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1. 发明授权

US11571575B2 Autotitration of therapy using detected electrical activity 有权
公开(公告)号：US11571575B2
公开(公告)日：2023-02-07
申请号：US16344719
申请日：2017-09-14
申请人： Medtronic, Inc.
发明人： Xin Su , Thaddeus S. Brink , Dwight E. Nelson
IPC分类号： A61N1/36 , A61N1/372 , G16H20/30 , A61B5/24
摘要： This disclosure relates to devices, systems, and methods for autotitrating stimulation parameters. In one example, a method includes controlling an implantable medical device to deliver electrical stimulation to a patient according to a plurality of electrical stimulation parameter sets, each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets defining a respective electrical stimulation signal deliverable to the patient, obtaining, by one or more processors and for each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets, a respective signal representative of an electrical response sensed from the patient in response to the electrical stimulation delivered to the patient according to the respective electrical stimulation parameter set, and determining, by the one or more processors and based on the obtained respective signals, a primary electrical stimulation parameter set that defines electrical stimulation therapy deliverable to the patient by the implantable medical device.

2. 发明授权

US11253314B2 Ablation therapy to disrupt coordinated bladder contractions 有权
公开(公告)号：US11253314B2
公开(公告)日：2022-02-22
申请号：US16880524
申请日：2020-05-21
申请人： Medtronic, Inc.
发明人： Thaddeus S. Brink , Blake A. Hedstrom , Dwight E. Nelson , Ashish Singal , Xin Su
IPC分类号： A61B18/14 , A61B5/20 , A61B8/08 , A61B5/11 , A61B5/391 , A61B18/00 , A61B18/08 , A61B18/06 , A61B18/02 , A61B5/00
摘要： The disclosure describes devices, systems, and techniques for identifying and treating bladder dysfunction. In one example, a method includes identifying one or more focal points at respective locations of bladder tissue of a bladder of a patient, the one or more focal points initiating coordinated contractions of a detrusor muscle. The method may also, or alternatively, include ablating, for each of the one or more focal points, a respective portion of the bladder tissue at the respective location of the focal point. Ablation of these targeted portions of the bladder tissue may reduce the coordinated contractions of the detrusor muscle and alleviate overactive bladder symptoms.

3. 发明申请

US20210370072A1 STIMULATION VECTOR SELECTION USING PULSE WIDTH DATA 有权
公开(公告)号：US20210370072A1
公开(公告)日：2021-12-02
申请号：US17401202
申请日：2021-08-12
申请人： Medtronic, Inc.
发明人： David A. Dinsmoor , Xin Su
IPC分类号： A61N1/36 , A61N1/37 , A61N1/372
摘要： A medical device system includes an IMD configured to deliver a plurality of stimulation vectors and processing circuitry. The processing circuitry is configured to determine strength-duration curve data for the plurality of stimulation vectors, the strength-duration curve data representing, for respective pulse widths and stimulation vectors, a corresponding strength of electrical stimulation that evokes a physiological response, compare respective slopes of the strength-duration curve data for the plurality of stimulation vectors to one another, select at least one stimulation vector of the plurality of stimulation vectors based on the comparison of the respective slopes of the strength-duration curve data for the plurality of stimulation vectors, and cause the IMD to deliver the electrical stimulation to a neural target via the selected at least one stimulation vector.

4. 发明授权

US11123555B2 Lead placement for nerve stimulation 有权
公开(公告)号：US11123555B2
公开(公告)日：2021-09-21
申请号：US15958491
申请日：2018-04-20
申请人： Medtronic, Inc.
发明人： Xin Su , David A. Dinsmoor , Jason E. Agran
IPC分类号： A61N1/36 , A61N1/05 , A61B5/06 , A61N1/372 , A61B5/00 , A61B5/296 , A61B5/391
摘要： Example systems for positioning an implantable electrode may include a stimulation circuitry, a sensing circuitry, and processing circuitry. The stimulation circuitry may generate electrical stimulation deliverable to a patient. The sensing circuitry may sense electromyographic (EMG) responses. The processing circuitry may control the stimulation circuitry to deliver the electrical stimulation at a plurality of different stimulation metric levels at each of a plurality of different positions. The processing circuitry may sense, via the sensing circuitry, electromyographic (EMG) responses to the electrical stimulation. The processing circuitry may score one or more of the different positions for chronic implantation of at least one implantable electrode. The scoring may be based on a stimulation metric level greater than a predetermined metric threshold sufficient to evoke at least some of the sensed EMG responses, and a level of the at least some of the sensed EMG responses.

5. 发明授权

US10639479B2 Stimulation vector selection using pulse width data 有权
公开(公告)号：US10639479B2
公开(公告)日：2020-05-05
申请号：US15804719
申请日：2017-11-06
申请人： Medtronic, Inc.
发明人： David A. Dinsmoor , Xin Su
IPC分类号： A61N1/36 , A61N1/37 , A61N1/372
CPC分类号： A61N1/36175 , A61N1/36007 , A61N1/36062 , A61N1/36071 , A61N1/36125 , A61N1/36171 , A61N1/3708 , A61N1/37247
摘要： A method of programming an implantable medical device (IMD) configured to provide electrical stimulation via a plurality of stimulation vectors during delivery of the electrical stimulation of a plurality of pulse widths to a neural target. The method may comprise comparing strength-duration curve data for the plurality of stimulation vectors to one another, the strength-duration curve data representing, for respective pulse widths and stimulation vectors, a corresponding stimulation strength that evokes a physiological response associated with the neural target. The method may comprise selecting at least one stimulation vector of the plurality of stimulation vectors based on the comparison of the strength-duration curve data for the plurality of stimulation vectors. The method may comprise programming, in response to the selection, the IMD to deliver the electrical stimulation to the neural target via the selected at least one stimulation vector.

6. 发明申请

US20180304075A1 LEAD PLACEMENT FOR NERVE STIMULATION 审中-公开
公开(公告)号：US20180304075A1
公开(公告)日：2018-10-25
申请号：US15958491
申请日：2018-04-20
申请人： Medtronic, Inc.
发明人： Xin Su , David A. Dinsmoor , Jason E. Agran
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36007 , A61B5/04882 , A61N1/0551 , A61N1/36021 , A61N1/36071 , A61N1/36107 , A61N1/36128 , A61N1/36132 , A61N1/36135 , A61N1/36185 , A61N1/37247
摘要： Example systems for positioning an implantable electrode may include a stimulation circuitry, a sensing circuitry, and processing circuitry. The stimulation circuitry may generate electrical stimulation deliverable to a patient. The sensing circuitry may sense electromyographic (EMG) responses. The processing circuitry may control the stimulation circuitry to deliver the electrical stimulation at a plurality of different stimulation metric levels at each of a plurality of different positions. The processing circuitry may sense, via the sensing circuitry, electromyographic (EMG) responses to the electrical stimulation. The processing circuitry may score one or more of the different positions for chronic implantation of at least one implantable electrode. The scoring may be based on a stimulation metric level greater than a predetermined metric threshold sufficient to evoke at least some of the sensed EMG responses, and a level of the at least some of the sensed EMG responses.

7. 发明申请

US20170319849A1 SELECTIVE TERMINATION OF STIMULATION TO DELIVER POST-STIMULATION THERAPEUTIC EFFECT 审中-公开
公开(公告)号：US20170319849A1
公开(公告)日：2017-11-09
申请号：US15661936
申请日：2017-07-27
申请人： Medtronic, Inc.
发明人： Xin Su , Dwight E. Nelson
IPC分类号： A61N1/36 , A61B5/0488 , A61B5/00 , A61B5/20 , A61N1/05 , A61B5/11 , A61B5/04
CPC分类号： A61N1/36007 , A61B5/0031 , A61B5/04001 , A61B5/04882 , A61B5/1116 , A61B5/205 , A61B5/4047 , A61B5/4836 , A61N1/0514
摘要： In some examples, electrical stimulation is delivered to a patient such that selective termination of the stimulation causes a therapeutic effect in the patient after termination of the electrical stimulation to the patient. The electrical stimulation may be insufficient to produce a desired therapeutic effect in the patient during stimulation, but sufficient to induce a post-stimulation desired therapeutic effect following termination of the stimulation. In some examples, the electrical stimulation may be sub-threshold electrical stimulation. In some examples, the desired therapeutic effect may alleviate bladder dysfunction, bowel dysfunction, or other disorders. The stimulation may be selectively terminated in response to one or more therapy trigger events to induce the post-stimulation therapeutic effect.

8. 发明申请

US20170105784A1 THERAPY TO TREAT PELVIC FLOOR DYSFUNCTION AND/OR PAIN 审中-公开
公开(公告)号：US20170105784A1
公开(公告)日：2017-04-20
申请号：US15130344
申请日：2016-04-15
申请人： Medtronic, Inc.
发明人： Xin Su , Dwight E. Nelson , Jason E. Agran
IPC分类号： A61B18/12 , A61B18/14
CPC分类号： A61B18/1233 , A61B18/1492 , A61B2018/00434 , A61B2018/00517 , A61B2018/00577 , A61B2018/00791
摘要： In some examples, the disclosure describes devices, systems, and techniques for treating pain and/or pelvic floor dysfunction of a patient. For example, a method for treating pelvic floor dysfunction in a patient may include delivering, via a medical device, a therapy to one or more nerve fibers, wherein the therapy is configured to at least temporarily deactivate the one or more nerve fibers; and determining that the one or more nerve fibers was at least temporarily deactivated by delivering the therapy.

9. 发明申请

US20150119951A1 ELECTRICAL STIMULATION THERAPY FOR LOWER URINARY TRACT DYSFUNCTION AND SEXUAL REFLEX DYSFUNCTION 审中-公开
标题翻译：电刺激治疗下尿路性功能障碍和性反射功能障碍
公开(公告)号：US20150119951A1
公开(公告)日：2015-04-30
申请号：US14563677
申请日：2014-12-08
申请人： Medtronic, Inc.
发明人： Dwight E. Nelson , Xin Su , Thaddeus S. Brink , Blake A. Hedstrom
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36132 , A61B5/021 , A61B5/024 , A61B5/4255 , A61B5/4368 , A61B5/4393 , A61N1/08 , A61N1/36007 , A61N1/3606 , A61N1/36107 , A61N1/3615 , A61N1/36171 , A61N1/37247
摘要： Electrical stimulation therapy may be delivered to a patient to selectively and independently address different conditions of a pelvic floor disorder of the patient. The conditions of a pelvic floor disorder may include, for example, a lower urinary tract dysfunction (e.g., urinary or fecal incontinence) and sexual dysfunction (e.g., an impaired sexual reflex response to a sexual stimulus). In some examples, a system is configured to selectively deliver a first electrical stimulation therapy that is configured to elicit an inhibitory physiological response from the patient related to voiding, a second electrical stimulation therapy that is configured to improve a sexual reflex response of the patient to a sexual stimulus, and a third electrical stimulation therapy that is configured to both elicit the inhibitory physiological response from the patient related to voiding and increase a sexual response of the patient to a sexual stimulus.
摘要翻译：电刺激治疗可以递送给患者以选择性且独立地解决患者盆底疾病的不同情况。盆底疾病的状况可能包括例如下尿路功能障碍（例如尿或大便失禁）和性功能障碍（例如，对性刺激的性反射受损）。在一些示例中，系统被配置为选择性地递送第一电刺激疗法，其被配置为引起患者与排尿相关的抑制性生理反应，第二电刺激治疗被配置为改善患者的性反射反应性刺激和第三种电刺激疗法，其被配置为既引起来自患者的与排尿相关的抑制性生理反应并且增加患者对性刺激的性反应。

10. 发明申请

US20140378941A1 CORTICAL POTENTIAL MONITORING 有权
标题翻译：电磁潜能监测
公开(公告)号：US20140378941A1
公开(公告)日：2014-12-25
申请号：US14063919
申请日：2013-10-25
申请人： Medtronic, Inc.
发明人： Xin Su , Dwight E. Nelson
IPC分类号： A61N1/36 , A61M5/168
CPC分类号： A61N1/36139 , A61B5/0484 , A61B5/4255 , A61M5/1723 , A61N1/36007 , A61N1/37241
摘要： Techniques, devices, and systems may include screening effective therapies using cortical evoked potentials. In one example, a system may be configured to receive a first sensed cortical evoked potential of a patient that occurred in response to an induced sensation at an anatomical region different from a brain region of the patient and receive a second sensed cortical evoked potential that occurred in response to electrical stimulation delivered to one or more nerves associated with the anatomical region. The electrical stimulation may be at least partially defined by a set of therapy parameter values. The system may also compare a first value of a characteristic of the first sensed cortical evoked potential to a second value of the characteristic of the second sensed cortical evoked potential and determine, based on the comparison, efficacy of a therapy configured to treat a condition associated with the anatomical region.
摘要翻译：技术，设备和系统可能包括使用皮质诱发电位筛选有效的治疗方法。在一个示例中，系统可以被配置为接收响应于在不同于患者的脑区域的解剖区域处的诱发感觉而发生的患者的第一感测到的皮层诱发电位，并且接收发生的第二感测皮质诱发电位响应于递送到与解剖区域相关联的一个或多个神经的电刺激。电刺激可以至少部分地由一组治疗参数值限定。该系统还可以将第一感测皮质诱发电位的特征的第一值与第二感测皮层诱发电位的特征的第二值进行比较，并且基于比较确定被配置为治疗相关疾病的治疗的功效与解剖区域。

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