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41. 发明申请

US20140364443A1 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 有权
标题翻译： 1,4-二氢萘啶衍生物和药物组合物及其用途
公开(公告)号：US20140364443A1
公开(公告)日：2014-12-11
申请号：US14362735
申请日：2012-12-07
申请人： Rong Chen , Lin Feng , Zhengping Zhang , Fang Fang , Qingli Dong , Fulong Li , Lei Wang , Yao Hua , Shibao Yang , Peng Wang
发明人： Rong Chen , Lin Feng , Zhengping Zhang , Fang Fang , Qingli Dong , Fulong Li , Lei Wang , Yao Hua , Shibao Yang , Peng Wang
IPC分类号： C07D495/14 , C07D471/14 , C07D471/04
CPC分类号： C07D495/14 , C07D471/04 , C07D471/12 , C07D471/14 , C07D491/14
摘要： Disclosed are 1,4-dihydro-naphthyridine derivatives and pharmaceutical composition and uses thereof. The 1,4-dihydro-naphthyridine derivatives are a compound capable of inhibiting acetylcholinesterase activity and preventing extracellular calcium from flowing into a cell via a calcium channel, i.e., having a dual-activity, which are of potential importance as a pharmaceutical and can be used to prepare the drugs for treating cardiovascular diseases, cerebrovascular diseases and dementia.
摘要翻译：公开了1,4-二氢 - 萘啶衍生物及其药物组合物及其用途。 1,4-二氢 - 萘啶衍生物是能够抑制乙酰胆碱酯酶活性并防止细胞外钙通过钙通道流入细胞的化合物，即具有作为药物具有潜在重要性的双重活性，可以是用于制备治疗心血管疾病，脑血管疾病和痴呆症的药物。

42. 发明授权

US08512710B2 Class of therapeutic protein based molecules 有权
标题翻译：新型治疗蛋白基分子
公开(公告)号：US08512710B2
公开(公告)日：2013-08-20
申请号：US12861392
申请日：2010-08-23
申请人： Fang Fang , Michael Malakhov
发明人： Fang Fang , Michael Malakhov
IPC分类号： C12N9/24
CPC分类号： A61K38/47 , A61K38/00 , A61K39/00 , A61K48/0008 , C07K14/47 , C07K14/4703 , C07K14/4711 , C07K14/475 , C07K14/521 , C07K14/522 , C07K14/5421 , C07K14/775 , C07K14/8117 , C07K14/8128 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N7/00 , C12N9/2402 , C12N9/2405 , C12N15/86 , C12N2750/14143 , C12N2750/14145 , C12N2760/16111 , C12Y302/01018
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供了具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。本发明还包括具有唾液酸酶活性的治疗组合物，包括具有唾液酸酶催化结构域的蛋白质类化合物。本发明的化合物可用于治疗或预防病原体感染，以及用于治疗和减少变态反应和炎症反应。本发明还提供了通过重组病毒增强靶细胞转导的组合物和方法。这些组合物和方法可用于基因治疗。

43. 发明授权

US08398971B2 Methods, compounds, and compositions for treatment and prophylaxis in the respiratory tract 有权
标题翻译：用于治疗和预防呼吸道的方法，化合物和组合物
公开(公告)号：US08398971B2
公开(公告)日：2013-03-19
申请号：US12940742
申请日：2010-11-05
申请人： Fang Fang , David Wurtman , Ron Moss , Michael P. Malakhov
发明人： Fang Fang , David Wurtman , Ron Moss , Michael P. Malakhov
IPC分类号： A61K38/46
CPC分类号： A61K38/47 , A61K9/0014 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K9/0073 , A61K9/06 , A61K31/05 , A61K31/198 , A61K31/4172 , A61K31/7016 , A61K33/06 , A61K33/14 , A61K38/1808 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/34 , A61K49/0008 , C07K14/485 , C07K2319/00 , C12N9/2402 , C12N9/2477 , C12Q1/34 , C12Y302/01018 , G01N2500/00 , G01N2800/122 , A61K2300/00
摘要： The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes administering to the subject a compound or composition containing a therapeutically effective amount of a fusion protein comprising a sialidase or an active portion thereof and an anchoring domain. The therapeutically effective amount comprises an amount of the fusion protein that results in a reduction of the quanitity of mucus in the respiratory tract after administration of the compound or composition when compared to the quantity of mucus present prior to administration of the compound or composition.
摘要翻译：本发明提供一种减少所述呼吸道中粘液水平升高的受试者呼吸道中的粘液的量的方法。该方法包括向受试者施用含有治疗有效量的包含唾液酸酶或其活性部分和锚定结构域的融合蛋白的化合物或组合物。治疗有效量包括与施用化合物或组合物之前存在的粘液的量相比，在施用化合物或组合物之后导致呼吸道中的粘液数量减少的量的融合蛋白。

44. 发明申请

US20130059693A1 High Efficient and High Power Plane Centric Gear Unit 审中-公开
标题翻译：高效高功率平面中心减速器
公开(公告)号：US20130059693A1
公开(公告)日：2013-03-07
申请号：US13603449
申请日：2012-09-05
申请人： ZUPENG FANG , DAN FANG , FANG FANG , YAFENG ZHAO
发明人： ZUPENG FANG , DAN FANG , FANG FANG , YAFENG ZHAO
IPC分类号： F16H1/32
CPC分类号： F16H1/32
摘要： A plane centric gear unit has a circumferentially floating ring gear 1. Both ends of the ring gear 1 are respectively fixed with cloth boards 3 equipped with hollow shaft sleeves 4; the reaction forces of the ring gear 1 and external gear 2 are equal and in opposite directions, and act on inner ring bearings 7 of the hollow shaft sleeves 4 on the same straight line; the outer ring bearings 8 of the hollow shaft sleeves 4 are unloaded, therefore the sum of the bearing reaction forces is reduced, the total transmission efficiency and power reaches above 97% and tens of thousands KW grade, the noises are lower, the gear surface contact pressure is about 1/10 of the external mesh pair, the gear surface contact life is increased by 1000 times than the external mesh pair, and the total weight is reduced by 2˜3 times.
摘要翻译：平面中心减速器具有周向浮动的环形齿轮1.齿圈1的两端分别固定有装有中空轴套4的布板3; 环形齿轮1和外齿轮2的反作用力相等且相反方向，并且作用在同一直线上的中空轴套4的内圈轴承7上; 空心轴套4的外圈轴承8被卸载，因此轴承反作用力的总和减小，总传动效率和功率达到97％以上，几万KW级，噪声较低，齿轮面接触压力约为外啮合对的1/10，齿轮表面接触寿命比外啮合对增加1000倍，总重量减少2〜3倍。

45. 发明申请

US20120141590A1 Technology for the Preparation of Microparticles 审中-公开
标题翻译：微粒制备技术
公开(公告)号：US20120141590A1
公开(公告)日：2012-06-07
申请号：US13250653
申请日：2011-09-30
申请人： Michael Malakhov , Fang Fang
发明人： Michael Malakhov , Fang Fang
IPC分类号： A61K9/50 , C07K14/435 , C07K14/81 , C07K14/77 , C07K9/00 , C07H15/234 , C07D499/68 , C07H21/02 , A61K38/08 , A61K38/31 , C07D305/14 , C07D307/937 , C08B37/02 , C08B37/16 , C07C227/00 , C07C323/58 , A61K31/7088 , A61P3/02 , A61P37/02 , A61K47/36 , C12N9/24 , C12N9/76 , C12N9/36 , C12N9/22 , C12N7/00 , C12N7/02 , C07K14/765
CPC分类号： A61K9/1682 , A61K9/0048 , A61K9/0075 , A61K9/1652 , A61K9/1658 , A61K9/19 , A61K9/5089 , A61K31/198 , A61K31/337 , A61K31/343 , A61K31/405 , A61K31/43 , A61K31/555 , A61K31/557 , A61K31/5575 , A61K31/65 , A61K31/7036 , A61K31/721 , A61K31/724 , A61K35/76 , A61K38/08 , A61K38/12 , A61K38/14 , A61K38/168 , A61K38/1709 , A61K38/1808 , A61K38/38 , A61K38/385 , A61K38/42 , A61K38/465 , A61K38/47 , A61K38/4826 , C07D305/14 , C07K9/008 , C07K14/765 , C12N7/00 , C12N9/96 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/50 , C12N2330/30 , C12N2770/00021 , C12N2770/00051 , C12Y301/21001 , C12Y301/27005 , C12Y302/00 , C12Y302/01017 , C12Y302/01018 , C12Y304/21004 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/401 , Y02A50/402 , Y02A50/411 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/49 , Y02A50/491
摘要： Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.
摘要翻译：通过使溶剂中的大分子或小分子的溶液与抗溶剂和抗衡离子接触，并冷却溶液来制备微球体。微球可用于制备具有限定尺寸的药物，营养品，化妆品等。

46. 发明申请

US20120014405A1 Drop Counter And Flow Meter For Apparatus And Method For Determining The Thermal Stability Of Fluids 有权
标题翻译：用于确定流体热稳定性的装置和滴定计流量计和方法
公开(公告)号：US20120014405A1
公开(公告)日：2012-01-19
申请号：US12850468
申请日：2010-08-04
申请人： David G. Anderson , Larry M. Youngblood , Guoxing Yang , Larry A. Spino , Scott K. Berkhous , Fang Fang
发明人： David G. Anderson , Larry M. Youngblood , Guoxing Yang , Larry A. Spino , Scott K. Berkhous , Fang Fang
IPC分类号： G01N33/22 , G01N25/00
CPC分类号： G01N33/2805
摘要： A thermal oxidation tester is shown for determining thermal stability of a fluid, particularly hydrocarbons when subjected to elevated temperatures. The tendency of the heated fluid to oxidize and (1) form deposits on a surface of a heater tube and (2) form solids therein, are both measured at a given flow rate, temperature and time. The measured results are used to determine whether a fluid sample passes or fails the test. Sample flow rate is important in the jet fuel thermal oxidation test. Current practice requires manual drop counting or flow confirmation with the use of volumetric glassware. An apparatus is described to precisely measure the flow rate and automatically perform flow rate check using a drip rate method and/or volumetric method.
摘要翻译：示出了热氧化测试仪，用于确定流体，特别是当受到升高的温度时的烃的热稳定性。加热的流体氧化的趋势和（1）在加热器管的表面上形成沉积物，和（2）在其中形成固体，都是在给定的流速，温度和时间下测量的。测量结果用于确定流体样品是否通过或未通过测试。样品流速在喷气燃料热氧化试验中很重要。目前的做法是使用容积式玻璃器皿进行手动滴定计数或流量确认。描述了一种设备来精确地测量流量并且使用滴流法和/或体积法自动执行流量检查。

47. 发明授权

US08084036B2 Broad spectrum anti-viral therapeutics and prophylaxis 有权
标题翻译：广谱抗病毒治疗和预防
公开(公告)号：US08084036B2
公开(公告)日：2011-12-27
申请号：US10718986
申请日：2003-11-21
申请人： Mang Yu , Fang Fang , Michael Malakhov
发明人： Mang Yu , Fang Fang , Michael Malakhov
IPC分类号： A61K39/00 , C12N9/36
CPC分类号： B82Y5/00 , A61K38/47 , A61K38/57
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. The invention provides compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. The invention also provides compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。优选的靶细胞是上皮细胞。本发明提供了用于预防病毒性疾病（例如流行性感冒）的组合物和方法，使用具有锚定结构域的化合物，所述化合物具有可结合与细胞外作用以干扰靶细胞的病毒感染的酶活性连接的靶细胞。本发明还提供了用于使用具有锚定结构域的化合物来预防病毒性疾病例如流感的组合物和方法，所述化合物具有可以结合与蛋白酶抑制剂连接的靶细胞，其可以在细胞外作用以干扰靶细胞的病毒感染。

48. 发明授权

US07804935B2 Fuzzy logic guided inverse treatment planning 有权
标题翻译：模糊逻辑指导逆治疗计划
公开(公告)号：US07804935B2
公开(公告)日：2010-09-28
申请号：US10570227
申请日：2004-08-27
申请人： Fang-Fang Yin , Jae Ho Kim , Hui Yan
发明人： Fang-Fang Yin , Jae Ho Kim , Hui Yan
IPC分类号： A61N5/10
CPC分类号： A61N5/1031
摘要： A fuzzy inference system for use in modulating radiation treatment includes a fuzzifer for inputting imaging data, and inference device operatively to the fuzzifer for analyzing the imaging data and determining radiation treatment target from non-treatment target, and a defuzzifier for modulating radiation treatment pursuant to the analysis from the inference device.
摘要翻译：用于调制放射治疗的模糊推理系统包括：用于输入成像数据的模糊器，以及可操作地将模拟器的推理装置用于分析成像数据和从非处理靶标确定放射线治疗目标，以及用于根据推理装置的分析。

49. 发明申请

US20100217040A1 2, 2', 6, 6'- TETRASUBSTITUTED AMINOPHOSPHINE LIGAND AND ITS SYNTHESIS METHOD 有权
标题翻译： 2，2'，6,6'-四唑基氨基磷酰胺配体及其合成方法
公开(公告)号：US20100217040A1
公开(公告)日：2010-08-26
申请号：US12377000
申请日：2007-08-10
申请人： Wanbin Zhang , Fang Xie , Fang Fang
发明人： Wanbin Zhang , Fang Xie , Fang Fang
IPC分类号： C07F9/50
CPC分类号： C07F9/46
摘要： The present invention relates to a 2,2′,6,6′-tetrasubstituted aminophosphine ligand and its synthesis method. The structure of the ligand is shown as below. Its synthesis method comprises: Step (1) coupling 2,6-dinitrochlorobenzene as the starting material to obtain 2,2′,6,6′-tetranitrobiphenyl; Step (2): hydrogenating the 2,2′,6,6′-tetranitrobiphenyl with Pd/C to obtain 2,2′,6,6′-tetraminobiphenyl; Step (3): reacting the 2,2′,6,6′-tetraminobiphenyl with a phosphine halide to obtain the 2,2′,6,6′-tetrasubstituted aminophosphine ligand. The ligand of the present invention is an achiral compound, and its preparation method is simple. The ligand can be converted to a chiral bimetallic catalyst with single configuration eventually through introduction of external chirality. Moreover, the ligand can be used in various asymmetric reaction catalyzed by metals with high reactivity and stereoselectivity.
摘要翻译：本发明涉及2,2'，6,6'-四取代氨基膦配体及其合成方法。配体的结构如下所示。其合成方法包括：步骤（1）以2,6-二硝基氯苯为原料，得到2,2'，6,6'-四硝基联苯; 步骤（2）：用Pd / C氢化2,2'，6,6'-四硝基二苯并得到2,2'，6,6'-四氨基联苯; 步骤（3）：使2,2'，6,6'-四磺酰联苯与卤化膦反应，得到2,2'，6,6'-四取代氨基膦配体。本发明的配体是非手性化合物，其制备方法简单。最终可以通过引入外部手性将配体转化为具有单一配置的手性双金属催化剂。此外，配体可用于由具有高反应性和立体选择性的金属催化的各种不对称反应中。

50. 发明授权

US07582303B2 Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E 失效
标题翻译：禽类戊型肝炎病毒，疫苗和防止禽流感 - 脾肿大综合征和哺乳动物性肝炎的方法
公开(公告)号：US07582303B2
公开(公告)日：2009-09-01
申请号：US11184574
申请日：2005-07-19
申请人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
发明人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
IPC分类号： A61K39/29 , C12Q1/70 , C12Q1/68
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/54 , C12N7/00 , C12N2770/28022 , C12N2770/28034 , C12Q1/707 , G01N33/576
摘要： The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns immunogenic compositions comprising this new virus or recombinant products such as the nucleic acid and vaccines that protect an avian or mammalian species from viral infection or hepatitis-splenomegaly syndrome caused by the hepatitis E virus. Also included in the scope of the invention is a method for propagating, inactivating or attenuating a hepatitis E virus comprising inoculating an embryonated chicken egg with a live, pathogenic hepatitis E virus and recovering the virus or serially passing the pathogenic virus through additional embryonated chicken eggs until the virus is rendered inactivated or attenuated. Further, this invention concerns diagnostic reagents for detecting an avian hepatitis E viral infection or diagnosing hepatitis-splenomegaly syndrome in an avian or mammalian species comprising an antibody raised or produced against the immunogenic compositions and antigens such as ORF2 proteins expressed in a baculovirus vector, E. coli, etc. The invention additionally encompasses methods for detecting avian HEV nucleic acid sequences using nucleic acid hybridization probes or oligonucleotide primers for polymerase chain reaction (PCR).
摘要翻译：本发明涉及具有SEQ ID NO：1所示核苷酸序列或其互补链的新颖的分离型禽类戊型肝炎病毒。本发明还涉及包含这种新病毒或重组产物（例如核酸和疫苗）的免疫原性组合物，其保护禽类或哺乳动物物种免受由戊型肝炎病毒引起的病毒感染或肝炎 - 脾肿大综合症。本发明的范围还包括传播，灭活或减毒戊型肝炎病毒的方法，包括用活的致病性戊型肝炎病毒接种含胚鸡蛋，并回收该病毒或通过另外的含胚鸡蛋串联通过病原性病毒直到病毒灭活或减毒。此外，本发明涉及用于检测禽流感病毒感染或诊断禽流感或哺乳动物物种中的肝炎 - 脾肿大综合征的诊断试剂，其包含针对免疫原性组合物产生或产生的抗体，例如杆状病毒载体中表达的ORF2蛋白大肠杆菌等。本发明另外包括使用核酸杂交探针或用于聚合酶链反应（PCR）的寡核苷酸引物检测禽类HEV核酸序列的方法。

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