专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US08017909B2 Ion trap 有权
标题翻译：离子阱
公开(公告)号：US08017909B2
公开(公告)日：2011-09-13
申请号：US12521706
申请日：2007-12-27
申请人： Alexander Makarov , Mikhail A Monastyrskiy , Dmitry E. Grinfeld
发明人： Alexander Makarov , Mikhail A Monastyrskiy , Dmitry E. Grinfeld
IPC分类号： H01J49/42 , H01J49/26
CPC分类号： H01J49/423 , H01J49/427
摘要： An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.
摘要翻译：离子阱包括基本上细长的电极10,20，其中一些电极10,10沿着其伸长轴线弯曲并且在它们之间限定捕获体积。该捕集体向伸长方向截面的横截面面积与远离其末端的截面积（例如朝向捕集阱的中部）不同。在优选实施例中，陷阱具有多个细长电极，其中相对电极具有不同的曲率半径，使得陷阱向其四肢展开。因此，可以捕获并喷射更宽质量范围的离子，提供更高的空间电荷容量（对于给定的陷阱长度），并且能够在喷射时聚焦更清晰的离子束。

42. 发明授权

US07858929B2 Ion energy spread reduction for mass spectrometer 有权
标题翻译：质谱仪的离子能量扩散减少
公开(公告)号：US07858929B2
公开(公告)日：2010-12-28
申请号：US12296831
申请日：2007-04-13
申请人： Alexander Makarov , Mikhail Monastyrskiy , Dimitry E. Grinfield
发明人： Alexander Makarov , Mikhail Monastyrskiy , Dimitry E. Grinfield
IPC分类号： H01J49/26 , H01J27/02 , B01D59/44
CPC分类号： H01J49/06
摘要： A method for reducing the energy spread of ions over a specific and limited mass to charge ratio range is disclosed, along with an ion deceleration arrangement for implementing such a method. An electric field, having an electric field strength E is generated by a deceleration electrode arrangement (250). Ions of a specific and limited mass to charge ratio range, but having a spread of energies, are directed into the decelerating electric field generated by the deceleration electrode arrangement (250). The decelerating electric field is then removed, once substantially all of the ions of the specific mass to charge ratio range have entered the decelerating electric field. By matching the electric field strength E to the energy spread of the ions upon entry into the electric field, the energy spread of the said ions is reduced. Preferred embodiments of the invention employ energy dispersion upstream of the ion deceleration arrangement. For example, an ion mirror arrangement (200) may be used, the ions reflecting off an ion mirror (220) within that ion mirror arrangement (200) to promote energy defocusing.
摘要翻译：公开了一种用于在特定且有限的质荷比范围内减小离子的能量扩散的方法，以及用于实现这种方法的离子减速布置。具有电场强度E的电场由减速电极装置（250）产生。特定且有限的质荷比范围但具有能量扩散的离子被引导到由减速电极装置（250）产生的减速电场。然后，除去减速电场，一旦基本上所有特定质荷比的离子进入减速电场。通过将电场强度E与进入电场的离子的能量扩散相匹配，所述离子的能量扩散减小。本发明的优选实施例在离子减速装置的上游采用能量分散。例如，可以使用离子镜装置（200），离子反射离开反射镜装置（200）内的离子反射镜（220）以促进能量散焦。

43. 发明授权

US07728290B2 Orbital ion trap including an MS/MS method and apparatus 有权
标题翻译：轨道离子阱包括MS / MS方法和装置
公开(公告)号：US07728290B2
公开(公告)日：2010-06-01
申请号：US12166296
申请日：2008-07-01
申请人： Alexander Makarov
发明人： Alexander Makarov
IPC分类号： H01J49/00
CPC分类号： H01J49/425 , H01J49/004
摘要： A method of obtaining a mass spectrum of elements in a sample is disclosed. Sample precursor ions having a mass to charge ratio M/Z are generated, and fragmented at a dissociation site, so as to produce fragment ions of mass to charge ratio m/z. The fragment ions are guided into an ion trap of the electrostatic or “Orbitrap” type, the fragment ions entering the trap in groups dependent upon the precursor ions M/Z. The mass to charge ratio of each group is determined from the axial movement of ions in the trap. The electric field in the trap is distorted. Ions of the same m/z, that are derived from different pre-cursor ions, are then separated, because the electric field distortion causes the axial movement to become dependent upon factors other than m/z alone.
摘要翻译：公开了一种获得样品中元素质谱的方法。产生具有质荷比M / Z的样品前体离子，并在解离位点断裂，以产生质荷比m / z的碎片离子。碎片离子被引导到静电或“Orbitrap”类型的离子阱中，碎片离子依赖于前体离子M / Z而分成进入陷阱。每组的质荷比由捕集器中离子的轴向运动确定。陷阱中的电场失真。然后将由不同的前导离子导出的相同m / z的离子分离，因为电场失真导致轴向运动变得依赖于单独的m / z以外的因素。

44. 发明申请

US20100038532A1 Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method 有权
标题翻译：用于质谱仪和方法的高效大气压力界面
公开(公告)号：US20100038532A1
公开(公告)日：2010-02-18
申请号：US12513944
申请日：2007-11-07
申请人： Alexander Makarov , Reinhold Pesch , Robert Malek , Viachestav Kozlovskiy
发明人： Alexander Makarov , Reinhold Pesch , Robert Malek , Viachestav Kozlovskiy
IPC分类号： H01J49/04
CPC分类号： H01J49/062 , H01J3/14
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 60. The conduit 60 has an inlet opening towards a relatively high pressure chamber 40 and an outlet 70 opening towards a relatively low pressure chamber. The conduit 60 also has at least one side wall surrounding an ion transfer channel 115. The side wall includes a plurality of apertures 140 formed in the longitudinal direction of the side wall so as to permit a flow of gas from within the ion transfer channel 115 to a lower pressure region outside of the side wall of the conduit 60.
摘要翻译：用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括离子传递管道60.导管60具有朝向较高压力室40的入口开口和朝向较低压力室开口的出口70。导管60还具有围绕离子传递通道115的至少一个侧壁。侧壁包括在侧壁的纵向方向上形成的多个孔140，以允许来自离子传递通道115内的气体流到导管60的侧壁外侧的较低压力区域。

45. 发明申请

US20090166527A1 MASS SPECTROMETER ARRANGEMENT WITH FRAGMENTATION CELL AND ION SELECTION DEVICE 有权
标题翻译：大分光光度计布置与分离单元和离子选择器件
公开(公告)号：US20090166527A1
公开(公告)日：2009-07-02
申请号：US12296736
申请日：2007-04-13
申请人： Alexander Makarov
发明人： Alexander Makarov
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/42 , H01J49/0031 , H01J49/0045
摘要： A method of mass spectrometry having the steps of, in a first cycle: storing sample ions in a first ion storage device; ejecting the stored ions out of the first ion storage device into a separate ion selection device; selecting a subset of the ions in the ion selection device; ejecting the subset of ions selected within the ion selection device to a fragmentation device; directing ions from the fragmentation device back to the first ion storage device without passing them through the said ion selection device; receiving at least some of the ions ejected from the first ion storage device, or their derivatives, back into the first ion storage device; and storing the received ions in the first ion storage device.
摘要翻译：一种质谱法，其具有以下步骤：在第一循环中：将样品离子储存在第一离子存储装置中; 将存储的离子从第一离子存储装置中排出到单独的离子选择装置中; 选择离子选择装置中的离子的子集; 将离子选择装置内选择的离子的子集喷射到碎裂装置; 将离子从碎裂装置引导回第一离子存储装置，而不使它们通过所述离子选择装置; 将从所述第一离子存储装置或其衍生物排出的至少一些离子接收回所述第一离子存储装置; 以及将接收到的离子存储在第一离子存储装置中。

46. 发明申请

US20080258053A1 ALL-MASS MS/MS METHOD AND APPARATUS 有权
标题翻译：全质量MS / MS方法和装置
公开(公告)号：US20080258053A1
公开(公告)日：2008-10-23
申请号：US12166296
申请日：2008-07-01
申请人： Alexander Makarov
发明人： Alexander Makarov
IPC分类号： H01J49/26
CPC分类号： H01J49/425 , H01J49/004
摘要： A method of obtaining a mass spectrum of elements in a sample is disclosed. Sample precursor ions having a mass to charge ratio M/Z are generated, and fragmented at a dissociation site, so as to produce fragment ions of mass to charge ratio m/z. The fragment ions are guided into an ion trap of the electrostatic or “Orbitrap” type, the fragment ions entering the trap in groups dependent upon the precursor ions M/Z. The mass to charge ratio of each group is determined from the axial movement of ions in the trap. The electric field in the trap is distorted. Ions of the same m/z, that are derived from different pre-cursor ions, are then separated, because the electric field distortion causes the axial movement to become dependent upon factors other than m/z alone.
摘要翻译：公开了一种获得样品中元素质谱的方法。产生具有质荷比M / Z的样品前体离子，并在解离位点断裂，以产生质荷比m / z的碎片离子。碎片离子被引导到静电或“Orbitrap”类型的离子阱中，碎片离子依赖于前体离子M / Z而分成进入陷阱。每组的质荷比由捕集器中离子的轴向运动确定。陷阱中的电场失真。然后将由不同的前导离子导出的相同m / z的离子分离，因为电场失真导致轴向运动变得依赖于单独的m / z以外的因素。

47. 发明授权

US07399962B2 All-mass MS/MS method and apparatus 有权
标题翻译：全质量MS / MS方法和仪器
公开(公告)号：US07399962B2
公开(公告)日：2008-07-15
申请号：US10558184
申请日：2004-05-28
申请人： Alexander Makarov
发明人： Alexander Makarov
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/425 , H01J49/004
摘要： A method of obtaining a mass spectrum of elements in a sample is disclosed. Sample precursor ions having a mass to charge ratio M/Z are generated, and fragmented at a dissociation site, so as to produce fragment ions of mass to charge ratio m/z. The fragment ions are guided into an ion trap of the electrostatic or “Orbitrap” type, the fragment ions entering the trap in groups dependent upon the precursor ions M/Z. The mass to charge ratio of each group is determined from the axial movement of ions in the trap. The electric field in the trap is distorted. Ions of the same m/z, that are derived from different pre-cursor ions, are then separated, because the electric field distortion causes the axial movement to become dependent upon factors other than m/z alone.
摘要翻译：公开了一种获得样品中元素质谱的方法。产生具有质荷比M / Z的样品前体离子，并在解离位点断裂，以产生质荷比m / z的碎片离子。碎片离子被引导到静电或“Orbitrap”类型的离子阱中，碎片离子依赖于前体离子M / Z而分成进入陷阱。每组的质荷比由捕集器中离子的轴向运动确定。陷阱中的电场失真。然后将由不同的前导离子导出的相同m / z的离子分离，因为电场失真导致轴向运动变得依赖于单独的m / z以外的因素。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式