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31. 发明授权

US06423827B1 Limbic system-associated membrane protein 失效
标题翻译：边缘系统相关膜蛋白
公开(公告)号：US06423827B1
公开(公告)日：2002-07-23
申请号：US09135080
申请日：1998-08-17
申请人： Pat Ressler Levitt , Aurea Pimenta , Itzhak Fischer , Victoria Zhukareva
发明人： Pat Ressler Levitt , Aurea Pimenta , Itzhak Fischer , Victoria Zhukareva
IPC分类号： C07K14435
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention is directed to nucleic acid sequences encoding a limbic-system associated membrane protein (“LAMP”) and to purified proteins with LAMP activity. LAMP is a self-binding, antibody-like cell surface adhesion protein, the presence of which on one neuron of the limbic system stimulates the formation of connections with adjacent neurons. The invention provides a nucleic acid sequence encoding a polypeptide with at least about 90% homology to a LAMP self-binding domain, and corresponding proteins. The invention also provides nucleic acids that hybridize to LAMP encoding nucleic acids.
摘要翻译：本发明涉及编码边缘系统相关膜蛋白（“LAMP”）的核酸序列和具有LAMP活性的纯化蛋白。 LAMP是一种自我结合的抗体样细胞表面粘附蛋白，其在边缘系统的一个神经元上的存在刺激与相邻神经元的连接的形成。本发明提供编码与LAMP自身结合结构域和相应蛋白质具有至少约90％同源性的多肽的核酸序列。本发明还提供与LAMP编码核酸杂交的核酸。

32. 发明授权

US06403765B1 Truncated Apaf-1 and methods of use thereof 失效
标题翻译：截短的Apaf-1及其使用方法
公开(公告)号：US06403765B1
公开(公告)日：2002-06-11
申请号：US09098310
申请日：1998-06-16
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C07K14435
CPC分类号： C12N9/6475 , A61K48/00 , C07K14/4747
摘要： Truncated Apaf-1 nucleic acids and encoded polypeptides are provided. Also provided are self-oligomerizing caspase molecules capable of self-processing. In one embodiment the present invention provides methods for identifying apoptotic inhibitors and enhancers use whole cell or reconstituted component assay systems. In a further embodiment, truncated Apaf-1 and self-oligomerizing caspase constructs are described which can be provided to a cell, thereby inducing apoptosis.
摘要翻译：提供了截短的Apaf-1核酸和编码的多肽。还提供能够自我加工的自身低聚半胱天冬酶分子。在一个实施方案中，本发明提供用于鉴定凋亡抑制剂和增强子的方法，其使用全细胞或重组组分测定系统。在另一个实施方案中，描述了可以提供给细胞的截短的Apaf-1和自身寡聚半胱天冬酶构建体，从而诱导凋亡。

33. 发明授权

US06333312B1 Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases 有权
标题翻译：治疗以预防代谢性骨疾病的损失和/或增加骨质量
公开(公告)号：US06333312B1
公开(公告)日：2001-12-25
申请号：US09170936
申请日：1998-10-13
申请人： Thangavel Kuberasampath , Charles M. Cohen , Herrmann Oppermann , Engin Ozkaynak , David C. Rueger , John E. Smart , Roy H. L. Pang
发明人： Thangavel Kuberasampath , Charles M. Cohen , Herrmann Oppermann , Engin Ozkaynak , David C. Rueger , John E. Smart , Roy H. L. Pang
IPC分类号： C07K14435
CPC分类号： G01N33/6872 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , A61K2300/00
摘要： The invention is a treatment for increasing the bone mass or preventing bone loss in an individual afflicted with a bone disease which includes administering to the individual a morphogen in a therapeutically effective amount so as to maintain or stimulate bone formation.
摘要翻译：本发明是用于增加骨质量的骨量或预防骨质疏松症的治疗方法，其包括以治疗有效量向个体施用形态发生剂以维持或刺激骨形成。

34. 发明授权

US06310182B1 Compositions for the diagnosis and treatment of Chediak-Higashi syndrome 失效
标题翻译： Chediak-Higashi综合征的诊断和治疗组合
公开(公告)号：US06310182B1
公开(公告)日：2001-10-30
申请号：US09396540
申请日：1999-09-14
申请人： Jerry Kaplan , Charles M. Perou , Karen J. Moore
发明人： Jerry Kaplan , Charles M. Perou , Karen J. Moore
IPC分类号： C07K14435
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the differentiation and/or function of intracellular vesicles. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian bg gene, a gene that, when mutated, is responsible or the human Chediak-Higashi syndrome.
摘要翻译：本发明涉及鉴定参与细胞内小泡分化和/或功能的由此类核酸分子或其简并变体编码的新的核酸分子和蛋白质。本发明的核酸分子代表与哺乳动物bg基因相对应的基因，突变后负责的基因或人Chediak-Higashi综合征。

35. 发明授权

US06310034B1 Agouti polypeptide compositions 失效
标题翻译： Agouti多肽组合物
公开(公告)号：US06310034B1
公开(公告)日：2001-10-30
申请号：US09034088
申请日：1998-03-03
申请人： Richard P. Woychik , Scott J. Bultman , Edward J. Michaud
发明人： Richard P. Woychik , Scott J. Bultman , Edward J. Michaud
IPC分类号： C07K14435
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0362 , C07K14/47 , C12N2830/008 , C12N2830/85 , C12N2840/445
摘要： Disclosed are methods and compositions comprising novel agouti polypeptides and the polynucleotides which encode them. Also disclosed are DNA segments encoding these proteins derived from human and murine cell lines, and the use of these polynucleotides and polypeptides in a variety of diagnostic and therapeutic applications. Methods, compositions, kits, and devices are also provided for identifying compounds which are inhibitors of agouti activity, and for altering fatty acid synthetase activity and intracellular calcium levels in transformed cells.
摘要翻译：公开了包含新型agouti多肽和编码它们的多核苷酸的方法和组合物。还公开了编码来自人和鼠细胞系的这些蛋白质的DNA区段，以及这些多核苷酸和多肽在各种诊断和治疗应用中的用途。还提供了方法，组合物，试剂盒和装置，用于鉴定作为培养物活性抑制剂的化合物，以及用于改变转化细胞中的脂肪酸合成酶活性和细胞内钙水平。

36. 发明授权

US06291642B1 Mammalian cell cycle protein 失效
标题翻译：哺乳动物细胞周期蛋白
公开(公告)号：US06291642B1
公开(公告)日：2001-09-18
申请号：US08988856
申请日：1997-12-11
申请人： Jasminder Weinstein
发明人： Jasminder Weinstein
IPC分类号： C07K14435
CPC分类号： C07K14/4738 , A61K38/00 , C07K16/18
摘要： A novel mammalian cell cycle protein, p55CDC, DNA sequences encoding p55CDC, and a method for producing the protein are described. Also described are methods for detecting p55CDC and methods for modulating cell division by compounds which control the level or activity of p55CDC or p55CDC-associated protein complexes.
摘要翻译：描述了一种新型的哺乳动物细胞周期蛋白，p55CDC，编码p55CDC的DNA序列及其生产方法。还描述了用于检测p55CDC的方法和通过控制p55CDC或p55CDC相关蛋白复合物的水平或活性的化合物调节细胞分裂的方法。

37. 发明授权

US06274702B1 Bone stimulating factor 失效
标题翻译：骨刺激因子
公开(公告)号：US06274702B1
公开(公告)日：2001-08-14
申请号：US09044098
申请日：1998-03-19
申请人： Cherk Shing Tam
发明人： Cherk Shing Tam
IPC分类号： C07K14435
CPC分类号： C07K14/522 , A61K38/00 , C07K14/51
摘要： A polypeptide substance isolated from rat serum which, upon administration to rats incapable of producing PTH (parathyroidectomized rats), produces an increase in the observed bone mineral apposition rate. The substance has been isolated in two forms, a first larger polypeptide having a molecular weight twice that of a second smaller polypeptide. The first eleven amino acids of the sequence of the smaller polypeptide have been determined to be Gly Pro Gly Gly Ala Gly Glu Thr Lys Pro Ile (SEQ ID NO:3). The first seven amino acids of the larger polypeptide have been determined to be Gly Pro Gly Gly Ala Gly Glu (SEQ ID NO:2). The larger polypeptide might be the dimer of the smaller peptide. A nucleic acid probe, based on the amino acid sequence of the rat peptide was used to screen a human liver cDNA fetal library. A polypeptide was thus chemically synthesized according to the sequence Gly Ile Gly Lys Arg Thr Asn Glu His Thr Ala Asp Cys Lys Ile Lys Pro Asn Thr Leu His Lys Lys Ala Ala Glu Thr Leu Met Val Leu Asp Gln Asn Gln Pro (SEQ ID NO:11). The bone apposition rate in rats increases in a dose dependent fashion upon administration of this chemically synthesized compound. A modified polypeptide containing a cysteine alanine substitution was carried synthesized: Gly Ile Gly Lys Arg Thr Asn Glu His Thr Ala Asp Ala Lys Ile Lys Pro Asn Thr Leu His Lys Lys Ala Ala Glu Thr Leu Met Val Leu Asp Gln Asn Gln Pro (SEQ ID NO:13). Some of the bone stimulatory effects of the normal polypeptide were found for the modified polypeptide.
摘要翻译：从大鼠血清中分离出的多肽物质，当给予不能产生PTH（甲状旁腺切除的大鼠）的大鼠时，观察到的骨矿物结合率增加。该物质已经被分离成两种形式，第一种较大的多肽的分子量是第二较小多肽的两倍。已经确定较小多肽的序列的前11个氨基酸为Gly Pro Gly Gly Ala Gly Glu Thr Lys Pro Ile（SEQ ID NO：3）。已确定较大多肽的前7个氨基酸为Gly Pro Gly Gly Ala Gly Glu（SEQ ID NO：2）。较大的多肽可能是较小肽的二聚体。使用基于大鼠肽的氨基酸序列的核酸探针筛选人肝脏cDNA胎儿文库。因此，根据序列化学合成多肽Gly Ile Gly Lys Arg Thr Asn Glu His Thr Ala Asp Cys Lys Ile Lys Pro Asn Thr Leu His Lys Lys Ala Ala Glu Thr Leu Met Val Leu Asp Gln Asn Gln Pro（SEQ ID NO ：11）。在施用该化学合成的化合物时，大鼠的骨配合率以剂量依赖性方式增加。合成了含有半胱氨酸丙氨酸取代基的修饰多肽：Gly Ile Gly Lys Arg Thr Asn Glu His Thr Ala Asp Ala Lys Ile Lys Pro Asn Thr Leu His Lys Lys Ala Ala Glu Thr Leu Met Val Leu Asp Gln Asn Gln Pro（SEQ ID NO： ID NO：13）。针对修饰的多肽发现一些正常多肽的骨刺激作用。

38. 发明授权

US06242566B1 Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells 失效
标题翻译：配体（ACT-4-L）对活化的CD4 + T细胞表面的受体
公开(公告)号：US06242566B1
公开(公告)日：2001-06-05
申请号：US08195967
申请日：1994-02-10
申请人： Wayne Godfrey , Edgar G. Engleman
发明人： Wayne Godfrey , Edgar G. Engleman
IPC分类号： C07K14435
CPC分类号： C07K16/2875 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/28 , C07K16/2878 , C07K19/00 , C07K2319/00 , C07K2319/30
摘要： The invention provides ligands and fragments thereof to a receptor on the surface of activated CD4+ T-cells. An exemplary ligand is designated ACT-4-L-h-1. Preferred fragments include purified extracellular domains of ligands. The invention also provides humanized and human antibodies to the ligand. The invention further provides methods of using the ligand and the antibodies in treatment of diseases and conditions of the immune system. The invention also provides methods of monitoring activated CD4+ T-cells using the ligands or fragments thereof.
摘要翻译：本发明提供了其活化的CD4 + T细胞表面的受体的配体及其片段。示例性配体称为ACT-4-L-h-1。优选的片段包括纯化的配体的细胞外结构域。本发明还提供人源化和人抗体配体。本发明还提供了在治疗免疫系统的疾病和病症中使用配体和抗体的方法。本发明还提供了使用其配体或其片段监测活化的CD4 + T细胞的方法。

39. 发明授权

US06232291B1 Cytostatin III 有权
标题翻译：细胞抑素III
公开(公告)号：US06232291B1
公开(公告)日：2001-05-15
申请号：US09307817
申请日：1999-05-10
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： C07K14435
CPC分类号： C07K14/475 , C07K2319/00
摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

40. 发明授权

US06211339B1 Apoptosis polypeptide 失效
标题翻译：凋亡多肽
公开(公告)号：US06211339B1
公开(公告)日：2001-04-03
申请号：US09205814
申请日：1998-12-04
申请人： John M. Abrams , Po Chen , William Nordstrom
发明人： John M. Abrams , Po Chen , William Nordstrom
IPC分类号： C07K14435
CPC分类号： C07K14/43581 , C12N15/87
摘要： Disclosed is a Drosophila grim gene and encoded GRIM polypeptide, an activator of apoptosis. The disclosed nucleic acid sequences are useful in the production of the protein and as hybridization probes and primers. Expression of the GRIM protein causes programmed cell death. Preferred embodiments include expression of grim under the control of an inducible promoter and the use of such a construct in the control of an insect population.
摘要翻译：披露了果蝇严重的基因和编码GRIM多肽，凋亡的激活剂。所公开的核酸序列可用于生产蛋白质和杂交探针和引物。 GRIM蛋白的表达导致程序性细胞死亡。优选的实施方案包括在诱导型启动子的控制下的严酷的表达和这种构建体在控制昆虫群体中的用途。

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