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31. 发明申请

US20030073829A1 METHODS OF IDENTIFYING OF SCREENING FOR AGENTS THAT BINDS THE OB-Re 失效
标题翻译：识别OB-Re的药剂筛选方法
公开(公告)号：US20030073829A1
公开(公告)日：2003-04-17
申请号：US09116676
申请日：1998-07-16
发明人： NIKA ADHAM , BETH BOROWSKY , NIGEL LEVENS , RADEK C. SKODA
IPC分类号： A01N037/18 , A61K038/00 , C07H021/04 , A61K031/70 , A01N043/04 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74 , C07K005/00 , C07K007/00 , C07K016/00 , C07K017/00 , C12N005/00 , C12N005/02 , C12N005/06 , C12N005/10 , C12N015/85 , C12N015/87
CPC分类号： A61K31/70 , A61K38/00 , C07K14/705 , C12N2799/026
摘要： This invention provides an isolated nucleic acid encoding a polypeptide, a purified polypeptide, vectors comprising isolated nucleic acid encoding a polypeptide, cells comprising such vectors, antibodies directed to a polypeptide, nucleic acid probes useful for detecting nucleic acid encoding a polypeptide, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a polypeptide, nonhuman transgenic animals which express DNA encoding a normal or a mutant polypeptide, methods of isolating a polypeptide, methods of treatment eating disorders as well as methods of determining binding of compounds to polypeptides.
摘要翻译：本发明提供了编码多肽的分离的核酸，纯化的多肽，包含分离的编码多肽的核酸，包含此类载体的细胞，针对多肽的抗体，可用于检测编码多肽的核酸的核酸探针，反义寡核苷酸互补编码多肽的独特的核酸序列，表达编码正常或突变多肽的DNA的非人类转基因动物，分离多肽的方法，进食障碍的治疗方法以及确定化合物与多肽结合的方法。

32. 发明申请

US20030073232A1 Methods and vector constructs useful for production of recombinant AAV 有权
公开(公告)号：US20030073232A1
公开(公告)日：2003-04-17
申请号：US10255527
申请日：2002-09-26
申请人： The Trustees of the University of Pennsylvania
发明人： James M. Wilson , Weidong Xiao
IPC分类号： C07H021/04 , A61K039/12 , C12N007/00 , C12N007/01 , C12N007/02 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74 , C12N005/06 , C12N005/16
CPC分类号： C12N15/86 , C12N2750/14143
摘要： Methods for efficient production of recombinant AAV employ a host cell containing a first nucleic acid molecule comprising from 5null to 3null, a parvovirus P5 promoter, a spacer, an AAV rep sequence and an AAV cap gene sequence, wherein said spacer is of sufficient size to reduce expression of the rep78 and rep68 gene products; a second nucleic acid molecule comprising a minigene comprising a transgene flanked by AAV inverse terminal repeats (ITRs) and under the control of regulatory sequences directing expression thereof in a host cell; and helper functions essential to the replication and packaging of rAAV, which functions are not provided by the first or second nucleic acid molecules. Host cells and molecule constructs are also described.

33. 发明申请

US20030073159A1 HUMAN INHIBITOR OF APOPTOSIS GENE 1 无效
标题翻译：人类基因抑制剂1
公开(公告)号：US20030073159A1
公开(公告)日：2003-04-17
申请号：US08464588
申请日：1995-06-05
申请人： Human Genome Sciences, Inc.
发明人： WEI W HE , PETER L. HUDSON , CRAIG A. ROSEN
IPC分类号： C07H021/02 , C07H021/04 , A61K031/70 , A01N043/04 , C12P021/06 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74 , C12N005/00 , C12N005/02
CPC分类号： C07K14/4747 , A61K38/00
摘要： A human inhibitor of apoptosis polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of degenerative diseases, rheumatoid arthritis, septic shock, as an antiviral defense mechanism and to prevent the death of cells during trauma and strokes. Antagonists against such polypeptides and their use as a therapeutic to promote cell development, kill viral infections, promote tissue differentiation and development and maintain tissue homeostasis are also disclosed (tumors). Diagnostic methods for detecting mutations in the nucleic acid sequence encoding hIAP-1 protein are also disclosed.
摘要翻译：公开了编码这种多肽的凋亡多肽的人抑制剂和DNA（RNA），以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽治疗退行性疾病，类风湿性关节炎，败血性休克作为抗病毒防御机制并防止创伤和中风期间细胞死亡的方法。还公开了抗这些多肽的拮抗剂及其作为促进细胞发育，杀死病毒感染，促进组织分化和发育并维持组织体内平衡的治疗剂的用途（肿瘤）。还公开了用于检测编码hIAP-1蛋白的核酸序列中的突变的诊断方法。

34. 发明申请

US20030059934A1 Artificial chromosomes comprising EHV sequences 审中-公开
公开(公告)号：US20030059934A1
公开(公告)日：2003-03-27
申请号：US10105828
申请日：2002-03-25
发明人： Nikolaus Osterrieder , Jens Rudolph
IPC分类号： C12P021/06 , A61K039/12 , A61K039/245 , A61K039/255 , A61K039/265 , A61K039/27 , C12N007/00 , C12N007/01 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74 , C12N005/00 , C12N005/02
CPC分类号： C12N15/86 , A61K2039/5256 , C12N7/00 , C12N2710/16661 , C12N2710/16743 , C12N2710/16761 , C12N2800/204
摘要： The invention belongs to the field of animal health, in particular equine diseases caused by equine herpesvirus (EHV). The invention relates to artificial chromosomes comprising the genome of equine herpesviruses, methods of producing attenuated or virulent EHV with or without the insertion of foreign genes, EHV obtainable with said methods and pharmaceutical compositions comprising said viruses.

35. 发明申请

US20030049829A1 Concentration and lysis of adenovirus-infected cells in a single unit operation 失效
标题翻译：腺病毒感染细胞在单个手术中的浓缩和裂解
公开(公告)号：US20030049829A1
公开(公告)日：2003-03-13
申请号：US10085029
申请日：2002-03-01
发明人： Thomas J. Monica , Erik M. Whiteley
IPC分类号： A61K039/12 , A61K039/23 , A61K039/235 , C12N007/00 , C12N007/01 , C12N007/02 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74 , C12N005/00 , C12N005/02
CPC分类号： C12N15/86 , A61K48/00 , C12N1/066 , C12N7/00 , C12N2710/10351
摘要： A method is described to prepare intracellular biological entities (e.g. organisms, such as, e.g., viruses, particularlyAdenoviruses; organelles, or biological molecules), comprising subjecting cells containing the biological entities to continuous centrifugation, under conditions effective to concentrate the cells into a cell pellet; and ej ecting the pelleted cells from the centrifuge into a collection receptacle, under conditions effective to lyse cells; wherein no further steps effective to achieve cell lysis are performed.
摘要翻译：描述了一种制备细胞内生物实体（例如生物体，例如病毒，特别是腺病毒，细胞器或生物分子）的方法，包括在有效浓缩细胞进入细胞的条件下使包含生物实体的细胞连续离心颗粒并在有效裂解细胞的条件下将沉淀的细胞从离心机中收集到收集容器中; 其中不进行有效实现细胞裂解的其它步骤。

36. 发明申请

US20030040039A1 METHODS OF TREATING DIABETES MELLITUS WITH OB POLYPEPTIDES 失效
标题翻译：用OB多糖处理糖尿病的方法
公开(公告)号：US20030040039A1
公开(公告)日：2003-02-27
申请号：US09316393
申请日：1999-05-21
发明人： JEFFREY M. FRIEDMAN , YIYING ZHANG , RICARDO PROENCA
IPC分类号： C12P021/06 , C07K017/00 , C07K014/00 , C07K001/00 , C12N005/02 , C12N005/00 , C12N015/74 , C12N015/70 , C12N015/63 , C12N015/09 , C12N015/00 , A61K039/395 , A61K045/00 , C07H021/04 , G01N033/567 , A01N037/18 , A61K038/00 , G01N033/53
CPC分类号： C07K14/5759 , A01K2217/05 , A61K8/64 , A61K38/00 , A61K48/00 , A61Q19/06 , C07K16/18 , C07K2319/00 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , Y10S514/866 , Y10S514/909 , Y10S930/12 , Y10S930/14
摘要： The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulators may be put. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone. The present invention further provides nucleic acid molecules for use as molecular probes, or as primers for polymerase chain reaction (PCR) amplification, i.e., synthetic or natural oligonucleotides. In further aspects, the present invention provides a cloning vector, which comprises the nucleic acids of the invention; and a bacterial, insect, or a mammalian expression vector, which comprises the nucleic acid molecules of the invention, operatively associated with an expression control sequence. Accordingly, the invention further relates to a bacterial cell or a mammalian transfected or transformed with an appropriate expression vector, and correspondingly, to the use of the above mentioned constructs in the preparation of the modulators of the invention. Also provided are antibodies to the ob polypeptide. Moreover, a method for modulating body weight of a mammal is provided. In specific examples, genes encoding two isoforms of both the murine and human ob polypeptides are provided.
摘要翻译：本发明一般涉及包括哺乳动物和人在内的动物的体重控制，更具体地说，涉及本文中鉴定为重量调节剂的材料，以及可以将这些调节剂置于其上的诊断和治疗用途。在其最广泛的方面，本发明涉及阐明和发现核苷酸序列和由这些核苷酸或其简并变异体推测表达的蛋白质，其表现出参与控制哺乳动物体重的能力。物体中的核苷酸序列代表了对应于鼠和人类ob基因的基因，这些基因被假定在调节体重和肥胖中起关键作用。本文提供的初步数据表明，所讨论的基因的多肽产物作为激素起作用。本发明还提供用作分子探针的核酸分子，或用作聚合酶链反应（PCR）扩增的引物，即合成或天然寡核苷酸。在另外的方面，本发明提供了一种克隆载体，其包含本发明的核酸; 和细菌，昆虫或哺乳动物表达载体，其包含与表达调控序列有效连接的本发明的核酸分子。因此，本发明还涉及用合适的表达载体转染或转化的细菌细胞或哺乳动物，并且相应地涉及在制备本发明的调节剂中使用上述构建体。还提供了针对ob多肽的抗体。此外，提供了一种用于调节哺乳动物体重的方法。在具体实例中，提供编码鼠和人类ob多态的两种同种型的基因。

37. 发明申请

US20030032790A1 NOVEL VITAMIN D RECEPTOR RELATED POLYPEPTIDES, NUCLEIC ACID SEQUENCE ENCODING THE SAME AND USES THEREOF 失效
标题翻译：新维生素D受体相关多肽，编码其的核酸序列及其用途
公开(公告)号：US20030032790A1
公开(公告)日：2003-02-13
申请号：US09143828
申请日：1998-08-31
发明人： ANDERS BERKENSTAM , MATS DAHLBERG
IPC分类号： C12Q001/68 , G01N033/53 , C07H021/04 , A61K031/70 , A01N043/04 , C12P021/06 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74 , C12N005/00 , C12N005/02
CPC分类号： C07K14/721 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The present invention relates to novel vitamin D receptor related (VDRR) polypeptides, and formulations containing the same. Nucleic acid sequences encoding the VDRR polypeptides, expression vectors containing such sequences and host cells transformed with such expression vectors are also disclosed, as are methods for the expression of the novel VDRR polypeptides of the invention. The invention further relates to VDRR polypeptides for use as medicaments, and use of substances affecting VDRR signal transduction for the manufacture of medicaments for treating metabolic, proliferative or inflammatory conditions. The present invention also relates to methods for identifying clones encoding a VDRR polypeptide, methods for identifing ligands to a VDRR and methods for identifying substances for treatment of conditions affected by a VDRR polypeptide. More specifically, the novel VDRR polypeptide can be the polypeptide designated VDRRnull, which may be regulated by any small chemical molecule similar in structure to known ligands for nuclear receptors.
摘要翻译：本发明涉及新型的维生素D受体相关（VDRR）多肽及其制剂。还公开了编码VDRR多肽的核酸序列，含有这些序列的表达载体和用这种表达载体转化的宿主细胞，以及用于表达本发明的新型VDRR多肽的方法。本发明还涉及用作药物的VDRR多肽，以及影响VDRR信号转导的物质用于制备用于治疗代谢，增殖或炎性疾病的药物的用途。本发明还涉及用于鉴定编码VDRR多肽的克隆的方法，用于鉴定VDRR的配体的方法以及鉴定用于治疗受VDRR多肽影响的病症的物质的方法。更具体地，新型VDRR多肽可以是称为VDRRγ的多肽，其可以由结构上与核受体的已知配体相似的任何小的化学分子调节。

38. 发明申请

US20030022284A1 Uses of GDNF and GDNF receptor 有权
标题翻译：使用GDNF和GDNF受体
公开(公告)号：US20030022284A1
公开(公告)日：2003-01-30
申请号：US10033350
申请日：2001-11-02
发明人： Robert D. Klein , Mark W. Moore , Arnon Rosenthal , Anne M. Ryan
IPC分类号： G01N033/53 , G01N033/567 , C12P021/08 , C07K016/00 , C07K017/00 , C07K014/00 , C07K001/00 , C12N005/02 , C12N005/00 , C12N015/74 , C12N015/70 , C12N015/63 , C12N015/09 , C12N015/00 , C12P021/06
CPC分类号： C07K14/71 , A01K2217/05 , A61K38/00 , C07K16/22 , C07K2319/00
摘要： GDNFRnull, GDNFRnull extracellular domain (ECD), GDNFRnull variants, chimeric GDNFRnull (e.g., GDNFRnull immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFRnull-ligands, for example GDNF, by providing GDNFRnull to the cell. Also provided are methods for using GDNFRnull, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.
摘要翻译：公开了GDNFRalpha，GDNFRalpha细胞外结构域（ECD），GDNFRalpha变体，嵌合GDNFRα（例如，GDNFRα免疫粘附素）和与其结合的抗体（包括激动剂和中和抗体）。描述了这些分子的各种用途，包括通过向细胞提供GDNFRα来调节对GDNFRα-配体（例如GDNF）的响应来调节细胞活性和存活的方法。还提供了分别或复合的使用GDNFRalpha，GDNF或其激动剂来治疗肾脏疾病的方法。

39. 发明申请

US20030013183A1 FELINE IMMUNOGLOBULIN E MOLECULES AND RELATED METHODS 有权
标题翻译： FELINE IMMUNOGLOBULE E分子及相关方法
公开(公告)号：US20030013183A1
公开(公告)日：2003-01-16
申请号：US09479614
申请日：2000-01-07
发明人： CATHERINE MCCALL , ERIC WEBER
IPC分类号： C07H021/04 , A61K031/70 , A01N043/04 , C12N001/20 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74 , C12N015/85 , C12N015/87 , C12N001/00
CPC分类号： C07K16/4291 , A61K2039/505 , C07K16/00 , C07K2317/52 , Y10S424/805 , Y10S424/809 , Y10S530/862 , Y10S530/866 , Y10S530/868
摘要： The invention relates to: nucleic acid molecules encoding the light chain and heavy chain of feline immunoglobulin E (IgE), including species-specific regions of feline IgE; proteins encoded by the nucleic acid molecules; inhibitors to the nucleic acids and proteins; antibodies to the proteins; cells transformed with the nucleic acid molecules; assays employing the transformed cells, nucleic acids, antibodies and/or proteins or portions thereof; methods for treating IgE-mediated responses (ie. allergy) using the materials provided; methods for eliciting an immune response to IgE and kits containing the nucleic acid molecules, proteins or derivatives thereof (ie. antibodies).
摘要翻译：本发明涉及：编码猫免疫球蛋白E（IgE）的轻链和重链的核酸分子，包括猫类IgE的物种特异性区域; 由核酸分子编码的蛋白质; 核酸和蛋白质的抑制剂; 对蛋白质的抗体; 用核酸分子转化的细胞; 使用转化的细胞，核酸，抗体和/或蛋白质或其部分的测定; 使用提供的材料治疗IgE介导的反应（即过敏）的方法; 用于引发对IgE的免疫应答的方法和包含核酸分子，蛋白质或其衍生物（即，抗体）的试剂盒。

40. 发明申请

US20030013078A1 HIV-1 reporter viruses and their use in assaying anti-viral compounds 审中-公开
标题翻译： HIV-1报告病毒及其在测定抗病毒化合物中的应用
公开(公告)号：US20030013078A1
公开(公告)日：2003-01-16
申请号：US09876680
申请日：2001-06-07
发明人： Wade Blair , Timothy P. Spicer
IPC分类号： C12N015/867 , C12N007/01 , C12Q001/70 , C12P019/34 , A61K039/12 , C12N007/00 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74 , C12N015/86
CPC分类号： G01N33/502 , C12N15/86 , C12N2740/16043 , G01N33/5008 , G01N33/505 , G01N33/57415 , G01N2333/16
摘要： The present invention relates to HIV-1 proviral constructs, which produce replication competent HIV-1 reporter viruses. The invention also relates to the use of these HIV-1 reporter viruses in high throughput screening of anti-viral compounds.
摘要翻译：本发明涉及产生可复制的HIV-1报告病毒的HIV-1前病毒构建体。本发明还涉及这些HIV-1报道病毒在抗病毒化合物的高通量筛选中的用途。

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