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31. 发明申请

US20070135833A1 RADIOPAQUE EMBOLIC PROTECTION FILTER MEMBRANE 审中-公开
标题翻译：放射性保护过滤膜
公开(公告)号：US20070135833A1
公开(公告)日：2007-06-14
申请号：US11672323
申请日：2007-02-07
申请人： Dnyanesh Talpade , Peter Hirshman , Yem Chin , Sheng-Ping Zhong , Kinh-Luan Dao , James Hansen , Brian Lowe
发明人： Dnyanesh Talpade , Peter Hirshman , Yem Chin , Sheng-Ping Zhong , Kinh-Luan Dao , James Hansen , Brian Lowe
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/008 , A61F2230/0097 , A61F2250/0098 , A61M25/0108
摘要： An embolic protection filter assembly and method of making the same. In at least some embodiments, the present invention relates to embolic protection filters having at least one radiopaque component.
摘要翻译：一种栓塞式保护过滤器组件及其制造方法。在至少一些实施方案中，本发明涉及具有至少一个不透射线组分的栓塞保护过滤器。

32. 发明申请

US20050239508A1 Medical articles having therapeutic-agent-containing regions formed from coalesced polymer particles 有权
标题翻译：具有由聚结聚合物颗粒形成的含治疗剂的区域的医疗制品
公开(公告)号：US20050239508A1
公开(公告)日：2005-10-27
申请号：US10830950
申请日：2004-04-23
申请人： Marlene Schwarz , Robert Richard , Sheng-Ping Zhong
发明人： Marlene Schwarz , Robert Richard , Sheng-Ping Zhong
IPC分类号： A61L27/00 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , H04Q7/20
CPC分类号： A61L29/16 , A61F2250/0067 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： Medical articles, such as drug-releasing patches or implantable or insertable medical devices, which are made up of a medical article substrate and a therapeutic-agent-containing region. The therapeutic-agent-containing region is made up of (i) a water-dispersible therapeutic agent therapeutic agent and (ii) coalesced polymer particles supplied by an aqueous dispersion. Also described are methods of forming such medical articles, and methods of releasing a therapeutic agent within a patient using such medical articles.
摘要翻译：医疗制品，例如药物释放贴剂或可植入或可插入的医疗装置，其由医用制品基底和含治疗剂的区域构成。含治疗剂的区域由（i）水分散性治疗剂治疗剂和（ii）由水分散体供给的聚结聚合物粒子构成。还描述了形成这种医疗制品的方法，以及使用这种医疗用品在患者体内释放治疗剂的方法。

33. 发明申请

US20050220853A1 Controlled delivery of therapeutic agents from medical articles 审中-公开
标题翻译：治疗药物从医疗用品的控制递送
公开(公告)号：US20050220853A1
公开(公告)日：2005-10-06
申请号：US10816677
申请日：2004-04-02
申请人： Kinh-Luan Dao , Anastasia Panos , Yem Chin , Sheng-Ping Zhong
发明人： Kinh-Luan Dao , Anastasia Panos , Yem Chin , Sheng-Ping Zhong
IPC分类号： A61K9/00 , A61K9/70 , A61L27/54 , A61L29/16 , A61L31/16
CPC分类号： A61K9/7023 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/258 , A61L2300/45 , A61L2300/622
摘要： The present invention provides novel adenosine receptor antagonists, more particularly, A1 adenosine receptor antagonists. Pharmaceutical compositions comprising an A1 adenosine receptor antagonist disclosed herein and a pharmaceutically acceptable carrier are further provided. Compositions also include diagnostic assay-type probes comprising a novel A1 adenosine receptor antagonist that is labeled or conjugated with radioactive or non-radioactive material. Methods for treating A1 adenosine receptor related disorders comprising administering an A1 adenosine receptor antagonist of the invention are also disclosed. The novel A1 adenosine receptor antagonist compositions find further use in diagnostic and imaging methods.
摘要翻译：本发明提供了新的腺苷受体拮抗剂，更具体地说是Aβ1腺苷受体拮抗剂。进一步提供包含本文公开的A 1 N 2腺苷受体拮抗剂和药学上可接受的载体的药物组合物。组合物还包括诊断测定型探针，其包含被标记或与放射性或非放射性物质缀合的新的Aβ1 N受体拮抗剂。还公开了治疗A 1/2>腺苷受体相关病症的方法，其包括施用本发明的Aβ1 N 2腺苷受体拮抗剂。新型的A 1 +腺苷受体拮抗剂组合物进一步用于诊断和成像方法。

34. 发明申请

US20050165301A1 Medical devices visible by magnetic resonance imaging 有权
标题翻译：磁共振成像可见的医疗器械
公开(公告)号：US20050165301A1
公开(公告)日：2005-07-28
申请号：US10763690
申请日：2004-01-23
申请人： Scott Smith , Steven Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
发明人： Scott Smith , Steven Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
IPC分类号： A61B19/00 , A61M25/00 , A61M25/01 , G01R33/28 , A61B5/05
CPC分类号： G01R33/285 , A61B2090/3954 , A61M25/0043 , A61M25/0127 , G01R33/286
摘要： Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.
摘要翻译：描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。在一些实施例中，适于插入到本体中的医疗装置包括细长轴和围绕轴的一部分螺旋地延伸的导电路径。导电路径能够连接到电流源。医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。

35. 发明申请

US20050110214A1 Composite stent with inner and outer stent elements and method of using the same 有权
标题翻译：具有内外支架元件的复合支架及其使用方法
公开(公告)号：US20050110214A1
公开(公告)日：2005-05-26
申请号：US10962567
申请日：2004-10-13
申请人： Peter Shank , Sheng-Ping Zhong , Kinh-Luan Dao , F. Headley
发明人： Peter Shank , Sheng-Ping Zhong , Kinh-Luan Dao , F. Headley
IPC分类号： A61F2/00 , A61F2/86 , A63F3/08
CPC分类号： A61F2/82 , A61F2/07 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0076 , A61F2220/0008 , A61F2220/0041 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2250/0067 , A61L31/129 , A61L31/146 , B05D1/002
摘要： An endoprosthesis comprising a stent, a cover fully covering the stent wherein the cover has variable porosity in the radial direction; and an adhesion layer connecting the stent to the cover. Another aspect of the invention is a method of implanting an endoprosthesis which includes a stent, providing a cover with variable porosity in the radial direction, connecting the stent to the cover with an adhesion layer to form a covered stent, and implanting the covered stent within a body lumen of a patient.
摘要翻译：包括支架的内置假体，完全覆盖所述支架的盖，其中所述盖在径向上具有可变孔隙度; 以及将支架连接到盖上的粘合层。本发明的另一方面是植入内置假体的方法，其包括支架，在径向方向上提供具有可变孔隙率的覆盖物，用粘附层将支架连接到覆盖物以形成覆盖的支架，以及将覆盖的支架植入患者的体腔。

36. 发明授权

US06685718B1 Expandable ablation burr 失效
标题翻译：可扩展消融毛刺
公开(公告)号：US06685718B1
公开(公告)日：2004-02-03
申请号：US09629771
申请日：2000-07-31
申请人： Mark H. Wyzgala , Eric B. Hamilton , Thomas J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
发明人： Mark H. Wyzgala , Eric B. Hamilton , Thomas J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
IPC分类号： A61B1732
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/00557 , A61B2017/00867 , A61B2017/320004 , A61B2017/320733
摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. When the burr is rotated, the polymeric tube expands by centrifugal force. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes a system for preventing the loose ablated particulate from reembolizing in the distal vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end that is pulled back toward the guide catheter to ablate the lesion. The burr creates a seal when expanded to block the ablated particulate so that the aspiration system can remove the particulate from the patient vessel or stent. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath so that a slight vacuum can remove the large loose particulate form, the patient's vessel or stent.
摘要翻译：粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。当毛刺旋转时，聚合物管通过离心力膨胀。毛刺的最大膨胀由膨胀机构控制。公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。此外，本发明还包括一种用于防止松散的消融颗粒在远端脉管系统中再栓塞的系统。该系统包括消融毛刺，其具有设置在近端上的磨料，其被拉回导向导管以烧蚀病变。当膨胀时，毛刺产生密封以阻挡消融的颗粒，使得吸气系统可以从患者的血管或支架中移除颗粒。或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封，使得轻微的真空可以从患者的血管或支架中移除大的松散颗粒。

37. 发明授权

US06197051B1 Polycarbonate-polyurethane dispersions for thromobo-resistant coatings 有权
标题翻译：聚碳酸酯 - 聚氨酯分散体用于耐三氟乙烯涂料
公开(公告)号：US06197051B1
公开(公告)日：2001-03-06
申请号：US09248307
申请日：1999-02-11
申请人： Sheng-Ping Zhong
发明人： Sheng-Ping Zhong
IPC分类号： A61F206
CPC分类号： A61L33/062 , C08L75/04
摘要： A medical device is described which has on a surface thereof a bio-compatible coating. This bio-compatible coating is formed from a composition which includes an aqueous emulsion or dispersion of a polycarbonate-polyurethane composition containing one or more internal emulsifying agents.
摘要翻译：描述了在其表面上具有生物相容性涂层的医疗装置。该生物相容性涂层由包含含有一种或多种内部乳化剂的聚碳酸酯 - 聚氨酯组合物的水性乳液或分散体的组合物形成。

38. 发明授权

US06179817B2 Hybrid coating for medical devices 失效
标题翻译：医疗器械混合涂层
公开(公告)号：US06179817B2
公开(公告)日：2001-01-30
申请号：US09238707
申请日：1999-01-28
申请人： Sheng-Ping Zhong
发明人： Sheng-Ping Zhong
IPC分类号： A61J300
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/21 , A61L2300/608 , C08L75/04
摘要： Disclosed are hybrid coatings for implantable medical devices. Such coatings include a first layer of an aqueous dispersion or emulsion of an organic acid functional group containing polymer, a crosslinker and a therapeutic agent dispersed therein. The coating also includes a second layer of an aqueous solution or dispersion of an organic acid functional group-containing bio-active agent. The hybrid coatings are especially suited for preventing restenosis of endoprostheses by the combined action of the therapeutic agent and the bio-active agent. Methods of making and using devices coated with such compositions are also provided.
摘要翻译：公开了用于可植入医疗装置的混合涂层。这样的涂层包括分散有有机酸官能团的聚合物，交联剂和治疗剂的水性分散体或乳液的第一层。涂层还包括含有机酸官能团的生物活性剂的水溶液或分散体的第二层。混合涂层特别适用于通过治疗剂和生物活性剂的联合作用来防止内用假体的再狭窄。还提供了制造和使用涂有这些组合物的装置的方法。

39. 发明授权

US5702754A Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings 失效
标题翻译：提供具有亲水涂层的基底和具有这种涂层的基底，特别是医疗装置的方法
公开(公告)号：US5702754A
公开(公告)日：1997-12-30
申请号：US392141
申请日：1995-02-22
申请人： Sheng-Ping Zhong
发明人： Sheng-Ping Zhong
IPC分类号： A61M25/00 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/00 , A61L31/16 , C03C17/32 , C08J7/04 , C08L33/02 , C08L75/00 , C08L75/04 , C09D201/00 , B05D1/36 , B05D3/02 , B05D5/08 , B05D7/02
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L2300/21 , A61L2300/608 , A61L2420/08 , Y10T428/31565 , Y10T428/31573 , Y10T428/31576 , Y10T428/3158
摘要： A substrate such as a catheter or a guide wire is provided with a lubricous, hydrophilic abrasion-resistant coating by: a) coating said substrate with a first aqueous coating composition comprising an aqueous dispersion or emulsion of a polymer having organic acid functional groups and a polyfunctional crosslinking agent having functional groups capable of reacting with organic acid groups, and drying the coating to obtain a substantially water-insoluble coating layer having excess polyfunctional including functional groups being reactive with organic acid groups remaining, and b) contacting the dried coating layer obtained in a) with a second aqueous coating composition comprising an aqueous solution or dispersion of a hydrophilic polymer having organic acid functional groups, and drying the combined coating, the hydrophilic polymer thereby becoming bonded to the polymer of the first coating composition through the excess crosslinking agent. The drying can be carried out at ambient (room) temperature.
摘要翻译：诸如导管或引导线之类的基材通过以下方式设置有润滑的亲水性耐磨涂层：a）用第一含水涂料组合物涂覆所述基材，所述第一水性涂料组合物包含具有有机酸官能团的聚合物的水性分散体或乳液，和具有能够与有机酸基反应的官能团的多官能交联剂，并干燥该涂层以获得具有过剩多官能团的基本上不溶于水的涂层，所述多官能团包含与残留的有机酸基团反应的官能团，以及b）使获得的干燥涂层在a）中，使用包含具有有机酸官能团的亲水性聚合物的水溶液或分散体的第二水性涂料组合物，并干燥组合的涂层，亲水性聚合物因此通过过量交联剂与第一涂料组合物的聚合物结合。干燥可在室温下进行。

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