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31. 发明申请

US20160361719A1 A THERMAL CYCLER HAVING A TEMPERATURE ANALYSIS AND/OR VERIFICATION UNIT AND A METHOD FOR ANALYZING OR VERIFYING A THERMAL PERFORMANCE OF A THERMAL CYCLER AND FOR CALIBRATING THE THERMAL CYCLER 审中-公开
标题翻译：具有温度分析和/或验证单元的热循环器和用于分析或验证热循环器的热性能并用于校准热循环的方法
公开(公告)号：US20160361719A1
公开(公告)日：2016-12-15
申请号：US15103543
申请日：2014-12-02
申请人： HAIN LIFESIENCE GMBH
发明人： James COURTNEY
IPC分类号： B01L7/00 , C12P19/34
CPC分类号： B01L7/52 , B01L3/50851 , B01L2200/028 , B01L2200/147 , B01L2200/148 , B01L2300/025 , B01L2300/041 , B01L2300/0663 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1894 , C12P19/34
摘要： The invention relates to a thermal cycler (10) comprising a housing (12), the housing (12) accommodating a thermal block (14) having a plurality of sample wells (32), each for receiving a test sample in a sample vessel, electric heater means (18) for heating the thermal block (14), a power supply (24) and an electronic control (22) for controlling the electric heater means (18), and further comprising a temperature analysis and/or verification unit (28) for analyzing and/or verifying a thermal performance of the thermal block (14). The invention further relates to a method for analyzing or verifying a thermal performance of a thermal cycler (10) and for calibrating the thermal cycler (10). The thermal cycler (10) is characterized in that the temperature analysis and/or verification unit (28) is integrated into the housing (12) and is connected to the power supply (24) and to the electronic control (22) by means of an internal interface (26), whereas the method is characterized by the following steps: providing the thermal cycler (10) with an integrated temperature analysis and/or verification unit (28) and using the integrated temperature analysis and/or verification unit (28) for self-calibration of the thermal cycler (10).
摘要翻译：本发明涉及一种包括壳体（12）的热循环仪（10），所述壳体（12）容纳具有多个样品孔（32）的热块（14），每个样品孔用于在样品容器中接收测试样品，用于加热热块（14）的电加热器装置（18），用于控制电加热器装置（18）的电源（24）和电子控制装置（22），还包括温度分析和/或验证单元 28），用于分析和/或验证热块（14）的热性能。本发明还涉及一种用于分析或验证热循环仪（10）的热性能并用于校准热循环仪（10）的方法。热循环器（10）的特征在于，温度分析和/或验证单元（28）被集成到壳体（12）中，并且通过以下方式连接到电源（24）和电子控制器（22）内部接口（26），而该方法的特征在于以下步骤：向热循环仪（10）提供集成温度分析和/或验证单元（28），并使用集成温度分析和/或验证单元（28））用于热循环仪（10）的自校准。

32. 发明申请

US20160354773A1 COMPONENT OF A DEVICE, A DEVICE, AND A METHOD FOR PURIFYING AND TESTING BIOMOLECULES FROM BIOLOGICAL SAMPLES 审中-公开
标题翻译：装置的组件，装置和用于从生物样品中净化和测试生物分子的方法
公开(公告)号：US20160354773A1
公开(公告)日：2016-12-08
申请号：US14732423
申请日：2015-06-05
申请人： Yongmei Li , Li Li
发明人： Yongmei Li , Li Li
IPC分类号： B01L3/00 , G01N1/40 , C12Q1/68
CPC分类号： B01L3/502 , B01L3/508 , B01L3/52 , B01L3/561 , B01L3/565 , B01L2200/028 , B01L2200/0647 , B01L2200/085 , B01L2300/044 , B01L2300/0636 , B01L2300/0672 , B01L2300/087 , B01L2300/12 , B01L2400/043 , B01L2400/0481 , B01L2400/06 , C12Q1/6806 , G01N1/34 , G01N1/38 , G01N1/405 , G01N35/0098
摘要： The present disclosure relates to, inter alia, an easy-to-operate, fully closed component, which can be part of an instrument, for purification of biomolecules from biological samples, and subsequent transfer, and testing of the biomolecules, as well as an instrument comprising the component, and a method for using the component.
摘要翻译：本公开尤其涉及易于操作的完全封闭的组分，其可以是仪器的一部分，用于从生物样品中纯化生物分子，以及随后的转移和生物分子的测试，以及包括该组件的仪器以及使用该组件的方法。

33. 发明申请

US20160339420A1 MODULAR COOLING STORAGE SYSTEM 审中-公开
标题翻译：模块式冷却储存系统
公开(公告)号：US20160339420A1
公开(公告)日：2016-11-24
申请号：US15029348
申请日：2014-10-14
申请人： NSC MED GMBH
发明人： Dennis Machling , Robert Koppen
IPC分类号： B01L1/02 , F25D25/02 , F25D29/00 , F25D23/06 , F25D11/00 , A01N1/02 , F25D23/02
CPC分类号： B01L1/025 , A01N1/0252 , B01L2200/028 , B01L2200/143 , B01L2200/147 , B01L2300/0609 , B01L2300/1894 , F25D11/00 , F25D23/025 , F25D23/028 , F25D23/062 , F25D23/065 , F25D25/02 , F25D29/003 , F25D2201/14 , F25D2400/16 , F25D2400/361
摘要： A modular cooling storage system is disclosed, which has one or more storage containers, wherein each have cold-insulating walls including at least one side wall, a bottom, and a cover; wherein the cold-insulating walls each have two opposite lateral surfaces, which are connected to each other in a thickness direction by edge surfaces; and each storage container has at least one closable access opening. The lateral surfaces and/or edge surfaces of at least one of the walls of each storage container have integrated coupling elements, wherein the coupling elements are designed in such a way that the coupling elements engage with the coupling elements of a directly adjacent wall of a further storage container, wherein storage containers engaged with each other along a section of the walls of the storage containers have a common wall in the section.
摘要翻译：公开了一种模块化冷却存储系统，其具有一个或多个存储容器，其中每个存储容器具有包括至少一个侧壁，底部和盖子的冷绝缘壁; 其中所述冷绝缘壁各自具有两个相对的侧表面，所述侧表面在厚度方向上通过边缘表面彼此连接; 并且每个存储容器具有至少一个可关闭的进入开口。每个存储容器的至少一个壁的侧表面和/或边缘表面具有集成的联接元件，其中联接元件被设计成使得联接元件与直接相邻的壁的连接元件接合另外的存储容器，其中沿着存储容器的壁的一部分彼此接合的储存容器在该部分中具有共同的壁。

34. 发明授权

US09482603B2 Solid phase extraction device for dried sample cards 有权
标题翻译：干燥样品卡固相萃取装置
公开(公告)号：US09482603B2
公开(公告)日：2016-11-01
申请号：US14345009
申请日：2012-09-18
申请人： Waters Technologies Corporation
发明人： Darryl W. Brousmiche , Pamela C. Iraneta , Erin E. Chambers , Moon Chul Jung
IPC分类号： B01L3/00 , G01N1/40 , B01L7/00 , B01L9/06 , B01L9/00 , G01N1/28 , B01L3/02
CPC分类号： G01N1/405 , B01L3/0217 , B01L3/5021 , B01L3/5023 , B01L3/5085 , B01L3/523 , B01L7/52 , B01L9/06 , B01L9/52 , B01L2200/028 , B01L2200/0631 , B01L2200/0647 , B01L2200/0684 , B01L2200/0689 , B01L2200/082 , B01L2200/141 , B01L2200/16 , B01L2300/044 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0829 , B01L2400/0409 , B01L2400/043 , B01L2400/0677 , G01N1/4055 , G01N2001/288 , G01N2001/4061
摘要： Described is a device for solid phase extraction of a dried sample of a biological fluid. The device includes a support structure such as a plate or support block that has a first side to receive a dried sample card. The support structure also has a second side that is opposite the first side and a number of apertures that extend between the first and second sides. The device also includes a plurality of wells each containing a sample preparation material and having an inlet end that communicates with a respective aperture at the second side of the support structure. Each dried sample on the dried sample card is aligned with one of the apertures. Extraction samples in each well pass through the sample preparation material, such as a chromatographic sorbent, in the well to remove one or more constituents of the extraction sample.
摘要翻译：描述了用于固相萃取生物流体干燥样品的装置。该装置包括支撑结构，例如板或支撑块，其具有接收干燥样品卡的第一侧。支撑结构还具有与第一侧相对的第二侧和在第一和第二侧之间延伸的多个孔。该装置还包括多个孔，每个孔各自包含样品制备材料，并且具有与支撑结构的第二侧处的相应孔连通的入口端。干燥的样品卡上的每个干燥的样品与其中一个孔对准。每个孔中的提取样品通过孔中的样品制备材料，例如色谱吸附剂，以除去萃取样品中的一种或多种组分。

35. 发明授权

US09481903B2 Systems and methods for detection of cells using engineered transduction particles 有权
公开(公告)号：US09481903B2
公开(公告)日：2016-11-01
申请号：US13802461
申请日：2013-03-13
申请人： GeneWeave Biosciences, Inc.
发明人： Diego Ariel Rey , Shaunak Roy , Leonardo Maestri Teixeira , Ryan C. Griswold , Kenneth G. Olson , Bruce J. Richardson , Victor Yee
IPC分类号： C12Q1/70 , C12Q1/66 , C12Q1/02 , C12Q1/68 , G01N21/00 , C12Q1/04 , B01L3/00 , G01N21/01 , G01N21/76 , G01N21/03 , G01N21/13 , B01L7/00 , G01J1/00 , G01N35/00 , G01N35/04
CPC分类号： C12Q1/6897 , B01L3/502 , B01L3/50825 , B01L3/52 , B01L3/523 , B01L3/54 , B01L3/545 , B01L7/00 , B01L2200/028 , B01L2200/16 , B01L2300/021 , B01L2300/042 , B01L2300/047 , B01L2300/049 , B01L2300/0672 , B01L2400/0478 , B01L2400/06 , B01L2400/0683 , C12Q1/02 , C12Q1/04 , C12Q1/06 , C12Q1/10 , C12Q1/14 , C12Q1/66 , G01J1/00 , G01N21/01 , G01N21/03 , G01N21/13 , G01N21/76 , G01N21/763 , G01N2035/00346 , G01N2035/0405 , G01N2333/195
摘要： Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

36. 发明授权

US09470215B2 Miniaturized syringe pump system and modules 有权
标题翻译：小型注射泵系统和模块
公开(公告)号：US09470215B2
公开(公告)日：2016-10-18
申请号：US13701853
申请日：2011-06-06
申请人： Daniel L. Bantz , Paul M. Grippo , Donald S. McNeil , Kenneth D. Wynn , Angela Tseng
发明人： Daniel L. Bantz , Paul M. Grippo , Donald S. McNeil , Kenneth D. Wynn , Angela Tseng
IPC分类号： F04B17/03 , A61M5/145 , B01L3/02 , F04B19/00 , G01N35/10 , G01N35/00
CPC分类号： F04B17/03 , A61M5/1452 , A61M5/1456 , B01L3/0217 , B01L2200/028 , B01L2300/0861 , F04B19/006 , G01N35/1072 , G01N2035/00326
摘要： Provided is a liquid handling device for use in a liquid handling system including a plurality of the liquid handling devices assembled in side-by-side relationship at a center-to-center spacing of X. The device includes a barrel, plunger, motive device and electronics assembled together in an envelope having a front portion including at least the barrel and plunger, and a rear portion including at least a portion of the electronics. The rear portion has a thickness greater than X but no greater than 2X, and the front portion has a thickness no greater than X and is laterally offset relative to a center plane of the envelope, whereby the liquid handling device can be assembled with another reversely oriented liquid handling device at a center-to-center spacing of X and a total combined width no greater than 2X.
摘要翻译：本发明提供一种液体处理装置，其用于液体处理系统，该液体处理系统包括多个液体处理装置，它们以X轴的中心间隔并排组装。该装置包括筒，柱塞，动力装置以及电子器件组装在具有至少包括筒和柱塞的前部的封套中，以及包括至少一部分电子器件的后部。后部具有大于X但不大于2X的厚度，并且前部具有不大于X的厚度并且相对于外壳的中心平面横向偏移，由此可以将液体处理装置与另一个反向组装定向液体处理装置，其中心间距为X，总合并宽度不大于2X。

37. 发明申请

US20160288122A1 Test Cartridge with Integrated Transfer Module 有权
公开(公告)号：US20160288122A1
公开(公告)日：2016-10-06
申请号：US15182868
申请日：2016-06-15
申请人： STAT-DIAGNOSTICA & INNOVATION, S.L.
发明人： Jordi Carrera Fabra , Anna Comengés Casas , Rafael Bru Gibert
IPC分类号： B01L3/00 , C12Q1/68 , G01N33/536 , G01N35/10
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/5029 , B01L7/52 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/0627 , B01L2300/0681 , B01L2300/0803 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/065 , B01L2400/0694 , C12M23/42 , C12Q1/6806 , C12Q1/686 , G01N33/53 , G01N33/5304 , G01N33/536 , G01N35/1081 , G01N2035/1058
摘要： A system that includes a cartridge housing and a hollow transfer module, according to an embodiment is described herein. The cartridge housing further includes at least one sample inlet, a plurality of storage chambers, a plurality of reaction chambers, and a fluidic network. The fluidic network is designed to connect the at least one sample inlet, a portion of the plurality of storage chambers and the portion of the plurality of reaction chambers to a first plurality of ports located on an inner surface of the cartridge housing. The hollow transfer module includes a second plurality of ports along an outer surface of the transfer module that lead to a central chamber within the transfer module. The transfer module is designed to move laterally within the cartridge housing. The lateral movement of the transfer module aligns at least a portion of the first plurality of ports with at least a portion of the second plurality of ports.

38. 发明申请

US20160279635A1 SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF ANALYTES 有权
公开(公告)号：US20160279635A1
公开(公告)日：2016-09-29
申请号：US15172077
申请日：2016-06-02
申请人： CUE INC.
发明人： Clinton Sever , Ayub Khattak
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L3/5029 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0668 , B01L2200/0684 , B01L2200/0689 , B01L2200/087 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/025 , B01L2300/04 , B01L2300/044 , B01L2300/06 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/12 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , B01L2400/0487 , B01L2400/0677 , B01L2400/0683 , B05D3/002 , B05D2518/00 , C12Q1/6825 , F16K99/0032 , F16K99/0036 , F16K2099/0084 , G01N1/02 , G01N21/78 , G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N33/54306 , G01N33/54326 , G01N33/54333 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/581 , G01N35/00029 , G01N35/0098 , G01N35/08 , G01N35/1095 , G01N2001/027 , G01N2001/028 , G01N2035/00277 , G01N2035/00564 , G01N2458/30 , H04M1/72527 , H04M1/7253 , Y10T137/1797
摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

39. 发明授权

US09446411B2 Sample assembly for a measurement device 有权
标题翻译：测量装置的样品组件
公开(公告)号：US09446411B2
公开(公告)日：2016-09-20
申请号：US13958076
申请日：2013-08-02
申请人： Reametrix, Inc.
发明人： Bala S. Manian , Pramod Kummaya
IPC分类号： G01N21/00 , C12Q1/68 , G01N15/06 , B01L9/00 , B01L3/00
CPC分类号： B01L9/52 , B01L3/5027 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/148 , B01L2300/0803 , B01L2300/0816 , B01L2400/0409
摘要： A sample presentation apparatus comprises a round support movable in an optical assembly and having a flange region and an elevated gear shaped region having indexing gear cogs at intermediate radius locations of the support; a sample carrier slide holder removably supported on and movable with the support, the slide holder having at least one arm extending radially from a central hub of the sample carrier slide holder and being aligned between a first pair of indexing gear cogs; and at least one sample carrier slide removably supported on the support and aligned by the first pair of indexing gear cogs. In another embodiment of the invention, a self-aligning movable platform and support apparatus in an optical assembly comprises coarse and fine alignment mechanisms.
摘要翻译：样品展示装置包括可在光学组件中移动并且具有凸缘区域的圆形支撑件和在支撑件的中间半径位置处具有分度齿轮齿轮的升高的齿轮形状区域; 载体滑动架，可拆卸地支撑在支撑件上并可与支撑件一起移动，滑动架具有至少一个臂，其从样品载体滑动夹持器的中心轮毂径向延伸并对准第一对分度齿轮齿; 并且至少一个样品载体可拆卸地支撑在支撑件上并由第一对分度齿轮齿轮对准。在本发明的另一实施例中，光学组件中的自对准可移动平台和支撑装置包括粗略和精细对准机构。

40. 发明申请

US20160220994A1 DIAGNOSTIC CARTRIDGE, FLUID STORAGE AND DELIVERY APPARATUS THEREFOR AND METHODS OF CONSTRUCTION THEREOF 审中-公开
标题翻译：诊断盒，流体储存和输送装置及其构造方法
公开(公告)号：US20160220994A1
公开(公告)日：2016-08-04
申请号：US14609259
申请日：2015-01-29
申请人： David W. Wright
发明人： David W. Wright
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , A61B5/150022 , A61B5/150221 , A61B5/150274 , A61B5/150358 , A61B5/150755 , A61B5/157 , A61B2562/0295 , B01L3/502738 , B01L2200/028 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/047 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0633 , B01L2400/0638 , B01L2400/0683
摘要： A disposable, point-of-care diagnostic cartridge has a base with a reaction chamber and an inlet and a fluidic channel extending therebetween. An apparatus is fixed to the base. The apparatus includes a flexible upper layer having a reservoir containing fluid therein; a flexible lower layer, and a rigid substrate sandwiched between the upper and lower layers. The upper layer is fixed to the substrate with a first adhesive having a first bond force. The lower layer has a valve member in fluid communication with a through port in the base and the base inlet. The valve member has a closed state to seal off the through port and the inlet from fluid communication and an open state to bring the through port and the inlet into fluid communication. The valve member is moveable from the closed state to the open state under a force less than the first bond force.
摘要翻译：一次性护理诊断卡盒具有底座，其具有反应室以及在其间延伸的入口和流体通道。设备固定在基座上。该装置包括柔性上层，其中具有容纳流体的容器; 柔性下层和夹在上层和下层之间的刚性基材。上层用具有第一粘合力的第一粘合剂固定到基底上。下层具有与基座中的通孔和基座入口流体连通的阀构件。阀构件具有关闭状态，以密封通过端口和入口与流体连通和打开状态，以使通过端口和入口流体连通。阀构件在小于第一接合力的力下可从关闭状态移动到打开状态。

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