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1. 发明申请

US20040266708A1 Regulation of polynucleic acid activity and expression 审中-公开
标题翻译：调节多核酸活性和表达
公开(公告)号：US20040266708A1
公开(公告)日：2004-12-30
申请号：US10644288
申请日：2003-08-20
发明人： Paul Diamond
IPC分类号： A01K067/00 , C12N015/85 , A61K048/00
CPC分类号： C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2330/30
摘要： The invention provides methods and systems for controlling the expression and, in general, the cellular activity of preselected polynucleic acid molecules. The invention also provides methods and systems for genetically modifying cells and multi-cellular organisms to impart resistance to viruses. The invention further provides methods and systems for genetically modifying cells and multi-cellular organisms so that they diagnostically report viral infection. One aspect of the invention involves rendering target polynucleic nucleic acid molecules as functional templates for at least one template-directed polynucleic acid polymerase so that utilization of the polynucleic acid molecule as a template by the polymerase modulates the activity of the targeted polynucleic acid molecule. Other aspects of the invention of the invention involve rendering selected polynucleic nucleic acid molecules as targets for RNA silencing, whether or not the silencing is polymerase-mediated.
摘要翻译：本发明提供了用于控制预选的多核酸分子的表达和一般的细胞活性的方法和系统。本发明还提供用于遗传修饰细胞和多细胞生物以赋予对病毒抗性的方法和系统。本发明还提供用于遗传修饰细胞和多细胞生物体的方法和系统，使得它们诊断性地报告病毒感染。本发明的一个方面涉及使目标多核核酸分子作为至少一个模板指导的多核酸聚合酶的功能模板，使得通过聚合酶利用聚核酸分子作为模板来调节靶向多核酸分子的活性。本发明的其它方面涉及将选择的多核核酸分子作为RNA沉默的靶标，无论沉默是否是聚合酶介导的。

2. 发明申请

US20040259251A1 Oncosupporessive gene 失效
标题翻译：肿瘤基因
公开(公告)号：US20040259251A1
公开(公告)日：2004-12-23
申请号：US10483241
申请日：2004-07-14
发明人： Massimo Broggini , Maurizio D'Incalci
IPC分类号： C12N015/85
CPC分类号： C07K14/4703 , A61K2039/53
摘要： Isolation and characterization of an oncosuppressive gene which is involved in the apoptotic process and is regulated by p53 ad p73, polypeptide thereby encoded, sequences involved in gene regulation and genetic constructs thereof.
摘要翻译：参与凋亡过程并由p53 ad p73调控的抑癌基因的分离和表征，由此编码的多肽，参与基因调控的序列及其遗传构建体。

3. 发明申请

US20040259152A1 Novel methods of diagnosing and screening for modulators of tissue remodeling and treating related diseases 审中-公开
标题翻译：用于组织重塑和治疗相关疾病调节剂的诊断和筛选的新方法
公开(公告)号：US20040259152A1
公开(公告)日：2004-12-23
申请号：US10470576
申请日：2003-08-05
发明人： Richard Murray , Susan Watson , Stephen J. Weiss , Richard Glynne , Peter Hevezi
IPC分类号： G01N033/53 , C12N015/85
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： Described herein are methods that can be used for diagnosis of tissue remodeling, as well as tissue remodeling phenotypes. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate tissue remodeling. Additionally, molecular targets (genes and their products) for therapeutic intervention in disorders associated with tissue remodeling are described. Moreover, methods for using such molecular targets are described.
摘要翻译：本文描述了可用于组织重塑的诊断以及组织重塑表型的方法。本文还描述了可用于筛选候选生物活性剂以调节组织重塑能力的方法。此外，描述了用于治疗干预与组织重塑相关疾病的分子靶标（基因及其产物）。此外，描述了使用这种分子靶标的方法。

4. 发明申请

US20040259130A1 Transgenesis of early embyonic cells 审中-公开
标题翻译：早期脑脊液细胞的转基因
公开(公告)号：US20040259130A1
公开(公告)日：2004-12-23
申请号：US10812248
申请日：2004-03-29
发明人： Alex J. Harvey , Robert D. Ivarie
IPC分类号： C12Q001/68 , C12N015/85
CPC分类号： A01K67/0275 , A01K2227/30 , A01K2267/01 , C12N15/87
摘要： The present invention includes methods of producing an integrated transgene in an avian cell which include introducing a nucleic acid into an avian cell by electroporating and methods of producing a transgenic avian comprising injecting the cell comprising the transgene into an avian stage X embryo. The present invention also provides for methods of screening for nucleic acid integration in a cellular genome which include transforming a nucleic acid comprising a marker into a recipient avian cell and determining if the nucleic is present in equal copy number in cells of a colony produced by the recipient avian cell.
摘要翻译：本发明包括在禽细胞中产生整合的转基因的方法，其包括通过电穿孔将核酸引入禽类细胞，以及生产转基因禽类的方法，包括将包含转基因的细胞注射入禽类X胚胎。本发明还提供了筛选在细胞基因组中的核酸整合的方法，其包括将包含标记的核酸转化到接受者禽类细胞中，并确定核酸是否以相同拷贝数存在于由受体禽细胞。

5. 发明申请

US20040253730A1 Activated checkpoint therapy and methods of use thereof 审中-公开
公开(公告)号：US20040253730A1
公开(公告)日：2004-12-16
申请号：US10886751
申请日：2004-07-08
发明人： Chiang J. Li
IPC分类号： A61K048/00 , C12Q001/68 , C12N015/85
CPC分类号： G01N33/57484 , A61K31/38
摘要： Disclosed herein are novel methods and compositions for Activated Checkpoint Therapynull. Also disclosed are methods of treating cancer and apoptosis-associated disorders using cell cycle checkpoint activation modulators. The invention further discloses methods for screening for cell cycle checkpoint activation modulators and the cell cycle checkpoint activation modulators identified by those screening methods.

6. 发明申请

US20040253675A1 Method for GPCR assay with a coexpressed Galpha protein 审中-公开
标题翻译：用共表达的Galpha蛋白进行GPCR测定的方法
公开(公告)号：US20040253675A1
公开(公告)日：2004-12-16
申请号：US10774613
申请日：2004-02-10
申请人： Hitachi, Ltd.
发明人： Tomoko Takeshita , Jun Otomo
IPC分类号： C12P021/02 , C12N005/06 , C07K014/705 , C12N015/85
CPC分类号： C07K14/705 , G01N33/76
摘要： This invention provides a method for assaying activities of signal transduction that enables identification of a ligand with a single assay method, thereby simplifying and accelerating the assay method for identifying a ligand of a GPCR with unknown functions. In this method, RNA encoding a GPCR and RNA encoding a chimeric Gqnull subunit constituted by a portion of a G11 or Gq subunit and a portion of a G14, G15, or G16 subunit are transfected together to an oocyte removed from a Xenopus and selected by a conventional technique. After transfection of the RNAs, a ligand candidate substance is added to the oocyte that was cultured for a given period of time, and the activity is then assayed.
摘要翻译：本发明提供了一种用于测定信号转导活性的方法，该方法能够利用单一测定方法鉴定配体，从而简化并加速鉴定具有未知功能的GPCR配体的测定方法。在该方法中，编码由G11或Gq亚基部分和G14，G15或G16亚基的一部分构成的嵌合Gqalpha亚基的编码GPCR和RNA的RNA一起转染到从非洲爪蟾中去除的卵母细胞，并由常规技术。转染RNA后，将一种配体候选物质加入培养一定时间的卵母细胞，然后测定其活性。

7. 发明申请

US20040253601A1 Methods for overexpression of high molecular weight form of mannose binding lectin (MBL) and a specific formulation for active treatment for systemic infection with microorganism 有权
标题翻译：过表达高分子量形式的甘露糖结合凝集素（MBL）的方法和用于微生物全身感染的主动治疗的具体制剂
公开(公告)号：US20040253601A1
公开(公告)日：2004-12-16
申请号：US10641816
申请日：2003-08-15
发明人： Hong Mo Moon , Jung-Sun Yum , Byung Cheol Ahn
IPC分类号： C12Q001/68 , C07H021/04 , A61K038/17 , C07K014/47 , C12N015/85
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/6935 , A61K47/6937 , C07H21/04 , C07K14/4726
摘要： This invention comprises of construction of a recombinant CHO cell line that produces functional mannose binding lectin (MBL) and of special uses of MBL. Specially, use of MBL for development of a therapeutic agent for patients having systemic infection with viruses, bacteria, or fungus is described. More specifically, MBL as a trigger for complement activation and MBL so formulated to activate complement system for the purpose of treating patients with microbial infection.
摘要翻译：本发明包括构建产生功能性甘露糖结合凝集素（MBL）和MBL特殊用途的重组CHO细胞系。描述了使用MBL来开发用于患有病毒，细菌或真菌的全身感染的患者的治疗剂。更具体地说，MBL作为补体激活的触发剂和MBL，因此配制为激活补体系统，以治疗微生物感染患者。

8. 发明申请

US20040253590A1 COMPOSITIONS AND METHODS FOR MAKING MUTATIONS IN CELL LINES AND ANIMALS 审中-公开
公开(公告)号：US20040253590A1
公开(公告)日：2004-12-16
申请号：US10342923
申请日：2003-01-15
申请人： Athersys, Inc.
发明人： John Joseph Harrington , Paul David Jackson , Li Jiang
IPC分类号： C12Q001/68 , C12N015/85
CPC分类号： C12N15/102 , C12N15/01 , C12Q1/6897
摘要： Abstract of DisclosureThe present invention is directed generally to reduction or inactivation of gene function or gene expression in cells in vitro and in multiorganisms. The invention encompasses methods for mutating cells using a combination of mutagens, particularly wherein at least one mutagen is an insertional mutagen, to achieve homozygous gene mutation or mutation of multiple genes required cumulatively to achieve a phenotype to create knock-outs, knock-downs, and other modifications in the same cell. The invention is also directed to cells (and libraries thereof) and organisms created by the methods of the invention, including those in which at least one of the genes created by insertional mutagenesis is tagged by means of the insertion sequences thereby allowing identification of the mutated gene(s). The invention is also directed to libraries of mutated cells and their uses. The invention is also directed to methods of identifying mutations with methods of the invention, in cells (and libraries thereof) and organisms, by means of the insertional tag.

9. 发明申请

US20040253215A1 Methods and compositions for treating disorders 有权
标题翻译：用于治疗疾病的方法和组合物
公开(公告)号：US20040253215A1
公开(公告)日：2004-12-16
申请号：US10829926
申请日：2004-04-21
发明人： Frederick L. Hall , Erlinda M. Gordon
IPC分类号： A61K048/00 , C12N015/85 , C12N015/867
CPC分类号： C07K14/4738 , A61K48/00 , C12N15/85 , C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2800/108 , C12N2810/85
摘要： Methods and compositions for producing targeted delivery vectors are provided. Such vectors are useful for treating neoplastic disorders. Also provided are protocols for administering targeted delivery vectors in a clinical setting such that a therapeutic effect is achieved.
摘要翻译：提供了用于产生靶向递送载体的方法和组合物。这样的载体可用于治疗肿瘤性疾病。还提供了用于在临床环境中施用靶向递送载体的方案，使得实现治疗效果。

10. 发明申请

US20040253214A1 Compositions and methods for elimination of unwanted cells 失效
标题翻译：用于消除不想要的细胞的组合物和方法
公开(公告)号：US20040253214A1
公开(公告)日：2004-12-16
申请号：US10732438
申请日：2003-12-10
申请人： Mayo Foundation For Medical Education and Research, a Minnesota corporation
发明人： Stephen James Russell , Frances Joanne Morling , Adele Kay Fielding , Francois-Loic Cosset , Roberto Cattaneo
IPC分类号： A61K048/00 , C12N005/08 , C12N015/85
CPC分类号： C07K14/005 , A61K38/162 , A61K48/00 , C07K2319/00 , C07K2319/50 , C12N15/86 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2740/13022 , C12N2740/13043 , C12N2740/13045 , C12N2760/18422 , C12N2760/18622 , C12N2760/18722 , C12N2760/18822 , C12N2810/851 , C12N2840/203
摘要： Disclosed are compositions comprising a recombinant nucleic acid vector including a nucleotide sequence encoding a syncytium-inducing polypeptide expressible on a eukaryotic cell surface, and a host cell containing the recombinant vector and expressing the syncytium inducing polypeptide on its cell surface, the vectors and resultant host cells expressing the syncytium inducing polypeptide being useful for selective elimination of unwanted cells,
摘要翻译：公开了包含重组核酸载体的组合物，其包含编码在真核细胞表面上可表达的合胞体诱导多肽的核苷酸序列，和含有重组载体并在其细胞表面上表达合胞体诱导多肽的宿主细胞，载体和所得宿主表达合胞体诱导多肽的细胞可用于选择性消除不想要的细胞，

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