专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US12080531B2 Fourier transform quadrupole calibration method 有权
公开(公告)号：US12080531B2
公开(公告)日：2024-09-03
申请号：US17756928
申请日：2020-09-29
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： James Hager
IPC分类号： H01J49/00 , G06F17/14 , H01J49/06
CPC分类号： H01J49/0009 , G06F17/142 , H01J49/063
摘要： In one aspect, a method of calibrating a Fourier Transform (FT) multipole mass spectrometer is disclosed, which comprises measuring a plurality of secular frequencies of a calibrant ion in a multipole FT mass analyzer for a plurality of RF voltages (VRF) applied to at least one rod of the multipole mass analyzer, calculating Mathieu β and q parameters for each of 5 the measured secular frequencies, and determining RF voltage amplitude (VRF) for each calculated q parameter. For each calculated q parameter, an offset RF voltage amplitude (ΔVRF) corresponding to a deviation of the applied VRF and the calculated VRF is determined so as to generate a ΔVRFv.s. q calibration curve.

2. 发明申请

US20210327700A1 RF/DC Cutoff to Reduce Contamination and Enhance Robustness of Mass Spectrometry Systems 有权
公开(公告)号：US20210327700A1
公开(公告)日：2021-10-21
申请号：US17270485
申请日：2019-08-21
申请人： DH Technologies Development Pte. Ltd.
发明人： James Hager
IPC分类号： H01J49/06 , H01J49/00 , H01J49/24 , H01J49/10
摘要： Systems and methods described herein utilize a multipole ion guide that can receive ions from an ion source for transmission to downstream mass analyzers, while preventing unwanted/interfering/contaminating ions from being transmitted into the high-vacuum chambers of mass spectrometry systems. In various aspects, RF and/or DC signals can be provided to auxiliary electrodes interposed within a quadrupole rod set so as to control or manipulate the transmission of ions from the multipole ion guide.

3. 发明授权

US09997340B2 RF-only detection scheme and simultaneous detection of multiple ions 有权
公开(公告)号：US09997340B2
公开(公告)日：2018-06-12
申请号：US15021362
申请日：2014-09-12
申请人： DH Technologies Development PTE Ltd.
发明人： James Hager , Christopher M Lock
IPC分类号： H01J49/42 , H01J49/00 , H01J49/06
CPC分类号： H01J49/0036 , H01J49/005 , H01J49/063 , H01J49/4215
摘要： A mass spectrometer apparatus and method for conducting simultaneous MS/MS analysis including: a device to select a precursor ion having a specified m/z; a gas-filled collision cell; an RF-only multipole mass spectrometer, the mass spectrometer having a generator attached thereto for generating at least two auxiliary AC fields in the RF-only multipole mass spectrometer; a gate for providing a repulsive DC or AC barrier downstream to an exit of the RF-only multipole mass spectrometer; an ion detection system situated downstream from the DC or AC barrier for measuring an ion current derived from ions that overcome the repulsive barrier. The mass spectrometer may also be configured so that each of the auxiliary AC fields are generated by the introduction of individual auxiliary AC frequencies and each frequency is amplitude modulated at a unique frequency.

4. 发明授权

US11810771B2 Fourier transform mass spectrometer based on use of a fringing field to convert radial oscillations of excited ions to axial oscillations 有权
公开(公告)号：US11810771B2
公开(公告)日：2023-11-07
申请号：US16482476
申请日：2018-01-29
申请人： DH Technologies Development Pte. Ltd.
发明人： James Hager
IPC分类号： H01J49/00 , H01J49/06 , H01J49/42
CPC分类号： H01J49/0031 , H01J49/063 , H01J49/067 , H01J49/427
摘要： In one aspect, a mass analyzer is disclosed, which comprises a quadrupole having an input end for receiving ions and an output end through which ions can exit the quadrupole, said quadrupole having a plurality of rods to at least some of which an RF voltage can be applied for generating a quadrupolar field for causing radial confinement of the ions as they propagate through the quadrupole and further generating fringing fields in proximity of said output end. The mass analyzer further includes at least a voltage source for applying a voltage pulse to at least one of said rods so as to excite radial oscillations of at least a portion of the ions passing through the quadrupole at secular frequencies thereof, where the radially-excited ions interact with the fringing fields as they exit the quadrupole such that their radial oscillations are converted into axial oscillations.

5. 发明申请

US20230010966A1 Fourier Transform Quadrupole Calibration Method 有权
公开(公告)号：US20230010966A1
公开(公告)日：2023-01-12
申请号：US17756928
申请日：2020-09-29
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： James Hager
IPC分类号： H01J49/00 , G06F17/14 , H01J49/06
摘要： In one aspect, a method of calibrating a Fourier Transform (FT) multipole mass spectrometer is disclosed, which comprises measuring a plurality of secular frequencies of a calibrant ion in a multipole FT mass analyzer for a plurality of RF voltages (VRF) applied to at least one rod of the multipole mass analyzer adjusted q analyzer, calculating Mathieu β and q parameters for each of 5 the measured secular frequencies, and determining RF voltage amplitude (VRF) for each calculated q parameter. For each calculated q parameter, an offset RF voltage amplitude (ΔVRF) corresponding to a deviation of the applied VRF and the calculated VRF is determined so as to generate a ΔVRFv.s. q calibration curve.

6. 发明授权

US11869758B2 Mass separator for use in a mass spectrometry system 有权
公开(公告)号：US11869758B2
公开(公告)日：2024-01-09
申请号：US17270493
申请日：2019-08-21
申请人： DH Technologies Development Pte. Ltd.
发明人： James Hager
IPC分类号： H01J49/06 , H01J49/42
CPC分类号： H01J49/063 , H01J49/4225 , H01J49/4215
摘要： Systems and methods disclosed herein utilize an interface positioned between an ion source and an ion guide of a mass spectrometry system that can be useful to control transmission ions from an ion source to a downstream mass analyzer. In various aspects, the present disclosure provides methods of modulating an introduction of ions into an ion guide. In some embodiments, the present disclosure provides methods of making and using disclosed interface elements and mass spectrometry systems. In some embodiments, implementations of the present disclosure are useful in mass spectrometry systems, including, for example, improving signal-to-noise and reducing contamination.

7. 发明申请

US20220384173A1 Methods and Systems of Fourier Transform Mass Spectrometry 有权
公开(公告)号：US20220384173A1
公开(公告)日：2022-12-01
申请号：US17754968
申请日：2020-09-29
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： James Hager
IPC分类号： H01J49/42
摘要： In various aspects, methods and systems disclosed herein are capable of operating a Fourier Transform Mass Spectrometry (FTMS) quadrupole mass analyzer in two operational modes: transmitting mode and trapping mode. In the trapping mode, ions are first trapped and cooled within the FTMS quadrupole mass analyzer prior to being subjected to an excitation pulse and ejected from the FTMS quadrupole mass analyzer for detection. However, in transmitting mode, the FTMS quadrupole mass analyzer may provide more rapid analysis because the excitation pulse is applied to the ions of an ion beam that is being continuously transmitted through the FTMS quadrupole mass analyzer.

8. 发明公开

US20230147220A1 Mass Separator for Use in a Mass Spectrometry System 审中-公开
公开(公告)号：US20230147220A1
公开(公告)日：2023-05-11
申请号：US17270493
申请日：2019-08-21
申请人： DH Technologies Development Pte. Ltd.
发明人： James Hager
IPC分类号： H01J49/06 , H01J49/42
CPC分类号： H01J49/063 , H01J49/4225 , H01J49/4215
摘要： Systems and methods disclosed herein utilize an interface positioned between an ion source and an ion guide of a mass spectrometry system that can be useful to control transmission ions from an ion source to a downstream mass analyzer. In various aspects, the present disclosure provides methods of modulating an introduction of ions into an ion guide. In some embodiments, the present disclosure provides methods of making and using disclosed interface elements and mass spectrometry systems. In some embodiments, implementations of the present disclosure are useful in mass spectrometry systems, including, for example, improving signal-to-noise and reducing contamination.

9. 发明申请

US20210134573A1 Fourier Transform Mass Spectrometer 有权
公开(公告)号：US20210134573A1
公开(公告)日：2021-05-06
申请号：US16482476
申请日：2018-01-29
申请人： DH Technologies Development Pte. Ltd.
发明人： James Hager
IPC分类号： H01J49/00 , H01J49/06 , H01J49/42
摘要： In one aspect, a mass analyzer is disclosed, which comprises a quadrupole having an input end for receiving ions and an output end through which ions can exit the quadrupole, said quadrupole having a plurality of rods to at least some of which an RF voltage can be applied for generating a quadrupolar field for causing radial confinement of the ions as they propagate through the quadrupole and further generating fringing fields in proximity of said output end. The mass analyzer further includes at least a voltage source for applying a voltage pulse to at least one of said rods so as to excite radial oscillations of at least a portion of the ions passing through the quadrupole at secular frequencies thereof, where the radially-excited ions interact with the fringing fields as they exit the quadrupole such that their radial oscillations are converted into axial oscillations.

10. 发明申请

US20160225593A1 RF-Only Detection Scheme and Simultaneous Detection of Multiple Ions 有权
标题翻译：仅RF检测方案和多个离子的同时检测
公开(公告)号：US20160225593A1
公开(公告)日：2016-08-04
申请号：US15021362
申请日：2014-09-12
申请人： DH Technologies Development PTE. Ltd.
发明人： James Hager , Christopher M Lock
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/0036 , H01J49/005 , H01J49/063 , H01J49/4215
摘要： A mass spectrometer apparatus and method for conducting simultaneous MS/MS analysis including: a device to select a precursor ion having a specified m/z; a gas-filled collision cell; an RF-only multipole mass spectrometer, the mass spectrometer having a generator attached thereto for generating at least two auxiliary AC fields in the RF-only multipole mass spectrometer; a gate for providing a repulsive DC or AC barrier downstream to an exit of the RF-only multipole mass spectrometer; an ion detection system situated downstream from the DC or AC barrier for measuring an ion current derived from ions that overcome the repulsive barrier. The mass spectrometer may also be configured so that each of the auxiliary AC fields are generated by the introduction of individual auxiliary AC frequencies and each frequency is amplitude modulated at a unique frequency.
摘要翻译：用于同时进行MS / MS分析的质谱仪装置和方法，包括：选择具有指定m / z的前体离子的装置; 充气碰撞池; RF仅多极质谱仪，质谱仪具有附接到其上的发生器，用于在仅RF多极质谱仪中产生至少两个辅助AC场; 用于在RF仅多极质谱仪的出口下游提供排斥的DC或AC屏障的门; 离子检测系统位于DC或AC屏障的下游，用于测量源自克服排斥屏障的离子的离子电流。质谱仪也可以被配置成使得每个辅助AC场是通过引入各个辅助AC频率而产生的，并且每个频率以唯一的频率进行幅度调制。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式