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1. 发明授权

US07807174B2 Class of therapeutic protein based molecules 有权
标题翻译：基于治疗蛋白质的分子类
公开(公告)号：US07807174B2
公开(公告)日：2010-10-05
申请号：US10939262
申请日：2004-09-10
申请人： Fang Fang , Michael Malakhov
发明人： Fang Fang , Michael Malakhov
IPC分类号： A61K39/00 , C12N9/36
CPC分类号： C12N9/2402 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N2760/16111 , C12Y302/01018
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供了具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。本发明还包括具有唾液酸酶活性的治疗组合物，包括具有唾液酸酶催化结构域的蛋白质类化合物。本发明的化合物可用于治疗或预防病原体感染，以及用于治疗和减少变态反应和炎症反应。本发明还提供了通过重组病毒增强靶细胞转导的组合物和方法。这些组合物和方法可用于基因治疗。

2. 发明授权

US07645448B2 Class of therapeutic protein based molecules 有权
公开(公告)号：US07645448B2
公开(公告)日：2010-01-12
申请号：US12256230
申请日：2008-10-22
申请人： Fang Fang , Michael Malakhov
发明人： Fang Fang , Michael Malakhov
IPC分类号： A61K38/46 , C12N9/14
CPC分类号： C12N9/2402 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N2760/16111 , C12Y302/01018
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.

3. 发明申请

US20090142327A1 Novel Class of Therapeutic Protein Based Molecules 有权
标题翻译：新型的基于治疗蛋白质的分子
公开(公告)号：US20090142327A1
公开(公告)日：2009-06-04
申请号：US12256230
申请日：2008-10-22
申请人： Fang Fang , Michael Malakhov
发明人： Fang Fang , Michael Malakhov
IPC分类号： A61K38/47 , C12N9/24 , A61P31/16
CPC分类号： C12N9/2402 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N2760/16111 , C12Y302/01018
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供了具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。本发明还包括具有唾液酸酶活性的治疗组合物，包括具有唾液酸酶催化结构域的蛋白质类化合物。本发明的化合物可用于治疗或预防病原体感染，以及用于治疗和减少变态反应和炎症反应。本发明还提供了通过重组病毒增强靶细胞转导的组合物和方法。这些组合物和方法可用于基因治疗。

4. 发明申请

US20050112751A1 Novel class of therapeutic protein based molecules 有权
标题翻译：新型的基于治疗蛋白质的分子
公开(公告)号：US20050112751A1
公开(公告)日：2005-05-26
申请号：US10939262
申请日：2004-09-10
申请人： Fang Fang , Michael Malakhov
发明人： Fang Fang , Michael Malakhov
IPC分类号： A61K39/00 , C07H21/04 , C12N1/21 , C12N9/24 , C12N9/36 , C12N15/74
CPC分类号： C12N9/2402 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N2760/16111 , C12Y302/01018
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供了具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。本发明还包括具有唾液酸酶活性的治疗组合物，包括具有唾液酸酶催化结构域的蛋白质类化合物。本发明的化合物可用于治疗或预防病原体感染，以及用于治疗和减少变态反应和炎症反应。本发明还提供了通过重组病毒增强靶细胞转导的组合物和方法。这些组合物和方法可用于基因治疗。

5. 发明申请

US20130156703A1 Methods, Compounds, and Compositions For Treatment and Prophylaxis in the Respiratory Tract 审中-公开
公开(公告)号：US20130156703A1
公开(公告)日：2013-06-20
申请号：US13769095
申请日：2013-02-15
申请人： Fang Fang , David Wurtman , Ron Moss , Michael Malakhov
发明人： Fang Fang , David Wurtman , Ron Moss , Michael Malakhov
IPC分类号： A61K38/47
CPC分类号： A61K38/47 , A61K9/0014 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K9/0073 , A61K9/06 , A61K31/05 , A61K31/198 , A61K31/4172 , A61K31/7016 , A61K33/06 , A61K33/14 , A61K38/1808 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/34 , A61K49/0008 , C07K14/485 , C07K2319/00 , C12N9/2402 , C12N9/2477 , C12Q1/34 , C12Y302/01018 , G01N2500/00 , G01N2800/122 , A61K2300/00
摘要： The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes administering to the subject a compound or composition containing a therapeutically effective amount of a fusion protein comprising a sialidase or an active portion thereof and an anchoring domain. The therapeutically effective amount comprises an amount of the fusion protein that results in a reduction of the quanitity of mucus in the respiratory tract after administration of the compound or composition when compared to the quantity of mucus present prior to administration of the compound or composition.

6. 发明申请

US20070259414A1 Methods and Compositions for Protein Expression and Purification 审中-公开
标题翻译：蛋白质表达和纯化的方法和组合物
公开(公告)号：US20070259414A1
公开(公告)日：2007-11-08
申请号：US11751441
申请日：2007-05-21
申请人： Tauseef Butt , Stephen Weeks , Hiep Tran , Michael Malakhov , Oxana Malakhova
发明人： Tauseef Butt , Stephen Weeks , Hiep Tran , Michael Malakhov , Oxana Malakhova
IPC分类号： C12N5/00 , C12N1/16 , C12N1/20 , C12N9/14 , C12N15/63
CPC分类号： C12P21/02 , C07K14/00 , C07K2319/02 , C07K2319/21 , C07K2319/60 , C07K2319/95 , C12N15/62
摘要： Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
摘要翻译：公开了用于增强宿主细胞中异源融合蛋白的表达水平和分泌的方法。

7. 发明申请

US20060216785A1 Methods and compositions for protein expression and purification 有权
公开(公告)号：US20060216785A1
公开(公告)日：2006-09-28
申请号：US11363660
申请日：2006-02-28
申请人： Tauseef Butt , Steven Weeks , Hiep Tran , Michael Malakhov , Oxana Malakhova
发明人： Tauseef Butt , Steven Weeks , Hiep Tran , Michael Malakhov , Oxana Malakhova
IPC分类号： C07K14/47 , C07H21/04 , C12P21/06 , C12N1/21 , C12N1/18 , C12N15/74
CPC分类号： C12P21/02 , C07K14/00 , C07K2319/02 , C07K2319/21 , C07K2319/60 , C07K2319/95 , C12N15/62
摘要： Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.

8. 发明授权

US08512710B2 Class of therapeutic protein based molecules 有权
标题翻译：新型治疗蛋白基分子
公开(公告)号：US08512710B2
公开(公告)日：2013-08-20
申请号：US12861392
申请日：2010-08-23
申请人： Fang Fang , Michael Malakhov
发明人： Fang Fang , Michael Malakhov
IPC分类号： C12N9/24
CPC分类号： A61K38/47 , A61K38/00 , A61K39/00 , A61K48/0008 , C07K14/47 , C07K14/4703 , C07K14/4711 , C07K14/475 , C07K14/521 , C07K14/522 , C07K14/5421 , C07K14/775 , C07K14/8117 , C07K14/8128 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N7/00 , C12N9/2402 , C12N9/2405 , C12N15/86 , C12N2750/14143 , C12N2750/14145 , C12N2760/16111 , C12Y302/01018
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供了具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。本发明还包括具有唾液酸酶活性的治疗组合物，包括具有唾液酸酶催化结构域的蛋白质类化合物。本发明的化合物可用于治疗或预防病原体感染，以及用于治疗和减少变态反应和炎症反应。本发明还提供了通过重组病毒增强靶细胞转导的组合物和方法。这些组合物和方法可用于基因治疗。

9. 发明申请

US20120141590A1 Technology for the Preparation of Microparticles 审中-公开
标题翻译：微粒制备技术
公开(公告)号：US20120141590A1
公开(公告)日：2012-06-07
申请号：US13250653
申请日：2011-09-30
申请人： Michael Malakhov , Fang Fang
发明人： Michael Malakhov , Fang Fang
IPC分类号： A61K9/50 , C07K14/435 , C07K14/81 , C07K14/77 , C07K9/00 , C07H15/234 , C07D499/68 , C07H21/02 , A61K38/08 , A61K38/31 , C07D305/14 , C07D307/937 , C08B37/02 , C08B37/16 , C07C227/00 , C07C323/58 , A61K31/7088 , A61P3/02 , A61P37/02 , A61K47/36 , C12N9/24 , C12N9/76 , C12N9/36 , C12N9/22 , C12N7/00 , C12N7/02 , C07K14/765
CPC分类号： A61K9/1682 , A61K9/0048 , A61K9/0075 , A61K9/1652 , A61K9/1658 , A61K9/19 , A61K9/5089 , A61K31/198 , A61K31/337 , A61K31/343 , A61K31/405 , A61K31/43 , A61K31/555 , A61K31/557 , A61K31/5575 , A61K31/65 , A61K31/7036 , A61K31/721 , A61K31/724 , A61K35/76 , A61K38/08 , A61K38/12 , A61K38/14 , A61K38/168 , A61K38/1709 , A61K38/1808 , A61K38/38 , A61K38/385 , A61K38/42 , A61K38/465 , A61K38/47 , A61K38/4826 , C07D305/14 , C07K9/008 , C07K14/765 , C12N7/00 , C12N9/96 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/50 , C12N2330/30 , C12N2770/00021 , C12N2770/00051 , C12Y301/21001 , C12Y301/27005 , C12Y302/00 , C12Y302/01017 , C12Y302/01018 , C12Y304/21004 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/401 , Y02A50/402 , Y02A50/411 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/49 , Y02A50/491
摘要： Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.
摘要翻译：通过使溶剂中的大分子或小分子的溶液与抗溶剂和抗衡离子接触，并冷却溶液来制备微球体。微球可用于制备具有限定尺寸的药物，营养品，化妆品等。

10. 发明授权

US08084036B2 Broad spectrum anti-viral therapeutics and prophylaxis 有权
标题翻译：广谱抗病毒治疗和预防
公开(公告)号：US08084036B2
公开(公告)日：2011-12-27
申请号：US10718986
申请日：2003-11-21
申请人： Mang Yu , Fang Fang , Michael Malakhov
发明人： Mang Yu , Fang Fang , Michael Malakhov
IPC分类号： A61K39/00 , C12N9/36
CPC分类号： B82Y5/00 , A61K38/47 , A61K38/57
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. The invention provides compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. The invention also provides compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。优选的靶细胞是上皮细胞。本发明提供了用于预防病毒性疾病（例如流行性感冒）的组合物和方法，使用具有锚定结构域的化合物，所述化合物具有可结合与细胞外作用以干扰靶细胞的病毒感染的酶活性连接的靶细胞。本发明还提供了用于使用具有锚定结构域的化合物来预防病毒性疾病例如流感的组合物和方法，所述化合物具有可以结合与蛋白酶抑制剂连接的靶细胞，其可以在细胞外作用以干扰靶细胞的病毒感染。

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