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41. 发明授权

US07403813B1 Systems and methods for detection of VT and VF from remote sensing electrodes 有权
公开(公告)号：US07403813B1
公开(公告)日：2008-07-22
申请号：US10998026
申请日：2004-11-24
申请人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Anders Bjorling , Yelena Nabutovsky , Kjell Noren
发明人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Anders Bjorling , Yelena Nabutovsky , Kjell Noren
IPC分类号： A61B5/0468
CPC分类号： A61B5/0468 , A61N1/3621 , A61N1/36535 , A61N1/36542 , A61N1/36564
摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

42. 发明授权

US5722994A Implantable heart defibrillator 失效
标题翻译：植入心脏除颤器
公开(公告)号：US5722994A
公开(公告)日：1998-03-03
申请号：US714310
申请日：1996-09-18
申请人： Kjell Noren , Pia Hagel
发明人： Kjell Noren , Pia Hagel
IPC分类号： A61N1/39
CPC分类号： A61N1/3956
摘要： An implantable defibrillator has an electrode lead system a sensing unit for sensing the condition of the heart and emitting a condition signal corresponding to that condition, a control unit for determining the heart's condition from the condition signal and, if a state of fibrillation is present, sending a command signal to a shock pulse generator, which, depending on the command signal, delivers at least one defibrillation shock to the heart via the electrode lead system. The shock being formal of one or more low-energy pulses with an energy less than 2 Joules and a very high voltage, i.e. more than 1,000 Volts. Each low-energy pulse thus has a voltage greatly exceeding the voltage in a conventional defibrillation shock and less energy than the energy in a conventional defibrillation shock.
摘要翻译：可植入除颤器具有电极引导系统，用于感测心脏状况并发出与该状态相对应的状态信号的感测单元，用于根据状态信号确定心脏状况的控制单元，如果存在原纤维状态，向冲击脉冲发生器发送命令信号，该脉冲发生器根据命令信号经由电极引导系统向心脏传递至少一次除颤电击。一种或多种能量小于2焦耳的低能量脉冲和非常高的电压（即大于1000伏特）的形式的冲击。因此，每个低能量脉冲具有大大超过常规除颤电击中的电压的电压和比常规除颤电击中的能量更少的能量。

43. 发明授权

US5615684A Medical device for detecting hemodynamic conditions of a heart 失效
标题翻译：用于检测心脏血液动力学状况的医疗装置
公开(公告)号：US5615684A
公开(公告)日：1997-04-01
申请号：US429614
申请日：1995-04-27
申请人： Pia Hagel , Kjell Noren , Kurt Hoegnelid
发明人： Pia Hagel , Kjell Noren , Kurt Hoegnelid
IPC分类号： A61B5/022 , A61N1/362 , A61N1/365 , A61N1/39 , A61B5/021
CPC分类号： A61N1/36564 , A61N1/3621 , A61N1/3956
摘要： A device for detecting hemodynamic conditions in a heart, in particular conditions corresponding to dangerous arrhythmias contains a sensing unit for a physiological variable, such as blood pressure, the unit emitting a signal on the basis of the variable having an average value, a signal conditioning unit connected to the sensing unit, a calculation unit connected to the signal conditioning unit and a comparator after the calculation unit. The calculation unit is devised to calculate a variability measure relative to the signal's average value, the variability measure being correlated to average blood pressure, and the variability measure is compared in the comparator to an adjustable threshold value corresponding to a specific hemodynamic condition, whereupon the comparator emits an indication signal when the variability measure falls below the threshold value.
摘要翻译：用于检测心脏中的血液动力学状况的装置，特别是与危险性心律失常相对应的条件包括用于生理变量例如血压的感测单元，该单元基于具有平均值的变量发出信号，信号调理连接到感测单元的单元，连接到信号调节单元的计算单元和计算单元之后的比较器。计算单元被设计为计算相对于信号平均值的可变性度量，可变性度量与平均血压相关，并且可变性度量在比较器中被比较到对应于特定血液动力学条件的可调阈值，当可变性测量值低于阈值时，比较器发出指示信号。

44. 发明授权

US4905696A Method and apparatus for P-synchronously stimulating the heart of a patient 失效
标题翻译： P同步刺激患者心脏的方法和装置
公开(公告)号：US4905696A
公开(公告)日：1990-03-06
申请号：US105671
申请日：1987-10-07
申请人： Dave Amundson , Asa Hedin , Kjell Noren
发明人： Dave Amundson , Asa Hedin , Kjell Noren
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： An impedance measurement, used for controlling the pulse generation rate of the pacer, is obtained by placing an electrode in the ventricular portion, rather than the atrial portion, of the heart. The characteristic p-wave in the electrocardiogram is detected as a rapid inflection or notch in the impedance signal, with a stimulation pulse being generated with a time delay following detection of such a notch.

45. 发明申请

US20130325359A1 HEMODYNAMIC STATUS ASSESSMENT 有权
标题翻译：动态状态评估
公开(公告)号：US20130325359A1
公开(公告)日：2013-12-05
申请号：US14000844
申请日：2011-03-18
申请人： Karin Jarverud , Anders Bjorling , Malin Hollmark , Kjell Noren , Tomas Svensson , Stefan Hjelm
发明人： Karin Jarverud , Anders Bjorling , Malin Hollmark , Kjell Noren , Tomas Svensson , Stefan Hjelm
IPC分类号： G06F19/00
CPC分类号： G06F19/34 , A61B5/0464 , A61B5/0538 , A61N1/36521 , A61N1/36535 , G06F19/00 , G06F19/12 , G06F19/24 , G16H50/50
摘要： A patient-specific hemodyanmic status model is determined from impedance data collected during periods of normal and abnormal hemodynamic status by deriving parameter values of a set of multiple impedance-derivable parameters from impedance signals collected during periods of normal hemodynamic status and in connection with periods of abnormal hemodynamic status. The parameter values are employed to estimate coefficients of a linear parametric status model. These coefficients can then be used together with parameter values determined from impedance signals determined during status assessment periods in order to determine a current hemdoynamic status of the patient.
摘要翻译：通过从正常血液动力学状态期间收集的阻抗信号中导出一组多个阻抗可导出参数的参数值，并与正常血液动力学状态期间相关联的时期，从正常和异常血液动力学状态期间收集的阻抗数据确定患者特异性血液动力学状态模型异常血液动力学状态。参数值用于估计线性参数状态模型的系数。然后可以将这些系数与在状态评估周期期间确定的阻抗信号确定的参数值一起使用，以便确定患者的当前血液动力学状态。

46. 发明申请

US20120310296A1 DETERMINATION OF CARDIAC RESYNCHRONIZATION THERAPY SETTINGS 有权
标题翻译：心脏康复治疗方法的确定
公开(公告)号：US20120310296A1
公开(公告)日：2012-12-06
申请号：US13471167
申请日：2012-05-14
申请人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
发明人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
IPC分类号： A61N1/365
CPC分类号： A61N1/36507 , A61N1/3682 , A61N1/3684 , A61N1/37252
摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.
摘要翻译：用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

47. 发明授权

US08285377B2 Pacing, sensing and other parameter maps based on localization system data 有权
标题翻译：基于定位系统数据的起搏，感应和其他参数图
公开(公告)号：US08285377B2
公开(公告)日：2012-10-09
申请号：US12553413
申请日：2009-09-03
申请人： Stuart Rosenberg , Kyungmoo Ryu , Allen Keel , Wenbo Hou , Thao Thu Nguyen , Steve Koh , Kjell Noren , Michael Yang
发明人： Stuart Rosenberg , Kyungmoo Ryu , Allen Keel , Wenbo Hou , Thao Thu Nguyen , Steve Koh , Kjell Noren , Michael Yang
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36585 , A61N1/368 , A61N1/3684
摘要： An exemplary method generates a map of a pacing parameter, a sensing parameter or one or more other parameters based in part on location information acquired using a localization system configured to locate electrodes in vivo (i.e., within a patient's body). Various examples map capture thresholds, qualification criteria for algorithms, undesirable conditions and sensing capabilities. Various other methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法基于部分地基于使用配置成在体内（即，在患者体内）定位电极的定位系统获取的位置信息来生成起搏参数，感测参数或一个或多个其它参数的图。各种示例映射捕获阈值，算法的资格标准，不良条件和感测能力。还公开了各种其它方法，装置，系统等。

48. 发明授权

US08133187B2 Implantable medical device with heart condition detection 有权
标题翻译：具有心脏状态检测的可植入医疗器械
公开(公告)号：US08133187B2
公开(公告)日：2012-03-13
申请号：US12095216
申请日：2005-12-16
申请人： Nils Holmström , Kjell Noren
发明人： Nils Holmström , Kjell Noren
IPC分类号： A61B5/0255
CPC分类号： A61B7/00 , A61B7/04 , A61N1/36514 , A61N1/36578
摘要： A method for detecting a condition of a heart of a patient using an implantable medical device, including the steps of sensing acoustic signals indicative of heart sounds of the heart of the patient; extracting signals corresponding to a first heart sound (S1) and a second heart sound (S2) from sensed signals; calculating an energy value corresponding to a signal corresponding to the first heart sound (S1) and an energy value corresponding to the second heart sound (S2); calculating a relation between the energy value corresponding to the first heart sound and the energy value corresponding to the second heart sound for successive cardiac cycles; and using at least one relation to detect the condition or a change of the condition. A medical device for determining the posture of a patient and a computer readable medium encoded with instructions are used to perform the inventive method.
摘要翻译：一种用于使用可植入医疗装置检测患者心脏状态的方法，包括以下步骤：感测指示患者心脏的心脏声音的声学信号; 从感测信号中提取对应于第一心音（S1）和第二心音（S2）的信号; 计算对应于对应于第一心音（S1）的信号的能量值和对应于第二心音（S2）的能量值; 计算对应于第一心音的能量值与对应于第二心音的能量值之间的关系，用于连续的心动周期; 并使用至少一个关系来检测条件或条件的变化。用于确定患者姿势的医疗装置和用指令编码的计算机可读介质用于执行本发明的方法。

49. 发明申请

US20090306732A1 CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION USING ELECTROMECHANICAL DELAY FROM REALTIME ELECTRODE MOTION TRACKING 有权
标题翻译：使用电动延迟从实际电极运动跟踪的心脏再生治疗优化
公开(公告)号：US20090306732A1
公开(公告)日：2009-12-10
申请号：US12416771
申请日：2009-04-01
申请人： Stuart Rosenberg , Allen Keel , Kyungmoo Ryu , Wenbo Hou , Kjell Noren , Thao Thu Nguyen , Michael Yang
发明人： Stuart Rosenberg , Allen Keel , Kyungmoo Ryu , Wenbo Hou , Kjell Noren , Thao Thu Nguyen , Michael Yang
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61B5/0422 , A61B5/0452 , A61B5/1107 , A61B5/6876 , A61B2562/043 , A61N1/36514 , A61N1/36578 , A61N1/3684 , A61N1/37252
摘要： An exemplary method includes providing a mechanical activation time (MA time) for a myocardial location, the location defined at least in part by an electrode and the mechanical activation time determined at least in part by movement of the electrode; providing an electrical activation time (EA time) for the myocardial location; and determining an electromechanical delay (EMD) for the myocardial location based on the difference between the mechanical activation time (MA time) and the electrical activation time (EA time).
摘要翻译：示例性方法包括提供用于心肌位置的机械活化时间（MA时间），至少部分地由电极限定的位置和至少部分地通过电极的移动确定的机械激活时间; 为心肌位置提供电激活时间（EA时间）; 并且基于机械激活时间（MA时间）和电激活时间（EA时间）之间的差异来确定心肌位置的机电延迟（EMD）。

50. 发明申请

US20090143690A1 Detection of ischemia 有权
标题翻译：检测缺血
公开(公告)号：US20090143690A1
公开(公告)日：2009-06-04
申请号：US11667505
申请日：2004-10-11
申请人： Anders Bjorling , Kjell Noren
发明人： Anders Bjorling , Kjell Noren
IPC分类号： A61B5/0402 , A61B5/02 , A61B5/053 , A61N1/365
CPC分类号： A61B5/029 , A61B5/02028 , A61B5/053 , A61B5/0538 , A61N1/36521 , A61N1/36557 , A61N1/3684
摘要： In an ischemia detection method, and in an ischemia detector and a cardiac stimulator embodying an ischemia detector, a workload of a patient is measured, as is an ejection fraction (EF) associated with the heart of the patient is determined. A predetermined reference relation between EF and workload for the patient is stored, and an analysis unit detects a state of ischemia of the patient from deviation in the determined EF for various workloads from the stored reference relation.
摘要翻译：在局部缺血检测方法中，在局部缺血检测器和体内缺血检测器的心脏刺激器中，测量患者的工作量，并确定与患者心脏相关联的射血分数（EF）。存储EF和患者的工作负荷之间的预定参考关系，并且分析单元从所存储的参考关系中检测出针对各种工作负载的所确定的EF中的患者的局部缺血状态。

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