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31. 发明授权

US06833002B2 Stent delivery catheter assembly and method of use 有权
标题翻译：支架输送导管组装及使用方法
公开(公告)号：US06833002B2
公开(公告)日：2004-12-21
申请号：US09885468
申请日：2001-06-19
申请人： Richard S. Stack , Udayan Patel , William J. Boyle , Kent C. B. Stalker , Paul F. Muller
发明人： Richard S. Stack , Udayan Patel , William J. Boyle , Kent C. B. Stalker , Paul F. Muller
IPC分类号： A61F206
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958
摘要： A deformable sheath is attached to a catheter and introduced intravascularly to be expanded against an arterial wall and entrap plaque therebetween. A stent is subsequently deployed within the expanded sheath and the sheath is then withdrawn from within the vasculature to leave the stent expanded against the arterial wall with the plaque entrapped therebetween.
摘要翻译：可变形护套附着在导管上，血管内引入以相对于动脉壁扩张并在其间夹带斑块。随后将支架部署在扩张的护套内，然后从脉管系统中撤出护套，以使支架膨胀抵靠动脉壁，其间夹有斑块。

32. 发明授权

US08367063B2 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 有权
公开(公告)号：US08367063B2
公开(公告)日：2013-02-05
申请号：US12782376
申请日：2010-05-18
申请人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
发明人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
IPC分类号： A61K39/395 , A61K39/00 , C07K16/24 , C07K16/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.

33. 发明授权

US07718776B2 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 有权
标题翻译：人抗OPGL中和抗体作为选择性OPGL途径抑制剂
公开(公告)号：US07718776B2
公开(公告)日：2010-05-18
申请号：US10408901
申请日：2003-04-07
申请人： William J. Boyle , Eugene Medlock , John J. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
发明人： William J. Boyle , Eugene Medlock , John J. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
IPC分类号： C12P21/08 , C07K16/00 , C12P21/04 , A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.
摘要翻译：提供了与骨保护素配体（OPGL）相互作用的单克隆抗体和产生它们的杂交瘤。还提供了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。进一步提供使用OPGL抗体检测样品中OPGL量的方法。

34. 发明申请

US20090274688A1 Antibodies to OPGL 有权
标题翻译： OPGL的抗体
公开(公告)号：US20090274688A1
公开(公告)日：2009-11-05
申请号：US11981664
申请日：2007-10-30
申请人： William J. Boyle , Francis H. Martin , Jose R. Corvalan , C. Geoffrey Davis
发明人： William J. Boyle , Francis H. Martin , Jose R. Corvalan , C. Geoffrey Davis
IPC分类号： A61K39/395 , A61K31/711 , C12N15/63 , C12N5/10 , C12P21/02 , A61P19/00 , G01N33/536 , C07K16/24
CPC分类号： C07K16/2875 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/241 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.
摘要翻译：描述了与骨保护素配体（OPGL）相互作用的抗体。描述了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。描述使用OPGL抗体检测样品中OPGL的量的方法。

35. 发明授权

US06284740B1 Osteoprotegerin 失效
标题翻译：骨保护素
公开(公告)号：US06284740B1
公开(公告)日：2001-09-04
申请号：US08974186
申请日：1997-11-18
申请人： William J. Boyle , David L. Lacey , Frank J. Calzone , Ming-Shi Chang
发明人： William J. Boyle , David L. Lacey , Frank J. Calzone , Ming-Shi Chang
IPC分类号： A01N4304
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译：本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合骨保护素的抗体和药物组合物的核酸。多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。

36. 发明授权

US6136023A Welded sinusoidal wave stent 有权
标题翻译：焊接正弦波支架
公开(公告)号：US6136023A
公开(公告)日：2000-10-24
申请号：US136394
申请日：1998-08-19
申请人： William J. Boyle
发明人： William J. Boyle
IPC分类号： A61F2/00 , A61F2/90 , A61F2/06
CPC分类号： A61F2/90 , A61F2/88 , B21F45/008 , A61F2240/001 , A61F2250/0014
摘要： A wire stent having a preformed series of peaks alternating with valleys. The wire is formed from a malleable or resilient material and can be wound into a continuous helix. Each pair of peaks and valleys constitutes a wave. The stent has a number of waves per circumferential revolution such that the adjoining waves align off-peak to off-valley with one or more such adjoining waves being affixed to each other at the off-peak to off-valley locations. The waves can be welded at all locations or only at the circumferential revolutions at the proximal and distal ends of the stent, or intermittently, or in barber pole fashion or along one or more longitudinal axes.
摘要翻译：具有与谷交替的预成型系列峰的线支架。导线由可延展的或弹性的材料形成，并且可以缠绕成连续的螺旋。每一对峰谷构成一波。每个圆周旋转支架具有多个波浪，使得邻接的波对准偏离峰值到偏离山谷，其中一个或多个这样的邻接波在非高峰到非谷值位置彼此固定。波可以在所有位置处或仅在支架的近端和远端的周向旋转处或者间歇地或以理发杆方式或沿着一个或多个纵向轴线焊接。

37. 发明授权

US6015938A Osteoprotegerin 失效
公开(公告)号：US6015938A
公开(公告)日：2000-01-18
申请号：US974022
申请日：1997-11-18
申请人： William J. Boyle , David L. Lacey , Frank J. Calzone , Ming-Shi Chang
发明人： William J. Boyle , David L. Lacey , Frank J. Calzone , Ming-Shi Chang
IPC分类号： A01K67/027 , A61K35/74 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/705 , C07K14/715 , C07K16/28 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/15 , G01N33/53 , C12N5/00
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.

38. 发明授权

US5913896A Interwoven dual sinusoidal helix stent 失效
标题翻译：交织双正弦螺旋支架
公开(公告)号：US5913896A
公开(公告)日：1999-06-22
申请号：US887585
申请日：1997-07-03
申请人： William J. Boyle , Rosalinda A. Wong , James M. Shy
发明人： William J. Boyle , Rosalinda A. Wong , James M. Shy
IPC分类号： A61F2/90 , A61F2/06 , A61M29/00 , A61M29/02
CPC分类号： A61F2/90 , Y10S623/901
摘要： A method and apparatus for a radially expandable stent for implantation within a body vessel, comprising a first and second wire having a series of alternating peaks and valleys. The valleys of the first wire are braided with the peaks of the second wire forming a braided region with the interwoven first and second wire being wound into a continuous helix having a hollow cylindrical shape. The peaks of the first wire of the continuous helix may be welded to the adjacent valleys of the second wire of the continuous helix. The peaks and valleys of the first wire may symmetrically intersect with the peaks and valleys of the second wire to form a uniform series of crossings thereby permitting even expansion of the first and second wires. The proximal end of the first wire may be attached to the proximal end of the second wire. The distal end of the first wire may be attached to the distal end of the second wire. A means within the interwoven first and second wires of the continuous helix may be included for expansion thereof.
摘要翻译：一种用于植入体内容器的可径向扩张的支架的方法和装置，包括具有一系列交替的峰和谷的第一和第二线。第一线的谷被编织，其中第二线的峰形成编织区域，交织的第一和第二线缠绕成具有中空圆柱形状的连续螺旋。连续螺旋的第一线的峰可以焊接到连续螺旋的第二线的相邻的谷。第一线的峰和谷可以与第二线的峰和谷对称地相交，以形成均匀的一系列交叉，从而允许第一和第二线的均匀膨胀。第一线的近端可以附接到第二线的近端。第一线的远端可以附接到第二线的远端。可以包括连续螺旋的交织的第一和第二丝线内的装置用于其连续扩张。

39. 发明授权

US4734091A Filtered manifold apparatus and method for ophthalmic irrigation 失效
标题翻译：过滤式歧管装置和眼科灌洗方法
公开(公告)号：US4734091A
公开(公告)日：1988-03-29
申请号：US88986
申请日：1987-08-21
申请人： William J. Boyle , Thomas F. Irish
发明人： William J. Boyle , Thomas F. Irish
IPC分类号： A61F9/007 , A61M3/02 , A61M5/00
CPC分类号： A61M3/0241 , A61F9/00736 , Y10T137/87877
摘要： An apparatus and a method for opthalmic irrigation provide sterile, filtered irrigation fluid to the eye at high flow rates. The apparatus includes a filter capable of removing particulates on the order of 0.8 microns, and preferably as small as 0.22 microns. A distribution manifold is disclosed whereby fluid from a common reservoir may be routed sequentially to plural recipient sites.
摘要翻译：用于眼睛冲洗的装置和方法以高流速向眼睛提供无菌的，过滤的灌洗液。该装置包括能够去除约0.8微米，优选小至0.22微米的微粒的过滤器。公开了一种分配歧管，其中来自公共储存器的流体可以顺序地路由到多个接收点。

40. 发明授权

US08455629B2 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 有权
标题翻译：人抗OPGL中和抗体作为选择性OPGL途径抑制剂
公开(公告)号：US08455629B2
公开(公告)日：2013-06-04
申请号：US13360454
申请日：2012-01-27
申请人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
发明人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
IPC分类号： C07H21/04 , C12P21/02 , C12P21/08 , C12N5/16
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.
摘要翻译：提供了与骨保护素配体（OPGL）相互作用的单克隆抗体和产生它们的杂交瘤。还提供了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。进一步提供使用OPGL抗体检测样品中OPGL量的方法。

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