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1. 发明授权

US07582303B2 Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E 失效
标题翻译：禽类戊型肝炎病毒，疫苗和防止禽流感 - 脾肿大综合征和哺乳动物性肝炎的方法
公开(公告)号：US07582303B2
公开(公告)日：2009-09-01
申请号：US11184574
申请日：2005-07-19
申请人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
发明人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
IPC分类号： A61K39/29 , C12Q1/70 , C12Q1/68
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/54 , C12N7/00 , C12N2770/28022 , C12N2770/28034 , C12Q1/707 , G01N33/576
摘要： The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns immunogenic compositions comprising this new virus or recombinant products such as the nucleic acid and vaccines that protect an avian or mammalian species from viral infection or hepatitis-splenomegaly syndrome caused by the hepatitis E virus. Also included in the scope of the invention is a method for propagating, inactivating or attenuating a hepatitis E virus comprising inoculating an embryonated chicken egg with a live, pathogenic hepatitis E virus and recovering the virus or serially passing the pathogenic virus through additional embryonated chicken eggs until the virus is rendered inactivated or attenuated. Further, this invention concerns diagnostic reagents for detecting an avian hepatitis E viral infection or diagnosing hepatitis-splenomegaly syndrome in an avian or mammalian species comprising an antibody raised or produced against the immunogenic compositions and antigens such as ORF2 proteins expressed in a baculovirus vector, E. coli, etc. The invention additionally encompasses methods for detecting avian HEV nucleic acid sequences using nucleic acid hybridization probes or oligonucleotide primers for polymerase chain reaction (PCR).
摘要翻译：本发明涉及具有SEQ ID NO：1所示核苷酸序列或其互补链的新颖的分离型禽类戊型肝炎病毒。本发明还涉及包含这种新病毒或重组产物（例如核酸和疫苗）的免疫原性组合物，其保护禽类或哺乳动物物种免受由戊型肝炎病毒引起的病毒感染或肝炎 - 脾肿大综合症。本发明的范围还包括传播，灭活或减毒戊型肝炎病毒的方法，包括用活的致病性戊型肝炎病毒接种含胚鸡蛋，并回收该病毒或通过另外的含胚鸡蛋串联通过病原性病毒直到病毒灭活或减毒。此外，本发明涉及用于检测禽流感病毒感染或诊断禽流感或哺乳动物物种中的肝炎 - 脾肿大综合征的诊断试剂，其包含针对免疫原性组合物产生或产生的抗体，例如杆状病毒载体中表达的ORF2蛋白大肠杆菌等。本发明另外包括使用核酸杂交探针或用于聚合酶链反应（PCR）的寡核苷酸引物检测禽类HEV核酸序列的方法。

2. 发明申请

US20050255461A1 Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E 失效
标题翻译：禽类戊型肝炎病毒，疫苗和防止禽流感 - 脾肿大综合征和哺乳动物性肝炎的方法
公开(公告)号：US20050255461A1
公开(公告)日：2005-11-17
申请号：US11184574
申请日：2005-07-19
申请人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
发明人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
IPC分类号： C07K14/08 , C12N7/00 , C12N15/38 , C12Q1/70 , G01N33/576 , C07H21/04 , C07K14/02
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/54 , C12N7/00 , C12N2770/28022 , C12N2770/28034 , C12Q1/707 , G01N33/576
摘要： The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns immunogenic compositions comprising this new virus or recombinant products such as the nucleic acid and vaccines that protect an avian or mammalian species from viral infection or hepatitis-splenomegaly syndrome caused by the hepatitis E virus. Also included in the scope of the invention is a method for propagating, inactivating or attenuating a hepatitis E virus comprising inoculating an embryonated chicken egg with a live, pathogenic hepatitis E virus and recovering the virus or serially passing the pathogenic virus through additional embryonated chicken eggs until the virus is rendered inactivated or attenuated. Further, this invention concerns diagnostic reagents for detecting an avian hepatitis E viral infection or diagnosing hepatitis-splenomegaly syndrome in an avian or mammalian species comprising an antibody raised or produced against the immunogenic compositions and antigens such as ORF2 proteins expressed in a baculovirus vector, E. coli, etc. The invention additionally encompasses methods for detecting avian HEV nucleic acid sequences using nucleic acid hybridization probes or oligonucleotide primers for polymerase chain reaction (PCR).
摘要翻译：本发明涉及具有SEQ ID NO：1所示核苷酸序列或其互补链的新颖的分离型禽类戊型肝炎病毒。本发明还涉及包含这种新病毒或重组产物（例如核酸和疫苗）的免疫原性组合物，其保护禽类或哺乳动物物种免受由戊型肝炎病毒引起的病毒感染或肝炎 - 脾肿大综合症。本发明的范围还包括传播，灭活或减毒戊型肝炎病毒的方法，包括用活的致病性戊型肝炎病毒接种含胚鸡蛋，并回收该病毒或通过另外的含胚鸡蛋串联通过病原性病毒直到病毒灭活或减毒。此外，本发明涉及用于检测禽流感病毒感染或诊断禽流感或哺乳动物物种中的肝炎 - 脾肿大综合征的诊断试剂，其包含针对免疫原性组合物产生或产生的抗体，例如杆状病毒载体中表达的ORF2蛋白大肠杆菌等。本发明另外包括使用核酸杂交探针或用于聚合酶链反应（PCR）的寡核苷酸引物检测禽类HEV核酸序列的方法。

3. 发明授权

US07005130B2 Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E 失效
公开(公告)号：US07005130B2
公开(公告)日：2006-02-28
申请号：US10029840
申请日：2001-12-31
申请人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
发明人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
IPC分类号： A61K39/29 , C12Q1/70 , C12Q1/68 , C12N15/00 , C12N15/09 , C12N7/00 , C12N7/04 , C07H21/04
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/54 , C12N7/00 , C12N2770/28022 , C12N2770/28034 , C12Q1/707 , G01N33/576
摘要： The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns immunogenic compositions comprising this new virus or recombinant products such as the nucleic acid and vaccines that protect an avian or mammalian species from viral infection or hepatitis-splenomegaly syndrome caused by the hepatitis E virus. Also included in the scope of the invention is a method for propagating, inactivating or attenuating a hepatitis E virus comprising inoculating an embryonated chicken egg with a live, pathogenic hepatitis E virus and recovering the virus or serially passing the pathogenic virus through additional embryonated chicken eggs until the virus is rendered inactivated or attenuated. Further, this invention concerns diagnostic reagents for detecting an avian hepatitis E viral infection or diagnosing hepatitis-splenomegaly syndrome in an avian or mammalian species comprising an antibody raised or produced against the immunogenic compositions and antigens such as ORF2 proteins expressed in a baculovirus vector, E. coli, etc. The invention additionally encompasses methods for detecting avian HEV nucleic acid sequences using nucleic acid hybridization probes or oligonucleotide primers for polymerase chain reaction (PCR).

4. 发明授权

US07842298B2 Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E 有权
标题翻译：禽类戊型肝炎病毒，疫苗和防止禽流感 - 脾肿大综合征和哺乳动物性肝炎的方法
公开(公告)号：US07842298B2
公开(公告)日：2010-11-30
申请号：US12507576
申请日：2009-07-22
申请人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
发明人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
IPC分类号： A16K39/12 , A61K39/29 , C12Q1/70 , C12Q1/68
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/54 , C12N7/00 , C12N2770/28022 , C12N2770/28034 , C12Q1/707 , G01N33/576
摘要： The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns immunogenic compositions comprising this new virus or recombinant products such as the nucleic acid and vaccines that protect an avian or mammalian species from viral infection or hepatitis-splenomegaly syndrome caused by the hepatitis E virus. Also included in the scope of the invention is a method for propagating, inactivating or attenuating a hepatitis E virus comprising inoculating an embryonated chicken egg with a live, pathogenic hepatitis E virus and recovering the virus or serially passing the pathogenic virus through additional embryonated chicken eggs until the virus is rendered inactivated or attenuated. Further, this invention concerns diagnostic reagents for detecting an avian hepatitis E viral infection or diagnosing hepatitis-splenomegaly syndrome in an avian or mammalian species comprising an antibody raised or produced against the immunogenic compositions and antigens such as ORF2 proteins expressed in a baculovirus vector, E. coli, etc. The invention additionally encompasses methods for detecting avian HEV nucleic acid sequences using nucleic acid hybridization probes or oligonucleotide primers for polymerase chain reaction (PCR).
摘要翻译：本发明涉及具有SEQ ID NO：1所示核苷酸序列或其互补链的新颖的分离型禽类戊型肝炎病毒。本发明还涉及包含这种新病毒或重组产物（例如核酸和疫苗）的免疫原性组合物，其保护禽类或哺乳动物物种免受由戊型肝炎病毒引起的病毒感染或肝炎 - 脾肿大综合症。本发明的范围还包括传播，灭活或减毒戊型肝炎病毒的方法，包括用活的致病性戊型肝炎病毒接种含胚鸡蛋，并回收该病毒或通过另外的含胚鸡蛋串联通过病原性病毒直到病毒灭活或减毒。此外，本发明涉及用于检测禽流感病毒感染或诊断禽流感或哺乳动物物种中的肝炎 - 脾肿大综合征的诊断试剂，其包含针对免疫原性组合物产生或产生的抗体，例如杆状病毒载体中表达的ORF2蛋白大肠杆菌等。本发明另外包括使用核酸杂交探针或用于聚合酶链反应（PCR）的寡核苷酸引物检测禽类HEV核酸序列的方法。

5. 发明申请

US20100034845A1 AVIAN HEPATITIS E VIRUS, VACCINES AND METHODS OF PROTECTING AGAINST AVIAN HEPATITIS-SPLENOMEGALY SYNDROME AND MAMMALIAN HEPATITIS E 有权
标题翻译： AVIAN HEPATITIS E病毒，疫苗和防治AVIAN HEPATITIS-SPLENOMEGALY SYNDROME和MAMMALIAN HEPATITIS E的方法
公开(公告)号：US20100034845A1
公开(公告)日：2010-02-11
申请号：US12507576
申请日：2009-07-22
申请人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
发明人： Xiang-Jin Meng , Gholamreza Haqshenas , Fang-Fang Huang
IPC分类号： A61K39/29 , C07H21/04 , C07K14/02 , A61K31/7088 , C12Q1/70
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/54 , C12N7/00 , C12N2770/28022 , C12N2770/28034 , C12Q1/707 , G01N33/576
摘要： The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns immunogenic compositions comprising this new virus or recombinant products such as the nucleic acid and vaccines that protect an avian or mammalian species from viral infection or hepatitis-splenomegaly syndrome caused by the hepatitis E virus. Also included in the scope of the invention is a method for propagating, inactivating or attenuating a hepatitis E virus comprising inoculating an embryonated chicken egg with a live, pathogenic hepatitis E virus and recovering the virus or serially passing the pathogenic virus through additional embryonated chicken eggs until the virus is rendered inactivated or attenuated. Further, this invention concerns diagnostic reagents for detecting an avian hepatitis E viral infection or diagnosing hepatitis-splenomegaly syndrome in an avian or mammalian species comprising an antibody raised or produced against the immunogenic compositions and antigens such as ORF2 proteins expressed in a baculovirus vector, E. coli, etc. The invention additionally encompasses methods for detecting avian HEV nucleic acid sequences using nucleic acid hybridization probes or oligonucleotide primers for polymerase chain reaction (PCR).
摘要翻译：本发明涉及具有SEQ ID NO：1所示核苷酸序列或其互补链的新颖的分离型禽类戊型肝炎病毒。本发明还涉及包含这种新病毒或重组产物（例如核酸和疫苗）的免疫原性组合物，其保护禽类或哺乳动物物种免受由戊型肝炎病毒引起的病毒感染或肝炎 - 脾肿大综合症。本发明的范围还包括传播，灭活或减毒戊型肝炎病毒的方法，包括用活的致病性戊型肝炎病毒接种含胚鸡蛋，并回收该病毒或通过另外的含胚鸡蛋串联通过病原性病毒直到病毒灭活或减毒。此外，本发明涉及用于检测禽流感病毒感染或诊断禽流感或哺乳动物物种中的肝炎 - 脾肿大综合征的诊断试剂，其包含针对免疫原性组合物产生或产生的抗体，例如杆状病毒载体中表达的ORF2蛋白大肠杆菌等。本发明另外包括使用核酸杂交探针或用于聚合酶链反应（PCR）的寡核苷酸引物检测禽类HEV核酸序列的方法。

6. 发明申请

US20190381165A1 Vaccines and Diagnostics for Novel Porcine Orthoreoviruses 审中-公开
公开(公告)号：US20190381165A1
公开(公告)日：2019-12-19
申请号：US16557210
申请日：2019-08-30
申请人： Xiang-Jin Meng , Dianjun Cao , Athmaran Narayanappa
发明人： Xiang-Jin Meng , Dianjun Cao , Athmaran Narayanappa , Elankumaran Subbiah
IPC分类号： A61K39/15 , C07K14/005 , C12N7/00
摘要： Provided herein are diagnostics and vaccines to identify control and prevent novel porcine orthoreovirus type 3 (POV3) isolated from diarrheic feces of piglets from outbreaks in three states and ring-dried swine blood meal from multiple sources.

7. 发明授权

US07517976B2 Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) 失效
标题翻译：从猪繁殖与呼吸综合征病毒（PRRSV）分离的多核酸
公开(公告)号：US07517976B2
公开(公告)日：2009-04-14
申请号：US11369944
申请日：2006-03-08
申请人： Prem S. Paul , Xiang-Jin Meng , Patrick Halbur , Igor Morozov , Melissa A. Lum
发明人： Prem S. Paul , Xiang-Jin Meng , Patrick Halbur , Igor Morozov , Melissa A. Lum
IPC分类号： C07H21/00 , C12N1/00 , C12N5/00 , C12N15/00 , C12P1/00 , C12N15/40
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5254 , A61K2039/543 , A61K2039/552 , C12N7/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , G01N33/56983 , Y10S424/815
摘要： The present invention provides a purified preparation containing a polynucleic acid encoding at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), proteins at least 80% but less than 100% homologous with those encoded by one or more of ORF 2, ORF 3, ORF 4 and ORF 5 of an Iowa strain of PRRSV, proteins at least 97% but less than 100% homologous with proteins encoded by one or both of ORF 6 and ORF 7 of an Iowa strain of PRRSV, antigenic regions of such proteins which are at least 5 amino acids in length and which effectively stimulate immunological protection in a porcine host against a subsequent challenge with a PRRSV isolate, and combinations thereof, in which amino acids non-essential for antigenicity may be conservatively substituted. The present invention also concerns a polypeptide encoded by such a polynucleic acid; a vaccine comprising an effective amount of such a polynucleic acid or protein; antibodies which specifically bind to such a polynucleic acid or protein; methods of producing the same; and methods of raising an effective immunological response against a PRRSV, treating a pig infected by a PRRSV, and detecting a PRRSV.
摘要翻译：本发明提供了一种纯化的制剂，其含有编码选自由爱滋病猪繁殖与呼吸综合征病毒（PRRSV）的一个或多个开放阅读框（ORF's）编码的蛋白质的至少一种多肽的多核苷酸，蛋白质与由PRRSV的爱荷华菌株的ORF 2，ORF 3，ORF 4和ORF 5中的一种或多种编码的那些编码的至少80％但小于100％的同源物，与编码的蛋白质至少97％但小于100％同源的蛋白质由PRRSV的爱荷华菌株的ORF 6和ORF 7中的一个或两个，长度为至少5个氨基酸的这种蛋白质的抗原性区域，并且其有效地刺激猪宿主中的免疫保护，免于随后用PRRSV分离物攻击，及其组合，其中对于抗原性不是必需的氨基酸可以被保守地取代。本发明还涉及由这种多核酸编码的多肽; 包含有效量的这样的多核酸或蛋白质的疫苗; 特异性结合这种多核酸或蛋白质的抗体; 生产方法; 以及提高针对PRRSV的有效免疫应答，治疗由PRRSV感染的猪和检测PRRSV的方法。

8. 发明授权

US5695766A Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome 失效
标题翻译：在猪和疫苗中产生病变的高毒性猪繁殖和呼吸综合征病毒，可保护猪免受所述综合征
公开(公告)号：US5695766A
公开(公告)日：1997-12-09
申请号：US131625
申请日：1993-10-05
申请人： Prem S. Paul , Patrick G. Halbur , Xiang-Jin Meng , Young S. Lyoo , Melissa Anne Lum
发明人： Prem S. Paul , Patrick G. Halbur , Xiang-Jin Meng , Young S. Lyoo , Melissa Anne Lum
IPC分类号： G01N33/53 , A61K39/00 , A61K39/12 , A61P31/04 , A61P31/12 , C07K7/08 , C07K14/00 , C07K14/01 , C07K14/08 , C07K16/00 , C12N7/00 , C12N15/09 , C12N15/40 , C12P21/02 , C12P21/08 , G01N33/569 , A61K39/145 , C12N7/02 , C12N7/06 , C12N7/08
CPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , G01N33/56983 , A61K2039/5254 , A61K2039/543 , A61K2039/552 , A61K39/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , Y10S424/815
摘要： The present invention provides a vaccine which protects pigs from a virus and/or an infectious agent causing a porcine respiratory and reproductive disease, a method of protecting a pig from a disease caused by a virus and/or an infectious agent which causes a respiratory and reproductive disease, a method of producing a vaccine against a virus and/or an infectious agent causing a porcine reproductive and respiratory disease, and a biologically pure sample of a virus and/or infectious agent associated with a porcine respiratory and reproductive disease, particularly the Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), and an isolated polynucleotide which is at least 90% homologous with a polynucleotide obtained from the genome of a virus and/or infectious agent which causes a porcine respiratory and reproductive disease.
摘要翻译：本发明提供了一种保护猪免受引起猪呼吸和生殖疾病的病毒和/或感染因子的疫苗，一种保护猪免受由病毒引起的疾病和/或传染性疾病引起呼吸和生殖疾病，产生针对病毒和/或引起猪繁殖和呼吸系统疾病的感染性疾病的疫苗的方法，以及与猪呼吸和生殖疾病相关的病毒和/或感染因子的生物学纯样本，特别是猪繁殖和呼吸综合征病毒（PRRSV）的衣阿华菌株和与从引起猪呼吸和生殖疾病的病毒和/或感染因子的基因组获得的多核苷酸至少90％同源的分离的多核苷酸。

9. 发明申请

US20160129103A1 CHIMERIC INFECTIOUS DNA CLONES, CHIMERIC PORCINE CIRCOVIRUSES AND USES THEREOF 审中-公开
公开(公告)号：US20160129103A1
公开(公告)日：2016-05-12
申请号：US14940799
申请日：2015-11-13
申请人： Xiang-Jin Meng , Martijn Fenaux , Patrick G. Halbur
发明人： Xiang-Jin Meng , Martijn Fenaux , Patrick G. Halbur
IPC分类号： A61K39/12 , C12N7/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.

10. 发明授权

US09132185B2 Modified live-attenuated vaccines (MLV) created by DNA shuffling against porcine reproductive and respiratory syndrome virus (PRRSV) 有权
标题翻译：通过针对猪生殖和呼吸综合征病毒（PRRSV）的DNA改组产生的改良的减毒疫苗（MLV）
公开(公告)号：US09132185B2
公开(公告)日：2015-09-15
申请号：US13701729
申请日：2011-06-02
申请人： Yanyan Ni , Yaowei Huang , Xiang-Jin Meng
发明人： Yanyan Ni , Yaowei Huang , Xiang-Jin Meng
IPC分类号： A61K39/12 , C12N7/00 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N7/00 , C12N2770/10034 , C12N2770/10052
摘要： The present invention provides a novel infectious cDNA clone of porcine reproductive and respiratory syndrome virus (PRRSV), particularly for PRRSV strain VR2385; an improved DNA-launched reverse genetics system for PRRSV; infectious chimeric PRRSV viruses generated through DNA shuffling; modified live-attenuated virus vaccines (MLV) using DNA shuffled chimeric viruses; chimeric viral proteins produced through shuffled chimeric viruses; PRRSV antigens and subunit vaccines based on shuffled chimeric viral proteins; and method of producing broadly protective PRRSV vaccines using DNA shuffling techniques.
摘要翻译：本发明提供猪繁殖与呼吸综合征病毒（PRRSV）的新型感染性cDNA克隆，特别是PRRSV株VR2385的感染性cDNA克隆; 用于PRRSV的改进的DNA推出的反向遗传学系统; 通过DNA改组产生的感染性嵌合PRRSV病毒; 使用DNA洗牌嵌合病毒的改良的活减毒病毒疫苗（MLV）; 通过混洗嵌合病毒产生的嵌合病毒蛋白; 基于混洗嵌合病毒蛋白的PRRSV抗原和亚单位疫苗; 以及使用DNA改组技术生产广泛保护性PRRSV疫苗的方法。

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