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1. 发明授权

US08630709B2 Computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction 有权
标题翻译：用于选择治疗慢性心脏功能障碍的颈部迷走神经电刺激治疗方案的计算机实现系统和方法
公开(公告)号：US08630709B2
公开(公告)日：2014-01-14
申请号：US13314138
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61N1/36114 , A61N1/37235 , A61N1/37247
摘要： A computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. An external programmer includes a plurality of therapy profiles stored in memory. The therapy profiles include different sets of stimulation parameters that cooperatively define alternating cycles of stimuli application and stimuli inhibition for a neurostimulator that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes. A programming wand is configured to provide the set of stimulation parameters chosen by the user to the neurostimulator through wireless telemetry. Finally, an implantable neurostimulator device includes a stimulation therapy lead terminated by helical electrodes and electrically coupled to the neurostimulator. The implantable neurostimulator is configured to therapeutically stimulate the cervical vagus nerve through the helical electrodes by triggering bi-directional action potentials as specified by the selected set of stimulation parameters.
摘要翻译：提供了一种用于选择用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激的治疗方案的计算机实现的系统和方法。外部编程器包括存储在存储器中的多个治疗简档。治疗概况包括不同组的刺激参数，其协作地定义刺激应用的交替循环和神经刺激器的刺激抑制，所述神经刺激器被调谐以显着激活心脏的内在神经系统并传播激活患者的中心反射。编程棒被配置为通过无线遥测将用户选择的一组刺激参数提供给神经刺激器。最后，植入式神经刺激器装置包括由螺旋电极终止并电耦合到神经刺激器的刺激治疗引线。可植入神经刺激器被配置为通过触发由所选择的一组刺激参数指定的双向动作电位来通过螺旋电极治疗性地刺激颈部迷走神经。

2. 发明授权

US10188856B1 Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction 有权
公开(公告)号：US10188856B1
公开(公告)日：2019-01-29
申请号：US13314119
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/18 , A61N1/05 , A61N1/36
摘要： An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials.

3. 发明授权

US08918190B2 Implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction 有权
标题翻译：用于评估患有慢性心脏功能障碍的患者的自主心血管驱动的植入式装置
公开(公告)号：US08918190B2
公开(公告)日：2014-12-23
申请号：US13314133
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/32
CPC分类号： A61N1/36167 , A61B5/02 , A61B5/02438 , A61B5/4836 , A61B5/686 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： An implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. The neurostimulator includes a recordable memory storing a baseline heart rate. The neurostimulator includes an integrated leadless heart rate sensor configured to continually monitor heart rate in light of the baseline heart rate.
摘要翻译：提供了一种用于评估患有慢性心脏功能障碍的患者的自主心血管驱动的可植入装置。刺激治疗引线包括构造成符合颈部迷走神经鞘的外径的螺旋电极和电连接到螺旋电极的一组连接器引脚。神经刺激器包括一个电插座，连接器插头牢固地和电连接到该插座中。神经刺激器还包括脉冲发生器，其被配置为在刺激应用和刺激抑制的交替周期中通过螺旋电极治疗性地刺激迷走神经，该循环被调谐到两者以显着激活心脏的内在神经系统，并通过触发双向激活来传入激活患者的中心反射，方向动作电位。神经刺激器包括存储基线心率的可记录存储器。神经刺激器包括集成无引线心率传感器，其配置成根据基线心率不断监测心率。

4. 发明授权

US08688212B2 Implantable neurostimulator-implemented method for managing bradycardia through vagus nerve stimulation 有权
标题翻译：通过迷走神经刺激治疗心动过缓的植入式神经刺激器实施方法
公开(公告)号：US08688212B2
公开(公告)日：2014-04-01
申请号：US13554656
申请日：2012-07-20
申请人： Imad Libbus , Badri Amurthur , Bruce H. Kenknight
发明人： Imad Libbus , Badri Amurthur , Bruce H. Kenknight
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61B5/0464 , A61N1/36114 , A61N1/36139 , A61N1/36167 , A61N1/36171 , A61N1/36175
摘要： A method for managing bradycardia through vagus nerve stimulation is provided. An implantable neurostimulator configured to deliver electrical therapeutic stimulation in both afferent and efferent directions of a patient's cervical vagus nerve is provided. An operating mode is stored, which includes parametrically defining a maintenance dose of the electrical therapeutic stimulation tuned to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. The maintenance dose is delivered via a pulse generator through a pair of helical electrodes via an electrically coupled nerve stimulation therapy lead independent of cardiac cycle. The patient's physiology is monitored, and upon sensing a condition indicative of bradycardia, the delivery of the maintenance dose is suspended. A progressively increasing amount of time is spent waiting via a controller and, upon sensing a condition indicative of an absence or termination of the bradycardia, a progressively increasing partial maintenance dose is delivered via the pulse generator.
摘要翻译：提供了通过迷走神经刺激来控制心动过缓的方法。提供了一种可植入神经刺激器，其被配置为在患者的颈部迷走神经的传入方向和传出方向上递送电疗治疗刺激。存储操作模式，其包括参数地定义通过连续循环，间歇和周期性电脉冲来恢复心脏自主平衡的电治疗刺激的维持剂量。维持剂量通过脉冲发生器通过一对螺旋电极通过电耦合的神经刺激治疗导联而独立于心动周期递送。监测患者的生理状态，并且在感测到指示心动过缓的状况时，停止维持剂量的递送。通过控制器花费等待时间的逐渐增加，并且在感测到指示不存在或终止心动过缓的状况时，通过脉冲发生器递送逐渐增加的部分维持剂量。

5. 发明申请

US20130158618A1 Computer-Implemented System And Method For Selecting Therapy Profiles Of Electrical Stimulation Of Cervical Vagus Nerves For Treatment Of Chronic Cardiac Dysfunction 有权
标题翻译：计算机实施系统及选择治疗慢性心脏功能障碍的子宫颈迷走神经电刺激治疗方案
公开(公告)号：US20130158618A1
公开(公告)日：2013-06-20
申请号：US13314138
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/36053 , A61N1/36114 , A61N1/37235 , A61N1/37247
摘要： A computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. An external programmer includes a plurality of therapy profiles stored in memory. The therapy profiles include different sets of stimulation parameters that cooperatively define alternating cycles of stimuli application and stimuli inhibition for a neurostimulator that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes. A programming wand is configured to provide the set of stimulation parameters chosen by the user to the neurostimulator through wireless telemetry. Finally, an implantable neurostimulator device includes a stimulation therapy lead terminated by helical electrodes and electrically coupled to the neurostimulator. The implantable neurostimulator is configured to therapeutically stimulate the cervical vagus nerve through the helical electrodes by triggering bi-directional action potentials as specified by the selected set of stimulation parameters.
摘要翻译：提供了一种用于选择用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激的治疗方案的计算机实现的系统和方法。外部编程器包括存储在存储器中的多个治疗简档。治疗方案包括不同组的刺激参数，其协调地定义刺激应用的交替循环和神经刺激器的刺激抑制，所述神经刺激器被调谐以显着激活心脏的内在神经系统并传播激活患者的中心反射。编程棒被配置为通过无线遥测将用户选择的一组刺激参数提供给神经刺激器。最后，植入式神经刺激器装置包括由螺旋电极终止并电耦合到神经刺激器的刺激治疗引线。可植入神经刺激器被配置为通过触发由所选择的一组刺激参数指定的双向动作电位来通过螺旋电极来治疗性地刺激颈部迷走神经。

6. 发明申请

US20130158616A1 Implantable Device For Evaluating Autonomic Cardiovascular Drive In A Patient Suffering From Chronic Cardiac Dysfunction 有权
标题翻译：用于评估慢性心脏功能障碍患者自主心血管驱动的植入式装置
公开(公告)号：US20130158616A1
公开(公告)日：2013-06-20
申请号：US13314133
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/36167 , A61B5/02 , A61B5/02438 , A61B5/4836 , A61B5/686 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： An implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. The neurostimulator includes a recordable memory storing a baseline heart rate. The neurostimulator includes an integrated leadless heart rate sensor configured to continually monitor heart rate in light of the baseline heart rate.
摘要翻译：提供了一种用于评估患有慢性心脏功能障碍的患者的自主心血管驱动的可植入装置。刺激治疗引线包括构造成符合颈部迷走神经鞘的外径的螺旋电极和电连接到螺旋电极的一组连接器引脚。神经刺激器包括一个电插座，连接器插头牢固地和电连接到该插座中。神经刺激器还包括脉冲发生器，其被配置为在刺激应用和刺激抑制的交替周期中通过螺旋电极治疗性地刺激迷走神经，该循环被调谐到两者以显着激活心脏的内在神经系统，并通过触发双向激活来传入激活患者的中心反射，方向动作电位。神经刺激器包括存储基线心率的可记录存储器。神经刺激器包括集成无引线心率传感器，其配置成根据基线心率不断监测心率。

7. 发明授权

US08577458B1 Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring 有权
标题翻译：用于提供电刺激颈部迷走神经用于治疗慢性心脏功能障碍的无植入式器械的无植入装置
公开(公告)号：US08577458B1
公开(公告)日：2013-11-05
申请号：US13314126
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/05
CPC分类号： A61N1/3702 , A61N1/36114 , A61N1/36139 , A61N1/36175
摘要： An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. Finally, the neurostimulator includes an integrated leadless heart rate sensor configured to sense heart rate and to record the sensed heart rate as data into a memory.
摘要翻译：提供了一种用于提供用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激用于无引导心率监测的可植入装置。刺激治疗引线包括构造成符合颈部迷走神经鞘的外径的螺旋电极和电连接到螺旋电极的一组连接器引脚。神经刺激器包括一个电插座，连接器插头牢固地和电连接到该插座中。神经刺激器还包括脉冲发生器，其被配置为在刺激应用和刺激抑制的交替周期中通过螺旋电极治疗性地刺激迷走神经，该循环被调谐到两者以显着激活心脏的内在神经系统，并通过触发双向激活来传入激活患者的中心反射，方向动作电位。最后，神经刺激器包括被配置为感测心率并将感测的心率作为数据记录到存储器中的集成的无引线心率传感器。

8. 发明申请

US20130184773A1 Vagus Nerve Neurostimulator With Multiple Patient-Selectable Modes For Treating Chronic Cardiac Dysfunction 有权
标题翻译：迷走神经神经刺激器具有多种患者可选择的治疗慢性心脏功能障碍的模式
公开(公告)号：US20130184773A1
公开(公告)日：2013-07-18
申请号：US13352244
申请日：2012-01-17
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/3727
摘要： A vagus nerve neurostimulator system with multiple patient-selectable modes for treating chronic cardiac dysfunction is provided. An implantable neurostimulator includes a pulse generator coupled to a therapy lead terminated by a pair of helical electrodes positioned over a cervical vagus nerve. The pulse generator is configured to deliver through the helical electrodes continuously-cycling, intermittent and periodic electrical stimulation that is parametrically defined to bi-directionally propagate through nerve fibers in the cervical vagus nerve. The implantable neurostimulator includes a magnetic switch configured to switch the pulse generator between a plurality of operating modes that are each separately selectable in response to a unique and remotely-applied magnetic signal. An external controller includes patient-actuatable controls configured to enable selection of one of the operating modes of the pulse generator. The external controller includes an electromagnetic transmitter configured to output the magnetic signal uniquely associated with the operating mode as selected with the controls.
摘要翻译：提供了一种具有多种患者可选择的用于治疗慢性心脏功能障碍的模式的迷走神经神经刺激器系统。可植入的神经刺激器包括一个脉冲发生器，该脉冲发生器耦合到由位于颈部迷走神经上的一对螺旋电极终止的治疗引线。脉冲发生器被配置为通过螺旋电极连续循环，间歇和周期性电刺激传递，其被参数限定以通过颈部迷走神经中的神经纤维双向传播。可植入神经刺激器包括磁开关，其被配置为在多个操作模式之间切换脉冲发生器，所述多个操作模式可以响应于独特的和远程施加的磁信号而分别可选择。外部控制器包括被配置为能够选择脉冲发生器的一个操作模式的患者致动控制。外部控制器包括电磁发射机，其被配置为输出与通过控制选择的操作模式唯一相关联的磁信号。

9. 发明申请

US20130158622A1 Implantable Device For Facilitating Control Of Electrical Stimulation Of Cervical Vagus Nerves For Treatment Of Chronic Cardiac Dysfunction 有权
标题翻译：用于促进控制电刺激颈椎迷走神经治疗慢性心脏功能障碍的植入装置
公开(公告)号：US20130158622A1
公开(公告)日：2013-06-20
申请号：US13314130
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/37217 , A61N1/36114
摘要： An implantable device for facilitating control of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. Finally, the neurostimulator includes a programmable switch configured to alter the triggering of the bi-directional action potentials in response to a magnetic signal received from outside the housing.
摘要翻译：提供了一种用于促进控制用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激的可植入装置。刺激治疗引线包括构造成符合颈部迷走神经鞘的外径的螺旋电极和电连接到螺旋电极的一组连接器引脚。神经刺激器包括一个电插座，连接器插头牢固地和电连接到该插座中。神经刺激器还包括脉冲发生器，其被配置为在刺激应用和刺激抑制的交替周期中通过螺旋电极治疗性地刺激迷走神经，该循环被调谐到两者以显着激活心脏的内在神经系统，并通过触发双向激活来传入激活患者的中心反射，方向动作电位。最后，神经刺激器包括可编程开关，其被配置为响应于从壳体外部接收的磁信号来改变双向动作电位的触发。

10. 发明授权

US08571654B2 Vagus nerve neurostimulator with multiple patient-selectable modes for treating chronic cardiac dysfunction 有权
标题翻译：迷走神经神经刺激器具有多种患者可选择的治疗慢性心脏功能障碍的模式
公开(公告)号：US08571654B2
公开(公告)日：2013-10-29
申请号：US13352244
申请日：2012-01-17
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/3727
摘要： A vagus nerve neurostimulator system with multiple patient-selectable modes for treating chronic cardiac dysfunction is provided. An implantable neurostimulator includes a pulse generator coupled to a therapy lead terminated by a pair of helical electrodes positioned over a cervical vagus nerve. The pulse generator is configured to deliver through the helical electrodes continuously-cycling, intermittent and periodic electrical stimulation that is parametrically defined to bi-directionally propagate through nerve fibers in the cervical vagus nerve. The implantable neurostimulator includes a magnetic switch configured to switch the pulse generator between a plurality of operating modes that are each separately selectable in response to a unique and remotely-applied magnetic signal. An external controller includes patient-actuatable controls configured to enable selection of one of the operating modes of the pulse generator. The external controller includes an electromagnetic transmitter configured to output the magnetic signal uniquely associated with the operating mode as selected with the controls.
摘要翻译：提供了一种具有多种患者可选择的用于治疗慢性心脏功能障碍的模式的迷走神经神经刺激器系统。可植入的神经刺激器包括一个脉冲发生器，该脉冲发生器耦合到由位于颈部迷走神经上的一对螺旋电极终止的治疗引线。脉冲发生器被配置为通过螺旋电极连续循环，间歇和周期性电刺激传递，其被参数限定以通过颈部迷走神经中的神经纤维双向传播。可植入神经刺激器包括磁开关，其被配置为在多个操作模式之间切换脉冲发生器，所述多个操作模式可以响应于独特的和远程施加的磁信号而分别可选择。外部控制器包括被配置为能够选择脉冲发生器的一个操作模式的患者致动控制。外部控制器包括电磁发射机，其被配置为输出与通过控制选择的操作模式唯一相关联的磁信号。

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