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1. 发明授权

US06730779B2 Antibody that specifically binds an Mch4 polypeptide 有权
标题翻译：特异性结合Mch4多肽的抗体
公开(公告)号：US06730779B2
公开(公告)日：2004-05-04
申请号：US09952768
申请日：2001-09-10
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
IPC分类号： C07K1600
CPC分类号： C12N9/6475 , A61K38/00
摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.
摘要翻译：本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。

2. 发明授权

US06376226B1 Recombinant, active caspases and uses thereof 有权
公开(公告)号：US06376226B1
公开(公告)日：2002-04-23
申请号：US09561756
申请日：2000-04-26
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C12N948
CPC分类号： C12N9/6475
摘要： Rev-caspases comprising a primary product in which the small subunit is N-terminal to the large subunit are provided. Rev-caspases are used for screening and identifying caspase inhibitors and enhancers. Rev-caspase genes can be delivered to cells for gene therapy.

3. 发明授权

US06190912B1 Blk genes and uses thereof in apoptosis 失效
标题翻译： Blk基因，基因产物及其在凋亡中的用途
公开(公告)号：US06190912B1
公开(公告)日：2001-02-20
申请号：US09052877
申请日：1998-03-31
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C12N1500
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K2319/00 , G01N2500/00
摘要： Genes and gene products of Blk, a pro-apoptotic protein in the Bcl-2 gene family, are provided. Effector molecules that either increase or decrease Blk and thus promote or inhibit apoptosis are described. The Blk genes and proteins and effector molecules may be used to treat diseases that have unwanted cell proliferation used to promote cell growth.
摘要翻译：提供了Bcl-2基因家族中的促凋亡蛋白的基因和基因产物。描述了增加或减少Blk并因此促进或抑制细胞凋亡的效应分子。 Blk基因和蛋白质和效应分子可用于治疗用于促进细胞生长的具有不希望的细胞增殖的疾病。

4. 发明授权

US6063760A Fadd-like anti-apoptotic molecules, flame-1 and flame-2, methods of using the same, and compositions for and methods of making the same 失效
标题翻译： Fadd样抗凋亡分子，火焰-1和火焰-2，使用它们的方法，组合物及其制备方法
公开(公告)号：US6063760A
公开(公告)日：2000-05-16
申请号：US109273
申请日：1998-06-30
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K48/00 , A61P25/28 , A61P31/18 , A61P43/00 , C07K14/47 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C12Q1/00 , A01N37/18 , C07K5/00 , C07K7/00
CPC分类号： B82Y30/00 , C07K14/47 , C07K14/4747 , A61K38/00
摘要： Two FADD-like anti-apoptotic proteins FLAME-1 and FLAME-2 that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic acid molecules and making the proteins. Pharmaceutical compositions and methods of using the same are disclosed. Reagents, kits and methods of identifying compounds that inhibit anti-apoptotic activity of the proteins and methods of identifying compounds that inhibit binding activity of the proteins are disclosed.
摘要翻译：公开了调节Fas / TNFR1或UV诱导的凋亡的两种FADD样抗凋亡蛋白FLAME-1和FLAME-2。公开了编码蛋白质的核苷酸序列，作为使用核酸分子和制备蛋白质的方法。公开了药物组合物及其使用方法。公开了鉴定抑制蛋白质的抗凋亡活性的化合物的试剂，试剂盒和方法以及鉴定抑制蛋白质结合活性的化合物的方法。

5. 发明授权

US06897296B2 Antibody that specifically binds an Mch5 polypeptide 失效
标题翻译：特异性结合Mch5多肽的抗体
公开(公告)号：US06897296B2
公开(公告)日：2005-05-24
申请号：US10668955
申请日：2003-09-22
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
IPC分类号： C12N15/09 , A61K38/00 , C12N9/64 , C12N15/57 , C07K16/00
CPC分类号： C12N9/6475 , A61K38/00
摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.
摘要翻译：本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。还提供了编码功能片段的基因和核酸，例如FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。还提供了分离的Mch4或Mch5多肽或其功能片段，其包括FADD样结构域Mch4A，Mch4B，Mch5A和Mch5B。

6. 发明授权

US06600024B1 Blk genes, gene products and uses thereof in apoptosis 有权
标题翻译： Blk基因，基因产物及其在细胞凋亡中的用途
公开(公告)号：US06600024B1
公开(公告)日：2003-07-29
申请号：US09709790
申请日：2000-11-07
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C07K1600
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K2319/00 , G01N2500/00
摘要： Genes and gene products of Blk, a pro-apoptotic protein in the Bcl-2 gene family, are provided. Effector molecules that either increase or decrease Blk and thus promote or inhibit apoptosis are described. The Blk genes and proteins and effector molecules may be used to treat diseases that have unwanted cell proliferation used to promote cell growth.
摘要翻译：提供了Bcl-2基因家族中的促凋亡蛋白的基因和基因产物。描述了增加或减少Blk并因此促进或抑制细胞凋亡的效应分子。 Blk基因和蛋白质和效应分子可用于治疗用于促进细胞生长的具有不希望的细胞增殖的疾病。

7. 发明授权

US06407215B1 Antibodies to Mch2, an apoptotic cysteine protease 有权
标题翻译： Mch2的抗体，凋亡半胱氨酸蛋白酶
公开(公告)号：US06407215B1
公开(公告)日：2002-06-18
申请号：US09376156
申请日：1999-08-17
申请人： Gerald Litwack , Emad S. Alnemri , Teresa Fernandez-Alnemri
发明人： Gerald Litwack , Emad S. Alnemri , Teresa Fernandez-Alnemri
IPC分类号： C07K1640
CPC分类号： C12N9/6475 , A61K38/00
摘要： A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2&agr;, and an inactive isoform of it, Mch2&bgr;, are disclosed. Isolated nucleic acid molecules that encode Mch2&agr; and Mch2&bgr;, respectively, are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with the protein or the nucleic acid molecules are disclosed. Fragments of nucleic acid molecules that encode Mch2&agr; and Mch2&bgr; having at least 10 nucleotides and oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleotide sequence of at least 10 nucleotides are disclosed. Recombinant expression vectors that comprise the nucleic acid molecule that encode Mch2&agr; or Mch2&bgr;, and host cells that comprise such recombinant vectors are disclosed. Antibodies that bind to an epitope on Mch2&agr; and/or Mch2&bgr; are disclosed. Methods of identifying inhibitors, activators and substrates of Mch2&agr; are disclosed. Antisense compounds and methods of using the same are disclosed.
摘要翻译：公开了一种基本上纯的蛋白质，其是凋亡Ced-3 / Ice半胱氨酸蛋白酶基因家族Mch2alpha及其非活性同种型Mch2beta的成员。公开了分别编码Mch2alpha和Mch2beta的分离的核酸分子。公开了包含与蛋白质或核酸分子组合的药学上可接受的载体的药物组合物。公开了编码具有至少10个核苷酸的Mch2alpha和Mch2beta的核酸分子的片段和包含与至少10个核苷酸的核苷酸序列互补的核苷酸序列的寡核苷酸分子。公开了包含编码Mch2alpha或Mch2beta的核酸分子的重组表达载体和包含这种重组载体的宿主细胞。公开了结合Mch2alpha和/或Mch2beta上的表位的抗体。公开了鉴定Mch2alpha的抑制剂，活化剂和底物的方法。公开了反义化合物及其使用方法。

8. 发明授权

US6037461A FADD-like anti-apoptotic molecules, methods of using the same, and compositions for and methods of making the same 失效
公开(公告)号：US6037461A
公开(公告)日：2000-03-14
申请号：US859167
申请日：1997-05-20
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K48/00 , A61P25/28 , A61P31/18 , A61P43/00 , C07K14/47 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C12Q1/00 , C07H21/00 , C12N15/00 , C12P21/06 , G01N33/574
CPC分类号： B82Y30/00 , C07K14/47 , C07K14/4747 , A61K38/00
摘要： Two FADD-like anti-apoptotic proteins that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic acid molecules and making the proteins. Pharmaceutical compositions and methods of using the same are disclosed. Reagents, kits and methods of identifying compounds that inhibit anti-apoptotic activity of the proteins and methods of identifying compounds that inhibit binding activity of the proteins are disclosed.

9. 发明授权

US5851815A MCH4 and MCH5, apoptotic proteases 失效
标题翻译： MCH4和MCH5，凋亡蛋白酶
公开(公告)号：US5851815A
公开(公告)日：1998-12-22
申请号：US618408
申请日：1996-03-19
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
IPC分类号： A61K38/00 , C12N9/64 , C12N9/50 , C12N9/48
CPC分类号： C12N9/6475 , A61K38/00
摘要： The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof are also provided.
摘要翻译：本发明提供编码Mch4的分离基因或编码Mch5的分离基因及其功能片段。还提供了编码Mch4或Mch5的分离的核酸序列或其功能片段。基因或核酸序列可以是对应于Mch4或Mch5核苷酸序列的编码链或非编码链的单链或双链核酸。还提供了分离的Mch4或Mch5多肽或其功能片段。

10. 发明授权

US06462175B1 Mch3, a novel apoptotic protease, nucleic acids encoding and methods of use 失效
标题翻译： Mch3，一种新的凋亡蛋白酶，核酸编码和使用方法
公开(公告)号：US06462175B1
公开(公告)日：2002-10-08
申请号：US08556627
申请日：1995-11-13
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
IPC分类号： C07K447
CPC分类号： C12N9/6475 , C07K2319/00
摘要： The invention provides an isolated gene encoding Mch3, or functional fragment thereof. Also provided is an isolated nucleic acid sequence encoding Mch3 or functional fragment thereof. The gene or nucleic acid sequence can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch3 nucleotide sequence. An isolated Mch3 polypeptide or functional fragment thereof is also provided.
摘要翻译：本发明提供编码Mch3的分离基因或其功能片段。还提供了编码Mch3的分离的核酸序列或其功能片段。基因或核酸序列可以是对应于Mch3核苷酸序列的编码链或非编码链的单链或双链核酸。还提供了分离的Mch3多肽或其功能片段。

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