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31. 发明授权

US09548193B2 Quadrupole mass spectrometer with quadrupole mass filter as a mass separator 有权
标题翻译：具有四极质量过滤器的四极质谱仪作为质量分离器
公开(公告)号：US09548193B2
公开(公告)日：2017-01-17
申请号：US12994019
申请日：2008-05-26
申请人： Kazuo Mukaibatake , Shigenobu Nakano , Minoru Fujimoto
发明人： Kazuo Mukaibatake , Shigenobu Nakano , Minoru Fujimoto
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/4215 , H01J49/429
摘要： In a scan measurement in which a mass scan is repeated across a predetermined mass range, when a voltage is returned from a termination voltage of one scan to an initiation voltage for the next scan, an undershoot or other drawbacks occur to destabilize the voltage value. Therefore, an appropriate waiting time is required. Conventionally, this waiting time has been set to be constant regardless of the analysis conditions. On the other hand, in the quadrupole mass spectrometer according to the present invention, the mass difference ΔM between the scan termination mass and the scan initiation mass is computed based on the specified mass range, and a different settling time is set in accordance with this mass difference. When the mass difference ΔM is small and hence requires only a short voltage stabilization time, a relatively short settling time is set. This shortens the cycle period of the mass scan, which increases the temporal resolution.
摘要翻译：在其中质量扫描在预定质量范围内重复的扫描测量中，当电压从一次扫描的终止电压返回到下次扫描的起始电压时，会发生下冲或其他缺点，以使电压值不稳定。因此，需要适当的等待时间。通常，无论分析条件如何，该等待时间都被设定为恒定。另一方面，在本发明的四极质谱仪中，基于规定的质量范围来计算扫描终止质量和扫描开始质量之间的质量差ΔM，并根据该设定设定不同的建立时间质量差异当质量差ΔM小时，仅需要短的电压稳定时间时，设定较短的建立时间。这缩短了质量扫描的循环周期，这增加了时间分辨率。

32. 发明授权

US09496126B2 Systems and methods for improved robustness for quadrupole mass spectrometry 有权
标题翻译：改善四极杆质谱稳定性的系统和方法
公开(公告)号：US09496126B2
公开(公告)日：2016-11-15
申请号：US14690307
申请日：2015-04-17
申请人： Thermo Finnigan LLC
发明人： Johnathan Wayne Smith
IPC分类号： H01J49/32 , H01J47/06 , G01N30/00 , H01J49/42 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/0036 , H01J49/025
摘要： A method for analyzing a sample by mass spectrometry includes producing ions from the sample, delivering the ions to an entrance of a multipole, and applying oscillatory and resolving DC voltages to electrodes of the multipole. The oscillatory and resolving DC voltages cause the multipole to selectively transmit to its distal end ions within a range of mass-to-charge ratios (m/z's) determined by the amplitudes of the oscillatory and resolving DC voltages. The method further includes acquiring data representative of the spatial distributions of ions transmitted by the multipole at a plurality of consecutive time points, and deconvolving the acquired data to produce a mass spectrum. Deconvolving the acquired data includes processing the data to compress a dynamic range of intensity values in the data.
摘要翻译：通过质谱分析样品的方法包括从样品中产生离子，将离子输送到多极的入口，以及向多极的电极施加振荡和分解的DC电压。振荡和分辨的DC电压导致多极选择性地在由振荡和分辨的DC电压的振幅确定的质荷比（m / z）范围内向其远端离子传输。该方法还包括获取表示在多个连续时间点由多极发射的离子的空间分布的数据，并且对所获取的数据进行解卷积以产生质谱。解卷积采集的数据包括处理数据以压缩数据中的强度值的动态范围。

33. 发明申请

US20160317971A1 Isotopic enrichment of helium-3 through glass 审中-公开
标题翻译：氦-3通过玻璃同位素富集
公开(公告)号：US20160317971A1
公开(公告)日：2016-11-03
申请号：US14999374
申请日：2016-04-29
申请人： Gary Michael McMurtry , James Robert DeLuze
发明人： Gary Michael McMurtry , James Robert DeLuze
IPC分类号： B01D59/14 , H01J49/00 , H01J49/42 , C01B23/00 , B01D53/22 , B01D53/30 , B01D71/04 , G01N33/00 , H01J49/04
CPC分类号： C01B23/0047 , B01D53/228 , B01D53/30 , B01D59/12 , B01D71/04 , G01N33/0036 , H01J49/421 , H01J49/4215
摘要： Disclosed is a mass selective fluid bandpass filter. This filter provides for selecting gas molecules of a specific mass from a gas sample containing molecules of two or more mass species. This provides for a low power, low cost apparatus for producing 3He from terrestrial sources of helium gas by selective enrichment. This invention further discloses a portable, field deployable means of 3He/4He ratio determination employing one or more of the effects consisting of: statistical linear regression plots of heat ramps, variable emission currents within a quadruple mass spectrometer, use of a quadrupole mass spectrometer in concert with ultrahigh vacuum maintained by non evaporable getter pumps, and/or construction of vacuum housing structures from non-steel or non-stainless steel alloys, and/or non metallic materials selected from a group consisting of: aluminum, titanium, ceramics, or glass. This provides a compact, sensitive field deployable unit with low power consumption.
摘要翻译：公开了一种质量选择性流体带通滤波器。该过滤器用于从含有两种或多种质量物质的分子的气体样品中选择特定物质的气体分子。这提供了一种低功率，低成本的装置，用于通过选择性富集从氦气的陆地源产生3He。本发明进一步公开了一种使用以下一种或多种效应的3He / 4He比率测定的便携式现场可部署装置，其特征包括：热斜率的统计线性回归图，四重质谱仪内的可变发射电流，四极质谱仪由非蒸发式吸气泵维持的超高真空的协奏曲和/或从非钢或非不锈钢合金构成的真空壳体结构，和/或选自以下的非金属材料：铝，钛，陶瓷或玻璃。这提供了具有低功耗的紧凑，灵敏的现场可部署单元。

34. 发明授权

US09466474B2 Triple quadrupole mass spectrometer 有权
标题翻译：三重四极杆质谱仪
公开(公告)号：US09466474B2
公开(公告)日：2016-10-11
申请号：US14909764
申请日：2013-08-08
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda
IPC分类号： H01J49/26 , H01J49/42 , H01J49/06 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/005 , H01J49/06 , H01J49/24
摘要： The present triple quadrupole mass spectrometer determines the relationship between a parameter, such as the mass-to-charge ratio of a precursor ion or that of a product ion, and the optimal collision-gas pressure giving the highest signal intensity in an MRM measurement, derives an approximate equation expressing that relationship, and stores the information representing the equation in an optimum collision-gas pressure calculation information storage section. When a measurement is to be performed, an analysis operator enters the mass-to-charge ratio of a precursor ion or product ion of a target compound. Based on the approximate equation read from the storage section, an optimum collision-gas pressure calculator determines the optimum collision-gas pressure for the specified precursor ion or product ion, and sets this pressure as a measurement condition for the apparatus.
摘要翻译：本发明的三重四极杆质谱仪确定了前体离子或产物离子的质荷比等参数与在MRM测量中给出最高信号强度的最佳碰撞气体压力之间的关系，导出表示该关系的近似式，并将表示该方程的信息存储在最佳碰撞气体压力计算信息存储部中。当进行测量时，分析算子输入目标化合物的前体离子或产物离子的质荷比。基于从存储部分读取的近似方程，最佳碰撞气体压力计算器确定用于指定的前体离子或产物离子的最佳碰撞气体压力，并将该压力设定为该装置的测量条件。

35. 发明申请

US20160225593A1 RF-Only Detection Scheme and Simultaneous Detection of Multiple Ions 有权
标题翻译：仅RF检测方案和多个离子的同时检测
公开(公告)号：US20160225593A1
公开(公告)日：2016-08-04
申请号：US15021362
申请日：2014-09-12
申请人： DH Technologies Development PTE. Ltd.
发明人： James Hager , Christopher M Lock
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/0036 , H01J49/005 , H01J49/063 , H01J49/4215
摘要： A mass spectrometer apparatus and method for conducting simultaneous MS/MS analysis including: a device to select a precursor ion having a specified m/z; a gas-filled collision cell; an RF-only multipole mass spectrometer, the mass spectrometer having a generator attached thereto for generating at least two auxiliary AC fields in the RF-only multipole mass spectrometer; a gate for providing a repulsive DC or AC barrier downstream to an exit of the RF-only multipole mass spectrometer; an ion detection system situated downstream from the DC or AC barrier for measuring an ion current derived from ions that overcome the repulsive barrier. The mass spectrometer may also be configured so that each of the auxiliary AC fields are generated by the introduction of individual auxiliary AC frequencies and each frequency is amplitude modulated at a unique frequency.
摘要翻译：用于同时进行MS / MS分析的质谱仪装置和方法，包括：选择具有指定m / z的前体离子的装置; 充气碰撞池; RF仅多极质谱仪，质谱仪具有附接到其上的发生器，用于在仅RF多极质谱仪中产生至少两个辅助AC场; 用于在RF仅多极质谱仪的出口下游提供排斥的DC或AC屏障的门; 离子检测系统位于DC或AC屏障的下游，用于测量源自克服排斥屏障的离子的离子电流。质谱仪也可以被配置成使得每个辅助AC场是通过引入各个辅助AC频率而产生的，并且每个频率以唯一的频率进行幅度调制。

36. 发明授权

US09384953B2 Tandem quadrupole mass spectrometer 有权
标题翻译：串联四极杆质谱仪
公开(公告)号：US09384953B2
公开(公告)日：2016-07-05
申请号：US14439731
申请日：2012-11-13
申请人： SHIMADZU CORPORATION
发明人： Shinjiro Fujita
IPC分类号： H01J49/26 , H01J49/00 , H01J49/42
CPC分类号： H01J49/005 , H01J49/0031 , H01J49/4215
摘要： A measurement condition memory stores a CID gas condition table indicating a relation between the scan speed of a mass scan by a front-stage quadrupole mass filter and a CID gas supply pressure. If the scan speed is high, an influence of a decrease in speed of ions due to collisions with a CID gas inside a collision cell is relatively large. An appropriate CID gas supply pressure that reduces the decay of a peak waveform on a mass spectrum and makes the ion intensity as high as possible is examined in advance for each scan speed, and is stored in advance. During measurement of a target sample, if a precursor ion scan measurement mode or the like is designated, a CID gas supply pressure corresponding to the currently set scan speed is obtained based on the CID gas condition table, and the CID gas supplier is controlled.
摘要翻译：测量条件存储器存储表示前级四极杆质量过滤器的质量扫描的扫描速度与CID气体供给压力之间的关系的CID气体条件表。如果扫描速度高，则碰撞室内的CID气体碰撞引起的离子速度下降的影响相对较大。针对每个扫描速度预先检查适当的CID气体供应压力，其减少质谱上峰值波形的衰减并使离子强度尽可能高，并且预先存储。在目标样品的测量中，如果指定了前体离子扫描测量模式等，则基于CID气体条件表获得与当前设定的扫描速度相对应的CID气体供给压力，并控制CID气体供给器。

37. 发明申请

US20160181076A1 Tuning a Mass Spectrometer Using Optimization 审中-公开
标题翻译：使用优化调谐质谱仪
公开(公告)号：US20160181076A1
公开(公告)日：2016-06-23
申请号：US14575802
申请日：2014-12-18
申请人： Thermo Finnigan LLC
发明人： Johnathan Wayne SMITH
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/0009 , H01J49/4215
摘要： Systems, methods, and apparatuses are provided for tuning a mass spectrometer. An optimization process can be performed to determine optimal parameters for various physical parameters of elements of the mass spectrometer. A cost function (metric) can be defined for optimizing a measured signal output from the spectrometer. The metric can include an intensity term and a rectangularity term. The rectangularity term can provide a quantification of an extent that a measured signal corresponding to a first mass-to-charge ratio approximates a rectangle. The parameter values can be adjusted to find an optimal cost value of the cost function. Techniques may particularly useful when a quadrupole is operated in a broad-stability mode.
摘要翻译：提供了用于调谐质谱仪的系统，方法和装置。可以执行优化过程以确定质谱仪元件的各种物理参数的最佳参数。可以定义成本函数（度量）来优化来自光谱仪的测量信号输出。度量可以包括强度项和矩形项。矩形项可以提供对应于第一质荷比的测量信号近似于矩形的程度的量化。可以调整参数值以找到成本函数的最优成本值。当四极杆在宽稳定性模式下操作时，技术可能特别有用。

38. 发明授权

US09202676B2 Method and system for quantitative and qualitative analysis using mass spectrometry 有权
标题翻译：使用质谱定量和定性分析的方法和系统
公开(公告)号：US09202676B2
公开(公告)日：2015-12-01
申请号：US14367235
申请日：2012-11-28
申请人： DH Technologies Development Pte. Ltd.
发明人： John Lawrence Campbell , James Hager
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/0031 , H01J49/42 , H01J49/4215
摘要： In some embodiments, a quantitative analysis of at least one ion signal associated with a sample, which is detected by a mass spectrometer having at least two tandem quadrupole instruments, is employed to select one of the following operational modes for further mass analysis of the sample: (a) utilizing both quadrupole instruments as mass resolving filters, and (b) utilizing one quadrupole instrument as a mass resolving filter and utilizing the other as a linear ion trap. In some embodiments, the quantitative analysis of the ion signal comprises comparing the ion signal intensity with a predefined threshold.
摘要翻译：在一些实施方案中，采用与具有至少两个串联四极杆仪器的质谱仪检测到的与样品相关联的至少一个离子信号的定量分析来选择以下操作模式之一用于样品的进一步质量分析：（a）利用四极仪器作为质量分辨率滤波器，（b）利用一个四极仪器作为质量分辨率滤波器，并利用另一个作为线性离子阱。在一些实施例中，离子信号的定量分析包括将离子信号强度与预定阈值进行比较。

39. 发明申请

US20150340212A1 TANDEM QUADRUPOLE MASS SPECTROMETER 有权
标题翻译： TANDEM QUADRUPOLE质谱仪
公开(公告)号：US20150340212A1
公开(公告)日：2015-11-26
申请号：US14442650
申请日：2012-11-22
申请人： SHIMADZU CORPORATION
发明人： Manabu UEDA
IPC分类号： H01J49/00 , H01J49/24
CPC分类号： H01J49/4215 , G01N30/7266 , H01J49/004 , H01J49/005 , H01J49/24
摘要： A dwell time calculation table (51a) showing a correspondence relation between a CID gas pressure inside a collision cell (31) and a dwell time for data collection is stored in a processing condition parameter memory (51) of a controller (50). In the table (51a), as the CID gas pressure becomes higher, the dwell time becomes longer. When an instruction to execute an MRM measurement mode is given, the controller (50) determines the dwell time in accordance with the currently set CID gas pressure, and controls a data collector (41) to accumulate detection signals from an ion detector (34) during the determined dwell time and obtain the accumulated value. If the CID gas pressure inside the collision cell (31) is high, a decrease in ion speed becomes remarkable, and the rising of the ion intensity becomes slow. However, if the dwell time becomes long, influences of the slow rising on the accumulated value are relatively reduced, and the accuracy of the accumulated value is enhanced. Accordingly, the quantitative accuracy can be enhanced.
摘要翻译：示出了在碰撞单元（31）内的CID气体压力与数据采集的停留时间之间的对应关系的停留时间计算表（51a）存储在控制器（50）的处理条件参数存储器（51）中。在台（51a）中，随着CID气体压力变高，停留时间变长。当给出执行MRM测量模式的指令时，控制器（50）根据当前设置的CID气体压力确定停留时间，并且控制数据收集器（41）累积来自离子检测器（34）的检测信号，在确定的停留时间内获得累积值。如果碰撞池（31）内的CID气体压力高，则离子速度的降低变得显着，离子强度的上升变慢。然而，如果停留时间变长，则缓慢上升对累积值的影响相对降低，并且累积值的精度提高。因此，可以提高定量精度。

40. 发明申请

US20150262807A1 MASS SPECTROMETER 有权
标题翻译：质谱仪
公开(公告)号：US20150262807A1
公开(公告)日：2015-09-17
申请号：US14722868
申请日：2015-05-27
申请人： CANON ANELVA CORPORATION
发明人： Megumi NAKAMURA , Masayuki SUGIYAMA , Lei CHEN , Yoshiyuki TAKIZAWA
IPC分类号： H01J49/42 , H01J49/24 , H01J49/14
CPC分类号： H01J49/4215 , H01J49/025 , H01J49/147 , H01J49/24
摘要： An object of the present invention is to provide a mass spectrometer having a simple structure and being capable of precisely measuring a total pressure and performing mass spectrometry with high precision. A mass spectrometer according to one embodiment includes a quadrupole configured to selectively pass therethrough an ion of a target gas having a predetermined mass-to-charge ratio among components of a measurement gas ionized by an ion source, an ion detector configured to detect an ion current value based on the ion of the target gas that passes through the quadrupole, a total pressure measurer configured to detect a photoelectric current value based on vacuum ultraviolet light generated when the ion source ionizes the measurement gas, and an arithmetic unit configured to calculate a partial pressure of the target gas by using the photoelectric current value and the ion current value.
摘要翻译：本发明的目的是提供一种结构简单且能够精确地测量总压力并以高精度进行质谱的质谱仪。根据一个实施方案的质谱仪包括四极，其构造成选择性地通过离子源离子化的测量气体的组分中具有预定质量比的目标气体的离子，被配置为检测离子的离子检测器基于通过四极杆的目标气体的离子的当前值，基于当离子源电离测量气体时产生的真空紫外光检测光电流值的总压力测量器，以及运算单元，被配置为计算通过使用光电流值和离子电流值对目标气体的分压。

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