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1. 发明授权

US09284330B2 1,4-dihydro-naphthyridine derivative and pharmaceutical composition and use thereof 有权
标题翻译： 1,4-二氢 - 萘啶衍生物及其药物组合物及其用途
公开(公告)号：US09284330B2
公开(公告)日：2016-03-15
申请号：US14362735
申请日：2012-12-07
申请人： Rong Chen , Lin Feng , Zhengping Zhang , Fang Fang , Qingli Dong , Fulong Li , Lei Wang , Yao Hua , Shibao Yang , Peng Wang
发明人： Rong Chen , Lin Feng , Zhengping Zhang , Fang Fang , Qingli Dong , Fulong Li , Lei Wang , Yao Hua , Shibao Yang , Peng Wang
IPC分类号： C07D495/14 , C07D471/14 , C07D471/04 , C07D471/12 , C07D491/14
CPC分类号： C07D495/14 , C07D471/04 , C07D471/12 , C07D471/14 , C07D491/14
摘要： Disclosed are 1,4-dihydro-naphthyridine derivatives and pharmaceutical composition and uses thereof. The 1,4-dihydro-naphthyridine derivatives are a compound capable of inhibiting acetylcholinesterase activity and preventing extracellular calcium from flowing into a cell via a calcium channel, i.e., having a dual-activity, which are of potential importance as a pharmaceutical and can be used to prepare the drugs for treating cardiovascular diseases, cerebrovascular diseases and dementia.
摘要翻译：公开了1,4-二氢 - 萘啶衍生物及其药物组合物及其用途。 1,4-二氢 - 萘啶衍生物是能够抑制乙酰胆碱酯酶活性并防止细胞外钙通过钙通道流入细胞的化合物，即具有作为药物具有潜在重要性的双重活性，可以是用于制备治疗心血管疾病，脑血管疾病和痴呆症的药物。

2. 发明申请

US20150132151A1 WATER LEVEL FLOW SPEED-INCREASING GENERATING STATION, POWER STATION, WATER SUPPLY STATION, AND OFFSHORE FLOATING CITY 审中-公开
标题翻译：水位流量增速发电站，电站，供水站和海上浮动城市
公开(公告)号：US20150132151A1
公开(公告)日：2015-05-14
申请号：US14476244
申请日：2014-09-03
申请人： Zupeng FANG , Dan FANG , Yafeng ZHAO , Lei WANG , Fang FANG
发明人： Zupeng FANG , Dan FANG , Yafeng ZHAO , Lei WANG , Fang FANG
IPC分类号： F04D1/00
CPC分类号： F04D1/00 , F03B17/06 , F05B2240/132 , F05B2240/133 , F05B2240/93 , F05B2240/931 , F05B2240/97 , Y02E10/28
摘要： The present invention relates to the field of hydraulic machinery, and relates to, by using the law of motion conversion and Bernoulli's equation, a generating station formed with a water level speed-increasing water tunnel set on a special ship or offshore floating city increasing a natural flow velocity V1≦1 msec of a water source to a high speed of V2≧200 msec to propel a turbine, and drive a generator; a power station formed with the turbine driving various load machinery; and a water supply station formed with an outlet of the speed-increasing water tunnel being connected to a lift tube. Hence, the present invention can replace high dams of a small number, to convert planar flow dynamics of wide rivers, seas, and oceans into inexhaustible, cheap, clean, and sustainable energy, which is a major theme project of the third industrial revolution.
摘要翻译：本发明涉及液压机械领域，并且涉及通过使用运动转换定律和伯努利方程式，一个发电站形成了一个设置在特殊船舶或海上浮动城市上的水位加速水道自然流速V1＆nlE; 1毫秒的水源到V2的高速≥200毫秒，以推动涡轮，并驱动发电机; 用涡轮驱动各种负载机械形成的电站; 并且形成有加速水道的出口的供水站连接到提升管。因此，本发明可以取代少数几座水坝，将宽阔的河流，海洋和海洋的平面流动动力转化成为第三次工业革命的重大课题的不竭，廉价，清洁，可持续的能源。

3. 发明授权

US08729303B2 2,2′,6,6′-tetrasubstituted aminophosphine ligand and its synthesis method 有权
标题翻译： 2,2'，6,6'-四取代氨基膦配体及其合成方法
公开(公告)号：US08729303B2
公开(公告)日：2014-05-20
申请号：US12377000
申请日：2007-08-10
申请人： Wanbin Zhang , Fang Xie , Fang Fang
发明人： Wanbin Zhang , Fang Xie , Fang Fang
IPC分类号： C07F9/02
CPC分类号： C07F9/46
摘要： The present invention relates to a 2,2′,6,6′-tetrasubstituted aminophosphine ligand and its synthesis method. The structure of the ligand is shown as below. Its synthesis method comprises: Step (1) coupling 2,6-dinitrochlorobenzene as the starting material to obtain 2,2′,6,6′-tetranitrobiphenyl; Step (2): hydrogenating the 2,2′,6,6′-tetranitrobiphenyl with Pd/C to obtain 2,2′,6,6′-tetraminobiphenyl; Step (3): reacting the 2,2′,6,6′-tetraminobiphenyl with a phosphine halide to obtain the 2,2′,6,6′-tetrasubstituted aminophosphine ligand. The ligand of the present invention is an achiral compound, and its preparation method is simple. The ligand can be converted to a chiral bimetallic catalyst with single configuration eventually through introduction of external chirality. Moreover, the ligand can be used in various asymmetric reaction catalyzed by metals with high reactivity and stereoselectivity.
摘要翻译：本发明涉及2,2'，6,6'-四取代氨基膦配体及其合成方法。配体的结构如下所示。其合成方法包括：步骤（1）以2,6-二硝基氯苯为原料，得到2,2'，6,6'-四硝基联苯; 步骤（2）：用Pd / C氢化2,2'，6,6'-四硝基二苯并得到2,2'，6,6'-四氨基联苯; 步骤（3）：使2,2'，6,6'-四磺酰联苯与卤化膦反应，得到2,2'，6,6'-四取代氨基膦配体。本发明的配体是非手性化合物，其制备方法简单。最终可以通过引入外部手性将配体转化为具有单一配置的手性双金属催化剂。此外，配体可用于由具有高反应性和立体选择性的金属催化的各种不对称反应中。

4. 发明申请

US20130156703A1 Methods, Compounds, and Compositions For Treatment and Prophylaxis in the Respiratory Tract 审中-公开
公开(公告)号：US20130156703A1
公开(公告)日：2013-06-20
申请号：US13769095
申请日：2013-02-15
申请人： Fang Fang , David Wurtman , Ron Moss , Michael Malakhov
发明人： Fang Fang , David Wurtman , Ron Moss , Michael Malakhov
IPC分类号： A61K38/47
CPC分类号： A61K38/47 , A61K9/0014 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K9/0073 , A61K9/06 , A61K31/05 , A61K31/198 , A61K31/4172 , A61K31/7016 , A61K33/06 , A61K33/14 , A61K38/1808 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/34 , A61K49/0008 , C07K14/485 , C07K2319/00 , C12N9/2402 , C12N9/2477 , C12Q1/34 , C12Y302/01018 , G01N2500/00 , G01N2800/122 , A61K2300/00
摘要： The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes administering to the subject a compound or composition containing a therapeutically effective amount of a fusion protein comprising a sialidase or an active portion thereof and an anchoring domain. The therapeutically effective amount comprises an amount of the fusion protein that results in a reduction of the quanitity of mucus in the respiratory tract after administration of the compound or composition when compared to the quantity of mucus present prior to administration of the compound or composition.

5. 发明授权

US07696324B2 Humanized antibodies 失效
标题翻译：人源化抗体
公开(公告)号：US07696324B2
公开(公告)日：2010-04-13
申请号：US11519322
申请日：2006-09-11
申请人： Fang Fang , Lori Kohlstaedt , John Reno
发明人： Fang Fang , Lori Kohlstaedt , John Reno
IPC分类号： C07K16/28 , C12P21/08
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2821 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C07K2319/00 , Y02A50/412
摘要： Humanized antibodies that bind ICAM-1 are provided. Antibodies include those selected from: SEQ ID NO:1 and 3 (HumA); SEQ ID NO:5 and 7 (HumB); SEQ ID NO:9 and 11 (HumC); SEQ ID NO:13 and 15 (HumD); SEQ ID NO:17 and 19 (HumE); SEQ ID NO:21 and 23 (HumF); SEQ ID NO:25 and 27 (HumG); SEQ ID NO:29 and 31 (HumH); and SEQ ID NO:33 and 35 (HumI). Subsequences of the humanized antibodies capable of binding an ICAM-1 epitope are also provided. Methods of inhibiting pathogen infection (e.g., HRV) of a cell employing humanized antibodies capable of binding an ICAM-1 epitope are further provided.
摘要翻译：提供了结合ICAM-1的人源化抗体。抗体包括选自：SEQ ID NO：1和3（HumA）的那些; SEQ ID NO：5和7（HumB）; SEQ ID NO：9和11（HumC）; SEQ ID NO：13和15（HumD）; SEQ ID NO：17和19（HumE）; SEQ ID NO：21和23（HumF）; SEQ ID NO：25和27（HumG）; SEQ ID NO：29和31（HumH）; 和SEQ ID NO：33和35（HumI）。还提供了能够结合ICAM-1表位的人源化抗体的子序列。还提供了使用能够结合ICAM-1表位的人源化抗体抑制细胞病原体感染（例如HRV）的方法。

6. 发明授权

US07672165B2 Methods for active boosting to minimize capacitive coupling effect between adjacent gates of flash memory devices 有权
标题翻译：用于主动升压以最小化闪存器件的相邻栅极之间的电容耦合效应的方法
公开(公告)号：US07672165B2
公开(公告)日：2010-03-02
申请号：US12031640
申请日：2008-02-14
申请人： Tuan D Pham , Masaaki Higashitani , Hao Fang Fang , Gerrit Jan Hemink
发明人： Tuan D Pham , Masaaki Higashitani , Hao Fang Fang , Gerrit Jan Hemink
IPC分类号： G11C16/00
CPC分类号： G11C16/0483 , H01L23/5222 , H01L27/105 , H01L27/115 , H01L27/11526 , H01L27/11534 , H01L2924/0002 , H01L2924/00
摘要： A NAND flash memory device incorporates a unique booster plate design. The booster plate is biased during read and program operations and the coupling to the floating gates in many cases reduces the voltage levels necessary to program and read the charge stored in the gates. The booster plate also shields against unwanted coupling between floating gates. Self boosting, local self boosting, and erase area self boosting modes used with the unique booster plate further improve read/write reliability and accuracy. A more compact and reliable memory device can hence be realized according to the present invention.
摘要翻译： NAND闪存器件采用独特的增压板设计。升压板在读取和编程操作期间被偏置，并且在许多情况下与浮动栅极的耦合降低了编程和读取存储在门中的电荷所需的电压电平。升压板还屏蔽浮动栅极之间的不必要的耦合。自升压，局部自升压，以及独特升压板使用的擦除区域自升压模式，进一步提高了读/写可靠性和精度。因此，根据本发明可以实现更紧凑和可靠的存储器件。

7. 发明申请

US20090195089A1 Mover of a Linear Motor with an Outer Heat Radiating Housing 审中-公开
标题翻译：具有外热辐射壳体的直线电机的移动器
公开(公告)号：US20090195089A1
公开(公告)日：2009-08-06
申请号：US12024095
申请日：2008-01-31
申请人： Lieh-Feng HUANG , Fang-Fang Tai
发明人： Lieh-Feng HUANG , Fang-Fang Tai
IPC分类号： H02K9/22 , H02K41/02 , H02K5/04
CPC分类号： H02K41/02 , H02K5/18 , H02K5/20
摘要： A mover of a linear motor with an outer heat radiating housing comprises a body and an outer heat radiating housing. The body includes an iron core and coils. The outer heat radiating housing covers the body and is integrally jointed to the body. The outer heat radiating housing is defined with a plurality of passages. When the current is supplied to the coils of the body, the body will be driven, the heat energy produced by the body can be conducted to the outer heat radiating housing sufficiently. In addition, after the cooling liquid is conducted to the passages, the heat radiating effect of the mover can be improved.
摘要翻译：具有外部散热壳体的线性电动机的动子包括主体和外部散热壳体。身体包括铁芯和线圈。外部散热壳体覆盖主体并且一体地连接到主体。外部散热壳体限定有多个通道。当电流被提供给主体的线圈时，主体将被驱动，由主体产生的热能可以充分地传导到外部散热壳体。此外，在将冷却液引导到通道之后，可以提高动子的散热效果。

8. 发明申请

US20090046830A1 Computerized tomography image reconstruction 有权
标题翻译：计算机断层扫描图像重建
公开(公告)号：US20090046830A1
公开(公告)日：2009-02-19
申请号：US12287514
申请日：2008-10-10
申请人： Fang-Fang Yin
发明人： Fang-Fang Yin
IPC分类号： A61B6/00
CPC分类号： A61B6/482 , A61B6/032 , A61B6/466 , A61B6/583
摘要： Systems and methods include coordinated (KV) and megaelectronvolt (MV) computerized tomography (CT) imaging. KV and MV data are combined using a normalization process in order to generate CT images. The resulting CT images can include an improved signal to noise ratio in comparison to CT images generated using either KV or MV imaging alone. The coordinated KV and MV imaging process may be accomplished in significantly less time than using KV or MV imaging alone. This time savings has advantages in treatment verification. The MV projections are optionally generated using MV x-rays configured for x-ray treatment. In these cases the combined projections will reflect the treatment volume.
摘要翻译：系统和方法包括协调（KV）和兆伏特（MV）计算机断层摄影（CT）成像。使用归一化处理来组合KV和MV数据以产生CT图像。与使用KV或MV成像单独产生的CT图像相比，所得到的CT图像可以包括改善的信噪比。协调的KV和MV成像过程可以在比单独使用KV或MV成像的时间更短的时间内完成。这次节省在治疗验证中有优势。可以使用配置用于X射线处理的MV x射线来生成MV投影。在这些情况下，组合预测将反映治疗量。

9. 发明授权

US07453976B1 Computerized tomography image reconstruction 有权
标题翻译：计算机断层扫描图像重建
公开(公告)号：US07453976B1
公开(公告)日：2008-11-18
申请号：US11193160
申请日：2005-07-29
申请人： Fang-Fang Yin
发明人： Fang-Fang Yin
IPC分类号： G01N23/00
CPC分类号： A61B6/482 , A61B6/032 , A61B6/466 , A61B6/583
摘要： Systems and methods include coordinated (KV) and megaelectronvolt (MV) computerized tomography (CT) imaging. KV and MV data are combined using a normalization process in order to generate CT images. The resulting CT images can include an improved signal to noise ratio in comparison to CT images generated using either KV or MV imaging alone. The coordinated KV and MV imaging process may be accomplished in significantly less time than using KV or MV imaging alone. This time savings has advantages in treatment verification. The MV projections are optionally generated using MV x-rays configured for x-ray treatment. In these cases the combined projections will reflect the treatment volume.
摘要翻译：系统和方法包括协调（KV）和兆伏特（MV）计算机断层摄影（CT）成像。使用归一化处理来组合KV和MV数据以产生CT图像。与使用KV或MV成像单独产生的CT图像相比，所得到的CT图像可以包括改善的信噪比。协调的KV和MV成像过程可以在比单独使用KV或MV成像的时间更短的时间内完成。这次节省在治疗验证中有优势。可以使用配置用于X射线处理的MV x射线来生成MV投影。在这些情况下，组合预测将反映治疗量。

10. 发明授权

US07419982B2 Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts 失效
标题翻译：结晶形式的5-氯-6- {2,6-二氟-4- [3-（甲基氨基）丙氧基]苯基} -N - [（1S）-2,2,2-三氟-1-甲基乙基] [1 ，2,4]三唑并[1,5-a]嘧啶-7-胺盐
公开(公告)号：US07419982B2
公开(公告)日：2008-09-02
申请号：US11437291
申请日：2006-05-19
申请人： Fang Fang Qi , Mannching Sherry Ku , Yanzhong Wu , David M. Blum
发明人： Fang Fang Qi , Mannching Sherry Ku , Yanzhong Wu , David M. Blum
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts; processes for the production thereof; pharmaceutical compositions thereof; and methods for inhibiting tumor growth therewith.
摘要翻译：本发明涉及5-氯-6- {2,6-二氟-4- [3-（甲基氨基）丙氧基]苯基} -N - [（1S）-2,2,2-三氟-1- - 甲基乙基] [1,2,4]三唑并[1,5-a]嘧啶-7-胺盐; 生产过程; 其药物组合物; 以及抑制肿瘤生长的方法。

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