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41. 发明授权

US4810486A Bone-seeking complexes of technetium-99m 失效
标题翻译：锝-99m寻骨综合体
公开(公告)号：US4810486A
公开(公告)日：1989-03-07
申请号：US160605
申请日：1988-02-29
申请人： James D. Kelly , David V. Griffiths
发明人： James D. Kelly , David V. Griffiths
IPC分类号： A61K51/00 , A61K51/04 , C07F9/38 , A61K49/02
CPC分类号： C07F9/3865 , A61K51/0489 , A61K2123/00
摘要： A composition for use in the preparation of a bone-scanning agent comprises a mixture of a bis-phosphonic acid of formula (I), wherein R.sup.1 and R.sup.3 may be the same or different group selected from H, --SO.sub.3 H and a lower aliphatic group which may optionally contain one or more hetero atoms and which contains at least one --SO.sub.3 H group; R.sup.2 is a group selected from H, --OH, --NH.sub.2, --NHMe, --NMe.sub.2 and lower alkyl optionally substituted by one or more polar groups; R.sup.4 is a group selected from H, --OH, --NH.sub.2 --NHMe, --NMe.sub.2, --SO.sub.3 H and a lower alkyl optionally substituted by one or more polar groups; and n is 0 or 1; with the proviso that when n is 0, R.sup.1 is not H and that when n is 1, R.sup.1 and R.sup.3 cannot both be H; or a non-toxic salt thereof, together with a reducing agent for pertechnetate ions. Technetium-99m, as an aqueous solution of pertechnetate ions, is added to the composition to form a complex of Tc-99m, and the bisphosphonate. The complex is useful as a bone-scanning agent and is rapidly taken up in bone to give scans of high definition.
摘要翻译： PCT No.PCT / GB87 / 00456 Sec。 371日期1988年2月29日第 102（e）日期1988年2月29日PCT Filed 1987年6月29日PCT公布。第WO88 / 00061号公报 1988年1月14日。用于制备骨扫描剂的组合物包含式（I）的双膦酸的混合物，其中R 1和R 3可以相同或不同，选自H， -SO 3 H和可以任选地含有一个或多个杂原子并且含有至少一个-SO 3 H基团的低级脂族基团; R2是选自H，-OH，-NH2，-NHMe，-NMe2和任选被一个或多个极性基团取代的低级烷基的基团; R4是选自H，-OH，-NH2 + L，-NHMe，-NMe2，-SO3H和任选被一个或多个极性基团取代的低级烷基的基团; 并且n为0或1; 条件是当n为0时，R1不为H，当n为1时，R1和R3不能同时为H; 或其无毒盐，以及高锝酸盐离子的还原剂。将锝-99m作为高锝酸盐离子的水溶液加入到组合物中以形成Tc-99m和双膦酸盐的络合物。该复合物作为骨扫描剂是有用的，并且被快速地吸收在骨中以给出高清晰度的扫描。

42. 发明授权

US4766073A Expression of biologically active PDGF analogs in eucaryotic cells 失效
标题翻译：生物活性PDGF类似物在真核细胞中的表达
公开(公告)号：US4766073A
公开(公告)日：1988-08-23
申请号：US896485
申请日：1986-08-13
申请人： Mark J. Murray , James D. Kelly
发明人： Mark J. Murray , James D. Kelly
IPC分类号： A61K35/16 , A61K38/00 , C12N15/67 , C12N15/78 , C12N15/00 , C12N5/00 , C12P21/00 , C12P19/34
CPC分类号： A61K35/16 , C12N15/67 , C12N15/78 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , Y10S930/12 , Y10S930/221
摘要： Methods for expressing a variety of biologically active PDGF analogs in eucaryotic cells are disclosed. The methods generally comprise introducing into a eucaryotic host cell a DNA construct capable of directing the expression and secretion of biologically active PDGF analogs in eucaryotic cells. The DNA construct contains a transcriptional promoter followed downstream by a suitable DNA sequence. The DNA sequence may encode a protein substantially homologous to the A-chain or the B-chain of PDGF, or a portion thereof, or an A-B heterodimer. In addition, a portion of the DNA sequence may encode at least a portion of the A-chain, while another portion encodes at least a portion of the B-chain of PDGF. Eucaryotic cells transformed with these DNA constructs are also disclosed. Methods of promoting the growth of mammalian cells, comprising incubating the cells with a biologically active PDGF analog expressed by a eucaryotic host cell transformed with such a DNA construct, are also disclosed.
摘要翻译：公开了在真核细胞中表达多种生物活性PDGF类似物的方法。所述方法通常包括向真核宿主细胞中引入能够指导生物活性PDGF类似物在真核细胞中的表达和分泌的DNA构建体。 DNA构建体含有转录启动子，后续是合适的DNA序列。 DNA序列可以编码与PDGF或其一部分或A-B异源二聚体的A链或B链基本同源的蛋白质。此外，DNA序列的一部分可以编码A链的至少一部分，而另一部分编码PDGF的至少一部分B链。还公开了用这些DNA构建体转化的真核细胞。还公开了促进哺乳动物细胞生长的方法，包括用由这种DNA构建体转化的真核宿主细胞表达的生物活性PDGF类似物孵育细胞。

43. 发明授权

US4642229A Bone-seeking complexes of Technetium-99m 失效
标题翻译：锝-99m骨寻找复合物
公开(公告)号：US4642229A
公开(公告)日：1987-02-10
申请号：US600408
申请日：1984-04-16
申请人： Stephen A. Cumming , James D. Kelly
发明人： Stephen A. Cumming , James D. Kelly
IPC分类号： A61K51/00 , A61K51/04 , C07F9/38 , A61K43/00 , A61K49/00 , A61K49/02
CPC分类号： A61K51/0478 , A61K51/0489 , C07F9/386 , A61K2123/00
摘要： A bone-seeking, Technetium-99m-ethylene glycol-1,2-bisphosphonate complex has been found to be useful as a bone-scanning agent. The complex, which is prepared by adding Technetium-99m, as an aqueous solution of pertechnetate, to a composition comprising a mixture of ethylene glycol-1,2-bisphosphonic acid or a non-toxic salt thereof with a reducing agent for pertechnetate, is taken up rapidly in bone to give scans of high definition and compares favorably in this and other respects to other bone-scanning agents.
摘要翻译：已经发现寻骨锝-99m-乙二醇-1,2-二膦酸复合物可用作骨扫描剂。通过添加锝-99m作为高锝酸盐水溶液制备的络合物包含乙二醇-1,2-二膦酸或其无毒盐与高锝酸盐的还原剂的混合物的组合物是在骨头中快速摄取以提供高清晰度的扫描，并且在其它方面与其它骨扫描剂相比有利。

44. 发明授权

US4335095A Indium-111 oxine complex composition 失效
标题翻译：铟-111氧杂复合物组合物
公开(公告)号：US4335095A
公开(公告)日：1982-06-15
申请号：US128923
申请日：1980-03-10
申请人： James D. Kelly
发明人： James D. Kelly
IPC分类号： G01N33/60 , A61K51/00 , A61K51/04 , A61K51/12 , A61K49/00 , A61K43/00
CPC分类号： A61K51/1203 , A61K51/0478 , A61K2123/00
摘要： An indium-111 preparation comprises a complex of indium-111 with a quinoline compound carrying an 8-hydroxyl group, e.g. oxine, present in an aqueous medium which also contains a surface active agent to prevent the complex from becoming bound to the surface of the vessel on autoclaving, and optionally a buffer to improve blood cell labelling efficiency. The surface active agent is preferably non-ionic, e.g. a polyoxyethylene sorbitan ester of a fatty acid. The buffer is preferably N-2-hydroxyethylpiperazine-N'-2-ethanesulphonic acid.
摘要翻译：铟-111制剂包含铟-111与携带8-羟基的喹啉化合物的络合物，例如存在于还含有表面活性剂的水性介质中，以防止复合物在高压灭菌时结合到血管表面，以及任选的缓冲液，以提高血细胞标记效率。表面活性剂优选为非离子的，例如，脂肪酸的聚氧乙烯脱水山梨糖醇酯。缓冲剂优选为N-2-羟乙基哌嗪-N'-2-乙磺酸。

45. 发明授权

US08217008B2 Methods of treating inflammatory disease using a soluble IL-20 receptor 有权
标题翻译：使用可溶性IL-20受体治疗炎性疾病的方法
公开(公告)号：US08217008B2
公开(公告)日：2012-07-10
申请号：US12899700
申请日：2010-10-07
申请人： Donald C. Foster , Wenfeng Xu , Karen L. Madden , James D. Kelly , Cindy A. Sprecher , Cameron S. Brandt , Mark W. Rixon , Scott R. Presnell , Brian A. Fox
发明人： Donald C. Foster , Wenfeng Xu , Karen L. Madden , James D. Kelly , Cindy A. Sprecher , Cameron S. Brandt , Mark W. Rixon , Scott R. Presnell , Brian A. Fox
IPC分类号： A61K38/03 , A61K45/00 , C07K14/54 , C12P21/02 , A61P17/00 , C12N15/09 , C12N5/07
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译：具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。两个亚基优选连接在一起。在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。轻链和重链通过二硫键连接。

46. 发明授权

US08171334B2 Apparatus and method to interface two different clock domains 有权
标题翻译：接口两个不同时钟域的设备和方法
公开(公告)号：US08171334B2
公开(公告)日：2012-05-01
申请号：US12824463
申请日：2010-06-28
申请人： James D. Kelly
发明人： James D. Kelly
IPC分类号： G06F1/00 , G06F1/12 , G06F5/06
CPC分类号： G06F5/06
摘要： A gearbox is placed between two clock domains to allow data to be transferred from one domain to the other. Although the two domains may operate at the same clock frequency, typically one domain has a faster clock speed than the other. The gearbox is disposed between the two clock domains to control timing of data transfer from one to the other, by selecting a pattern which identifies when data is made transparent for the transfer. The gearbox allows a number of clock ratios to be selected, so that a particular clock ratio between the two domains may be readily selected in the gearbox for the data transfer.
摘要翻译：齿轮箱放置在两个时钟域之间，以允许数据从一个域传输到另一个域。尽管两个域可以在相同的时钟频率下工作，但通常一个域具有比另一个更快的时钟速度。齿轮箱设置在两个时钟域之间，以通过选择识别数据何时使传输透明的模式来控制数据从一个到另一个的数据传输的定时。齿轮箱允许选择多个时钟比，使得两个域之间的特定时钟比可以容易地在用于数据传输的变速箱中选择。

47. 发明授权

US5748917A Line data architecture and bus interface circuits and methods for dual-edge clocking of data to bus-linked limited capacity devices 失效
标题翻译：线路数据架构和总线接口电路和方法，用于将数据双边缘计时到总线连接的有限容量设备
公开(公告)号：US5748917A
公开(公告)日：1998-05-05
申请号：US579884
申请日：1995-12-28
申请人： William Todd Krein , Charles M. Flaig , James D. Kelly
发明人： William Todd Krein , Charles M. Flaig , James D. Kelly
IPC分类号： G06F13/42 , G06F13/38
CPC分类号： G06F13/4217
摘要： A data system architecture and interface circuits permit slow devices having limited signal capacities to launch and receive information from a central bus. Data is clocked onto the bus with a master circuit at the leading and trailing edges of the bus clock so that portions of a large multibit signal are launched without having to wait for the initiation of a next clock cycle. Accordingly, data portions are launched during both leading and trailing edges of the clock signal. In the case of a simple bus device not able to accommodate inclusion of a slave interface circuit, the received signal packet is provided in adapted form anticipating that only a second half portion of the signal packet will actually be registered as received.
摘要翻译：数据系统架构和接口电路允许具有有限信号容量的慢速设备从中央总线发射和接收信息。在总线时钟的前沿和下降沿，数据通过主电路在总线上被计时，从而在不必等待下一个时钟周期的启动的情况下启动大量多位信号的部分。因此，数据部分在时钟信号的前沿和后沿都被启动。在简单总线装置不能容纳从属接口电路的情况下，接收的信号分组以适合的形式提供，预期信号分组的仅一半部分实际上将被注册为接收的。

48. 发明授权

US5630077A System and method for coordinating access to a bus 失效
标题翻译：用于协调访问总线的系统和方法
公开(公告)号：US5630077A
公开(公告)日：1997-05-13
申请号：US626905
申请日：1996-04-04
申请人： William T. Krein , Charles M. Flaig , James D. Kelly
发明人： William T. Krein , Charles M. Flaig , James D. Kelly
IPC分类号： G06F13/364 , G06F13/00
CPC分类号： G06F13/364
摘要： To optimize system bus utilization in a computer system, a bus coordinator is included in the computer system to coordinate the transfer of information signals on the bus. Each time a source node wishes to transfer information to a destination node, the source node sends a request to the coordinator along with the identification of the destination node. Upon receiving this request, the coordinator determines whether the destination node has capacity to receive information signals. If the destination node has capacity, then the coordinator grants control of the system bus to the source node to allow the source node to send information signals to the destination node via the system bus. Otherwise, the source node is denied control of the system bus until the destination node has capacity to receive information signals. By granting control of the system bus to a source node only when the destination node has capacity to receive information signals, the coordinator ensures that no system bus time is wasted on unsuccessful information transfers. Thus, bus utilization is optimized.
摘要翻译：为了优化计算机系统中的系统总线利用率，计算机系统中包括总线协调器，以协调总线上信息信号的传输。每当源节点希望将信息传送到目的地节点时，源节点与目的地节点的标识一起向协调器发送请求。在接收到该请求之后，协调器确定目的地节点是否具有接收信息信号的能力。如果目标节点具有容量，则协调器将系统总线的控制权授予源节点，以允许源节点通过系统总线向目的地节点发送信息信号。否则，源节点被拒绝对系统总线的控制，直到目的节点具有接收信息信号的能力。只有当目的地节点具有接收信息信号的能力时，通过将系统总线的控制权授予源节点，协调器才能确保不会在不成功的信息传输上浪费系统总线时间。因此，优化了总线利用率。

49. 发明授权

US5592631A Bus transaction reordering using side-band information signals 失效
标题翻译：使用边带信息信号对总线事务重新排序
公开(公告)号：US5592631A
公开(公告)日：1997-01-07
申请号：US432620
申请日：1995-05-02
申请人： James D. Kelly , R. Stephen Polzin
发明人： James D. Kelly , R. Stephen Polzin
IPC分类号： G06F13/364 , G06F13/366
CPC分类号： G06F13/364
摘要： The present invention, generally speaking, provides a system and method of decoupling the address and data buses of a system bus using side band information signals. A computer system with which the invention may be used has a system bus including an address bus and a data bus and has, operatively connected to said system bus, multiple master devices, including a microprocessor, and multiple slave devices. In accordance with one embodiment of the invention, the address bus and the data bus are decoupled by providing, in addition to signals carried by the system bus, first side-band signals including, for each master device besides the microprocessor, an address arbitration signal, and providing, in addition to signals carried by the system bus, second side-band signals including, for each slave device, an address termination signal, a data arbitration signal, and a read-ready signal indicating that a respective slave device has data to present on the system bus. An address arbitration vector is formed, composed of address arbitration signals for the master devices, an address termination vector is formed, composed of address termination signals for the slave devices, and a read-ready vector is formed, composed of read-ready signals for the slave devices. The address arbitration vector and the address termination vector are sampled. Using a queue structure having a front and a rear, pairs of address arbitration and address termination vectors sampled at different sampling times are queued. Given a pair of address arbitration and address termination vectors at the head of the queue structure and a subsequent, corresponding read-ready vector, a data arbitration signal is issued to one of the slave devices and one of the master devices, as a "paired data bus grant."
摘要翻译：本发明一般地提供了一种使用边带信息信号去除系统总线的地址和数据总线的系统和方法。可以使用本发明的计算机系统具有包括地址总线和数据总线的系统总线，并且具有可操作地连接到所述系统总线的多个主设备，包括微处理器和多个从设备。根据本发明的一个实施例，地址总线和数据总线除了由系统总线携带的信号之外还提供第一边带信号，除了微处理器之外还包括每个主设备的地址仲裁信号并且除了由系统总线承载的信号之外，还提供第二边带信号，包括针对每个从设备的地址终止信号，数据仲裁信号和指示相应从设备具有数据的可读准备信号在系统总线上呈现。形成地址仲裁向量，由主设备的地址仲裁信号组成，形成地址终止向量，由从设备的地址终止信号组成，并且形成就绪向量，其包括用于从设备。对地址仲裁向量和地址终止向量进行采样。使用具有前端和后端的队列结构，对在不同采样时间采样的地址仲裁和地址终止矢量进行排队。给定在队列结构的头部的一对地址仲裁和地址终止向量以及随后的对应的可读向量，向其中一个从设备和一个主设备发出数据仲裁信号作为“配对数据总线授权。

50. 发明授权

US5590130A Bus protocol using separate clocks for arbitration and data transfer 失效
标题翻译：总线协议使用单独的时钟进行仲裁和数据传输
公开(公告)号：US5590130A
公开(公告)日：1996-12-31
申请号：US510557
申请日：1995-08-02
申请人： William T. Krein , Charles M. Flaig , James D. Kelly
发明人： William T. Krein , Charles M. Flaig , James D. Kelly
IPC分类号： G06F13/364 , G06F13/42 , H04L12/417
CPC分类号： G06F13/364 , G06F13/4217
摘要： A bus system uses separate clocks for arbitration and data transfer. The arbitration clock signal is used for synchronizing bus request and grant events, and the data clock signal is used for synchronizing data transmission and reception. In particular, the data clock signal, which is generated by a bus master node without any temporal relationship to the arbitration clock signal, is transmitted by the bus master node through the bus to a slave node, where the received data signal is synchronized with the data clock signal transmitted therewith.
摘要翻译：总线系统使用单独的时钟进行仲裁和数据传输。仲裁时钟信号用于同步总线请求和授权事件，并且数据时钟信号用于同步数据发送和接收。特别地，由总线主节点生成的与仲裁时钟信号没有任何时间关系的数据时钟信号由总线主节点通过总线传输到从节点，其中所接收的数据信号与数据时钟信号。

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