专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US5789434A Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors 失效
标题翻译：取代的4-联芳基丁酸的衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US5789434A
公开(公告)日：1998-08-04
申请号：US539409
申请日：1995-11-06
申请人： Harold Clinton Eugene Kluender , Guenter Hans Heinz Herbert Benz , David Ross Brittelli , William Harrison Bullock , Kerry Jeanne Combs , Brian Richard Dixon , Stephan Schneider , Jill Elizabeth Wood , Michael Christopher VanZandt , Donald John Wolanin , Scott M. Wilhelm
发明人： Harold Clinton Eugene Kluender , Guenter Hans Heinz Herbert Benz , David Ross Brittelli , William Harrison Bullock , Kerry Jeanne Combs , Brian Richard Dixon , Stephan Schneider , Jill Elizabeth Wood , Michael Christopher VanZandt , Donald John Wolanin , Scott M. Wilhelm
IPC分类号： A61K31/19 , A61K31/215 , A61K31/275 , A61K31/4035 , A61K31/47 , A61P35/00 , A61P43/00 , C07C17/12 , C07C17/16 , C07C17/20 , C07C22/04 , C07C25/18 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C57/38 , C07C59/48 , C07C59/56 , C07C59/68 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/145 , C07C69/616 , C07C69/63 , C07C69/712 , C07C69/738 , C07C69/757 , C07C205/34 , C07C205/56 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/18 , C07C235/84 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/40 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/00 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07D498/04 , C07F9/141 , C07F9/40 , A61K31/405 , A61K31/40
CPC分类号： C07D207/08 , A61K31/4035 , A61K31/47 , C07C17/12 , C07C17/16 , C07C17/208 , C07C205/34 , C07C205/56 , C07C22/04 , C07C229/34 , C07C229/40 , C07C233/54 , C07C235/84 , C07C25/18 , C07C255/21 , C07C255/57 , C07C271/22 , C07C271/26 , C07C271/28 , C07C271/58 , C07C317/44 , C07C323/52 , C07C323/61 , C07C323/62 , C07C327/32 , C07C45/28 , C07C45/46 , C07C45/56 , C07C45/72 , C07C47/228 , C07C47/277 , C07C49/813 , C07C55/02 , C07C59/56 , C07C59/84 , C07C59/88 , C07C59/90 , C07C59/92 , C07C61/04 , C07C61/06 , C07C62/22 , C07C62/38 , C07C63/72 , C07C65/24 , C07C65/34 , C07C69/616 , C07C69/712 , C07C69/738 , C07C69/757 , C07D207/16 , C07D207/404 , C07D209/48 , C07D209/68 , C07D213/30 , C07D213/50 , C07D213/70 , C07D215/36 , C07D221/14 , C07D257/04 , C07D263/32 , C07D277/30 , C07D277/74 , C07D295/192 , C07D307/28 , C07D307/32 , C07D307/33 , C07D307/54 , C07D307/68 , C07D307/93 , C07D307/935 , C07D311/96 , C07D317/30 , C07D317/60 , C07D333/22 , C07D333/28 , C07D333/34 , C07D405/06 , C07D409/12 , C07D413/06 , C07D471/04 , C07D491/04 , C07F9/1415 , C07F9/4059 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula ##STR1## in which each T represents a substituent group; x is 0, 1, or 2; D represents ##STR2## .delta. is 0 or 1; U' represents O, S, or N, with the proviso that when U' is N, then .delta.=0, and when U' is O or S, then .delta.=1; R.sup.14 is any of a variety of substituent groups; and G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, R.sup.11 represents H or an alkyl group, R.sup.12 represents an alkyl group, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids; and pharmaceutically acceptable salts thereof.
摘要翻译：基质金属蛋白酶抑制剂，含有它们的药物组合物，以及使用它们治疗各种生理条件的方法。目前要求保护的化合物具有其中每个T表示取代基的广义化学式“IMAGE”; x为0,1或2; D表示 delta为0或1; U'表示O，S或N，条件是当U'为N时，则δ= 0，当U'为O或S时，则δ= 1; R14是各种取代基中的任意一种; 和G表示M，其中M表示-CO 2 H，-CON（R 11）2或-CO 2 R 12，R 11表示H或烷基，R 12表示烷基，R 13表示任何侧链的M， 19个非环状天然存在的氨基酸; 及其药学上可接受的盐。

32. 发明授权

US5770763A Difunctional bitricyclodecatriene monomers 失效
公开(公告)号：US5770763A
公开(公告)日：1998-06-23
申请号：US705630
申请日：1996-08-30
申请人： David C. Martin , Jeffrey S. Moore , Larry J. Markoski , Kenneth A. Walker , Gary E. Spilman
发明人： David C. Martin , Jeffrey S. Moore , Larry J. Markoski , Kenneth A. Walker , Gary E. Spilman
IPC分类号： C07C37/055 , C07C39/17 , C07C63/38 , C07C63/49 , C07C63/72 , C07C211/61 , C07C233/65 , C07C265/14 , C08G65/40 , C08G69/26 , C08G69/32 , C07C205/12
CPC分类号： C08G69/32 , C07C211/61 , C07C233/65 , C07C265/14 , C07C29/147 , C07C37/00 , C07C63/38 , C07C63/49 , C07C63/72 , C08G65/4012 , C08G69/26 , C07C2102/06 , C07C2103/08
摘要： Novel difunctionalized cyclobutabenzene monomers of the general formula: ##STR1## wherein Z can be hydrogens or a cyclobutane ring; and X and Y are carboxyl, amino, alcohol, isocyanate, acid halide, or bis-acyl halide groups. Exemplary difunctional bitricyclodecatriene monomers are �2,2'-bidicyclo�2.4.0!octa-1,3,5-triene!-5,5'-dicarboxylic acid (BXTA) and �2,2'-bitricyclo�6.2.0.0!deca-1,3,(6),7-triene!-7,7'-dicarboxylic acid (QXTA). The difunctionalized bitricyclodecatriene monomers can form part of a polymer backbone chain in which the multiple butane ring functionalities can be easily opened to produce strong, three-dimensional covalent bond crosslinking between polymer chains. The crosslinking can be induced simply by heating the polymer to a temperature in excess of 250.degree. C.

33. 发明授权

US5557002A Process for the preparation of biphenyl containing intermediates useful in making angiotensin II receptor antagonists 失效
标题翻译：用于制备可用于制备血管紧张素II受体拮抗剂的联苯含中间体的方法
公开(公告)号：US5557002A
公开(公告)日：1996-09-17
申请号：US466128
申请日：1995-06-06
申请人： Yoshio Urawa , Ken Furukawa , Toshikazu Shimizu , Yoji Yamagishi , Tomio Tsurugi , Tomio Ichino
发明人： Yoshio Urawa , Ken Furukawa , Toshikazu Shimizu , Yoji Yamagishi , Tomio Tsurugi , Tomio Ichino
IPC分类号： C07C63/72 , C07C65/105 , C07C69/732 , C07C69/76 , C07D213/73 , C07D213/75 , C07D263/10 , C07D263/12 , C07D263/14 , C07D309/12 , C07D413/12 , C07D471/04 , C07C309/65 , C07C69/767 , C07C309/73
CPC分类号： C07D213/73 , C07C63/72 , C07C65/105 , C07C69/732 , C07C69/76 , C07D213/75 , C07D263/10 , C07D263/12 , C07D263/14 , C07D309/12 , C07D413/12 , C07D471/04 , Y02P20/55
摘要： The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: ##STR1## The 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative can be prepared in a high yield according to the present invention from a 2-amino-5-halogeno-3-nitropyridine derivative through amidation, N-alkylation and reductive cyclization. The halogen atom introduced at the 5-position as a protective group against nitration can be eliminated simultaneously in the step which is conducted thereafter. Thus, this process is industrially advantageous.Further, the biphenyl derivative of the present invention is excellent in reactivity and purity of the product, thus being an intermediate suitable for the industrial production.
摘要翻译：本发明提供了制备由下式（II）表示的2-烷基-3-（联苯-4-基）甲基-3H-咪唑并[4,5-b]吡啶衍生物的工业上有利的方法，其为前体可用作抗高血压药物的血管紧张素II受体的拮抗剂，作为吡啶衍生物的取代基的前体的联苯衍生物，其制备方法和用于制备联苯衍生物的中间体：（II）2-烷基-3-（联苯-4-基）甲基-3H-咪唑并[4,5-b]吡啶衍生物可以按照本发明从2-氨基 - 5-卤代-3-硝基吡啶衍生物通过酰胺化，N-烷基化和还原环化。在其后进行的步骤中可以同时消除在5位引入作为硝化保护基的卤素原子。因此，该方法在工业上是有利的。此外，本发明的联苯衍生物的产物的反应性和纯度优异，因此是适于工业化生产的中间体。

34. 发明授权

US5552508A Difunctional bitricyclodecatriene monomers 失效
标题翻译：双功能双环癸烯单体
公开(公告)号：US5552508A
公开(公告)日：1996-09-03
申请号：US448637
申请日：1995-05-23
申请人： David C. Martin , Jeffrey S. Moore , Larry J. Mar koski , Kenneth A. Walker , Gary E. Spilman
发明人： David C. Martin , Jeffrey S. Moore , Larry J. Mar koski , Kenneth A. Walker , Gary E. Spilman
IPC分类号： C07C37/055 , C07C39/17 , C07C63/38 , C07C63/49 , C07C63/72 , C07C211/61 , C07C233/65 , C07C265/14 , C08G65/40 , C08G69/26 , C08G69/32 , C08G63/00
CPC分类号： C08G69/32 , C07C211/61 , C07C233/65 , C07C265/14 , C07C29/147 , C07C37/00 , C07C63/38 , C07C63/49 , C07C63/72 , C08G65/4012 , C08G69/26 , C07C2102/06 , C07C2103/08
摘要： Novel difunctionalized cyclobutabenzene monomers of the general formula: ##STR1## wherein Z can be hydrogens or a cyclobutane ring; and X and Y are carboxyl, amino, alcohol, isocyanate, acid halide, or bis-acyl halide groups. Exemplary difunctional bitricyclodecatriene monomers are [2,2'-bidicyclo[2.4.0]octa-1,3,5-triene]-5,5'-dicarboxylic acid (BXTA) and [2,2'-bitricyclo[6.2.0.0]deca-1,3,(6),7-triene]-7,7'-dicarboxylic acid (QXTA). The difunctionalized bitricyclodecatriene monomers can form part of a polymer backbone chain in which the multiple butane ring functionalities can be easily opened to produce strong, three-dimensional covalent bond crosslinking between polymer chains. The crosslinking can be induced simply by heating the polymer to a temperature in excess of 250.degree. C.
摘要翻译：新的具有以下通式的二官能化环丁苯类单体：其中Z可以是氢或环丁烷环; X和Y是羧基，氨基，醇，异氰酸酯，酰卤或双酰卤基。示例性双官能双环癸三烯单体是[2,2'-双环[2.4.0]八氢-1,3,5-三烯] -5,5'-二羧酸（BXTA）和[2,2'-二环[6.2.0.0 ]癸-1,3，（6），7-三烯] -7,7'-二羧酸（QXTA）。双官能化的双环癸三烯单体可以形成聚合物主链的一部分，其中多个丁烷环官能团可以容易地打开以在聚合物链之间产生强烈的三维共价键交联。可以简单地通过将聚合物加热到超过250℃的温度来诱导交联。

35. 发明授权

US5294738A Process for selective hydrodefluorination 失效
标题翻译：选择性氢氟化方法
公开(公告)号：US5294738A
公开(公告)日：1994-03-15
申请号：US863264
申请日：1992-04-03
申请人： Jeffrey S. Stults , Lawrence B. Fertel , William S. Derwin
发明人： Jeffrey S. Stults , Lawrence B. Fertel , William S. Derwin
IPC分类号： B01J23/04 , C07B61/00 , C07C51/00 , C07C51/06 , C07C51/377 , C07C63/72 , C07D209/48
CPC分类号： C07D209/48 , C07C51/00
摘要： A process for the selective hydrodefluorination of a tetrafluorophthalimide compound of the formula ##STR1## where X is 1 and R is a monovalent organo group; or X is 2 and R is a divalent organo group; comprises reacting (I) the tetrafluorophthalimide with zinc in an aqueous alkali metal hydroxide medium. The product may be hydrolyzed to form 3,4,6-trifluorophthalic acid.
摘要翻译：一种式（*化学结构*）I的四氟邻苯二甲酰亚胺化合物的选择性加氢脱氟的方法，其中X是1，R是一价有机基团; 或X为2，R为二价有机基团; 包括使（I）四氟邻苯二甲酰亚胺与锌在碱金属氢氧化物水溶液介质中反应。产物可以水解形成3,4,6-三氟邻苯二甲酸。

36. 发明授权

US5202469A Partially fluorinated dicarboxylic acid and the acid chloride thereof, and a process for their preparation 失效
标题翻译：部分氟化二氰基酸及其氯化物及其制备方法
公开(公告)号：US5202469A
公开(公告)日：1993-04-13
申请号：US718009
申请日：1991-06-20
申请人： Freimund Rohrscheid , Wolfgang Appel , Gunter Siegemund
发明人： Freimund Rohrscheid , Wolfgang Appel , Gunter Siegemund
IPC分类号： B01J31/26 , B01J31/32 , C07B61/00 , C07C51/265 , C07C63/72
CPC分类号： C07C63/72
摘要： Partially fluorinated dicarboxylic acid and the acid chloride thereof, a process for its preparation and its use.The compound of the formula (I) ##STR1## and the acid chloride thereof are prepared by air oxidation in the presence of a catalyst mixture composed of the ions of cobalt, manganese and bromine in an acid organic medium. The compounds can be used for the preparation of linear polycarboxamides and polycarboxylic acid esters.
摘要翻译：部分氟化二羧酸及其酰氯，其制备方法及其用途。在酸性有机介质中，在由钴，锰和溴的离子组成的催化剂混合物存在下，通过空气氧化制备式（I）化合物及其酰氯。该化合物可用于制备线性聚酰胺和多元羧酸酯。

37. 发明授权

US5153334A Partially fluorinated tetracarboxylic acid and the dianhydride thereof 失效
标题翻译：部分氟化四羧酸及其二氢化物
公开(公告)号：US5153334A
公开(公告)日：1992-10-06
申请号：US718020
申请日：1991-06-20
申请人： Freimund Rohrscheid , Wolfgang Appel , Gunter Siegemund
发明人： Freimund Rohrscheid , Wolfgang Appel , Gunter Siegemund
IPC分类号： B01J31/26 , B01J31/32 , C07B61/00 , C07C51/265 , C07C63/72
CPC分类号： C07C63/72
摘要： Partially fluorinated tetracarboxylic acid and the dianhydride thereof, a process for their preparation and their useA compound of the formula ##STR1## and the dianhydride thereof are prepared by air oxidation in the presence of a catalyst mixture composed of at least 2 heavy metal salts and also bromine in an acid organic medium. The compounds can be employed for the preparation of partially fluorinated polycondensates, such as polyimides, polycarboxamides, esters of polyamidecarboxylic acids, polyamides and imide-oligomers.
摘要翻译：部分氟化四羧酸及其二酐，其制备方法及其应用通式（I）的化合物及其二酐通过空气氧化在催化剂混合物存在下制备，所述催化剂混合物由至少2重的金属盐和溴在酸性有机介质中。该化合物可用于制备部分氟化缩聚物，如聚酰亚胺，聚酰胺酰胺，聚酰胺羧酸酯，聚酰胺和酰亚胺低聚物。

38. 发明授权

US5068409A Bis(4-halo-phthalic acid) quarter salt, process for their preparation and their use 失效
标题翻译： BIS（4-HALO-PHTHALIC ACID）季铵盐，其制备方法及其使用
公开(公告)号：US5068409A
公开(公告)日：1991-11-26
申请号：US579360
申请日：1990-09-07
申请人： Olga Vainberg , Leonard M. Shorr
发明人： Olga Vainberg , Leonard M. Shorr
IPC分类号： C07C63/00 , C07C63/68 , C07C63/72
CPC分类号： C07C63/68
摘要： The bis(4-halo-phthalic acid) quarter salt of formula ##STR1## wherein M is an alkali metal or ammonium, and X is a halogen atom is descibed. Further described is a process for its preparation and a method of purifying 4-halo-phthalic acid containing impurities, which comprises preparing therefrom a compound of formula I, separating the compound of formula I which precipitates from the mother liquor, washing it and recovering the 4-halo-phthalic acid.

39. 发明授权

US4946935A Fluorine-containing aromatic compound, process for preparing the same and use thereof 失效
标题翻译：含氟芳香族化合物，其制备方法及其用途
公开(公告)号：US4946935A
公开(公告)日：1990-08-07
申请号：US177446
申请日：1988-04-04
申请人： Yohnosuke Ohsaka , Tsutomu Kobayashi , Motonobu Kubo
发明人： Yohnosuke Ohsaka , Tsutomu Kobayashi , Motonobu Kubo
IPC分类号： C07C22/08 , C07C39/367 , C07C43/178 , C07C63/72 , C07D303/24 , C08G59/06 , C08G59/30 , C08G65/32 , C08G73/10 , H01L21/312
CPC分类号： C08G73/1039 , C07C22/08 , C07C39/367 , C07C43/1786 , C07C63/72 , C07D303/24 , C08G59/063 , C08G59/30 , C08G65/32 , H01L21/312
摘要： A novel fluorine-containing aromatic compound of the formula: ##STR1## wherein X is ##STR2## in which R.sub.f is a perfluoroalkyl group having 1 to 10 carbon atoms, R.sub.f ' is a perfluoroalkyl group having 1 to 12 carbon atoms, p is an integer of 1 to 3, q is an integer of 0 to 3, r is 0 or 1, s is an integer of 0 to 5 and t is an integer of 0 to 5,Y is X, a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or a fluoroalkyl group having 1 to 8 carbon atoms, andeach A is independently ##STR3## in which D is an amino, carboxyl, hydroxyl, methyl or haloformyl group, and n is an integer of 1 or 2, or ##STR4## can be used to derive various compounds, some of which are useful for preparing a fluorine-containing epoxy compound or polyimide with good properties.

40. 发明授权

US4863640A Monomers for high temperature fluorinated polyimides 失效
标题翻译：高温氟化聚酰亚胺单体
公开(公告)号：US4863640A
公开(公告)日：1989-09-05
申请号：US867716
申请日：1986-05-27
申请人： Daniel A. Scola
发明人： Daniel A. Scola
IPC分类号： C07C63/72 , C07C65/105 , C07C309/58
CPC分类号： C07C65/105 , C07C309/58 , C07C63/72
摘要： Fluorinated aromatic hydrocarbons including fluorinated aromatic carboxylic acids fluorinated aromatic dianhydrides and fluorinated aromatic dialkyl esters that serve as precursor monomers for high temperature fluorinated polyimides. The fluorinated aromatic carboxylic acid monomer comprises: ##STR1## wherein X is hydrogen, carboxyl, sulfonic acid, hydroxy, alkyl, halogen or nitro and hydrates of said acids. The fluorinated aromatic dianhydride monomer comprises: ##STR2## wherein x is hydrogen, carboxyl, sulfonic acid, hydroxy, alkyl, halogen or nitro. The fluorinated aromatic dialkyl ester monomer comprises: ##STR3## wherein X is hydrogen, carboxyl, sulfonic acid, hydroxy, alkyl, halogen or nitro and Y is an alkyl group and hydrates of said esters.
摘要翻译：作为高温氟化聚酰亚胺的前体单体的含氟芳香族羧酸氟化芳香族二酸酐和氟化芳香族二烷基酯的氟化芳香族烃。氟化芳族羧酸单体包括：其中X是所述酸的氢，羧基，磺酸，羟基，烷基，卤素或硝基和水合物。氟化芳族二酐单体包含：其中x是氢，羧基，磺酸，羟基，烷基，卤素或硝基。氟化芳族二烷基酯单体包括：其中X是氢，羧基，磺酸，羟基，烷基，卤素或硝基，Y是烷基和所述酯的水合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式