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1. 发明授权

US5534255A Monoclonal antibody specific to human .alpha..sub.2 -plasmin inhibitor 失效
标题翻译：对人α2-纤溶酶抑制剂特异性的单克隆抗体
公开(公告)号：US5534255A
公开(公告)日：1996-07-09
申请号：US716694
申请日：1991-06-17
申请人： Yoshihiko Sumi , Yukiya Koike , Yataro Ichikawa , Nobuhiko Yoshida , Nobuo Aoki
发明人： Yoshihiko Sumi , Yukiya Koike , Yataro Ichikawa , Nobuhiko Yoshida , Nobuo Aoki
IPC分类号： A61K38/00 , C07K14/81 , C07K16/38 , C12P21/08 , A61K39/00 , C07K16/00
CPC分类号： C07K16/38 , C07K14/8121 , A61K38/00 , Y10S530/864 , Y10S530/866
摘要： This invention provides a monoclonal antibody or its fragment specific to a human .alpha..sub.2 -plasmin inhibitor, said antibody having the function of specifically blocking that site of the human .alpha..sub.2 -plasmin inhibitor which inhibits the fibrinolytic activity of plasmin, and of suppressing said fibrinolytic activity inhibiting function of said .alpha..sub.2 -plasmin inhibitor, and also a hybridoma capable of producing the monoclonal antibody. Said monoclonal antibody or its fragment is useful for the immunological determination of a human .alpha..sub.2 -plasmin inhibitor, the separation or recovery of a human .alpha..sub.2 -plasmin inhibitor from a liquid containing the human .alpha..sub.2 -plasmin inhibitor, and the treatment of a thrombotic disease.
摘要翻译：本发明提供了对人α2-纤溶酶抑制剂特异性的单克隆抗体或其片段，所述抗体具有特异性阻断人α2-纤溶酶抑制剂的位点的功能，其抑制纤溶酶的纤维蛋白溶解活性，并抑制所述纤维蛋白溶解所述α2-纤溶酶抑制剂的活性抑制功能，以及能够产生单克隆抗体的杂交瘤。所述单克隆抗体或其片段可用于免疫测定人α2-纤溶酶抑制剂，从含有人α2-纤溶酶抑制剂的液体中分离或回收人α2-纤溶酶抑制剂，以及治疗血栓性疾病

2. 发明授权

US5187067A Immunological determination of free human protein S and C4bp-protein S complex 失效
标题翻译：游离人蛋白S和C4bp蛋白S复合物的免疫测定
公开(公告)号：US5187067A
公开(公告)日：1993-02-16
申请号：US670383
申请日：1991-03-14
申请人： Yukiya Koike , Kenji Wakabayashi , Yoshihiko Sumi , Yataro Ichikawa
发明人： Yukiya Koike , Kenji Wakabayashi , Yoshihiko Sumi , Yataro Ichikawa
IPC分类号： C07K16/18 , C07K16/36 , C12N5/18
CPC分类号： C07K16/18 , C07K16/36 , Y10S436/821 , Y10S436/824
摘要： A method of immunologically determining free human protein S in an assay sample, which comprises contacting a primary antibody fixed to an insoluble solid carrier and a labelled secondary antibody with the assay sample, the primary and secondary antibodies having the property of binding to different epitopes of free human protein S, and one of the primary and secondary antibodies being a monoclonal antibody having the property of not binding to a complex of the human protein S and human complement cofactor C4b-binding protein (C4bp) but specifically binding to the free human protein S. Also provided is a method of immunologically determining a complex of human protein S and human complement cofactor C4b-binding protein (C4bp) in an assay sample, which comprises contacting a primary antibody fixed to an insoluble solid carrier and a labelled secondary antibody with the assay sample, one of the primary and secondary antibodies being a monoclonal antibody having the property of not binding to free human protein S and human complement cofactor C4b-binding protein (C4bp) but binding specifically to the complex, and the other being an antibody having the property of binding to the human complement cofactor C4b-binding protein (4Cbp).
摘要翻译：一种在测定样品中免疫测定游离人蛋白S的方法，其包括将固定在不溶性固体载体上的第一抗体与标记的第二抗体与测定样品接触，所述第一抗体和第二抗体具有结合不同表位的性质游离人蛋白S，其中一种和第二种抗体是具有不与人类蛋白S和人补体辅因子C4b结合蛋白（C4bp）的复合物结合但与结合游离人蛋白质的特异性的单克隆抗体还提供了在测定样品中免疫测定人蛋白S和人补体辅因子C4b结合蛋白（C4bp）的复合物的方法，其包括将固定于不溶性固体载体的第一抗体和标记的第二抗体与测定样品，其中一种和第二种抗体是具有不结合特性的单克隆抗体 g释放人蛋白S和人补体辅因子C4b结合蛋白（C4bp），但与复合物特异性结合，另一种是具有与人补体辅因子C4b结合蛋白（4Cbp）结合的性质的抗体。

3. 发明授权

US5369038A Method for immunological assay of free lipoprotein associated coagulation inhibitor (LACI) and kit therefor 失效
标题翻译：免疫学检测免疫脂蛋白相关凝血抑制剂（LACI）及其试剂盒的方法
公开(公告)号：US5369038A
公开(公告)日：1994-11-29
申请号：US969368
申请日：1992-10-30
申请人： Yukiya Koike , Koji Suzuki , Yataro Ichikawa
发明人： Yukiya Koike , Koji Suzuki , Yataro Ichikawa
IPC分类号： C07K16/38 , G01N33/86 , G01N33/53 , C07K15/28 , C12Q1/00
CPC分类号： G01N33/86 , C07K16/38 , Y10S435/975
摘要： In methods for immunologically assaying free lipoprotein associated coagulation inhibitor (hereafter abbreviated as "LACI") in a human inspection sample using a first antibody immobilized on an insoluble carrier and a labeled second antibody, a method for immunological assay of free LACI and a kit therefor wherein(i) any one antibody of the first antibody and the second antibody is a monoclonal antibody recognizing the polypeptide (K3) of the following amino sequence ##STR1## (hereafter referred to as a "K3-antibody"), and (ii) the other antibody is a monoclonal antibody recognizing the polypeptide (K1) of the following amino acid sequence ##STR2## (hereafter referred to as a "K1-antibody").
摘要翻译：在使用固定在不溶性载体上的第一抗体和标记的第二抗体的人检查样品中免疫测定游离脂蛋白相关凝血抑制剂（以下简称为“LACI”）的方法中，游离LACI的免疫测定方法及其试剂盒其中（i）第一抗体和第二抗体的任何一个抗体是识别以下氨基酸序列的多肽（K3）的单克隆抗体LeuThrProAlaAspArgGlyLeuCysArg AlaAsnGluAsnArgPheTyrTyrAsnSer Val（以下称为“K3-抗体”），和（ii）另一种抗体是识别以下氨基酸序列的多肽（K1）的单克隆抗体AlaPheLysAlaAspAsp GlyProCysLysAlaIle MetLysArgPhePhePhePheAhelePhe（以下称为“K1抗体”）。

4. 发明授权

US07300763B2 Method of testing myelotoxicity with the use of flow cytometer 失效
标题翻译：使用流式细胞仪检测骨髓毒性的方法
公开(公告)号：US07300763B2
公开(公告)日：2007-11-27
申请号：US10297749
申请日：2001-06-08
申请人： Daishiro Miura , Shoko Ogata , Yukiya Koike
发明人： Daishiro Miura , Shoko Ogata , Yukiya Koike
IPC分类号： G01N33/567
CPC分类号： G01N33/5014 , G01N15/14 , G01N33/56966 , Y10T436/107497
摘要： The objects of the present invention are to solve low test efficiency and low accuracy which are problems encountered in the conventional methods for testing myelotoxicity of a drug by observing smears. To this end, markers for discriminating and identifying hematopoietic stem cells and blood cells at various differentiation stages in bone marrow are identified. From this point of view, cell surface antigens are specified. Thus, it is found that the myelotoxicity of a drug can be evaluated with a high efficiency at a high accuracy by using flow cytometry to analyze for a change in the quantity of bone marrow-derived cells expressing the cell surface antigens after administration of the drug to an animal.
摘要翻译：本发明的目的是解决通过观察涂片测定药物的骨髓毒性的常规方法中遇到的问题的低试验效率和低精度问题。鉴定鉴别和鉴定骨髓各种分化阶段造血干细胞和血细胞的标记。从这个角度来说，规定了细胞表面抗原。因此，通过使用流式细胞术可以高效率地评价药物的骨髓毒性，以分析施用药物后表达细胞表面抗原的骨髓来源的细胞数量的变化到一个动物

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