专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US07368474B2 Radiofluorination methods 失效
标题翻译：放射性氟化方法
公开(公告)号：US07368474B2
公开(公告)日：2008-05-06
申请号：US10508682
申请日：2003-03-20
申请人： Alan Cuthbertson , Magne Solbakken , Joseph Maduabuchi Arukwe , Hege Karlsen
发明人： Alan Cuthbertson , Magne Solbakken , Joseph Maduabuchi Arukwe , Hege Karlsen
IPC分类号： A61K51/08 , A61K101/02
CPC分类号： C07B59/008
摘要： The present invention relates to methods and reagents for [18F]-fluorination, particularly of peptides. The resultant 18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET). Thus, a compound of formula 18F-(Linker)-SH, such as a compound of formula (IV), (V), or (VI): 18F—(CH2CH2O)n—(CH2)m—SH (IV) 18F—(CH2)p—SH (V) may be reacted with an activated peptide as a means for 18F-labelling.
摘要翻译：本发明涉及[F 18 F] - 氟化，特别是肽的方法和试剂。所得的18 F标记的化合物可用作放射性药物，特别用于正电子发射断层扫描（PET）。因此，通式（IV）的化合物，如式（IV），（V）或（VI）的化合物： “在线公式”end =“lead”？> ^{18 F-（CH 2 2 CH 2 O） β-H（IV）<βin-line-formula description =“In-line Formulas”end =“tail”？> < ？in-line-formula description =“In-line Formulas”end =“lead”？> ^{18 F-（CH 2） -SH（V）<βin-line-formula description =“In-line Formulas”end =“tail”？>可与活化肽反应，作为标记的标记。}}

42. 发明申请

US20080057658A1 METHOD FOR FABRICATING A THICK COPPER LINE AND COPPER INDUCTOR RESULTING THEREFROM 有权
标题翻译：用于制造厚铜线和铜电解质的方法
公开(公告)号：US20080057658A1
公开(公告)日：2008-03-06
申请号：US11470552
申请日：2006-09-06
申请人： Isaiah O. Oladeji , Alan Cuthbertson
发明人： Isaiah O. Oladeji , Alan Cuthbertson
IPC分类号： H01L21/20
CPC分类号： H01L21/76885 , H01L21/76834 , H01L23/5227 , H01L23/53238 , H01L28/10 , H01L2924/0002 , H01L2924/00
摘要： A method of forming one or more inductors on a substrate is disclosed. The method includes forming a first dielectric material over the substrate, forming a trench in the first dielectric material, and substantially filling the trench with copper to form the one or more inductors. The first dielectric material is removed and a second dielectric material is formed over the copper. The second dielectric material is removed from an uppermost portion of the copper, thus leaving a portion of the second dielectric material on the sidewalls of the copper.
摘要翻译：公开了一种在衬底上形成一个或多个电感器的方法。该方法包括在衬底上形成第一介电材料，在第一介电材料中形成沟槽，并用铜基本上填充沟槽以形成一个或多个电感器。去除第一电介质材料，并在铜上形成第二电介质材料。第二电介质材料从铜的最上部去除，因此在铜的侧壁上留下一部分第二电介质材料。

43. 发明申请

US20070183977A1 Fluorescein-labelled peptides 失效
标题翻译：荧光素标记的肽
公开(公告)号：US20070183977A1
公开(公告)日：2007-08-09
申请号：US10560062
申请日：2004-07-07
申请人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken
发明人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken
IPC分类号： A61K49/00 , C07K7/64
CPC分类号： C07K14/70546 , A61K38/00
摘要： The invention relates to new peptide-based compounds and their use in diagnostic optical imaging. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compounds are labeled with fluorescein and may be used as contrast agents in optical imaging in diagnosis of angiogenesis-related diseases.
摘要翻译：本发明涉及新的基于肽的化合物及其在诊断光学成像中的应用。更具体地，本发明涉及这种基于肽的化合物作为与血管发生相关的受体结合的靶向载体的用途。这些化合物用荧光素标记，可用作造影剂用于光学成像诊断血管发生相关疾病。

44. 发明申请

US20070134155A1 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US20070134155A1
公开(公告)日：2007-06-14
申请号：US10559886
申请日：2004-11-05
申请人： Alan Cuthbertson , Bard Indrevoll , Morten Eriksen
发明人： Alan Cuthbertson , Bard Indrevoll , Morten Eriksen
IPC分类号： A61K51/00 , C07K7/06
CPC分类号： A61K51/08 , A61K38/085 , A61K49/0043 , A61K49/0056 , A61K51/088 , C07K7/14
摘要： The invention comprises pharmaceuticals of formula (I) Z-(L)n-V, wherein V denotes a peptide, L denotes an optional linker, Z denotes a group that optionally can carry an imaging moiety M, n denotes 0 or 1. The pharmaceuticals are active as therapeutic agents for the treatment of heart failure, cardiac arrhythmias and diseases were fibrosis is prominent such as COPD, liver fibrosis and atherosclerosis and are also useful as diagnostic agents for the diagnosis of heart failure and diseases were fibrosis is prominent such as COPD, liver fibrosis and atherosclerosis.
摘要翻译：本发明包括式（I）Z-（L）-N-V的药物，其中V表示肽，L表示任选的接头，Z表示任选地可携带成像部分M的基团， n表示0或1.药物作为治疗心力衰竭的治疗剂是有活性的，心律不齐，纤维化突出如COPD，肝纤维化和动脉粥样硬化等疾病，也可用作诊断心力衰竭的诊断剂，纤维化疾病如COPD，肝纤维化和动脉粥样硬化等疾病突出。

45. 发明申请

US20070104644A1 Inhibitor imaging agents 审中-公开
标题翻译：抑制剂成像剂
公开(公告)号：US20070104644A1
公开(公告)日：2007-05-10
申请号：US10560371
申请日：2004-11-12
申请人： Alan Cuthbertson , Magne Solbakken , Emma Bjurget
发明人： Alan Cuthbertson , Magne Solbakken , Emma Bjurget
IPC分类号： A61K51/00 , A61K49/10 , C07F13/00 , C07F5/00
CPC分类号： A61K31/18 , A61K47/6425 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K51/04 , A61K51/088
摘要： The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the sulphonamide hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imaging and diagnosis of the mammalian body.
摘要翻译：本发明公开了包含用成像部分标记的磺酰胺异羟肟酸酯类的特定类型的基质金属蛋白酶抑制剂（MMPi）的成像剂是用于体内成像和诊断哺乳动物体的有用的诊断成像剂。

46. 发明申请

US20070071670A1 Diagnostic imaging agents with mmp inhibitory activity 失效
标题翻译：具有抑制活性的诊断成像剂
公开(公告)号：US20070071670A1
公开(公告)日：2007-03-29
申请号：US10544945
申请日：2004-02-10
申请人： Anthony Storey , Julie Davis , Sally-Ann Ricketts , Marivi Medizabal , Alan Cuthbertson , Joseph Arukwe , Kirsty Heywood , Ian Wilson , Duncan Wynn , Michael Schafers , Bodu Levkau , Stefan Wagner , Hans-Jorg Breyholz , Klaus Kopka
发明人： Anthony Storey , Julie Davis , Sally-Ann Ricketts , Marivi Medizabal , Alan Cuthbertson , Joseph Arukwe , Kirsty Heywood , Ian Wilson , Duncan Wynn , Michael Schafers , Bodu Levkau , Stefan Wagner , Hans-Jorg Breyholz , Klaus Kopka
IPC分类号： A61K51/00 , C07D401/02
CPC分类号： A61K51/0497
摘要： The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
摘要翻译：本发明涉及诊断成像领域。具体地，本发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。本发明的一个实施方案是具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。本发明还公开了一种药物组合物，其包含适合哺乳动物给药形式的本发明的诊断显像剂。本发明还公开了合成本发明的诊断显像剂的中间体和用于制备本发明的药物组合物的试剂盒。本发明的药物组合物可用于诊断已知涉及特定基质金属蛋白酶的疾病。

47. 发明申请

US20060193773A1 Imaging agents 失效
标题翻译：成像剂
公开(公告)号：US20060193773A1
公开(公告)日：2006-08-31
申请号：US10566487
申请日：2004-07-21
申请人： Alan Cuthbertson , Magne Solbakken
发明人： Alan Cuthbertson , Magne Solbakken
IPC分类号： A61K51/00 , A61K38/12 , C07K7/64 , C07K5/12
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425
摘要： The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma.
摘要翻译：本发明涉及式（I）化合物及其作为靶向载体的用途，所述靶向载体与血管发生相关的受体结合。因此，这样的化合物可用于诊断或治疗例如恶性疾病，心脏病，子宫内膜异位，炎症相关疾病，类风湿性关节炎和卡波西肉瘤。

48. 发明授权

US06967156B2 Method to fabricate aligned dual damascene openings 有权
标题翻译：制造对准双镶嵌开口的方法
公开(公告)号：US06967156B2
公开(公告)日：2005-11-22
申请号：US10690998
申请日：2003-10-22
申请人： Yeow Kheng Lim , Wuping Liu , Tae Jong Lee , Bei Chao Zhang , Juan Boon Tan , Alan Cuthbertson , Chin Chuan Neo
发明人： Yeow Kheng Lim , Wuping Liu , Tae Jong Lee , Bei Chao Zhang , Juan Boon Tan , Alan Cuthbertson , Chin Chuan Neo
IPC分类号： H01L21/4763 , H01L21/768 , H01L29/06
CPC分类号： H01L21/76807 , H01L21/76829 , H01L21/76834
摘要： A method of forming an aligned dual damascene opening, comprising including the following sequential steps. A layer stack is formed over the metal structure. The layer stack comprises, in ascending order: a bottom etch stop layer; a lower dielectric material layer; a middle etch stop layer; a middle dielectric material layer; and an upper dielectric layer. A patterned mask layer is formed over the patterned upper dielectric layer leaving exposed opposing portions of the patterned upper dielectric layer. The middle dielectric material layer is patterned to form an opening therein using the patterned mask layer and the exposed portions of the upper dielectric layer as masks. Simultaneously patterning the patterned middle dielectric material layer using the patterned upper dielectric layer as a mask to form an inchoate upper trench opening; and the lower dielectric material layer using the patterned mask layer and the patterned middle etch stop layer as masks to form an inchoate lower via opening aligned with the inchoate upper trench opening.
摘要翻译：一种形成对准的双镶嵌开口的方法，包括以下顺序步骤。在金属结构上形成层叠。层叠层按升序包括底蚀刻停止层; 下介电材料层; 中间蚀刻停止层; 中间介电材料层; 和上介电层。图案化的掩模层形成在图案化的上介电层上，留下图案化的上介电层的暴露的相对部分。使用图案化掩模层和上介电层的暴露部分作为掩模，将中介电材料层图案化以形成开口。使用图案化的上电介质层作为掩模，同时对图案化的中间介电材料层进行图案化以形成初始上沟槽开口; 并且使用图案化掩模层和图案化的中间蚀刻停止层作为掩模的下部电介质材料层形成与前述上部沟槽开口对准的开口下部通孔。

49. 发明申请

US20050070466A1 Peptide-based compounds 有权
标题翻译：基于肽的化合物
公开(公告)号：US20050070466A1
公开(公告)日：2005-03-31
申请号：US10753729
申请日：2004-01-08
申请人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Archer , Harry Wadsworth
发明人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Archer , Harry Wadsworth
IPC分类号： A61K38/00 , A61K47/65 , A61K49/00 , A61K49/04 , A61K51/00 , A61K51/08 , A61P1/02 , A61P1/04 , A61P9/00 , A61P9/08 , A61P9/10 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07K7/00 , C07K7/06 , C07K14/745 , A61K38/12 , C07K7/64
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
摘要翻译：本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。

50. 发明申请

US20050002865A1 Diagnostic/therapeutic agents 审中-公开
标题翻译：诊断/治疗剂
公开(公告)号：US20050002865A1
公开(公告)日：2005-01-06
申请号：US10734730
申请日：2003-12-15
申请人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08 , A61K51/12
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式