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1. 发明申请

US20100038532A1 Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method 有权
标题翻译：用于质谱仪和方法的高效大气压力界面
公开(公告)号：US20100038532A1
公开(公告)日：2010-02-18
申请号：US12513944
申请日：2007-11-07
申请人： Alexander Makarov , Reinhold Pesch , Robert Malek , Viachestav Kozlovskiy
发明人： Alexander Makarov , Reinhold Pesch , Robert Malek , Viachestav Kozlovskiy
IPC分类号： H01J49/04
CPC分类号： H01J49/062 , H01J3/14
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 60. The conduit 60 has an inlet opening towards a relatively high pressure chamber 40 and an outlet 70 opening towards a relatively low pressure chamber. The conduit 60 also has at least one side wall surrounding an ion transfer channel 115. The side wall includes a plurality of apertures 140 formed in the longitudinal direction of the side wall so as to permit a flow of gas from within the ion transfer channel 115 to a lower pressure region outside of the side wall of the conduit 60.
摘要翻译：用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括离子传递管道60.导管60具有朝向较高压力室40的入口开口和朝向较低压力室开口的出口70。导管60还具有围绕离子传递通道115的至少一个侧壁。侧壁包括在侧壁的纵向方向上形成的多个孔140，以允许来自离子传递通道115内的气体流到导管60的侧壁外侧的较低压力区域。

2. 发明授权

US08148679B2 Efficient atmospheric pressure interface for mass spectrometers and method 有权
标题翻译：用于质谱仪和方法的高效大气压力界面
公开(公告)号：US08148679B2
公开(公告)日：2012-04-03
申请号：US12513944
申请日：2007-11-07
申请人： Alexander Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
发明人： Alexander Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
IPC分类号： H01J37/301 , H01J49/04 , H01J49/24 , H01J3/18
CPC分类号： H01J49/062 , H01J3/14
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 60. The conduit 60 has an inlet opening towards a relatively high pressure chamber 40 and an outlet 70 opening towards a relatively low pressure chamber. The conduit 60 also has at least one side wall surrounding an ion transfer channel 115. The side wall includes a plurality of apertures 140 formed in the longitudinal direction of the side wall so as to permit a flow of gas from within the ion transfer channel 115 to a lower pressure region outside of the side wall of the conduit 60.
摘要翻译：用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括离子传递管道60.导管60具有朝向较高压力室40的入口开口和朝向较低压力室开口的出口70。导管60还具有围绕离子传递通道115的至少一个侧壁。侧壁包括在侧壁的纵向方向上形成的多个孔140，以允许来自离子传递通道115内的气体流到导管60的侧壁外侧的较低压力区域。

3. 发明授权

US07982183B2 Ion transfer tube with spatially alternating DC fields 有权
标题翻译：离子转移管与空间交替的直流场
公开(公告)号：US07982183B2
公开(公告)日：2011-07-19
申请号：US12513939
申请日：2007-11-07
申请人： Alexander Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
发明人： Alexander Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
IPC分类号： H01J49/24 , H01J49/04 , H01J3/18 , H01J37/301
CPC分类号： H01J49/065
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of a mass spectrometer includes an electrode assembly (120) with a first plurality of ring electrodes (205) arranged in alternating relation with a second plurality of ring electrodes (210). The first plurality of ring electrodes (205) are narrower than the second plurality of ring electrodes (210) in a longitudinal direction, but the first plurality of ring electrodes have a relatively high magnitude voltage of a first polarity applied to them whereas the second plurality of ring electrodes (210) have a relatively lower magnitude voltage applied to them, of opposing polarity to that applied to the first set of ring electrodes (205). In this manner, ions passing through the ion transfer arrangement experience spatially alternating asymmetric electric fields that tend to focus ions away from the inner surface of the channel wall and towards the channel plane or axis of symmetry.
摘要翻译：用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括具有与第二多个环形电极（210）交替设置的第一多个环形电极（205）的电极组件（120）。第一多个环形电极（205）在纵向方向上比第二多个环形电极（210）窄，但是第一多个环形电极具有施加到它们的第一极性的相对高的幅度电压，而第二个多个环形电极环形电极（210）具有相对于施加到第一组环形电极（205）的相反极性的相对较低的施加到它们的幅度电压。以这种方式，通过离子转移装置的离子经历空间交替的不对称电场，其倾向于将离子聚焦离开通道壁的内表面并朝向通道平面或对称轴线。

4. 发明授权

US08148680B2 Ion transfer arrangement with spatially alternating DC and viscous ion flow 有权
标题翻译：离子转移排列与空间交替的直流和粘性离子流
公开(公告)号：US08148680B2
公开(公告)日：2012-04-03
申请号：US12513954
申请日：2007-11-07
申请人： Alexander Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
发明人： Alexander Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
IPC分类号： H01J37/301 , H01J49/04 , H01J49/24 , H01J3/18
CPC分类号： H01J49/062 , H01J3/14
摘要： A method of transporting gas and entrained ions between higher and lower pressure regions of a mass spectrometer comprises providing an ion transfer conduit 60 between the higher and lower pressure regions. The ion transfer conduit 60 includes an electrode assembly 300 which defines an ion transfer channel. The electrode assembly 300 has a first set of ring electrodes 305 of a first width D1, and a second set of ring electrodes of a second width D2 (≧D1) and interleaved with the first ring electrodes 305. A DC voltage of magnitude V1 and a first polarity is supplied to the first ring electrodes 205 and a DC voltage of magnitude V2 which may be less than or equal to the magnitude of V1 but with an opposed polarity is applied to the second ring electrodes 310. The pressure of the ion transfer conduit 60 is controlled so as to maintain viscous flow of gas and ions within the ion transfer channel.
摘要翻译：在质谱仪的较高压力区域和较低压力区域之间输送气体和夹带离子的方法包括在较高压力区域和较低压力区域之间提供离子转移导管60。离子传递管道60包括限定离子传递通道的电极组件300。电极组件300具有第一组宽度为D1的环形电极305和第二组宽度D2（≧D1）的第二组环形电极，并与第一环形电极305交错。将第一极性提供给第一环形电极205，并且可以将小于或等于V1的大小但具有相对极性的幅度为V2的DC电压施加到第二环形电极310.离子转移的压力管道60被控制以便保持气体和离子在离子传递通道内的粘性流动。

5. 发明授权

US08642949B2 Efficient atmospheric pressure interface for mass spectrometers and method 有权
标题翻译：用于质谱仪和方法的高效大气压力界面
公开(公告)号：US08642949B2
公开(公告)日：2014-02-04
申请号：US13413568
申请日：2012-03-06
申请人： Alexander A. Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
发明人： Alexander A. Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
IPC分类号： H01J37/301 , H01J49/04 , H01J49/24 , H01J3/18
CPC分类号： H01J49/062 , H01J3/14
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 60. The conduit 60 has an inlet opening towards a relatively high pressure chamber 40 and an outlet 70 opening towards a relatively low pressure chamber. The conduit 60 also has at least one side wall surrounding an ion transfer channel 115. The side wall includes a plurality of apertures 140 formed in the longitudinal direction of the side wall so as to permit a flow of gas from within the ion transfer channel 115 to a lower pressure region outside of the side wall of the conduit 60.
摘要翻译：用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括离子传递管道60.导管60具有朝向较高压力室40的入口开口和朝向较低压力室开口的出口70。导管60还具有围绕离子传递通道115的至少一个侧壁。侧壁包括在侧壁的纵向方向上形成的多个孔140，以允许来自离子传递通道115内的气体流到导管60的侧壁外侧的较低压力区域。

6. 发明申请

US20070023630A1 Method and apparatus for mass spectormetry 有权
标题翻译：质谱法的方法和装置
公开(公告)号：US20070023630A1
公开(公告)日：2007-02-01
申请号：US10573394
申请日：2004-09-24
申请人： Robert Malek , Oliver Lange , Reinhold Pesch , Stevan Horning
发明人： Robert Malek , Oliver Lange , Reinhold Pesch , Stevan Horning
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0027
摘要： The present invention relates to mass spectrometry and, more particularly, to the scheduling of the steps involved in performing mass spectrometry. The present invention will be of particular benefit to types of mass spectrometry that generate large quantities of data and hence give rise to lengthy data-processing. The present invention provides a method of mass spectrometry comprising a plurality of cycles, each cycle comprising the steps of (a) preparing ions to be analysed by a mass spectrometer; (b) using a detector of the mass spectrometer to collect data from the ions prepared in step (a); and (c) processing the data collected in step (b) with processing means; wherein at least a part of step (a) and/or a part of step (b) of a cycle is performed concurrently with part (c) of a previous cycle.
摘要翻译：本发明涉及质谱，更具体地，涉及执行质谱法所涉及步骤的调度。本发明对于产生大量数据的质谱的类型特别有益，因此引起冗长的数据处理。本发明提供一种包含多个循环的质谱方法，每个循环包括以下步骤：（a）制备待通过质谱仪分析的离子; （b）使用质谱仪的检测器从步骤（a）中制备的离子收集数据; 和（c）用处理装置处理在步骤（b）中收集的数据; 其中与先前循环的部分（c）同时执行循环的步骤（a）和/或步骤（b）的一部分的至少一部分。

7. 发明申请

US20100038533A1 Ion Transfer Arrangement with Spatially Alternating DC and Viscous Ion Flow 有权
标题翻译：离子转移布置与空间交替DC和粘性离子流
公开(公告)号：US20100038533A1
公开(公告)日：2010-02-18
申请号：US12513954
申请日：2007-11-07
申请人： Alexander A. Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
发明人： Alexander A. Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
IPC分类号： H01J49/02
CPC分类号： H01J49/062 , H01J3/14
摘要： A method of transporting gas and entrained ions between higher and lower pressure regions of a mass spectrometer comprises providing an ion transfer conduit 60 between the higher and lower pressure regions. The ion transfer conduit 60 includes an electrode assembly 300 which defines an ion transfer channel. The electrode assembly 300 has a first set of ring electrodes 305 of a first width D1, and a second set of ring electrodes of a second width D2 (≧D1) and interleaved with the first ring electrodes 305. A DC voltage of magnitude V1 and a first polarity is supplied to the first ring electrodes 205 and a DC voltage of magnitude V2 which may be less than or equal to the magnitude of V1 but with an opposed polarity is applied to the second ring electrodes 310. The pressure of the ion transfer conduit 60 is controlled so as to maintain viscous flow of gas and ions within the ion transfer channel.
摘要翻译：在质谱仪的较高压力区域和较低压力区域之间输送气体和夹带离子的方法包括在较高压力区域和较低压力区域之间提供离子转移导管60。离子传递管道60包括限定离子传递通道的电极组件300。电极组件300具有第一组宽度为D1的环形电极305和第二组宽度D2（≧D1）的第二组环形电极，并与第一环形电极305交错。将第一极性提供给第一环形电极205，并且可以将小于或等于V1的大小但具有相对极性的幅度为V2的DC电压施加到第二环形电极310.离子转移的压力管道60被控制以便保持气体和离子在离子传递通道内的粘性流动。

8. 发明授权

US07576318B2 Method and apparatus for mass spectrometry 有权
标题翻译：质谱法和方法
公开(公告)号：US07576318B2
公开(公告)日：2009-08-18
申请号：US10573394
申请日：2004-09-24
申请人： Robert Malek , Oliver Lange , Reinhold Pesch , Stevan Horning
发明人： Robert Malek , Oliver Lange , Reinhold Pesch , Stevan Horning
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0027
摘要： The present invention relates to mass spectrometry and, more particularly, to the scheduling of the steps involved in performing mass spectrometry. The present invention will be of particular benefit to types of mass spectrometry that generate large quantities of data and hence give rise to lengthy data-processing. The present invention provides a method of mass spectrometry comprising a plurality of cycles, each cycle comprising the steps of (a) preparing ions to be analysed by a mass spectrometer; (b) using a detector of the mass spectrometer to collect data from the ions prepared in step (a); and (c) processing the data collected in step (b) with processing means; wherein at least a part of step (a) and/or a part of step (b) of a cycle is performed concurrently with part (c) of a previous cycle.
摘要翻译：本发明涉及质谱，更具体地，涉及执行质谱法所涉及步骤的调度。本发明对于产生大量数据的质谱的类型特别有益，因此引起冗长的数据处理。本发明提供一种包含多个循环的质谱方法，每个循环包括以下步骤：（a）制备待通过质谱仪分析的离子; （b）使用质谱仪的检测器从步骤（a）中制备的离子收集数据; 和（c）用处理装置处理在步骤（b）中收集的数据; 其中与先前循环的部分（c）同时执行循环的步骤（a）和/或步骤（b）的一部分的至少一部分。

9. 发明授权

US07351961B2 Measuring cell for ion cyclotron resonance spectrometer 有权
标题翻译：用于离子回旋共振光谱仪的测量池
公开(公告)号：US07351961B2
公开(公告)日：2008-04-01
申请号：US10573194
申请日：2004-09-24
申请人： Robert Malek , Frank Czemper
发明人： Robert Malek , Frank Czemper
IPC分类号： B01D59/44
CPC分类号： H01J49/38
摘要： This invention relates to a measuring cell for an Ion Cyclotron Resonance (ICR) spectrometer. The present invention provides a measurement cell for an FTMS spectrometer, comprising an excitation electrode arrangement positioned about a longitudinal axis which extends in a direction generally parallel to the field direction of an applied homogeneous magnetic field; and a trapping electrode arrangement, also positioned about the said longitudinal axis, for trapping ions longitudinally in the cell within a trapping region defined by the trapping electrode arrangement; wherein at least a part of the excitation electrode arrangement extends axially outwardly of the trapping region defined by the trapping electrode arrangement.
摘要翻译：本发明涉及用于离子回旋共振（ICR）光谱仪的测量池。本发明提供了一种用于FTMS光谱仪的测量单元，包括围绕纵向轴线定位的激励电极装置，所述纵向轴线在大致平行于所施加的均匀磁场的场方向的方向上延伸; 以及围绕所述纵向轴线定位的捕获电极装置，用于在由所述捕获电极装置限定的捕获区域内在所述电池中纵向俘获离子; 其中所述激励电极装置的至少一部分沿着由所述捕获电极装置限定的所述捕获区域轴向向外延伸。

10. 发明申请

US20070040114A1 Measuring cell for ion cyclotron resonance spectrometer 有权
标题翻译：用于离子回旋共振光谱仪的测量池
公开(公告)号：US20070040114A1
公开(公告)日：2007-02-22
申请号：US10573194
申请日：2004-09-24
申请人： Robert Malek , Frank Czemper
发明人： Robert Malek , Frank Czemper
IPC分类号： B01D59/44
CPC分类号： H01J49/38
摘要： This invention relates to a measuring cell for an Ion Cyclotron Resonance (ICR) spectrometer. The present invention provides a measurement cell for an FTMS spectrometer, comprising an excitation electrode arrangement positioned about a longitudinal axis which extends in a direction generally parallel to the field direction of an applied homogeneous magnetic field; and a trapping electrode arrangement, also positioned about the said longitudinal axis, for trapping ions longitudinally in the cell within a trapping region defined by the trapping electrode arrangement; wherein at least a part of the excitation electrode arrangement extends axially outwardly of the trapping region defined by the trapping electrode arrangement.
摘要翻译：本发明涉及用于离子回旋共振（ICR）光谱仪的测量池。本发明提供了一种用于FTMS光谱仪的测量单元，包括围绕纵向轴线定位的激励电极装置，所述纵向轴线在大致平行于所施加的均匀磁场的场方向的方向上延伸; 以及围绕所述纵向轴线定位的捕获电极装置，用于在由所述捕获电极装置限定的捕获区域内在所述电池中纵向俘获离子; 其中所述激励电极装置的至少一部分沿着由所述捕获电极装置限定的所述捕获区域轴向向外延伸。

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