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1. 发明授权

US5385576A Method for detecting ventricular fibrillation and apparatus for detecting and treating ventricular fibrillation 失效
标题翻译：心室颤动检测方法及心室颤动检测及治疗仪器
公开(公告)号：US5385576A
公开(公告)日：1995-01-31
申请号：US101727
申请日：1993-08-04
申请人： Kjell Noren , Pia Hagel , Kurt Hoegnelid
发明人： Kjell Noren , Pia Hagel , Kurt Hoegnelid
IPC分类号： A61B5/05 , A61B5/053 , A61N1/365 , A61N1/39
CPC分类号： A61N1/36521 , A61B5/0535 , A61N1/3962 , A61N1/395
摘要： In a method and apparatus for detecting ventricular fibrillation, a measured impedance signal, dependent on the blood volume in the heart, is evaluated, and ventricular fibrillation is assumed to be present if the level of the measured impedance signal falls below a predetermined threshold. This is based on the perception that as the heart fills with blood, given the presence of ventricular fibrillation, the level of the measured impedance signal will decrease. The apparatus also includes circuitry for treating the detected ventricular fibrillation.
摘要翻译：在用于检测心室颤动的方法和装置中，评估取决于心脏中的血液体积的测量阻抗信号，并且如果测得的阻抗信号的电平低于预定阈值，则认为存在心室颤动。这是基于以下认识：当心脏充满血液时，鉴于心室颤动的存在，测得的阻抗信号的水平将降低。该装置还包括用于治疗所检测的心室颤动的电路。

2. 发明授权

US5417715A Rate responsive heart stimulation 失效
标题翻译：速率响应心脏刺激
公开(公告)号：US5417715A
公开(公告)日：1995-05-23
申请号：US132815
申请日：1993-10-07
申请人： Kjell Noren , Sven-Erik Hedberg , Pia Hagel , Kurt Hoegnelid
发明人： Kjell Noren , Sven-Erik Hedberg , Pia Hagel , Kurt Hoegnelid
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/368 , A61N1/36521
摘要： A rate-responsive heart stimulator with a variable stimulation interval contains a measurement device which generates a measurement signal corresponding to the volume of blood in a heart during the blood-filling phase (diastole) and a comparator which compares the measurement signal with a defined threshold value corresponding to a defined degree of blood filling. The comparator generates a control signal when the measurement signal reaches the threshold value, the control signal representing the time elapsing since the last stimulation pulse, and controlling the heart stimulator's stimulation interval.
摘要翻译：具有可变刺激间隔的速率响应心脏刺激器包含测量装置，该测量装置在血液灌注阶段（舒张期）期间产生对应于心脏中的血液体积的测量信号，以及将测量信号与限定阈值进行比较的比较器值对应于确定的血液灌注程度。当测量信号达到阈值时，比较器产生控制信号，控制信号表示自上次刺激脉冲以来经过的时间，并且控制心脏刺激器的刺激间隔。

3. 发明授权

US5722994A Implantable heart defibrillator 失效
标题翻译：植入心脏除颤器
公开(公告)号：US5722994A
公开(公告)日：1998-03-03
申请号：US714310
申请日：1996-09-18
申请人： Kjell Noren , Pia Hagel
发明人： Kjell Noren , Pia Hagel
IPC分类号： A61N1/39
CPC分类号： A61N1/3956
摘要： An implantable defibrillator has an electrode lead system a sensing unit for sensing the condition of the heart and emitting a condition signal corresponding to that condition, a control unit for determining the heart's condition from the condition signal and, if a state of fibrillation is present, sending a command signal to a shock pulse generator, which, depending on the command signal, delivers at least one defibrillation shock to the heart via the electrode lead system. The shock being formal of one or more low-energy pulses with an energy less than 2 Joules and a very high voltage, i.e. more than 1,000 Volts. Each low-energy pulse thus has a voltage greatly exceeding the voltage in a conventional defibrillation shock and less energy than the energy in a conventional defibrillation shock.
摘要翻译：可植入除颤器具有电极引导系统，用于感测心脏状况并发出与该状态相对应的状态信号的感测单元，用于根据状态信号确定心脏状况的控制单元，如果存在原纤维状态，向冲击脉冲发生器发送命令信号，该脉冲发生器根据命令信号经由电极引导系统向心脏传递至少一次除颤电击。一种或多种能量小于2焦耳的低能量脉冲和非常高的电压（即大于1000伏特）的形式的冲击。因此，每个低能量脉冲具有大大超过常规除颤电击中的电压的电压和比常规除颤电击中的能量更少的能量。

4. 发明授权

US5615684A Medical device for detecting hemodynamic conditions of a heart 失效
标题翻译：用于检测心脏血液动力学状况的医疗装置
公开(公告)号：US5615684A
公开(公告)日：1997-04-01
申请号：US429614
申请日：1995-04-27
申请人： Pia Hagel , Kjell Noren , Kurt Hoegnelid
发明人： Pia Hagel , Kjell Noren , Kurt Hoegnelid
IPC分类号： A61B5/022 , A61N1/362 , A61N1/365 , A61N1/39 , A61B5/021
CPC分类号： A61N1/36564 , A61N1/3621 , A61N1/3956
摘要： A device for detecting hemodynamic conditions in a heart, in particular conditions corresponding to dangerous arrhythmias contains a sensing unit for a physiological variable, such as blood pressure, the unit emitting a signal on the basis of the variable having an average value, a signal conditioning unit connected to the sensing unit, a calculation unit connected to the signal conditioning unit and a comparator after the calculation unit. The calculation unit is devised to calculate a variability measure relative to the signal's average value, the variability measure being correlated to average blood pressure, and the variability measure is compared in the comparator to an adjustable threshold value corresponding to a specific hemodynamic condition, whereupon the comparator emits an indication signal when the variability measure falls below the threshold value.
摘要翻译：用于检测心脏中的血液动力学状况的装置，特别是与危险性心律失常相对应的条件包括用于生理变量例如血压的感测单元，该单元基于具有平均值的变量发出信号，信号调理连接到感测单元的单元，连接到信号调节单元的计算单元和计算单元之后的比较器。计算单元被设计为计算相对于信号平均值的可变性度量，可变性度量与平均血压相关，并且可变性度量在比较器中被比较到对应于特定血液动力学条件的可调阈值，当可变性测量值低于阈值时，比较器发出指示信号。

5. 发明授权

US5728281A Implantable medical device including an arrangement for measuring a blood property having a carbon reference electrode 失效
标题翻译：可植入医疗装置，包括用于测量具有碳参考电极的血液性质的装置
公开(公告)号：US5728281A
公开(公告)日：1998-03-17
申请号：US748543
申请日：1996-11-13
申请人： Nils Holmstrom , Pia Hagel , Kenth Nilsson
发明人： Nils Holmstrom , Pia Hagel , Kenth Nilsson
IPC分类号： A61B5/0408 , A61N1/05 , A61N1/365 , A61N1/375 , G01N27/26
CPC分类号： A61N1/375 , A61N1/05 , A61N1/36557
摘要： An implantable medical device for in vivo electrochemical measurements of blood properties, such as measurements of, inter alia, oxygen pressure, glucose and pH, avoids the problem with the reference electrodes currently in use which cause inflammatory reactions of tissue, by forming the reference electrode of carbon, preferably activated pyrolytic carbon.
摘要翻译：用于血液性质的体内电化学测量的植入式医疗装置，例如氧压，葡萄糖和pH的测量，避免了当前使用的参考电极的问题，其通过形成参比电极而引起组织的炎性反应的碳，优选活性热解碳。

6. 发明授权

US5431172A Method for detecting tachyarrhythmia of a heart by measuring patient activity and partial pressure of blood oxygen 失效
标题翻译：通过测量患者活动和血氧分压来检测心脏快速性心律失常的方法
公开(公告)号：US5431172A
公开(公告)日：1995-07-11
申请号：US119532
申请日：1993-09-13
申请人： Kurt Hoegnelid , Nils Holmstroem , Pia Hagel , Agneta Franksson
发明人： Kurt Hoegnelid , Nils Holmstroem , Pia Hagel , Agneta Franksson
IPC分类号： A61B5/145 , A61B5/1473 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/36557
摘要： For detecting tachyarrhythmia of the heart, the partial pressure of gases physically dissolved in the blood is measured, preferably the partial oxygen pressure pO.sub.2, and a fast variation and/or a variation of the measured partial pressure pO.sub.2 that exceeds a prescribed degree is utilized as a criterion for the detection of a tachyarrhythmia. An apparatus for treating tachyarrhythmia of the heart operating according to the above method includes a sensor for identifying the partial pressure of gases dissolved in the blood, an evaluation unit supplied with the sensor output for recognizing rapid changes of the partial pressure or changes of the partial pressure that exceed a prescribed degree, the output of the evaluation unit being connected to circuitry for triggering the tachyarrhythmia treatment.
摘要翻译：为了检测心脏的快速性心律失常，测量物理溶解在血液中的气体的分压，优选使用部分氧压力pO2，超过规定程度的测定的分压pO2的快速变化和/或变化被用作用于检测快速性心律失常的标准。用于治疗根据上述方法操作的心脏快速性心律失常的装置包括用于识别溶解在血液中的气体分压的传感器，提供有传感器输出的评估单元，用于识别分压的快速变化或部分变化超过规定程度的压力，评估单元的输出连接到用于触发快速性心律失常治疗的电路。

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