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41. 发明授权

US08758271B2 Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties 有权
标题翻译：用于发现动态和静态组织性质的非线性系统识别技术和装置
公开(公告)号：US08758271B2
公开(公告)日：2014-06-24
申请号：US12872630
申请日：2010-08-31
申请人： Ian W. Hunter , Yi Chen
发明人： Ian W. Hunter , Yi Chen
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A01G7/00 , A61B5/0048 , A61B5/0053 , A61B5/0055 , A61B5/0057 , A61B5/442 , A61B5/6824 , A61B9/00 , G01N3/24 , G01N3/40 , G01N2203/0069 , G01N2203/0218 , G01N2203/0246 , G01N2203/0278
摘要： A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. The probe can be coupled to the tissue surface. The device can include a reference surface configured to contact the tissue surface. The probe may include a set of interchangeable heads, the set including a head for lateral movement of the probe and a head for perpendicular movement of the probe. The perturbation can include extension of the tissue with the probe or sliding the probe across the tissue surface and may also include indentation of the tissue with the probe. In some embodiments, the actuator includes a Lorentz force linear actuator. The mechanical property may be determined using non-linear stochastic system identification. The mechanical property may be indicative of, for example, tissue compliance and tissue elasticity. The device can further include a handle for manual application of the probe to the surface of the tissue and may include an accelerometer detecting an orientation of the probe. The device can be used to test skin tissue of an animal, plant tissue, such as fruit and vegetables, or any other biological tissue.
摘要翻译：用于测量组织的机械特性的装置包括配置成相对于组织表面移动来干扰组织的探针，耦合到探针以移动探针的致动器，被配置成测量组织的响应的检测器扰动和耦合到致动器和检测器的控制器。控制器使用随机序列驱动致动器，并使用从检测器接收的测量响应来确定组织的机械特性。探针可以耦合到组织表面。该装置可以包括构造成接触组织表面的参考表面。探针可以包括一组可互换的头部，该组件包括用于探针的横向运动的头部和用于探针的垂直运动的头部。扰动可以包括用探针延伸组织或者将探针滑过组织表面，还可以包括用探针的组织的凹陷。在一些实施例中，致动器包括洛伦兹力线性致动器。可以使用非线性随机系统识别来确定机械特性。机械性能可以指示例如组织依从性和组织弹性。该装置还可以包括用于将探针手动施加到组织表面的手柄，并且可以包括检测探针取向的加速度计。该装置可用于测试动物，植物组织如水果和蔬菜或任何其他生物组织的皮肤组织。

42. 发明授权

US08624699B2 Electric coil and method of manufacture 有权
标题翻译：电线圈及其制造方法
公开(公告)号：US08624699B2
公开(公告)日：2014-01-07
申请号：US12590493
申请日：2009-11-09
申请人： Ian W. Hunter , Timothy A. Fofonoff
发明人： Ian W. Hunter , Timothy A. Fofonoff
IPC分类号： H01F5/00 , H01F27/29 , H01F27/28
CPC分类号： H01F41/02 , H01F5/00 , H01F27/2847 , H01F27/303 , H01F27/323 , H01F41/04 , H01F41/041 , H01F41/061 , H01F41/071 , H01F41/10 , H01F2027/297 , H02K3/04 , H02K7/075 , H02K7/1876 , H02K15/0421 , H02K33/18 , H02K35/04 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073
摘要： Instead of being made from one continuous piece of material, a coil includes multiple flat coil segments that are stacked together and electrically coupled in series. In many embodiments, the coil segments are U-shaped segments, and the segments are arranged so that each segment is rotated (e.g., by 270 degrees) with respect the segment it follows. The stacked coils may then be fastened together using, for example, bolts through the corners of the coil segments. The combined coil segments form a continuous coil.
摘要翻译：不是由一个连续的材料制成，线圈包括堆叠在一起并电耦合的多个扁平线圈段。在许多实施例中，线圈段是U形段，并且这些段被布置成使得每个段相对于其所遵循的段旋转（例如，270度）。然后可以使用例如螺栓穿过线圈段的角部将堆叠的线圈紧固在一起。组合的线圈段形成连续线圈。

43. 发明授权

US08328755B2 Controlled needle-free transport 有权
标题翻译：受控无针运输
公开(公告)号：US08328755B2
公开(公告)日：2012-12-11
申请号：US12906525
申请日：2010-10-18
申请人： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
发明人： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
IPC分类号： A61M5/30
CPC分类号： H02K41/02 , A61B17/20 , A61B17/205 , A61D7/00 , A61M5/19 , A61M5/30 , A61M2205/50 , A61M2205/6009 , A61M2205/825 , A61M2250/00
摘要： A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
摘要翻译：用于将物质转移到生物体的表面上的无针透皮传送装置包括用于储存物质的储存器，与储存器流体连通的喷嘴和与储存器连通的可控电磁致动器。称为洛伦兹力致动器的致动器包括固定磁体组件和移动线圈组件。线圈组件移动具有位于储存器内的端部的活塞。致动器接收电输入并且响应于相应的力产生作用在活塞上的相应的力并导致物质在储存器和生物体之间的无针转移。力的大小，方向和持续时间由电输入动态控制（例如，伺服控制），并且可以在致动循环的过程中改变。有利的是，执行器可以根据电气输入沿不同方向移动。

44. 发明申请

US20110311939A1 Plaque Removal and Differentiation of Tooth and Gum 有权
标题翻译：牙齿和牙齿的牙斑去除和分化
公开(公告)号：US20110311939A1
公开(公告)日：2011-12-22
申请号：US12969111
申请日：2010-12-15
申请人： Ian W. Hunter
发明人： Ian W. Hunter
IPC分类号： A61C17/02 , A61C17/00
CPC分类号： A61C17/02 , A61C19/063
摘要： A method of tooth treatment includes sensing a surface condition of tooth or gum and controlling ejection of a fluid jet against the tooth based on the sensed condition. The fluid may be a liquid and may be carried in a self-contained reservoir in a handle of a fluid ejection device. The liquid can be a cleansing solution and may contain cleaning particles. The ejection can be controlled to clean teeth at high pressure and to reduce pressure applied to gum, for example, to clean plaque. In some embodiments, the method may be used to remove soft tooth. The method may further include automatically scanning the fluid jet relative to a handle of an injection device. In an embodiment, the fluid is ejected by means of a fluid ejector comprising a stationary magnet assembly providing a magnetic field and a coil assembly, slidably disposed with respect to the magnet assembly, the coil assembly driving ejection of the fluid jet. Sensing the surface condition can include measuring a response of tissue to a mechanical perturbation and may include sensing an acoustic signal reflected from tissue. The mechanical perturbation can include applied force and the measured response can include deformation of the tissue. The method may further include mechanically disturbing the tissue with the fluid jet. A tooth treatment device includes a fluid ejector that ejects fluid against teeth and a servo controller controlling pressure of ejected fluid in response to a sensed surface condition. The fluid jet can have a diameter of less than 500 microns, a peak relative pressure of at least 1 kilopascal and velocity of at least 1 meter per second.
摘要翻译：牙齿治疗的方法包括感测牙齿或牙龈的表面状况，并根据检测到的状况控制针对牙齿的流体射流的喷射。流体可以是液体，并且可以在流体喷射装置的手柄中的独立储存器中携带。液体可以是清洁溶液并且可以含有清洁颗粒。可以控制喷射以在高压下清洁牙齿并减少施加到牙龈上的压力，例如清洁斑块。在一些实施例中，该方法可用于去除软齿。该方法还可以包括相对于注射装置的手柄自动扫描流体射流。在一个实施例中，通过包括提供磁场的固定磁体组件和相对于磁体组件可滑动地设置的线圈组件的流体喷射器喷射流体，线圈组件驱动喷射流体射流。感测表面状况可以包括测量组织对机械扰动的响应，并且可以包括感测从组织反射的声信号。机械扰动可以包括施加的力，并且测量的响应可以包括组织的变形。该方法还可以包括用流体射流机械地干扰组织。牙齿治疗装置包括喷射流体抵抗牙齿的流体喷射器和响应于检测到的表面状况控制喷射流体的压力的伺服控制器。流体射流可以具有小于500微米的直径，至少1千帕斯卡的峰值相对压力和至少1米/秒的速度。

45. 发明申请

US20110166549A1 BI-DIRECTIONAL MOTION OF A LORENTZ-FORCE ACTUATED NEEDLE-FREE INJECTOR (NFI) 有权
标题翻译： LORENTZ-FORCE无针式注射器（NFI）的双向运动
公开(公告)号：US20110166549A1
公开(公告)日：2011-07-07
申请号：US12960405
申请日：2010-12-03
申请人： Ian W. Hunter , Andrew J. Taberner , N. Catherine Hogan
发明人： Ian W. Hunter , Andrew J. Taberner , N. Catherine Hogan
IPC分类号： A61M5/307 , A61M5/31
CPC分类号： A61M5/30 , A61B10/0045 , A61B10/02 , A61B10/0283 , A61B2010/008 , A61M5/19 , A61M2005/3128 , A61M2205/8287
摘要： The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber. A bi-directional electromagnetic actuator is in communication with the chamber. The actuator, when activated, generates a pressure within the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.
摘要翻译：本发明涉及一种用于即时混合固体或粉末制剂及其后续递送至生物体的方法和相应装置。在一些实施方案中，将粉末制剂保持在第一室中。双向电磁致动器与腔室连通。致动器在被激活时在第一室内产生压力。压力导致粉末制剂和稀释剂及时混合以输送到生物体中。

46. 发明申请

US20110108339A1 Electric motor 有权
标题翻译：电动马达
公开(公告)号：US20110108339A1
公开(公告)日：2011-05-12
申请号：US12590495
申请日：2009-11-09
申请人： Ian W. Hunter
发明人： Ian W. Hunter
IPC分类号： B60K1/00 , H02K7/075 , H02K7/18 , B60L11/18 , H02K9/20
CPC分类号： H02K7/06 , B60G3/01 , B60G17/02 , B60G2202/40 , B60G2204/30 , B60G2300/50 , B60G2300/60 , B60K7/0007 , B60K17/356 , B60K17/358 , B60K25/08 , B60K2007/0038 , B60K2007/0092 , B60L2220/44 , B60L2220/50 , H02K3/04 , H02K7/00 , H02K7/065 , H02K7/075 , H02K7/1876 , H02K15/0421 , H02K33/00 , H02K33/18 , H02K35/00 , H02K35/04 , Y02T10/641
摘要： A rotary and linear motion device includes a magnetic stator assembly, opposed electromagnetic actuators, and a linear-to-rotary converter (e.g., cam). Each electromagnetic actuator includes a coil that is configured to reciprocate relative to the magnetic stator assembly or to linearly translate in a common direction relative to the magnetic stator assembly. The electromagnetic actuators are coupled to the linear-to-rotary converter and upon reciprocation or linear translation, drive the linear-to-rotary converter in rotary or linear motion. The device may be located inside a wheel, which may be part of a vehicle. If part of a wheel of a vehicle, the device can be used to provide propulsion, steering, braking, and suspension for the vehicle.
摘要翻译：旋转和线性运动装置包括磁性定子组件，相对的电磁致动器和线性到旋转转换器（例如，凸轮）。每个电磁致动器包括被配置为相对于磁性定子组件往复运动的线圈或者相对于磁性定子组件沿共同的方向线性平移。电磁致动器耦合到线性到旋转转换器，并且在往复或线性平移时，以线性或直线运动驱动线性到旋转转换器。该装置可以位于车轮内部，车轮可以是车辆的一部分。如果车辆的一部分车轮，该装置可用于为车辆提供推进，转向，制动和悬架。

47. 发明申请

US20110054354A1 Nonlinear System Identification Techniques and Devices for Discovering Dynamic and Static Tissue Properties 有权
标题翻译：用于发现动态和静态组织特性的非线性系统识别技术和设备
公开(公告)号：US20110054354A1
公开(公告)日：2011-03-03
申请号：US12872630
申请日：2010-08-31
申请人： Ian W. Hunter , Yi Chen
发明人： Ian W. Hunter , Yi Chen
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A01G7/00 , A61B5/0048 , A61B5/0053 , A61B5/0055 , A61B5/0057 , A61B5/442 , A61B5/6824 , A61B9/00 , G01N3/24 , G01N3/40 , G01N2203/0069 , G01N2203/0218 , G01N2203/0246 , G01N2203/0278
摘要： A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. The probe can be coupled to the tissue surface. The device can include a reference surface configured to contact the tissue surface. The probe may include a set of interchangeable heads, the set including a head for lateral movement of the probe and a head for perpendicular movement of the probe. The perturbation can include extension of the tissue with the probe or sliding the probe across the tissue surface and may also include indentation of the tissue with the probe. In some embodiments, the actuator includes a Lorentz force linear actuator. The mechanical property may be determined using non-linear stochastic system identification. The mechanical property may be indicative of, for example, tissue compliance and tissue elasticity. The device can further include a handle for manual application of the probe to the surface of the tissue and may include an accelerometer detecting an orientation of the probe. The device can be used to test skin tissue of an animal, plant tissue, such as fruit and vegetables, or any other biological tissue.
摘要翻译：用于测量组织的机械特性的装置包括配置成相对于组织表面移动来干扰组织的探针，耦合到探针以移动探针的致动器，被配置成测量组织的响应的检测器扰动和耦合到致动器和检测器的控制器。控制器使用随机序列驱动致动器，并使用从检测器接收的测量响应来确定组织的机械特性。探针可以耦合到组织表面。该装置可以包括构造成接触组织表面的参考表面。探针可以包括一组可互换的头部，该组件包括用于探针的横向运动的头部和用于探针的垂直运动的头部。扰动可以包括用探针延伸组织或者将探针滑过组织表面，还可以包括用探针的组织的凹陷。在一些实施例中，致动器包括洛伦兹力线性致动器。可以使用非线性随机系统识别来确定机械特性。机械性能可以指示例如组织依从性和组织弹性。该装置还可以包括用于将探针手动施加到组织表面的手柄，并且可以包括检测探针取向的加速度计。该装置可用于测试动物，植物组织如水果和蔬菜或任何其他生物组织的皮肤组织。

48. 发明申请

US20080269561A1 ENDOSCOPIC IMAGING SYSTEM 审中-公开
标题翻译：内窥镜成像系统
公开(公告)号：US20080269561A1
公开(公告)日：2008-10-30
申请号：US12111082
申请日：2008-04-28
申请人： Michael S. Banik , Dennis R. Boulais , Lucien Alfred Couvillon , Albert C.C. Chin , Ian W. Hunter
发明人： Michael S. Banik , Dennis R. Boulais , Lucien Alfred Couvillon , Albert C.C. Chin , Ian W. Hunter
IPC分类号： A61B1/008
CPC分类号： A61B1/008 , A61B1/00071 , A61B1/0008 , A61B1/00147 , A61B1/0016 , A61B1/0051 , A61B1/0052 , A61B1/0055 , A61B1/0057 , A61B1/015 , A61B1/04 , A61B1/05 , A61B1/0638 , A61B1/0676 , A61B1/0684 , A61B1/31 , A61B2017/00309 , A61B2017/00314 , A61B2017/00327 , A61B2017/0042
摘要： An endoscopic imaging system includes a reusable control cabinet having a number of actuators that control the orientation of a lightweight endoscope that is connectable thereto. The endoscope is used with a single patient and is then disposed. The endoscope includes an illumination mechanism, an image sensor and an elongate shaft having one or more lumens located therein. A polymeric articulation joint at the distal end of the endoscope allows the distal end to be oriented by the control cabinet. The endoscope is coated with a hydrophilic coating that reduces its coefficient of friction and because it is lightweight, requires less force to advance it to a desired location within a patient.
摘要翻译：内窥镜成像系统包括可重复使用的控制柜，其具有多个致动器，所述致动器控制可连接到其上的轻型内窥镜的取向。内窥镜与单个患者一起使用，然后被布置。内窥镜包括照明机构，图像传感器和具有位于其中的一个或多个管腔的细长轴。在内窥镜的远端处的聚合物关节运动接头允许远端由控制柜定向。内窥镜涂覆有亲水性涂层，其降低其摩擦系数，并且由于其重量轻，需要较小的力将其推进到患者体内的期望位置。

49. 发明授权

US06932939B2 System for high throughput sample preparation and analysis using column chromatography 有权
标题翻译：使用柱色谱的高通量样品制备和分析系统
公开(公告)号：US06932939B2
公开(公告)日：2005-08-23
申请号：US10855198
申请日：2004-05-27
申请人： Can Özbal , Ian W. Hunter , John Linton
发明人： Can Özbal , Ian W. Hunter , John Linton
IPC分类号： G01N27/62 , B01F13/00 , B01J19/00 , B01L3/00 , B01L3/02 , C40B60/14 , G01N1/00 , G01N1/36 , G01N21/33 , G01N21/64 , G01N21/65 , G01N21/77 , G01N21/78 , G01N30/16 , G01N30/24 , G01N30/46 , G01N30/62 , G01N30/72 , G01N30/84 , G01N35/00 , G01N35/10 , B01D15/08
CPC分类号： G01N30/466 , B01F5/0085 , B01F13/0059 , B01J19/0046 , B01J2219/0036 , B01J2219/00387 , B01J2219/00414 , B01J2219/00418 , B01J2219/00479 , B01J2219/00495 , B01J2219/00515 , B01J2219/00518 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00657 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/0072 , B01L3/0262 , B01L3/0268 , B01L3/505 , B01L3/5085 , B01L2300/0812 , B01L2300/0845 , C40B60/14 , G01N30/24 , G01N30/7233 , G01N30/7266 , G01N30/84 , G01N35/00009 , G01N35/1095 , G01N2030/628 , G01N2030/8417 , G01N2035/1037 , G01N2035/1046 , Y10T436/115831 , G01N30/18
摘要： A system and method high throughput sample preparation and analysis using column chromatography. Each port in a plurality of ports has a port input that interfaces with a first fluid source and a port output. A fluidic circuit is coupled to each port output and to a second fluid source, the fluidic circuit for controlling fluid flow from the plurality of ports and the second fluid source. The fluidic circuit is also coupled to a plurality of chromatography columns. An interface to an analyzer receives output from at least one of the plurality of chromatography columns. The plurality of chromatography columns is moved relative to the analyzer via a translation stage, such that sample output from one of the plurality of chromatography columns can be selectively presented to the analyzer.
摘要翻译：一种使用柱色谱法的高通量样品制备和分析的系统和方法。多个端口中的每个端口具有与第一流体源和端口输出接口的端口输入。流体回路耦合到每个端口输出端和第二流体源，流体回路用于控制来自多个端口和第二流体源的流体流。流体回路还耦合到多个色谱柱。分析仪的界面接收至少一个色谱柱的输出。多个色谱柱经由平移台相对于分析器移动，使得从多个色谱柱中的一个色谱柱输出的样品可以选择性地呈现给分析器。

50. 发明授权

US06309600B1 Apparatus for droplet microchemistry 失效
标题翻译：液滴微化学仪器
公开(公告)号：US06309600B1
公开(公告)日：2001-10-30
申请号：US09081700
申请日：1998-05-20
申请人： Ian W. Hunter
发明人： Ian W. Hunter
IPC分类号： G01N3510
CPC分类号： B01L3/0262 , B01F5/0085 , B01F13/0059 , B01J19/0046 , B01J2219/00515 , B01J2219/00518 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00657 , B01J2219/00659 , B01J2219/00702 , B01L3/0268 , B01L3/505 , B01L3/5085 , B01L3/5088 , B01L2300/0812 , B01L2300/0845 , G01N30/24 , G01N30/7233 , G01N30/84 , G01N2030/628 , G01N2030/8417 , G01N2035/1037
摘要： An apparatus and methods for performing microchemical manipulation and analysis of liquid samples. One or more droplets of liquid are loaded serially or in parallel onto a flexible member which may be a fiber or a tape, and are retained on the flexible member by virtue of surface adhesion. Microchemical operations may be performed on these droplets, the operations including mixing, dilution, concentration, heating, cooling, filtering, and analyzing, where the analyzing may include chemical, biochemical, optical, or other physical analyses.
摘要翻译：用于进行液体样品的微化学操作和分析的装置和方法。一个或多个液滴被串联地或平行地装载到可以是纤维或带的柔性构件上，并且由于表面粘附而保持在柔性构件上。可以对这些液滴进行微化学操作，包括混合，稀释，浓缩，加热，冷却，过滤和分析的操作，其中分析可以包括化学，生物化学，光学或其它物理分析。

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