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31. 发明申请

US20110125223A1 NEUROSTIMULATION SYSTEM AND METHOD FOR COMPOUNDING CURRENT TO MINIMIZE CURRENT SOURCES 有权
标题翻译：用于组合电流以最小化电流源的神经网络系统和方法
公开(公告)号：US20110125223A1
公开(公告)日：2011-05-26
申请号：US12952738
申请日：2010-11-23
申请人： Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
发明人： Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/36185 , A61N1/37223 , A61N1/37241 , A61N1/37288 , A61N2001/083
摘要： A neurostimulation system and method of providing therapy to a patient implanted with a plurality of electrodes using a plurality of electrical sources is provided. A source-electrode coupling configuration is determined from the electrical sources and electrodes. Electrical current is respectively conveyed between active ones of the plurality of electrical sources and active subsets of the plurality of electrodes in accordance with the determined source-electrode coupling configuration. The total number of the electrodes in the active electrode subsets is greater than the total number of the active electrical sources.
摘要翻译：提供了一种使用多个电源向注入多个电极的患者提供治疗的神经刺激系统和方法。源电极耦合配置由电源和电极确定。根据所确定的源电极耦合配置，电流分别在多个电源中的有效电源和多个电极的有效子集之间传送。有源电极子集中的电极总数大于有源电源的总数。

32. 发明申请

US20070156180A1 Methods and systems for treating osteoarthritis 有权
标题翻译：治疗骨关节炎的方法和系统
公开(公告)号：US20070156180A1
公开(公告)日：2007-07-05
申请号：US11322763
申请日：2005-12-30
申请人： Kristen Jaax , Rafael Carbunaru , Todd Whitehurst
发明人： Kristen Jaax , Rafael Carbunaru , Todd Whitehurst
IPC分类号： A61N1/02
CPC分类号： A61N1/32 , A61M5/14276 , A61M5/172 , A61M2205/054 , A61M2205/3523 , A61M2205/3569 , A61M2205/8243 , A61N1/36071 , A61N1/37205
摘要： Methods of treating osteoarthritis include applying at least one stimulus to a stimulation site within a patient with an implanted system control unit in accordance with one or more stimulation parameters. Systems for treating osteoarthritis include a system control unit configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters.
摘要翻译：治疗骨关节炎的方法包括根据一个或多个刺激参数用植入的系统控制单元对患者内的刺激部位施加至少一种刺激。用于治疗骨关节炎的系统包括系统控制单元，其被配置为根据一个或多个刺激参数将至少一个刺激施加到患者内的刺激部位。

33. 发明申请

US20070100389A1 Treatment of aphasia by electrical stimulation and/or drug infusion 失效
标题翻译：通过电刺激和/或药物输注治疗失语症
公开(公告)号：US20070100389A1
公开(公告)日：2007-05-03
申请号：US11264436
申请日：2005-11-01
申请人： Kristen Jaax , Rafael Carbunaru , Todd Whitehurst
发明人： Kristen Jaax , Rafael Carbunaru , Todd Whitehurst
IPC分类号： A61N1/00
CPC分类号： A61N1/36082 , A61M5/14276 , A61M2205/054 , A61M2205/3523 , A61M2205/3546 , A61M2205/3569 , A61M2205/8243 , A61M2210/0693 , A61N1/37205
摘要： Systems and methods are provided for applying electrical stimulation and/or introducing one or more stimulating drugs to the brain to treat or prevent aphasia, including through use of at least one system control unit (SCU) for controlling electrical pulses delivered via electrodes implanted in the brain and/or for producing drug infusion pulses to targeted areas in the brain.
摘要翻译：提供的系统和方法用于对脑进行电刺激和/或引入一种或多种刺激药物以治疗或预防失语，包括通过使用至少一个系统控制单元（SCU）来控制经由植入在脑和/或产生药物输注脉冲到脑中的目标区域。

34. 发明申请

US20060194724A1 Methods and systems for nerve regeneration 审中-公开
标题翻译：神经再生的方法和系统
公开(公告)号：US20060194724A1
公开(公告)日：2006-08-31
申请号：US11066993
申请日：2005-02-25
申请人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Kelly McClure , Kristen Jaax
发明人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Kelly McClure , Kristen Jaax
IPC分类号： A61K38/18 , A61N1/18
CPC分类号： A61K38/185 , A61K9/0024 , A61K38/45 , A61N1/326
摘要： An exemplary method of regenerating a nerve within a patient includes implanting a system control unit within the patient and applying a stimulus to the nerve with the system control unit in accordance with one or more control parameters. The stimulus is configured to promote regeneration of the nerve. An exemplary system for regenerating a nerve within a patient includes a system control unit configured to apply a stimulus to the nerve in accordance with one or more control parameters. The system control unit is implanted within the patient and the stimulus promotes the regeneration of the nerve.
摘要翻译：在患者内再生神经的示例性方法包括将系统控制单元植入患者体内，并根据一个或多个控制参数与系统控制单元向神经施加刺激。刺激被配置成促进神经再生。用于再生患者内的神经的示例性系统包括系统控制单元，其被配置为根据一个或多个控制参数将刺激应用于神经。系统控制单元植入患者体内，刺激促进神经再生。

35. 发明申请

US20050240229A1 Methods and systems for stimulation as a therapy for erectile dysfunction 审中-公开
标题翻译：刺激作为勃起功能障碍治疗的方法和系统
公开(公告)号：US20050240229A1
公开(公告)日：2005-10-27
申请号：US11141443
申请日：2005-05-31
申请人： Tood Whitehurst , James McGivern , Kristen Jaax , James Makous
发明人： Tood Whitehurst , James McGivern , Kristen Jaax , James Makous
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372
CPC分类号： A61N1/37211 , A61N1/36007 , A61N1/372 , A61N1/37205
摘要： Systems and methods for stimulating tissue affecting the penis to treat erectile dysfunction may include stimulation using at least one implantable system control unit (SCU).
摘要翻译：刺激影响阴茎治疗勃起功能障碍的组织的系统和方法可以包括使用至少一个可植入系统控制单元（SCU）的刺激。

36. 发明授权

US09345878B2 System and method for compensating for shifting of neurostimulation leads in a patient 有权
标题翻译：用于补偿患者神经刺激导线移位的系统和方法
公开(公告)号：US09345878B2
公开(公告)日：2016-05-24
申请号：US12495442
申请日：2009-06-30
申请人： Andrew DiGiore , Kristen Jaax , Courtney Lane
发明人： Andrew DiGiore , Kristen Jaax , Courtney Lane
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.
摘要翻译：提供了一种用于确定神经刺激引线相对于患者的刺激目标组织的位置变化的方法。该方法包括在患者的表面上植入第一接近传感器，在患者的表面上植入第二接近传感器，测量第一和第二接近传感器之间的距离的变化，并推断引线的位置变化相对于刺激目标组织的距离测量的变化。该方法还包括当第一和第二接近传感器之间的距离增加时，推断引线和刺激目标组织之间的距离的增加。该方法还包括传送电刺激能量以治疗刺激刺激目标组织，以及响应于所测量的距离变化来调制刺激参数。

37. 发明申请

US20100331922A1 SYSTEM AND METHOD FOR COMPENSATING FOR SHIFTING OF NEUROSTIMULATION LEADS IN A PATIENT 有权
标题翻译：用于补偿患者神经细胞发生突变的系统和方法
公开(公告)号：US20100331922A1
公开(公告)日：2010-12-30
申请号：US12495442
申请日：2009-06-30
申请人： Andrew DiGiore , Kristen Jaax , Courtney Lane
发明人： Andrew DiGiore , Kristen Jaax , Courtney Lane
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.
摘要翻译：提供了一种用于确定神经刺激引线相对于患者的刺激目标组织的位置变化的方法。该方法包括在患者的表面上植入第一接近传感器，在患者的表面上植入第二接近传感器，测量第一和第二接近传感器之间的距离的变化，并推断引线的位置变化相对于刺激目标组织的距离测量的变化。该方法还包括当第一和第二接近传感器之间的距离增加时，推断引线和刺激目标组织之间的距离的增加。该方法还包括传送电刺激能量以治疗刺激刺激目标组织，以及响应于所测量的距离变化来调制刺激参数。

38. 发明申请

US20110160797A1 METHODS TO CONCURRENTLY STIMULATE DIFFERENT BRAIN TARGETS 审中-公开
标题翻译：同时刺激不同脑部目标的方法
公开(公告)号：US20110160797A1
公开(公告)日：2011-06-30
申请号：US12976764
申请日：2010-12-22
申请人： James C. Makous , Courtney Lane , Kristen Jaax , Andrew DiGiore
发明人： James C. Makous , Courtney Lane , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/00 , A61N1/0534 , A61N1/36064 , A61N1/36171
摘要： A method for treating a patient having a dysfunction using a stimulation lead within the brain of a patient is provided. The stimulation lead carries a plurality of electrodes adjacent to a plurality of brain regions. Pulsed electrical waveforms having different sets of stimulation parameters are generated and then concurrently delivered to the plurality of electrodes, thereby concurrently stimulating the plurality of brain regions to treat the dysfunction.
摘要翻译：提供了一种使用患者脑内的刺激铅治疗具有功能障碍的患者的方法。刺激引线携带与多个脑区域相邻的多个电极。产生具有不同组刺激参数的脉冲电波形，然后同时传送到多个电极，从而同时刺激多个脑区域来治疗功能障碍。

39. 发明授权

US08315707B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08315707B2
公开(公告)日：2012-11-20
申请号：US13423245
申请日：2012-03-18
申请人： Kristen Jaax , Andrew DiGiore
发明人： Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method of operating a neurostimulation device comprises varying a first stimulation parameter under user control while fixing a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed second stimulation parameter, outputting a pulsed electrical waveform from the neurostimulation device between electrodes in accordance with the stimulation parameter sets, such that a therapeutic effect is achieved while allowing neural tissue to undergo neurological accommodation, changing the second stimulation parameter, varying the first stimulation parameter under user control while fixing the second changed stimulation parameter, generating another plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed changed second stimulation parameter, and outputting the pulsed electrical waveform from the neurostimulation device between the electrodes in accordance with the other stimulation parameter sets to maintain the therapeutic effect while the neural tissue is neurologically accommodated.
摘要翻译：操作神经刺激装置的方法包括在固定第二刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定的第二刺激参数产生多个刺激参数集，输出来自神经刺激装置，根据刺激参数组，使得在允许神经组织经历神经学调节的同时实现治疗效果，改变第二刺激参数，在固定第二改变的刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定改变的第二刺激参数产生另外多个刺激参数集合，并且根据另一个st从电极之间的神经刺激装置输出脉冲电波形模拟参数集，以在神经组织神经学适应的同时保持治疗效果。

40. 发明申请

US20120179222A1 SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMMODATION TO ELECTRICAL STIMULATION 有权
标题翻译：用于避免，反转和管理神经病学接受电刺激的系统和方法
公开(公告)号：US20120179222A1
公开(公告)日：2012-07-12
申请号：US13423245
申请日：2012-03-18
申请人： Kristen Jaax , DIGIORE ANDREW
发明人： Kristen Jaax , DIGIORE ANDREW
IPC分类号： A61N1/36
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method of operating a neurostimulation device comprises varying a first stimulation parameter under user control while fixing a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed second stimulation parameter, outputting a pulsed electrical waveform from the neurostimulation device between electrodes in accordance with the stimulation parameter sets, such that a therapeutic effect is achieved while allowing neural tissue to undergo neurological accommodation, changing the second stimulation parameter, varying the first stimulation parameter under user control while fixing the second changed stimulation parameter, generating another plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed changed second stimulation parameter, and outputting the pulsed electrical waveform from the neurostimulation device between the electrodes in accordance with the other stimulation parameter sets to maintain the therapeutic effect while the neural tissue is neurologically accommodated.
摘要翻译：操作神经刺激装置的方法包括在固定第二刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定的第二刺激参数产生多个刺激参数集，输出来自神经刺激装置，根据刺激参数组，使得在允许神经组织经历神经学调节的同时实现治疗效果，改变第二刺激参数，在固定第二改变的刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定改变的第二刺激参数产生另外多个刺激参数集合，并且根据另一个st从电极之间的神经刺激装置输出脉冲电波形模拟参数集，以在神经组织神经学适应的同时保持治疗效果。

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