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1. 发明申请

US20210207189A1 COMPOSITIONS, DEVICES, KITS AND METHODS USEFUL FOR REMOVAL OF PHOSPHOLIPIDS 有权
公开(公告)号：US20210207189A1
公开(公告)日：2021-07-08
申请号：US17144422
申请日：2021-01-08
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： Edouard S. P. Bouvier , Erin E. Chambers
IPC分类号： C12Q1/44 , G01N1/40 , G01N30/14
摘要： Novel compositions, devices, kits and methods useful for sample treatment are disclosed herein.

2. 发明授权

US09964545B2 Methods for quantifying polypeptides using mass spectrometry 有权
公开(公告)号：US09964545B2
公开(公告)日：2018-05-08
申请号：US15447838
申请日：2017-03-02
申请人： Waters Technologies Corporation
发明人： Erin E. Chambers , Martha Stapels , Joanne Mather
IPC分类号： G01N33/68 , G01N33/74 , G01N33/02 , G01N30/72 , G01N30/86 , G01N30/88
CPC分类号： G01N33/6848 , G01N30/7233 , G01N30/7266 , G01N30/8679 , G01N30/88 , G01N33/02 , G01N33/74 , G01N2030/8831 , Y10T436/24
摘要： A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of including an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent including an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent including an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole.

3. 发明申请

US20140366656A1 SOLID PHASE EXTRACTION DEVICE FOR DRIED SAMPLE CARDS 审中-公开
标题翻译：用于干燥样品卡的固相萃取装置
公开(公告)号：US20140366656A1
公开(公告)日：2014-12-18
申请号：US14345009
申请日：2012-09-18
申请人： Waters Technologies Corporation
发明人： Darryl W. Brousmiche , Pamela C. Iraneta , Erin E. Chambers , Moon Chul Jung
IPC分类号： G01N1/40 , B01L3/00
CPC分类号： G01N1/405 , B01L3/0217 , B01L3/5021 , B01L3/5023 , B01L3/5085 , B01L3/523 , B01L7/52 , B01L9/06 , B01L9/52 , B01L2200/028 , B01L2200/0631 , B01L2200/0647 , B01L2200/0684 , B01L2200/0689 , B01L2200/082 , B01L2200/141 , B01L2200/16 , B01L2300/044 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0829 , B01L2400/0409 , B01L2400/043 , B01L2400/0677 , G01N1/4055 , G01N2001/288 , G01N2001/4061
摘要： Described is a device for solid phase extraction of a dried sample of a biological fluid. The device includes a support structure such as a plate or support block that has a first side to receive a dried sample card. The support structure also has a second side that is opposite the first side and a number of apertures that extend between the first and second sides. The device also includes a plurality of wells each containing a sample preparation material and having an inlet end that communicates with a respective aperture at the second side of the support structure. Each dried sample on the dried sample card is aligned with one of the apertures. Extraction samples in each well pass through the sample preparation material, such as a chromatographic sorbent, in the well to remove one or more constituents of the extraction sample.
摘要翻译：描述了用于固相萃取生物流体干燥样品的装置。该装置包括支撑结构，例如板或支撑块，其具有接收干燥样品卡的第一侧。支撑结构还具有与第一侧相对的第二侧和在第一和第二侧之间延伸的多个孔。该装置还包括多个孔，每个孔各自包含样品制备材料，并且具有与支撑结构的第二侧处的相应孔连通的入口端。干燥的样品卡上的每个干燥的样品与其中一个孔对准。每个孔中的提取样品通过孔中的样品制备材料，例如色谱吸附剂，以除去萃取样品中的一种或多种组分。

4. 发明授权

US11747341B2 Methods of use for low-bind polypropylene plates and vials 有权
公开(公告)号：US11747341B2
公开(公告)日：2023-09-05
申请号：US16808233
申请日：2020-03-03
申请人： Waters Technologies Corporation
发明人： Moon Chul Jung , Mary Elizabeth Lame , Caitlin Dunning , Christopher John Hughes , Xiaoxiao Liu , Paula Orens , Yun Wang Alelyunas , Erin E. Chambers , David Dao , Robert Birdsall
IPC分类号： G01N33/68 , G01N30/06 , G01N30/72
CPC分类号： G01N33/6848 , G01N30/06 , G01N30/7233
摘要： The present disclosure relates to a method of analyzing a sample comprising a hydrophobic molecule. The method includes preparing an aqueous solution comprising the sample. The method also includes placing the solution in contact with a polypropylene substrate having a deactivated surface that reduces adsorption of the hydrophobic molecule relative to a polypropylene substrate that has not been deactivated. The method also includes analyzing the sample.

5. 发明申请

US20170242028A1 METHODS FOR QUANTIFYING POLYPEPTIDES USING MASS SPECTROMETRY 有权
公开(公告)号：US20170242028A1
公开(公告)日：2017-08-24
申请号：US15447838
申请日：2017-03-02
申请人： Waters Technologies Corporation
发明人： Erin E. Chambers , Martha Stapels , Joanne Mather
IPC分类号： G01N33/68 , G01N30/86 , G01N30/88 , G01N30/72
CPC分类号： G01N33/6848 , G01N30/7233 , G01N30/7266 , G01N30/8679 , G01N30/88 , G01N33/02 , G01N33/74 , G01N2030/8831 , Y10T436/24
摘要： A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of including an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent including an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent including an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole.

6. 发明授权

US09482603B2 Solid phase extraction device for dried sample cards 有权
标题翻译：干燥样品卡固相萃取装置
公开(公告)号：US09482603B2
公开(公告)日：2016-11-01
申请号：US14345009
申请日：2012-09-18
申请人： Waters Technologies Corporation
发明人： Darryl W. Brousmiche , Pamela C. Iraneta , Erin E. Chambers , Moon Chul Jung
IPC分类号： B01L3/00 , G01N1/40 , B01L7/00 , B01L9/06 , B01L9/00 , G01N1/28 , B01L3/02
CPC分类号： G01N1/405 , B01L3/0217 , B01L3/5021 , B01L3/5023 , B01L3/5085 , B01L3/523 , B01L7/52 , B01L9/06 , B01L9/52 , B01L2200/028 , B01L2200/0631 , B01L2200/0647 , B01L2200/0684 , B01L2200/0689 , B01L2200/082 , B01L2200/141 , B01L2200/16 , B01L2300/044 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0829 , B01L2400/0409 , B01L2400/043 , B01L2400/0677 , G01N1/4055 , G01N2001/288 , G01N2001/4061
摘要： Described is a device for solid phase extraction of a dried sample of a biological fluid. The device includes a support structure such as a plate or support block that has a first side to receive a dried sample card. The support structure also has a second side that is opposite the first side and a number of apertures that extend between the first and second sides. The device also includes a plurality of wells each containing a sample preparation material and having an inlet end that communicates with a respective aperture at the second side of the support structure. Each dried sample on the dried sample card is aligned with one of the apertures. Extraction samples in each well pass through the sample preparation material, such as a chromatographic sorbent, in the well to remove one or more constituents of the extraction sample.
摘要翻译：描述了用于固相萃取生物流体干燥样品的装置。该装置包括支撑结构，例如板或支撑块，其具有接收干燥样品卡的第一侧。支撑结构还具有与第一侧相对的第二侧和在第一和第二侧之间延伸的多个孔。该装置还包括多个孔，每个孔各自包含样品制备材料，并且具有与支撑结构的第二侧处的相应孔连通的入口端。干燥的样品卡上的每个干燥的样品与其中一个孔对准。每个孔中的提取样品通过孔中的样品制备材料，例如色谱吸附剂，以除去萃取样品中的一种或多种组分。

7. 发明申请

US20200284802A1 METHODS OF USE FOR LOW-BIND POLYPROPYLENE PLATES AND VIALS 审中-公开
公开(公告)号：US20200284802A1
公开(公告)日：2020-09-10
申请号：US16808233
申请日：2020-03-03
申请人： Waters Technologies Corporation
发明人： Moon Chul Jung , Mary Elizabeth Lame , Caitlin Dunning , Christopher John Hughes , Xiaoxiao Liu , Paula Orens , Yun Wang Alelyunas , Erin E. Chambers , David Dao , Robert Birdsall
IPC分类号： G01N33/68 , G01N30/72 , G01N30/06
摘要： The present disclosure relates to a method of analyzing a sample comprising a hydrophobic molecule. The method includes preparing an aqueous solution comprising the sample. The method also includes placing the solution in contact with a polypropylene substrate having a deactivated surface that reduces adsorption of the hydrophobic molecule relative to a polypropylene substrate that has not been deactivated. The method also includes analyzing the sample.

8. 发明授权

US09588130B2 Methods for quantifying polypeptides using mass spectrometry 有权
标题翻译：使用质谱法定量多肽的方法
公开(公告)号：US09588130B2
公开(公告)日：2017-03-07
申请号：US14394952
申请日：2013-03-14
申请人： Waters Technologies Corporation
发明人： Erin E. Chambers , Martha Stapels , Joanne Mather
IPC分类号： G01N33/68 , G01N33/74 , G01N30/72 , G01N33/02 , G01N30/86 , G01N30/88
CPC分类号： G01N33/6848 , G01N30/7233 , G01N30/7266 , G01N30/8679 , G01N30/88 , G01N33/02 , G01N33/74 , G01N2030/8831 , Y10T436/24
摘要： A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of including an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent including an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent including an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole.
摘要翻译：用于鉴定样品的多肽的方法可以包括（i）将疑似包含胰岛素的样品用碱处理; （ii）使用混合模式或聚合物反相介质和包含酸的第一溶剂通过固相萃取提取处理过的样品的第一级分; （iii）使用包括疏水表面基团和一种或多种可电离改性剂的色谱表面和包含酸的第二溶剂通过液相色谱分离第一级分的组分; 和（iv）通过质谱法分析第一级分的组分，从而使用对应于来自多肽的序列片段离子的信号鉴定多肽（如果存在）。该信号可以对应于在第一个四极中选择的完整的多电荷前体片段及其在最终四极中选择的相应的序列片段离子。

9. 发明授权

US10241117B2 Methods for quantifying polypeptides using mass spectrometry 有权
公开(公告)号：US10241117B2
公开(公告)日：2019-03-26
申请号：US15965613
申请日：2018-04-27
申请人： Waters Technologies Corporation
发明人： Erin E. Chambers , Martha Stapels , Joanne Mather
IPC分类号： G01N33/68 , G01N33/74 , G01N33/02 , G01N30/72 , G01N30/86 , G01N30/88
摘要： A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of including an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent including an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent including an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole.

10. 发明申请

US20180246119A1 METHODS FOR QUANTIFYING POLYPEPTIDES USING MASS SPECTROMETRY 审中-公开
公开(公告)号：US20180246119A1
公开(公告)日：2018-08-30
申请号：US15965613
申请日：2018-04-27
申请人： Waters Technologies Corporation
发明人： Erin E. Chambers , Martha Stapels , Joanne Mather
IPC分类号： G01N33/68 , G01N30/88 , G01N30/72 , G01N30/86 , G01N33/02 , G01N33/74
CPC分类号： G01N33/6848 , G01N30/7233 , G01N30/7266 , G01N30/8679 , G01N30/88 , G01N33/02 , G01N33/74 , G01N2030/8831 , Y10T436/24
摘要： A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of including an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent including an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent including an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole.

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