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31. 发明授权

US09138714B2 Microfluidic chip and a related method thereof 有权
标题翻译：微流控芯片及其相关方法
公开(公告)号：US09138714B2
公开(公告)日：2015-09-22
申请号：US13285855
申请日：2011-10-31
申请人： Victor Donald Samper , Ruben Julian Horvath-Klein , Marko Klaus Baller , Christian Friedrich Peter Rensch , Christoph Boeld , Xavier Yvon André Franci
发明人： Victor Donald Samper , Ruben Julian Horvath-Klein , Marko Klaus Baller , Christian Friedrich Peter Rensch , Christoph Boeld , Xavier Yvon André Franci
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00873 , B01J2219/00876 , B01J2219/00885 , B01J2219/00889 , B01J2219/00894 , B01J2219/00898 , B01J2219/00903 , B01J2219/00932 , B01J2219/00961 , B01J2219/0097 , B01J2219/00979 , B01L3/527 , B01L2200/027 , B01L2300/0816 , B01L2300/0867 , B01L2400/0478
摘要： A microfluidic chip includes a plurality of reagent sources for a feeding a plurality of reagents, each reagent source feeding a corresponding reagent among the plurality of reagents. A macro-chamber receives one or more reagents among the plurality of reagents from the plurality of reagent sources. A microfluidic reactor is coupled to the macro-chamber and the plurality of reagent sources and configured to receive two or more reagents among the plurality of reagents from at least one of the macro-chamber, the plurality of reagent sources, and react the two or more reagents to generate a reaction content.
摘要翻译：微流体芯片包括多个用于供给多个试剂的试剂源，每个试剂源在多个试剂中供给相应的试剂。大腔室从多个试剂源接收多个试剂中的一种或多种试剂。微流体反应器耦合到宏观室和多个试剂源，并被配置为从多个试剂源中的至少一个接收多个试剂中的两个或更多个试剂，并且反应两个或更多个试剂源更多的试剂产生反应含量。

32. 发明申请

US20140370611A1 PROCESS FOR DETERMINING THE REACTION MECHANISM OF A REACTION AND ASSOCIATED DEVICE 审中-公开
标题翻译：用于确定反应和相关装置的反应机理的方法
公开(公告)号：US20140370611A1
公开(公告)日：2014-12-18
申请号：US14362707
申请日：2012-12-06
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , ECOLE NORMALE SUPERIEURE
发明人： Charlie Gosse , Annie Lemarchand , Ludovic Jullien , Thomas Le Saux , Kais Zrelli
IPC分类号： G06F19/00
CPC分类号： G16C20/10 , B01J19/0033 , B01J19/0093 , B01J2219/00286 , B01J2219/00585 , B01J2219/00698 , B01J2219/00702 , B01J2219/00869 , B01J2219/00882 , B01J2219/00885 , B01J2219/00957 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01J2219/00995 , G16C10/00 , Y10T436/143333
摘要： The method according to the invention includes choosing a reaction presumed reaction mechanism; selecting, for said mechanism, at least one first function characteristic of a thermokinetic property that is invariant with the periodic variation frequency of a control parameter influencing said reaction, the first characteristic function being calculated at least from first-order oscillation amplitudes of the concentration of at least one of the species involved in said reaction. The method includes calculating a plurality of values of the first characteristic function from first-order oscillation amplitudes obtained experimentally and analyzing the calculated values of the first characteristic function to determine whether the first characteristic function is constant based on the calculated values, and if the first characteristic function is constant, assigning the presumed mechanism to said reaction.
摘要翻译：根据本发明的方法包括选择反应推定的反应机理; 对于所述机理，选择与影响所述反应的控制参数的周期性变化频率不变的热动力学性质的至少一个第一函数特征，所述第一特征函数至少从第一特征函数的一阶振荡幅度涉及所述反应的物质中的至少一种。该方法包括从实验获得的一阶振荡幅度计算第一特征函数的多个值，并分析第一特征函数的计算值，以基于计算值确定第一特征函数是否恒定，以及如果第一特征函数特征函数是恒定的，将推测机制分配给所述反应。

33. 发明申请

US20140274813A1 Chemical Synthesis and Analysis Via Integrated, Sequential and Series-Parallel Photochemical and Other Chemical Processes for Microfluidic, Lab-On-A-Chip, and Green-Chemistry Applications 有权
标题翻译：通过用于微流控，实验室在芯片和绿色化学应用的集成，顺序和串联并行光化学和其他化学过程的化学合成和分析
公开(公告)号：US20140274813A1
公开(公告)日：2014-09-18
申请号：US14287181
申请日：2014-05-26
申请人： LESTER LUDWIG
发明人： LESTER LUDWIG
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00835 , B01J2219/00853 , B01J2219/00867 , B01J2219/00869 , B01J2219/00936 , B01J2219/00959 , B01J2219/00961 , B01J2219/00963 , B01J2219/00966 , B01J2219/0097 , B01J2219/00986 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A microfluidic system comprising a plurality of photochemical reaction stages, the microfluidic system comprising a computational processor, a plurality of electrically-controllable photochemical reaction stages, and a series of controllable interconnections for connecting the photochemical reaction stages. In an implementation, the computational processor controls the electrically-controllable photochemical and other chemical reaction stages together with controllable interconnections so as to implement multi-step chemical processes. The microfluidic system can be configured to selectively drive a plurality of photochemical reactions within a mixture of chemical compounds via controlled emission of light of a plurality of wavelengths. The microfluidic system can be configured to comprise various interconnections and combinations of parallel and series chemical reaction stages, and can include a multichannel microfluidic chemical transfer bus. The microfluidic system can be configured to handle and process liquid, gasses, solids, and mixtures of these, and can used to implement anion relay chemistry, combinational chemistry, and synthon-based synthesis.
摘要翻译：一种包含多个光化学反应阶段的微流体系统，所述微流体系统包括计算处理器，多个电可控光化学反应级和用于连接光化学反应级的一系列可控互连。在一个实施方案中，计算处理器控制电可控的光化学和其它化学反应级以及可控互连，以便实现多步化学过程。微流体系统可以被配置为通过受控发射多个波长的光来选择性地驱动化学化合物的混合物内的多个光化学反应。微流体系统可以被配置为包括并联和串联化学反应级的各种互连和组合，并且可以包括多通道微流控化学传递总线。微流体系统可以被配置为处理和处理液体，气体，固体和它们的混合物，并且可以用于实现阴离子中继化学，组合化学和基于合成子的合成。

34. 发明授权

US08828210B2 Microfluidic systems 有权
标题翻译：微流控系统
公开(公告)号：US08828210B2
公开(公告)日：2014-09-09
申请号：US12738268
申请日：2008-10-16
申请人： Chris Abell , Wilhelm T. S. Huck , Daniel Bratton , Graeme Whyte , Luis M. Fidalgo
发明人： Chris Abell , Wilhelm T. S. Huck , Daniel Bratton , Graeme Whyte , Luis M. Fidalgo
IPC分类号： B01J19/08 , B01D17/06 , B01J19/00 , B01L3/00 , G01N35/00
CPC分类号： B01J19/0093 , B01J2219/00576 , B01J2219/00599 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/0086 , B01J2219/00891 , B01J2219/0097 , B01L3/502761 , B01L3/502784 , B01L2300/0867 , B01L2400/0415 , B01L2400/043 , G01N2035/00158
摘要： This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).
摘要翻译：本发明涉及微流体系统，更具体地涉及用于访问乳液流中微滴（114）的内容物的方法和装置。一种在微流体系统中接触乳液液滴（114）的内容物的方法，所述方法包括：使乳液与第二流体（118）的连续的非乳化流一起流动，以在所述第二流体（118）之间提供界面（120）乳液和所述第二流体流（118）; 并且在实施例中应用电（112a，112b）和磁场中的一个或两个穿过所述界面（120）以改变所述乳液的所述液滴（114）的轨迹，以使所述液滴与所述第二流体流（118）; 以及访问所述第二流（118）中的所述液滴（114）的所述内容物。

35. 发明申请

US20120091004A1 MICROFLUIDIC SYSTEMS 有权
标题翻译：微流体系统
公开(公告)号：US20120091004A1
公开(公告)日：2012-04-19
申请号：US12738268
申请日：2008-10-16
申请人： Chris Abell , Wilhelm T.S. Huck , Daniel Bratton , Graeme Whyte , Luis M. Fidalgo
发明人： Chris Abell , Wilhelm T.S. Huck , Daniel Bratton , Graeme Whyte , Luis M. Fidalgo
IPC分类号： B01J19/08 , B01D17/06 , B01F15/00 , B01F3/08
CPC分类号： B01J19/0093 , B01J2219/00576 , B01J2219/00599 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/0086 , B01J2219/00891 , B01J2219/0097 , B01L3/502761 , B01L3/502784 , B01L2300/0867 , B01L2400/0415 , B01L2400/043 , G01N2035/00158
摘要： This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).
摘要翻译：本发明涉及微流体系统，更具体地涉及用于访问乳液流中微滴（114）的内容物的方法和装置。一种在微流体系统中接触乳液液滴（114）的内容物的方法，所述方法包括：使乳液与第二流体（118）的连续的非乳化流一起流动，以在所述第二流体（118）之间提供界面（120）乳液和所述第二流体流（118）; 并且在实施例中应用电（112a，112b）和磁场中的一个或两个穿过所述界面（120）以改变所述乳液的所述液滴（114）的轨迹，以使所述液滴与所述第二流体流（118）; 以及访问所述第二流（118）中的所述液滴（114）的所述内容物。

36. 发明申请

US20110214982A1 LEVITATION MICROREACTOR 审中-公开
标题翻译：引信微粒体
公开(公告)号：US20110214982A1
公开(公告)日：2011-09-08
申请号：US12719199
申请日：2010-03-08
申请人： Jeffrey John Hagen
发明人： Jeffrey John Hagen
IPC分类号： B01J19/08 , B05B5/025 , G01S11/14 , B01J19/00 , C25B1/00 , F17D1/08
CPC分类号： B01J19/0093 , B01J2219/00853 , B01J2219/0097 , B01J2219/00975 , B01J2219/00977 , G01N21/15 , G01N2021/035 , Y10T137/0391
摘要： Technologies are generally described for a levitation microreactor adapted to facilitate a chemical reaction. The levitation microreactor may comprise one or more levitation zones arranged in spatial communication with one another, each levitation zone including a levitator that is effective to levitate a reactant droplet. In some examples, a first levitation zone may include a first levitator effective to levitate a first reactant droplet, while a second levitation zone may include a second levitator effective to levitate a second reactant droplet. The second reactant droplet may be distinct from the first reactant droplet. Some example microreactors may further include a third levitation zone that is arranged in spatial communication with the first and second levitation zones. The third levitation zone may be effective to facilitate a chemical reaction on the first and second reactant droplets while the first and second reactant droplets are levitated to produce a product.
摘要翻译：技术通常描述适用于促进化学反应的悬浮微反应器。悬浮微反应器可以包括彼此空间连通地布置的一个或多个悬浮区域，每个悬浮区域包括有效地悬浮反应物液滴的悬浮液。在一些实例中，第一悬浮区可以包括有效地悬浮第一反应物液滴的第一悬浮液，而第二悬浮区可以包括有效漂浮第二反应物液滴的第二悬浮液。第二反应物液滴可以不同于第一反应物液滴。一些示例性的微反应器还可以包括与第一和第二悬浮区域空间连通的第三悬浮区域。第三悬浮区可以有效地促进第一和第二反应物液滴的化学反应，同时第一和第二反应物液滴悬浮以产生产物。

37. 发明申请

US20090191096A1 Microchemical Chip 审中-公开
标题翻译：微化学芯片
公开(公告)号：US20090191096A1
公开(公告)日：2009-07-30
申请号：US11572898
申请日：2005-07-28
申请人： Kuninori Yokomine
发明人： Kuninori Yokomine
IPC分类号： G01N33/00
CPC分类号： G01N21/0303 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/0097 , B01L3/502707 , B01L3/502715 , B01L2300/0816 , B01L2300/12
摘要： A microchemical chip of the present invention has a base composed of a ceramic and a light-transmitting member. The base composed of a ceramic is provided with a channel, a fluid supplying section disposed on the upstream side of the channel, a fluid reacting section disposed on the downstream side of the fluid supplying section, and a detecting section disposed on the downstream side of the fluid reacting section. The light-transmitting member is disposed so as to cover the detecting section of the base. With this configuration, the channel is formed in the base composed of a ceramic excellent in chemical resistance and heat resistance, thereby enabling reliability to be improved. Since the light-transmitting member is disposed so as to cover the detecting section, the reaction product can be inspected by an optical technique, for example, thereby enabling detection accuracy to be improved.
摘要翻译：本发明的微细化学芯片具有由陶瓷和透光部件构成的基体。由陶瓷构成的基座设置有通道，设置在通道的上游侧的流体供给部，设置在流体供给部的下游侧的流体反应部，以及设置在流体供给部的下游侧的检测部流体反应段。透光部件设置成覆盖基部的检测部。利用这种构造，通道形成在耐化学性和耐热性优异的陶瓷基体中，从而提高可靠性。由于透光部件设置成覆盖检测部分，所以可以通过光学技术来检查反应产物，从而能够提高检测精度。

38. 发明申请

US20090142845A1 FLOW REACTOR METHOD AND APPARATUS 审中-公开
标题翻译：流动反应器方法和装置
公开(公告)号：US20090142845A1
公开(公告)日：2009-06-04
申请号：US12063254
申请日：2006-08-10
申请人： Otman Benali , Martyn John Deal , Coulton Heath Legge , Robert Charles Wheeler , Rodrigo Zapiain Bazdresch
发明人： Otman Benali , Martyn John Deal , Coulton Heath Legge , Robert Charles Wheeler , Rodrigo Zapiain Bazdresch
IPC分类号： G01N31/00 , B01J19/00 , G01N21/00
CPC分类号： G01N35/08 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01J19/0093 , B01J2219/00835 , B01J2219/00891 , B01J2219/0097 , Y10T436/10
摘要： A method of conducting a chemical reaction in a flow reactor comprises the steps of pumping at least one liquid reaction plug bounded at both ends by liquid spacer plugs along a reaction channel of the reactor; and conducting the chemical reaction in the reaction plug inside the reaction channel, wherein the liquid reaction plug comprises one or more reagents dispersed in a reaction solvent, the liquid spacer plugs are immiscible in the reaction solvent, and the reagents are substantially insoluble in the spacer plugs; and wherein the aspect ratio of the at least one reaction plug is at least about 10.
摘要翻译：在流动反应器中进行化学反应的方法包括以下步骤：沿着反应器的反应通道泵送在两端界定的至少一个液体反应塞; 并且在反应通道内的反应塞中进行化学反应，其中液体反应塞包含分散在反应溶剂中的一种或多种试剂，液体间隔塞不混溶在反应溶剂中，试剂基本上不溶于间隔物插头并且其中所述至少一个反应塞的纵横比为至少约10。

39. 发明授权

US07507380B2 Microchemical nanofactories 失效
标题翻译：微化学纳米工艺
公开(公告)号：US07507380B2
公开(公告)日：2009-03-24
申请号：US11086074
申请日：2005-03-21
申请人： Chih-Hung Chang , Brian Kevin Paul , Vincent Thomas Remcho
发明人： Chih-Hung Chang , Brian Kevin Paul , Vincent Thomas Remcho
IPC分类号： B01J8/00 , B01J10/00 , B32B3/20 , B32B3/12
CPC分类号： B01F5/0475 , B01F5/0485 , B01F13/0062 , B01F13/0066 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00833 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00912 , B01J2219/00914 , B01J2219/00916 , B01J2219/0097 , B01J2219/00972 , C08G83/003 , F28F2210/02 , Y10T428/24562 , Y10T428/24612 , Y10T428/24661 , Y10T428/24744
摘要： Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one valve, and often plural, selectively actuatable valves. Detectors, including optical detectors, also can be used to detect product and other materials as they flow by, or are otherwise presented to, the detector. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. The apparatus is particularly useful for making compounds requiring iterative reaction schemes, and further can be used to make compounds having morphological structures that resemble the morphology of the apparatus itself, such as dendrimers.
摘要翻译：公开了用于化学合成和/或分析的装置，系统和方法的实施例。公开的装置的一个实施例包括限定反应器和分离器的层压的微流体结构。这种装置或其部分通常具有约1微米至约100微米的尺寸。为了实现合成过程，所公开的设备的实施例通常包括至少一个阀，并且通常是多个可选择性致动的阀。检测器，包括光学检测器，也可用于检测产品和其他材料，因为它们流过或以其他方式呈现给检测器。单个装置可以串联耦合并联，以形成用于制备化合物的系统。该装置对于制备需要迭代反应方案的化合物特别有用，并且还可用于制备具有类似于装置本身形态的形态结构的化合物，例如树枝状大分子。

40. 发明申请

US20080226516A1 MICROREACTOR SYSTEM 审中-公开
标题翻译：微机系统
公开(公告)号：US20080226516A1
公开(公告)日：2008-09-18
申请号：US12018477
申请日：2008-01-23
申请人： Mio Suzuki , Shigenori Togashi , Tadashi Sano
发明人： Mio Suzuki , Shigenori Togashi , Tadashi Sano
IPC分类号： B01J19/00
CPC分类号： B01J19/0093 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F13/1013 , B01F13/1022 , B01J2219/00783 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/00934 , B01J2219/00941 , B01J2219/00959 , B01J2219/0097 , B01J2219/00984
摘要： It is an object of the present invention to ensure quite high-speed and highly efficient production using the microreactors and facilitate transition from laboratory-basis synthesis to industrial production.A microreactor system collecting a mixture solution obtained by mixing up material solutions in a microreactor includes a plurality of microreactors arranged in parallel; a flowmeter disposed on a downstream side; a detector detecting a composition of the mixture solution; and a processing device calculating both a reaction time from when the material solutions are mixed up until the detector detects the composition of the mixture solution and an yield of the target product. The processing device includes means for changing the amount of each of the material solutions supplied by the pump in each of the microreactors; means for calculating and storing the reaction time and the yield of the target product for every change in the supply amount; and means for deciding which of the plurality of microreactors is selected on the basis of the reaction time and the yield of the target product.
摘要翻译：本发明的目的是确保使用微反应器的相当高速和高效的生产，并促进从实验室基础合成向工业生产的转变。收集通过在微反应器中混合材料溶液获得的混合溶液的微反应器系统包括平行布置的多个微反应器; 设置在下游侧的流量计; 检测器，检测混合溶液的组成; 以及计算从材料溶液混合直到检测器检测到混合溶液的组成和目标产物的产率的反应时间的处理装置。处理装置包括用于改变由每个微反应器中的泵供应的每种材料溶液的量的装置; 用于每次供应量变化计算和存储目标产品的反应时间和产量的装置; 以及用于基于目标产品的反应时间和产量来决定多个微反应器中的哪一个被选择的装置。

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