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31. 发明申请

US20150039049A1 SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS 有权
公开(公告)号：US20150039049A1
公开(公告)日：2015-02-05
申请号：US14503259
申请日：2014-09-30
申请人： Nevro Corporation
发明人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal cord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

32. 发明申请

US20150032182A1 SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译：用于抑制具有减少的副作用的疼痛的选择性高频脊柱调节，以及相关系统和方法
公开(公告)号：US20150032182A1
公开(公告)日：2015-01-29
申请号：US14512325
申请日：2014-10-10
申请人： Nevro Corporation
发明人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal cord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
摘要翻译：公开了用于抑制疼痛的选择性高频脊髓调节，减少侧面影响和相关系统和方法。在特定实施例中，可以将大约1.5KHz至大约50KHz范围内的高频调制施加到患者的脊弦区域以解决腰背痛而不产生不想要的感觉和/或运动副作用。在其他实施例中，根据类似参数的调制可以应用于其他脊柱或周边位置以解决其他指示。

33. 发明申请

US20150018893A1 TIMING CONTROL FOR PAIRED PLASTICITY 有权
标题翻译：配对塑料的时序控制
公开(公告)号：US20150018893A1
公开(公告)日：2015-01-15
申请号：US14500325
申请日：2014-09-29
申请人： MicroTransponder, Inc. , The Board of Regents, The University of Texas System
发明人： Michael P. KILGARD , Larry CAULLER , Nazer ENGINEER , Christa McIntyre Rodriguez , Will ROSSELLINI
IPC分类号： A61N1/36 , A61F11/00
CPC分类号： A61N1/36167 , A61F11/00 , A61M21/00 , A61M21/02 , A61M2021/0016 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61M2021/0077 , A61M2205/3515 , A61M2230/06 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/50 , A61M2230/60 , A61M2230/65 , A61N1/36014 , A61N1/36053 , A61N1/36067 , A61N1/36082 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N5/0618 , A61N5/0622 , G09B19/00 , G09B19/003 , G09B23/28 , H04R25/75
摘要： Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
摘要翻译：用于配对训练的系统，方法和装置包括时间控制，以便可以同时提供训练和神经刺激。配对培训可能包括治疗，康复和绩效增强培训。影响神经的神经刺激，如影响皮层下的区域，如核碱基，脑脊髓或杏仁核，诱导脑中的可塑性，增强各种疗法的作用，例如用于治疗耳鸣，中风，创伤性脑损伤和创伤后应激障碍。

34. 发明授权

US08934967B2 Systems, methods and devices for treating tinnitus 有权
标题翻译：用于治疗耳鸣的系统，方法和装置
公开(公告)号：US08934967B2
公开(公告)日：2015-01-13
申请号：US12485860
申请日：2009-06-16
申请人： Michael Kilgard , Larry Cauller , Navzer Engineer , Christa McIntyre , Will Rosellini
发明人： Michael Kilgard , Larry Cauller , Navzer Engineer , Christa McIntyre , Will Rosellini
IPC分类号： A61N1/00 , A61N1/36 , G09B23/28 , A61M21/02
CPC分类号： A61N1/36167 , A61F11/00 , A61M21/00 , A61M21/02 , A61M2021/0016 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61M2021/0077 , A61M2205/3515 , A61M2230/06 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/50 , A61M2230/60 , A61M2230/65 , A61N1/36014 , A61N1/36053 , A61N1/36067 , A61N1/36082 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N5/0618 , A61N5/0622 , G09B19/00 , G09B19/003 , G09B23/28 , H04R25/75
摘要： Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
摘要翻译：用于配对训练的系统，方法和装置包括时间控制，以便可以同时提供训练和神经刺激。配对培训可能包括治疗，康复和绩效增强培训。影响神经的神经刺激，如影响皮层下的区域，如基底核，坐骨神经或杏仁核诱导脑中的可塑性，增强各种疗法的作用，例如用于治疗耳鸣，中风，创伤性脑损伤和创伤后应激障碍。

35. 发明授权

US08918190B2 Implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction 有权
标题翻译：用于评估患有慢性心脏功能障碍的患者的自主心血管驱动的植入式装置
公开(公告)号：US08918190B2
公开(公告)日：2014-12-23
申请号：US13314133
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/32
CPC分类号： A61N1/36167 , A61B5/02 , A61B5/02438 , A61B5/4836 , A61B5/686 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： An implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. The neurostimulator includes a recordable memory storing a baseline heart rate. The neurostimulator includes an integrated leadless heart rate sensor configured to continually monitor heart rate in light of the baseline heart rate.
摘要翻译：提供了一种用于评估患有慢性心脏功能障碍的患者的自主心血管驱动的可植入装置。刺激治疗引线包括构造成符合颈部迷走神经鞘的外径的螺旋电极和电连接到螺旋电极的一组连接器引脚。神经刺激器包括一个电插座，连接器插头牢固地和电连接到该插座中。神经刺激器还包括脉冲发生器，其被配置为在刺激应用和刺激抑制的交替周期中通过螺旋电极治疗性地刺激迷走神经，该循环被调谐到两者以显着激活心脏的内在神经系统，并通过触发双向激活来传入激活患者的中心反射，方向动作电位。神经刺激器包括存储基线心率的可记录存储器。神经刺激器包括集成无引线心率传感器，其配置成根据基线心率不断监测心率。

36. 发明授权

US08886328B2 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 有权
公开(公告)号：US08886328B2
公开(公告)日：2014-11-11
申请号：US14199867
申请日：2014-03-06
申请人： Nevro Corporation
发明人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
IPC分类号： A61N1/18 , A61N1/372 , A61N1/36 , A61N1/05 , A61N1/06
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region to address low back pain without creating unwanted sensory and/or motor side effects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

37. 发明授权

US08874221B2 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 有权
公开(公告)号：US08874221B2
公开(公告)日：2014-10-28
申请号：US13830886
申请日：2013-03-14
申请人： Nevro Corporation
发明人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05 , A61N1/06
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region to address low back pain without creating unwanted sensory and/or motor side effects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

38. 发明申请

US20140288616A1 SYSTEMS AND METHODS FOR IMPLANTING ELECTRODE LEADS FOR USE WITH IMPLANTABLE NEUROMUSCULAR ELECTRICAL STIMULATOR 有权
标题翻译：用于植入电极引线的系统和方法，用于可植入神经电刺激器
公开(公告)号：US20140288616A1
公开(公告)日：2014-09-25
申请号：US14295153
申请日：2014-06-03
申请人： MAINSTAY MEDICAL LIMITED
发明人： Prashant Brijmohansingh RAWAT , Henry Thomas DEMORETT , Jason Alan SHIROFF
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61B17/3468 , A61B19/54 , A61B90/39 , A61B2019/5466 , A61B2090/3966 , A61N1/0558 , A61N1/36003 , A61N1/36067 , A61N1/36071 , A61N1/36157 , A61N1/36167
摘要： A system of implanting electrode leads for restoring muscle function to the lumbar spine to treat low back pain is provided. The system provides efficient implantation of the leads, including the ability to verify deployment of anchoring mechanisms on the lead using an impedance assessment, such that the implanted lead may be secured within the patient and used to restore muscle function of local segmental muscles associated with the lumbar spine stabilization system.
摘要翻译：提供了一种植入用于将肌肉功能恢复到腰椎以治疗腰痛的电极引线的系统。该系统提供引线的有效植入，包括使用阻抗评估来验证在引线上部署锚定机构的能力，使得植入的引线可以固定在患者体内，并且用于恢复与之相关的局部节段性肌肉的肌肉功能腰椎稳定系统。

39. 发明授权

US08843211B2 System and method for increasing relative intensity between cathodes and anodes of neurostimulation system using pulse slicing 有权
标题翻译：使用脉冲切片增加阴极和神经刺激系统阳极之间的相对强度的系统和方法
公开(公告)号：US08843211B2
公开(公告)日：2014-09-23
申请号：US13727576
申请日：2012-12-26
申请人： Boston Scientific Neuromodulation Corporation
发明人： Dongchul Lee
IPC分类号： A61N1/08 , A61N1/36 , A61N1/05
CPC分类号： A61N1/36146 , A61N1/0553 , A61N1/36167
摘要： A method and neurostimulation system for providing therapy to a patient is provided. A plurality of electrodes is placed adjacent to tissue of the patient. A plurality of first electrical pulses is delivered to a first set of the electrodes, at least a second electrical pulse is delivered to a second set of the electrodes during the deliverance of each of the first electrical pulses, and at least a third electrical pulse is delivered to a third set of the electrodes during the deliverance of each of the first electrical pulses. The first electrical pulses have a first polarity, and each of the second electrical pulse(s) and third electrical pulses(s) has a second a second polarity opposite to the first polarity. The second and third electrical pulses are temporarily offset from each other.
摘要翻译：提供了一种用于向患者提供治疗的方法和神经刺激系统。多个电极邻近患者的组织放置。多个第一电脉冲被传送到第一组电极，在每个第一电脉冲的释放期间，至少第二电脉冲被传送到第二组电极，并且至少第三电脉冲是在每个第一电脉冲的释放期间传送到第三组电极。第一电脉冲具有第一极性，并且第二电脉冲和第三电脉冲中的每一个具有与第一极性相反的第二极性。第二和第三电脉冲彼此临时偏移。

40. 发明申请

US20140277250A1 Low Frequency Electrical Stimulation Therapy for Pelvic Floor Disorders 审中-公开
标题翻译：低频电刺激治疗盆底疾病
公开(公告)号：US20140277250A1
公开(公告)日：2014-09-18
申请号：US14210981
申请日：2014-03-14
申请人： Medtronic, Inc.
发明人： Xin Su , Dwight E. Nelson , Timothy J. Ness
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/36135 , A61N1/36167
摘要： In some examples, relatively low frequency (e.g., less than about 50 Hertz) electrical stimulation therapy is delivered to a target tissue site proximate to one or more of the T9, T10, T11, T12, L1, L2, or L3 (“T9-L3”) spinal nerves of a patient to manage a pelvic floor disorder, such as urinary retention, fecal retention, or both. The relatively low frequency electrical stimulation therapy is configured to excite the one or more of the T9-L3 spinal nerves, which may generate an activating response from the patient related to voiding and help promote voiding by the patient. For example, the low frequency electrical stimulation may be configured to help improve the patient's pelvic sensations, which may help the patient better control urination.
摘要翻译：在一些示例中，相对低频率（例如，小于约50赫兹）的电刺激治疗被递送到靠近T9，T10，T11，T12，L1，L2或L3中的一个或多个的靶组织位点（“T9 -L3“）脊髓神经来治疗盆底疾病，例如尿潴留，粪便保留或两者。相对低频的电刺激治疗被配置为激发一个或多个T9-L3脊神经，其可以产生患者与排尿相关的激活反应并且有助于促进患者的排尿。例如，低频电刺激可以被配置为帮助改善患者的盆腔感觉，这可以帮助患者更好地控制排尿。

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