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31. 发明授权

US4812163A Phenoxyacetic acids and herbicides comprising them as active ingredients 失效
标题翻译：苯氧基乙酸和除草剂包含它们作为活性成分
公开(公告)号：US4812163A
公开(公告)日：1989-03-14
申请号：US172988
申请日：1988-03-18
申请人： Toshiyuki Hiramatsu , Shizuo Azuma , Koji Nakagawa , Yataro Ichikawa
发明人： Toshiyuki Hiramatsu , Shizuo Azuma , Koji Nakagawa , Yataro Ichikawa
IPC分类号： A01N43/60 , C07D241/44 , C07D207/08 , C07D403/12
CPC分类号： C07D241/44 , A01N43/60
摘要： A phenoxyacetic acid represented by the following formula (I) ##STR1## wherein X represents a halogen atom or CF.sub.3, R.sup.1 and R.sup.3 are identical or different and each represents a hydrogen atom or an alkyl group having not more than 5 carbon atoms, R.sup.2 represents a hydrogen atom, a lower alkyl group, a phenyl group, a benzyl group, --CH.sub.2 CH.sub.2 SCH.sub.3, --CH.sub.2 OH, --CH(CH.sub.3)OH, --CH.sub.2 SH, --CH.sub.2 COOCH.sub.3, ##STR2## or R.sup.2 and R.sup.3 together may form --CH.sub.2 CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH(OH)--, and n is 0, 1 or 2, or a salt at the carboxyl group of the phenoxyacetic acid of the above formula in which R.sup.1 is a hydrogen atom. The compound is useful, as a herbicide, for eradicating weeds, especially narrow-leaved weeds.
摘要翻译：由下式（I）表示的苯氧基乙酸其中X表示卤素原子或CF 3，R 1和R 3相同或不同，表示氢原子或碳原子数5以下的烷基，R 2表示氢原子，低级烷基，苯基，苄基，-CH 2 CH 2 SCH 3，-CH 2 OH，-CH（CH 3）OH，-CH 2 SH，-CH 2 COOCH 3， CH 2 CH 2 CH 2 - 或-CH 2 CH 2 CH（OH） - ，n为0,1或2，或上述式中的苯氧基乙酸的羧基上的盐，其中R1为氢原子。该化合物作为除草剂用于根除杂草，特别是窄叶杂草。

32. 发明授权

US4789636A Double-stranded DNA having sequences complementary to a single-stranded DNA and derived from mungbean yellow mosaic virus 失效
标题翻译：双链DNA具有与单链DNA互补的衍生自绿豆黄花叶病毒的序列
公开(公告)号：US4789636A
公开(公告)日：1988-12-06
申请号：US647829
申请日：1984-09-05
申请人： Tsuto Morinaga , Kin-ichiro Miura , Kunitada Shimotohno , Masato Ikegami , Yataro Ichikawa
发明人： Tsuto Morinaga , Kin-ichiro Miura , Kunitada Shimotohno , Masato Ikegami , Yataro Ichikawa
IPC分类号： C12N15/09 , C07H21/04 , C12N15/75 , C12N15/81 , C12N15/82 , C12N15/00 , C12P19/34 , C12P21/00
CPC分类号： C12N15/75 , C12N15/81 , C12N15/8203
摘要： Double-stranded DNA characterized by having sequences complementary to a single-stranded DNA which has a molecular size of about 2.67 Kb and is derived from mungbean yellow mosaic virus, and giving the restriction endonuclease cleavage map shown in FIG. 1 of the accompanying drawings; anddouble-stranded DNA characterized by having sequences complementary to a single-straned DNA which has a molecular size of about 2.70 Kb and is derived from mungbean yellow mosaic virus, and giving the restriction endonuclease cleavage map shown in FIG. 2 of the accompanying drawings; and hybrid DNAs having the double-stranded DNAs inserted thereinto.
摘要翻译：其特征在于具有与分子大小约2.67Kb并衍生自绿豆黄花叶病毒的单链DNA互补的序列，并给出图1所示的限制性内切核酸酶切割图。附图1; 特征在于具有与分子大小约2.70Kb并衍生自绿豆黄色花叶病毒的单链DNA的序列互补的双链DNA，并给出图1所示的限制性内切核酸酶切割图。附图2; 以及插入双链DNA的杂交DNA。

33. 发明授权

US3983159A Process for producing biphenylpolycarboxylic acid ester 失效
标题翻译：联苯多羧酸酯的制备方法
公开(公告)号：US3983159A
公开(公告)日：1976-09-28
申请号：US498182
申请日：1974-08-16
申请人： Yataro Ichikawa , Teizo Yamaji
发明人： Yataro Ichikawa , Teizo Yamaji
IPC分类号： C07C67/00 , C07C69/76
CPC分类号： C07C67/00 , C07C69/76
摘要： The oxidative coupling of benzenecarboxylic acid esters to form the corresponding biphenylpolycarboxylic acid esters, comprising contacting a benzenecarboxylic acid ester having at least one hydrogen atom bonded to the nuclear carbon atom of the benzene ring, such as methyl benzeate, with molecular oxygen in a liquid phase using a catalyst comprising at least one compound selected from organic carboxylates of palladium, such as palladium acetate and .beta.-dikete complexes of palladium, such as acetylacetone-palladium complex. Use of at least one zirconium compound, such as zirconium oxystearate in conjunction with the catalyst gives rise to an increased catalytic activity.
摘要翻译：苯甲酸酯的氧化偶合形成相应的联苯多羧酸酯，包括将具有至少一个与苯环的核碳原子键合的氢原子的苯甲酸酯如苯甲酸甲酯与液相中的分子氧接触使用包含至少一种选自钯的有机羧酸盐，例如乙酸钯和钯的β-二乙基络合物如乙酰丙酮 - 钯络合物的化合物的催化剂。使用至少一种锆化合物，例如氧化钼硬脂酸锆与催化剂结合产生增加的催化活性。

34. 发明授权

US3978092A Process for the preparation of unsaturated carbonyl compounds 失效
标题翻译：不饱和羰基化合物的制备方法
公开(公告)号：US3978092A
公开(公告)日：1976-08-31
申请号：US467618
申请日：1974-05-06
申请人： Yataro Ichikawa , Mamoru Yamamoto
发明人： Yataro Ichikawa , Mamoru Yamamoto
IPC分类号： C07C45/51 , C07C47/21 , C07D307/42 , C07D307/46 , C07C47/20 , C07C47/45
CPC分类号： C07D307/42 , C07C45/513 , C07C45/515 , C07C47/21 , C07D307/46
摘要： An unsaturated carbonyl compound, for example, one expressed by the following formula ##EQU1## is prepared by maintaining at an elevated temperature an allyl acetal of an .alpha.,.beta.-unsaturated aldehyde, for example, one expressed by the following formula ##EQU2## or a novel dienyl ether derived from it, for example, one expressed by the following formula ##EQU3## The allyl acetal can be derived, for example, from .beta.-methylcrotonaldehyde having 5 carbon atoms and prenyl alcohol having 5 carbon atoms. It is possible therefore to introduce an allyl residue containing at least 3 carbon atoms into the carbon atoms at the .gamma.-position to the carbonyl group of an .alpha., .beta.-unsaturated aldehyde containing at least 5 carbon atoms by a reaction consisting of the reduced number of steps. Moreover, the unsaturated aldehyde having the increased number of carbon atoms can be formed at a high yield by a relatively simple reaction.
摘要翻译：通过保持在升高的温度下制备不饱和羰基化合物，例如由下式表示的CH 3 CH 3 | H3C-C = CH-CH 2 -CH 2 -C = CH-CHO的一种不饱和羰基化合物，其中α，β-不饱和的烯丙基缩醛醛，例如，由下式表示的CH 3 CH 3 || CH 2 -CH = C-CH 3 H3C-C = CH-CH 2 O-CH 2 -CH = C-CH 3 | CH 3或新型二烯基醚衍生物例如，由下式表示的CH 3 CH 3 || CH 2 = C-CH = CH-O-CH 2 -CH = C-CH 3所示的烯丙基缩醛可以衍生自例如具有5碳的β-甲基巴豆醛具有5个碳原子的原子和异戊醇。因此，可以通过由减少的数目组成的反应将含有至少3个碳原子的烯丙基残基引入到含有至少5个碳原子的α，β-不饱和醛的γ-位上的碳原子的步骤。此外，可以通过相对简单的反应以高产率形成碳原子数增加的不饱和醛。

35. 发明授权

US3963787A Process for producing diphenyls 失效
标题翻译：生产二苯基的方法
公开(公告)号：US3963787A
公开(公告)日：1976-06-15
申请号：US326523
申请日：1973-01-24
申请人： Yataro Ichikawa , Teizo Yamaji
发明人： Yataro Ichikawa , Teizo Yamaji
IPC分类号： C07C2/84 , C07C17/26 , C07C43/205 , C07C43/20 , C07C15/14 , C07C25/00
CPC分类号： C07C17/269 , C07C2/84 , C07C43/2055 , C07C2531/04
摘要： The oxidative coupling of benzene or benzene derivatives to form the corresponding diphenyls, comprising contacting benzene or a benzene derivative, such as toluene, with molecular oxygen using as a catalyst organic carboxylates of palladium such as palladium acetate. Use of at least one zirconium compound such as zirconium oxystearate in conjunction with the catalyst gives rise to an increased catalytic activity. The diphenyls are intermediates for production of dyestuffs, pharmaceuticals and other chemicals, and also find application in the preparation of high-molecular-weight polyesters and polyamides.
摘要翻译：苯或苯衍生物的氧化偶合形成相应的二苯基，包括使用钯或乙酸钯的有机羧酸盐作为催化剂使苯或苯衍生物如甲苯与分子氧接触。使用至少一种锆化合物如氧化硬脂酸锆与催化剂结合产生增加的催化活性。二苯基是生产染料，药物和其他化学品的中间体，也可用于制备高分子量聚酯和聚酰胺。

36. 发明授权

US06270118B1 Slip prevention apparatus and vehicle equipped with the apparatus 失效
标题翻译：装有该装置的防滑装置和车辆
公开(公告)号：US06270118B1
公开(公告)日：2001-08-07
申请号：US09272929
申请日：1999-03-18
申请人： Yataro Ichikawa
发明人： Yataro Ichikawa
IPC分类号： B60S900
CPC分类号： B60B39/024 , B60B39/025 , B60B39/026 , B60B39/10 , B60S1/68 , B60T2210/13
摘要： An apparatus and a vehicle equipped with the apparatus for preventing slip and keeping a good running on the ground including a road covered with frozen water such as ice and/or snow by cooling a wheel surface of the vehicle and/or a ground surface just in front of a point where the wheel comes into contact therewith by using cold air directly produced by expansion of compressed air in the running of the vehicle in response to change in the vehicle driving condition and further, dealing with a hydroplaning of the wheel on a wet ground surface at not freezing seasons by injection of the compressed air.
摘要翻译：一种设备和车辆，其装备有用于防止滑动并保持在地面上良好行驶的装置，包括通过冷却车辆的车轮表面和/或地面的冰封和/或雪覆盖的道路，刚好在通过使用通过在车辆行驶状态的变化中在车辆的行驶中膨胀而直接产生的冷空气使车轮接触的位置的前方，并且进一步地，在湿润处理车轮的滑水通过注射压缩空气在不冷冻季节的地面。

37. 发明授权

US5534255A Monoclonal antibody specific to human .alpha..sub.2 -plasmin inhibitor 失效
标题翻译：对人α2-纤溶酶抑制剂特异性的单克隆抗体
公开(公告)号：US5534255A
公开(公告)日：1996-07-09
申请号：US716694
申请日：1991-06-17
申请人： Yoshihiko Sumi , Yukiya Koike , Yataro Ichikawa , Nobuhiko Yoshida , Nobuo Aoki
发明人： Yoshihiko Sumi , Yukiya Koike , Yataro Ichikawa , Nobuhiko Yoshida , Nobuo Aoki
IPC分类号： A61K38/00 , C07K14/81 , C07K16/38 , C12P21/08 , A61K39/00 , C07K16/00
CPC分类号： C07K16/38 , C07K14/8121 , A61K38/00 , Y10S530/864 , Y10S530/866
摘要： This invention provides a monoclonal antibody or its fragment specific to a human .alpha..sub.2 -plasmin inhibitor, said antibody having the function of specifically blocking that site of the human .alpha..sub.2 -plasmin inhibitor which inhibits the fibrinolytic activity of plasmin, and of suppressing said fibrinolytic activity inhibiting function of said .alpha..sub.2 -plasmin inhibitor, and also a hybridoma capable of producing the monoclonal antibody. Said monoclonal antibody or its fragment is useful for the immunological determination of a human .alpha..sub.2 -plasmin inhibitor, the separation or recovery of a human .alpha..sub.2 -plasmin inhibitor from a liquid containing the human .alpha..sub.2 -plasmin inhibitor, and the treatment of a thrombotic disease.
摘要翻译：本发明提供了对人α2-纤溶酶抑制剂特异性的单克隆抗体或其片段，所述抗体具有特异性阻断人α2-纤溶酶抑制剂的位点的功能，其抑制纤溶酶的纤维蛋白溶解活性，并抑制所述纤维蛋白溶解所述α2-纤溶酶抑制剂的活性抑制功能，以及能够产生单克隆抗体的杂交瘤。所述单克隆抗体或其片段可用于免疫测定人α2-纤溶酶抑制剂，从含有人α2-纤溶酶抑制剂的液体中分离或回收人α2-纤溶酶抑制剂，以及治疗血栓性疾病

38. 依法登记的发明

USH1148H Method of separating activated human protein C 失效
公开(公告)号：USH1148H
公开(公告)日：1993-03-02
申请号：US815870
申请日：1992-01-03
申请人： Kenji Wakabayashi , Yoshihiko Sumi , Yataro Ichikawa , Yoichi Sakata , Nobuo Aoki
发明人： Kenji Wakabayashi , Yoshihiko Sumi , Yataro Ichikawa , Yoichi Sakata , Nobuo Aoki
IPC分类号： C07K16/40 , C12N9/64
CPC分类号： C12N9/6464 , C07K16/40 , C12Y304/21069
摘要： A method of separating activated human protein C, which comprises bringing a mixture containing activated human protein C having a gamma-carboxyglutamic acid (Gla) domain in the presence of a calcium ion into contact with a fixed antibody comprising an insoluble carrier and fixed thereto an antibody to a complex of human protein C and a calcium ion bound to the Gla domain whereby the activated human protein C is captured by the fixed antibody in the form in which the calcium ion is bound to the Gla domain. A method is also provided for separating activated human protein C from a mixture containing human protein C and activated human protein C, which comprises bringing a first mixture containing human protein C and activated human protein C having a Gla domain into contact with a first fixed antibody comprising an insoluble carrier and fixed thereto a first antibody to human protein C but not to activated human protein C to form a second mixture substantially free from human protein C while the human protein C is captured by the first fixed antibody, and bringing the second mixture in the presence of a calcium ion into contact with a second fixed antibody comprising an insoluble carrier and fixed thereto a second antibody to a complex of human protein C and a calcium ion bound at the Gla domain, whereby the activated human protein C is captured by the second fixed antibody in the form in which the calcium ion is bound to the Gla domain.

39. 发明授权

US5187067A Immunological determination of free human protein S and C4bp-protein S complex 失效
标题翻译：游离人蛋白S和C4bp蛋白S复合物的免疫测定
公开(公告)号：US5187067A
公开(公告)日：1993-02-16
申请号：US670383
申请日：1991-03-14
申请人： Yukiya Koike , Kenji Wakabayashi , Yoshihiko Sumi , Yataro Ichikawa
发明人： Yukiya Koike , Kenji Wakabayashi , Yoshihiko Sumi , Yataro Ichikawa
IPC分类号： C07K16/18 , C07K16/36 , C12N5/18
CPC分类号： C07K16/18 , C07K16/36 , Y10S436/821 , Y10S436/824
摘要： A method of immunologically determining free human protein S in an assay sample, which comprises contacting a primary antibody fixed to an insoluble solid carrier and a labelled secondary antibody with the assay sample, the primary and secondary antibodies having the property of binding to different epitopes of free human protein S, and one of the primary and secondary antibodies being a monoclonal antibody having the property of not binding to a complex of the human protein S and human complement cofactor C4b-binding protein (C4bp) but specifically binding to the free human protein S. Also provided is a method of immunologically determining a complex of human protein S and human complement cofactor C4b-binding protein (C4bp) in an assay sample, which comprises contacting a primary antibody fixed to an insoluble solid carrier and a labelled secondary antibody with the assay sample, one of the primary and secondary antibodies being a monoclonal antibody having the property of not binding to free human protein S and human complement cofactor C4b-binding protein (C4bp) but binding specifically to the complex, and the other being an antibody having the property of binding to the human complement cofactor C4b-binding protein (4Cbp).
摘要翻译：一种在测定样品中免疫测定游离人蛋白S的方法，其包括将固定在不溶性固体载体上的第一抗体与标记的第二抗体与测定样品接触，所述第一抗体和第二抗体具有结合不同表位的性质游离人蛋白S，其中一种和第二种抗体是具有不与人类蛋白S和人补体辅因子C4b结合蛋白（C4bp）的复合物结合但与结合游离人蛋白质的特异性的单克隆抗体还提供了在测定样品中免疫测定人蛋白S和人补体辅因子C4b结合蛋白（C4bp）的复合物的方法，其包括将固定于不溶性固体载体的第一抗体和标记的第二抗体与测定样品，其中一种和第二种抗体是具有不结合特性的单克隆抗体 g释放人蛋白S和人补体辅因子C4b结合蛋白（C4bp），但与复合物特异性结合，另一种是具有与人补体辅因子C4b结合蛋白（4Cbp）结合的性质的抗体。

40. 发明授权

US4902614A Monoclonal antibody to human protein C 失效
标题翻译：人类蛋白C的单克隆抗体
公开(公告)号：US4902614A
公开(公告)日：1990-02-20
申请号：US804255
申请日：1985-12-03
申请人： Kenji Wakabayashi , Yoshihiko Sumi , Yataro Ichikawa , Yoichi Sakata , Jun Mimuro , Nobuo Aoki
发明人： Kenji Wakabayashi , Yoshihiko Sumi , Yataro Ichikawa , Yoichi Sakata , Jun Mimuro , Nobuo Aoki
IPC分类号： C07K16/40 , G01N33/86
CPC分类号： C07K16/40 , G01N33/86 , G01N2333/96461 , Y10S435/815
摘要： A monoclonal antibody which is specific to human protein C which has calcium bound at the gammacarboxyglutamic acid(Gla) domain and does not recognize human protein C which is not bound to calcium at the Gla domain. The monoclonal antibody is used in an immunoassay method for determining human protein C having a Gla domain and in a method for recovering human protein C having a Gal domain.
摘要翻译：对人蛋白C特异性的单克隆抗体，其具有在γ-氨基谷氨酸（Gla）结构域处结合钙并且不识别在Gla结构域不与钙结合的人蛋白质C。单克隆抗体用于测定具有Gla结构域的人蛋白C的免疫测定方法和用于回收具有Gal结构域的人蛋白C的方法。

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