉及化学和放射性核素成像领域。更具体地，涉及涉及N 4+化合物及其衍生物的成像，试剂盒和成像和治疗方法。

4. 发明申请

US20060246005A1 Poly(peptide) as a chelator: methods of manufacture and uses 审中-公开
标题翻译：聚（肽）作为螯合剂：制造和使用方法
公开(公告)号：US20060246005A1
公开(公告)日：2006-11-02
申请号：US11394664
申请日：2006-03-31
申请人： David Yang , Dong-Fang Yu , Chang Oh , Saady Kohanim , E. Kim , Ali Azhdarinia
发明人： David Yang , Dong-Fang Yu , Chang Oh , Saady Kohanim , E. Kim , Ali Azhdarinia
IPC分类号： A61K51/00
CPC分类号： A61K51/088 , A61K47/64 , A61K51/0478 , A61K51/0497
摘要： Novel compositions for imaging that include (a) a polypeptide that includes two or more consecutive amino acids that will function to non-covalently bind valent metal ions and (2) a valent metal ion chelated to at least one of the two consecutive amino acids, are disclosed. Also disclosed are methods of imaging using these novel compositions, such as methods of imaging a tumor within a subject. Methods of synthesizing an imaging agent and kits for preparing an imaging agent are also disclosed. Methods for determining the effectiveness of a candidate substance as an imaging agent that involve conjugating or chelating the candidate substance with a polypeptide that includes two or more consecutive amino acids that will function to non-covalently bind valent metal ions.
摘要翻译：用于成像的新型组合物包括（a）包含两个或更多个连续氨基酸的多肽，所述两个或多个连续的氨基酸将用于非共价结合价金属离子，和（2）螯合至两个连续氨基酸中的至少一个的价金属离子，被披露。还公开了使用这些新型组合物成像的方法，例如在受试者内成像肿瘤的方法。还公开了合成显影剂的方法和用于制备显影剂的试剂盒。用于确定作为显像剂的候选物质的有效性的方法，所述显像剂涉及使候选物质与包含两个或更多个连续氨基酸的多肽共轭或螯合候选物质，所述多个连续的氨基酸将用于非共价结合价金属离子。

5. 发明申请

US20100278731A1 Mechanism-Based Targeted Pancreatic Beta Cell Imaging and Therapy 审中-公开
标题翻译：基于机制的靶向胰腺β细胞成像和治疗
公开(公告)号：US20100278731A1
公开(公告)日：2010-11-04
申请号：US12610857
申请日：2009-11-02
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
IPC分类号： A61K51/04 , A61K49/10
CPC分类号： A61K51/0497
摘要： Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
摘要翻译：用于成像胰腺β细胞的组合物包含螯合剂 - 抗糖尿病药物缀合物和任选的螯合金属。

6. 发明授权

US07611693B2 Mechanism-based targeted pancreatic beta cell imaging and therapy 有权
标题翻译：基于机制的靶向胰腺β细胞成像和治疗
公开(公告)号：US07611693B2
公开(公告)日：2009-11-03
申请号：US10942615
申请日：2004-09-16
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Ali Azhdarinia , Jerry Bryant
IPC分类号： A61K49/00
CPC分类号： A61K51/0497
摘要： Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
摘要翻译：用于成像胰腺β细胞的组合物包含螯合剂 - 抗糖尿病药物缀合物和任选的螯合金属。

7. 发明授权

US08758723B2 Compositions and methods for cellular imaging and therapy 有权
标题翻译：细胞成像和治疗的组合和方法
公开(公告)号：US08758723B2
公开(公告)日：2014-06-24
申请号：US11737694
申请日：2007-04-19
申请人： David J. Yang , Chang-Sok Oh , Dong-Fang Yu , Ali Azhdarinia , Saady Kohanim
发明人： David J. Yang , Chang-Sok Oh , Dong-Fang Yu , Ali Azhdarinia , Saady Kohanim
IPC分类号： A61K51/00 , A61B5/055
CPC分类号： C07F13/005 , A61K47/547 , A61K51/0474 , A61K51/0491
摘要： The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving N4 compounds and derivatives.
摘要翻译：本发明一般涉及化学和放射性核素成像领域。更具体地，涉及涉及N4化合物和衍生物的成像，试剂盒和成像和治疗方法。

8. 发明授权

US08440168B2 Image-guided therapy of myocardial disease: composition, manufacturing and applications 失效
标题翻译：图像引导治疗心肌病：组成，制造和应用
公开(公告)号：US08440168B2
公开(公告)日：2013-05-14
申请号：US12340338
申请日：2008-12-19
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Richard Mendez , E. Edmund Kim
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Richard Mendez , E. Edmund Kim
IPC分类号： A61K51/04 , A61K49/00
CPC分类号： A61K51/0497 , A61K31/165 , C07C235/34 , C07F13/00 , C07F13/005
摘要： Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent.
摘要翻译：公开了用于成像和化疗和放射治疗的组合物和方法。更具体地说，本发明涉及包含与乙二胺缀合或嵌入的β-肾上腺素能受体靶向化合物的靶向物质的试剂。本发明还涉及这种用于心血管疾病成像和治疗的药剂的应用方法以及用于制备放射性标记的治疗剂或诊断剂的试剂盒。

9. 发明申请

US20090238756A1 IMAGE-GUIDED THERAPY OF MYOCARDIAL DISEASE: COMPOSITION, MANUFACTURING AND APPLICATIONS 失效
标题翻译：心肌梗死的图像指导治疗：组合物，制造和应用
公开(公告)号：US20090238756A1
公开(公告)日：2009-09-24
申请号：US12340338
申请日：2008-12-19
申请人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Richard Mendez , E. Edmund Kim
发明人： David J. Yang , Chang-Sok Oh , Saady Kohanim , Dong-Fang Yu , Richard Mendez , E. Edmund Kim
IPC分类号： A61K51/04 , C07C233/40 , A61K49/00 , A61K49/22 , A61K31/165 , A61P9/00 , A61K49/04 , A61K49/10 , C07F13/00
CPC分类号： A61K51/0497 , A61K31/165 , C07C235/34 , C07F13/00 , C07F13/005
摘要： Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent.
摘要翻译：公开了用于成像和化疗和放射治疗的组合物和方法。更具体地说，本发明涉及包含与乙二胺缀合或嵌入的β-肾上腺素能受体靶向化合物的靶向物质的试剂。本发明还涉及这种用于心血管疾病成像和治疗的药剂的应用方法以及用于制备放射性标记的治疗剂或诊断剂的试剂盒。

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