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1. 发明申请

US20190184081A1 ARTIFICIAL HEART 审中-公开
公开(公告)号：US20190184081A1
公开(公告)日：2019-06-20
申请号：US16217579
申请日：2018-12-12
申请人： Stephen K. Shu
发明人： Stephen K. Shu
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1055 , A61M1/1005 , A61M1/1048 , A61M1/1081 , A61M1/1087 , A61M1/1096 , A61M1/12 , A61M2205/3523 , A61M2205/50 , A61M2205/82 , A61M2205/8206 , A61M2205/8281 , A61M2205/8287 , A61M2210/125
摘要： Disclosed herein is a fully implantable artificial heart. The use of flat helical springs to align and reciprocate a bellows structure allows the bellows to pump blood, the multiple solenoids with floating magnetized rods and permanent magnet assemblies held by the flat helical springs provide the power. The artificial heart pumps blood with virtually no friction and no parts to wear out. The use of solenoids advantageously move blood in a gentle, controllable manner.

2. 发明授权

US09789256B2 Bi-directional motion of a lorentz-force actuated needle-free injector (NFI) 有权
公开(公告)号：US09789256B2
公开(公告)日：2017-10-17
申请号：US14504903
申请日：2014-10-02
申请人： Massachusetts Institute of Technology
发明人： Ian W. Hunter , Andrew J. Taberner , N. Catherine Hogan
IPC分类号： A61M5/30 , A61B10/00 , A61B10/02 , A61M5/19 , A61M5/31
CPC分类号： A61M5/30 , A61B10/0045 , A61B10/02 , A61B10/0283 , A61B2010/008 , A61M5/19 , A61M2005/3128 , A61M2205/8287
摘要： The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

3. 发明授权

US09078985B2 Dry powder nebulizer 有权
标题翻译：干粉雾化器
公开(公告)号：US09078985B2
公开(公告)日：2015-07-14
申请号：US13583606
申请日：2011-03-08
申请人： Nicola Jeanne Maynard , Hugh D. Smyth
发明人： Nicola Jeanne Maynard , Hugh D. Smyth
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00
CPC分类号： A61M15/0086 , A61M11/003 , A61M15/00 , A61M15/0006 , A61M15/0021 , A61M15/003 , A61M15/0035 , A61M15/009 , A61M2016/0015 , A61M2202/064 , A61M2205/0272 , A61M2205/8287 , A61M2206/16
摘要： A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.
摘要翻译：干粉递送装置可以被配置为向使用者的气道提供微粉化的干粉颗粒。该装置可以包括限定容纳至少一个磁响应物体的腔室的圆柱形容器，在该腔室外部的电动机，该腔室外部的磁体并与该电动机可旋转地联接;以及流出部件，其将气流引导至使用者。磁性响应物体可以涂覆有微粉化的干粉末颗粒，并且电动机可操作以使磁体围绕轴旋转。磁体的旋转产生磁场，使得响应于磁场的磁响应物体移动并与容器的侧壁碰撞，以使干粉颗粒解聚并使空腔中的干粉雾化。

4. 发明申请

US20140257236A1 INJECTION METHODS USING A SERVO-CONTROLLED NEEDLE-FREE INJECTOR 审中-公开
标题翻译：使用伺服控制无针注射器的注射方法
公开(公告)号：US20140257236A1
公开(公告)日：2014-09-11
申请号：US14280477
申请日：2014-05-16
申请人： Massachusetts Institute of Technology
发明人： Brian D. Hemond , Ian W. Hunter , Andrew J. Taberner , Dawn M. Wendell , N. Catherine Hogan
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/24 , A61M5/46 , A61M5/486 , A61M2205/3331 , A61M2205/3358 , A61M2205/3368 , A61M2205/50 , A61M2205/8287
摘要： A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.
摘要翻译：通过生物体表面注入物质的方法包括提供构造成通过所述表面注入物质的无针透皮输送装置。当感测到注射的参数并且使用伺服控制器基于所感测的参数来动态地调整至少一个喷射特性时，将物质与输送装置一起注入生物体。注射物质（i）在第一时间段期间，以第一注射压力注射物质的体积的第一部分，以及（ii）第二时间段，其中物质的剩余体积为在第二注射压力下注射。可以确定物质的粘度，并计算基于粘度注入物质的压力。物质可以通过使用计算的压力与输送装置一起注入。

5. 发明申请

US20130338566A1 IMPLANTABLE FLUID MANAGEMENT SYSTEM FOR THE REMOVAL OF EXCESS FLUID 有权
标题翻译：可移动流体管理系统，用于除去流体
公开(公告)号：US20130338566A1
公开(公告)日：2013-12-19
申请号：US13973984
申请日：2013-08-22
申请人： Sequana Medical AG
发明人： Daniel R. Burnett
IPC分类号： A61M27/00
CPC分类号： A61M27/002 , A61M1/28 , A61M5/14276 , A61M5/1723 , A61M27/006 , A61M39/24 , A61M2039/248 , A61M2205/103 , A61M2205/3331 , A61M2205/3334 , A61M2205/3355 , A61M2205/8206 , A61M2205/8237 , A61M2205/8287 , A61M2210/0693 , A61M2210/101 , A61M2210/1017 , A61M2210/1053 , A61M2210/106 , A61M2210/1064 , A61M2210/1085 , A61M2210/122 , A61M2230/005 , A61M2230/208 , A61M2230/50
摘要： An implantable fluid management device, designed to drain excess fluid from a variety of locations in a living host into a second location within the host, such as the bladder of that host. The device may be used to treat ascites, chronic pericardial effusions, normopressure hydrocephalus, hydrocephalus, pulmonary edema, or any fluid collection within the body of a human, or a non-human mammal.
摘要翻译：一种植入式流体管理装置，其设计成将多余的流体从活体内的各种位置排出到主体内的第二位置，例如该宿主的膀胱。该装置可用于治疗人体或非人哺乳动物体内的腹水，慢性心包积液，压迫性脑积水，脑积水，肺水肿或任何液体收集。

6. 发明授权

US08550976B2 Implantable driver with non-invasive transmural powering device for cardiac assist and combined assist and support devices 有权
标题翻译：可植入式驱动器，用于心脏辅助和组合辅助和支持装置的非侵入性透壁电力装置
公开(公告)号：US08550976B2
公开(公告)日：2013-10-08
申请号：US13310604
申请日：2011-12-02
申请人： John C. Criscione
发明人： John C. Criscione
IPC分类号： A61N1/362
CPC分类号： A61M1/1068 , A61M1/106 , A61M1/12 , A61M1/127 , A61M2205/8243 , A61M2205/8287
摘要： The present invention an implantable, sub-cutaneous, bellows-like device with one plate proximal (or superficial) to the skin surface and the other plate distal (or deep) to the skin surface having a component of a pneumatic/hydraulic driver for an implantable medical device such as a cardiac assist, cardiac support, or combined cardiac assist and support device and inducible magnet material on the distal plate of the bellows that can be magnetically drawn towards the proximal plate by the action of a magnet outside the body to contract the bellows or pressurize the fluid in the bellows.
摘要翻译：本发明是一种植入式，亚皮肤的波纹管状装置，其具有一个与皮肤表面近似（或表面）的板，而另一个板远离（或深）到皮肤表面，具有气动/液压驱动器的部件，用于植入式医疗装置，例如心脏辅助，心脏支架，或组合的心脏辅助和支持装置以及波纹管远端板上的可诱导磁体材料，其能够通过身体外部的磁体的作用被磁性地拉向近端板，从而收缩波纹管或加压波纹管中的流体。

7. 发明申请

US20130000640A1 DRY POWDER NEBULIZER 有权
公开(公告)号：US20130000640A1
公开(公告)日：2013-01-03
申请号：US13583606
申请日：2011-03-08
申请人： Nicola Jeanne Maynard , Hugh D. Smyth
发明人： Nicola Jeanne Maynard , Hugh D. Smyth
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M11/003 , A61M15/00 , A61M15/0006 , A61M15/0021 , A61M15/003 , A61M15/0035 , A61M15/009 , A61M2016/0015 , A61M2202/064 , A61M2205/0272 , A61M2205/8287 , A61M2206/16
摘要： A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

8. 发明申请

US20120089114A1 INJECTION METHODS USING A SERVO-CONTROLLED NEEDLE-FREE INJECTOR 有权
标题翻译：使用伺服控制无针注射器的注射方法
公开(公告)号：US20120089114A1
公开(公告)日：2012-04-12
申请号：US13269421
申请日：2011-10-07
申请人： Brian D. Hemond , Ian W. Hunter , Andrew J. Taberner , Dawn M. Wendell , N. Catherine Hogan
发明人： Brian D. Hemond , Ian W. Hunter , Andrew J. Taberner , Dawn M. Wendell , N. Catherine Hogan
IPC分类号： A61M5/31 , A61M5/307
CPC分类号： A61M5/30 , A61M5/24 , A61M5/46 , A61M5/486 , A61M2205/3331 , A61M2205/3358 , A61M2205/3368 , A61M2205/50 , A61M2205/8287
摘要： A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.
摘要翻译：通过生物体表面注入物质的方法包括提供构造成通过所述表面注入物质的无针透皮输送装置。当感测到注射的参数并且使用伺服控制器基于所感测的参数来动态地调整至少一个喷射特性时，将物质与输送装置一起注入生物体。注射物质（i）在第一时间段期间，以第一注射压力注射物质的体积的第一部分，以及（ii）第二时间段，其中物质的剩余体积为在第二注射压力下注射。可以确定物质的粘度，并计算基于粘度注入物质的压力。物质可以通过使用计算的压力与输送装置一起注入。

9. 发明申请

US20120012618A1 Fluid dispensing or feeding device 有权
标题翻译：流体分配或进料装置
公开(公告)号：US20120012618A1
公开(公告)日：2012-01-19
申请号：US12804072
申请日：2010-07-13
申请人： Hong Jen Wang
发明人： Hong Jen Wang
IPC分类号： B65D88/54
CPC分类号： A61M5/14216 , A61M5/1422 , A61M5/14244 , A61M5/172 , A61M2205/8287
摘要： A fluid dispensing device includes a pressurizing device coupled between a fluid bottle and a discharge tube for forcing the fluid to flow through the discharge tube without gravity, the pressurizing device includes a container having an inclined inner peripheral surface, and a piston slidably received in the container and having an outer peripheral portion for selectively engaging with the inclined inner peripheral surface of the container in order to pump the fluid into the discharge tube when the piston is moved toward the discharge tube with a coil, and for being selectively disengaged from the inner peripheral surface of the container when the piston is moved away from the discharge tube.
摘要翻译：流体分配装置包括联接在流体瓶和排出管之间的加压装置，用于迫使流体无重力地流过排放管，加压装置包括具有倾斜内周面的容器和可滑动地容纳在该容器中的活塞容器，并且具有用于选择性地与容器的倾斜内周面接合的外周部分，以便当活塞以线圈朝排出管移动时，将流体泵送到排放管中，并且用于选择性地从内部当活塞离开放电管时，容器的周边表面。

10. 发明授权

US08038641B2 Tools and methods for programming an implantable valve 有权
标题翻译：用于编程可植入阀的工具和方法
公开(公告)号：US08038641B2
公开(公告)日：2011-10-18
申请号：US12415590
申请日：2009-03-31
申请人： Brian M. Soares , LiJuan He , Allison H. Bedwinek , Kyle Jarger
发明人： Brian M. Soares , LiJuan He , Allison H. Bedwinek , Kyle Jarger
IPC分类号： A61M5/00 , F61K31/00
CPC分类号： A61M27/006 , A61B5/031 , A61B5/6864 , A61M39/22 , A61M2205/04 , A61M2205/3515 , A61M2205/6054 , A61M2205/8287 , A61M2209/04
摘要： A two-part tool for reading and adjusting an implantable valve, and methods of use. The tool includes a locator-indicator component that, when placed matingly on the patient's skin over the valve, provides magnetic reading of the valve setting. The tool also includes an adjustor component that couples to the locator-indicator component and is rotatable to change a valve setting.
摘要翻译：用于读取和调整植入式阀的两部分工具及其使用方法。该工具包括一个定位器指示器组件，当配对地放置在患者皮肤上的阀门上时，可以提供阀门设置的磁性读数。该工具还包括耦合到定位器指示器部件并且可旋转以改变阀设置的调节器部件。

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